{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:36:46Z","timestamp":1791491806238,"version":"4.3.4"},"reference-count":56,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese Institutes for Medical Research, Beijing","award":["CX23YZ06"],"award-info":[{"award-number":["CX23YZ06"]}]},{"name":"Chinese Institutes for Medical Research, Beijing","award":["ZLRK202308"],"award-info":[{"award-number":["ZLRK202308"]}]},{"name":"Beijing Hospitals Authority Clinical Medicine Development","award":["CX23YZ06"],"award-info":[{"award-number":["CX23YZ06"]}]},{"name":"Beijing Hospitals Authority Clinical Medicine Development","award":["ZLRK202308"],"award-info":[{"award-number":["ZLRK202308"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cerebral ischemia\u2013reperfusion injury significantly contributes to global morbidity and mortality. Loganin is a natural product with various neuroprotective effects; however, it lacks targeted specificity for particular cells or receptors, which may result in reduced therapeutic efficacy and an increased risk of side effects. To address the limitations of loganin, we developed LA-1, a novel compound incorporating an Arg-Gly-Asp (RGD) peptide to target integrin receptor \u03b1v\u03b23, enhancing brain-targeting efficacy. LA-1 exhibited optimal nanoscale properties, significantly improved cell viability, reduced ROS production, and enhanced survival rates in vitro. In vivo, LA-1 decreased infarct sizes, improved neurological function, and reduced oxidative stress and neuroinflammation. Proteomic analysis showed LA-1 modulates PI3K\/Akt and Nrf2\/HO-1 pathways, providing targeted neuroprotection. These findings suggest LA-1\u2019s potential for clinical applications in treating cerebral ischemia\u2013reperfusion injury.<\/jats:p>","DOI":"10.3390\/antiox13111339","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:59:54Z","timestamp":1730437194000},"page":"1339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An RGD-Conjugated Prodrug Nanoparticle with Blood\u2013Brain\u2013Barrier Penetrability for Neuroprotection Against Cerebral Ischemia\u2013Reperfusion Injury"],"prefix":"10.3390","volume":"13","author":[{"given":"Ayijiang","family":"Taledaohan","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, China"},{"name":"Department of Medicinal Chemistry, Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Beijing Laboratory of Biomedical Materials, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, 10 Xi Tou Tiao, You An Men, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maer Maer","family":"Tuohan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, China"},{"name":"Department of Medicinal Chemistry, Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Beijing Laboratory of Biomedical Materials, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, 10 Xi Tou Tiao, You An Men, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renbo","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, China"},{"name":"Department of Medicinal Chemistry, Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Beijing Laboratory of Biomedical Materials, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, 10 Xi Tou Tiao, You An Men, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, China"},{"name":"Department of Medicinal Chemistry, Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Beijing Laboratory of Biomedical Materials, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, 10 Xi Tou Tiao, You An Men, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liujia","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, 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