{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:48:28Z","timestamp":1790880508467,"version":"4.1.0"},"reference-count":43,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["EY031697"],"award-info":[{"award-number":["EY031697"]}]},{"name":"NIH","award":["EY034116"],"award-info":[{"award-number":["EY034116"]}]},{"name":"NIH","award":["NS129684"],"award-info":[{"award-number":["NS129684"]}]},{"name":"NIH","award":["AG081004"],"award-info":[{"award-number":["AG081004"]}]},{"name":"NIH","award":["P30EY022589"],"award-info":[{"award-number":["P30EY022589"]}]},{"name":"NIH","award":["HL136275"],"award-info":[{"award-number":["HL136275"]}]},{"name":"NIH","award":["HL171505"],"award-info":[{"award-number":["HL171505"]}]},{"name":"NIH","award":["AG081037"],"award-info":[{"award-number":["AG081037"]}]},{"name":"Research to Prevent Blindness (New York, NY)","award":["EY031697"],"award-info":[{"award-number":["EY031697"]}]},{"name":"Research to Prevent Blindness (New York, NY)","award":["EY034116"],"award-info":[{"award-number":["EY034116"]}]},{"name":"Research to Prevent Blindness (New York, NY)","award":["NS129684"],"award-info":[{"award-number":["NS129684"]}]},{"name":"Research to Prevent Blindness (New York, NY)","award":["AG081004"],"award-info":[{"award-number":["AG081004"]}]},{"name":"Research to Prevent Blindness (New York, NY)","award":["P30EY022589"],"award-info":[{"award-number":["P30EY022589"]}]},{"name":"Research to Prevent Blindness (New York, NY)","award":["HL136275"],"award-info":[{"award-number":["HL136275"]}]},{"name":"Research to Prevent Blindness (New York, NY)","award":["HL171505"],"award-info":[{"award-number":["HL171505"]}]},{"name":"Research to Prevent Blindness (New York, NY)","award":["AG081037"],"award-info":[{"award-number":["AG081037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Glaucoma, an optic neuropathy with the loss of retinal ganglion cells (RGCs), is a leading cause of irreversible vision loss. Oxidative stress and mitochondrial dysfunction have a significant role in triggering glia-driven neuroinflammation and subsequent glaucomatous RGC degeneration in the context of glaucoma. It has previously been shown that apolipoprotein A-I binding protein (APOA1BP or AIBP) has an anti-inflammatory function. Moreover, Apoa1bp\u2212\/\u2212 mice are characterized by retinal neuroinflammation and RGC loss. In this study, we found that AIBP deficiency exacerbated the oxidative stress-induced disruption of mitochondrial dynamics and function in the retina, leading to a further decline in visual function. Mechanistically, AIBP deficiency-induced oxidative stress triggered a reduction in glycogen synthase kinase 3\u03b2 and dynamin-related protein 1 phosphorylation, optic atrophy type 1 and mitofusin 1 and 2 expression, and oxidative phosphorylation, as well as the activation of mitogen-activated protein kinase (MAPK) in M\u00fcller glia dysfunction, leading to cell death and inflammatory responses. In vivo, the administration of recombinant AIBP (rAIBP) effectively protected the structural and functional integrity of retinal mitochondria under oxidative stress conditions and prevented vision loss. In vitro, incubation with rAIBP safeguarded the structural integrity and bioenergetic performance of mitochondria and concurrently suppressed MAPK activation, apoptotic cell death, and inflammatory response in M\u00fcller glia. These findings support the possibility that AIBP promotes RGC survival and restores visual function in glaucomatous mice by ameliorating glia-driven mitochondrial dysfunction and neuroinflammation.<\/jats:p>","DOI":"10.3390\/antiox13101252","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T04:42:15Z","timestamp":1729140135000},"page":"1252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["AIBP Protects M\u00fcller Glial Cells Against Oxidative Stress-Induced Mitochondrial Dysfunction and Reduces Retinal Neuroinflammation"],"prefix":"10.3390","volume":"13","author":[{"given":"Seunghwan","family":"Choi","sequence":"first","affiliation":[{"name":"Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1152-1509","authenticated-orcid":false,"given":"Soo-Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, La Jolla, CA 92039, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3779-7178","authenticated-orcid":false,"given":"Tonking","family":"Bastola","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"National Center for Microscopy and Imaging Research, Department of Neurosciences, University of California San Diego, La Jolla, CA 92039, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungsik","family":"Park","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9553-3202","authenticated-orcid":false,"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury I.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, La Jolla, CA 92039, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1117-4834","authenticated-orcid":false,"given":"Won-Kyu","family":"Ju","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92039, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","article-title":"Primary open-angle glaucoma","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat. 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