{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:25:24Z","timestamp":1768807524889,"version":"3.49.0"},"reference-count":47,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Society of Pneumology","award":["SEPAR N\u00ba 1383\/23"],"award-info":[{"award-number":["SEPAR N\u00ba 1383\/23"]}]},{"name":"Spanish Society of Pneumology","award":["N\u00ba 1616\/24"],"award-info":[{"award-number":["N\u00ba 1616\/24"]}]},{"name":"Spanish Society of Pneumology","award":["Project PID2020-114787RBI00"],"award-info":[{"award-number":["Project PID2020-114787RBI00"]}]},{"name":"Spanish Society of Pneumology","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["SEPAR N\u00ba 1383\/23"],"award-info":[{"award-number":["SEPAR N\u00ba 1383\/23"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["N\u00ba 1616\/24"],"award-info":[{"award-number":["N\u00ba 1616\/24"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["Project PID2020-114787RBI00"],"award-info":[{"award-number":["Project PID2020-114787RBI00"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>With the rationale that the oxidative potential of particulate matter (PM-OP) may induce oxidative stress and inflammation, we conducted the ASTHMA-FENOP study in which 44 asthmatic patients and 37 matched controls wore a personal sampler for 24 h, allowing the collection of fine and coarse PM fractions separately, to determine PM-OP by the dithiothreitol (DTT) and ascorbic acid (AA) methods. The levels of Interleukin 6 (IL-6) and the IL-6\/IL-10 ratio, as indicators of pro- and anti-inflammatory statuses, were determined by calculating the mean differences (MDs), odds ratios (ORs) and p-trends adjusted for sex, age, study level and body mass index. Positive associations for IL-6 levels in the form of adjusted MDs and ORs were obtained for all PM-OP metrics, reaching statistical significance for both OP-DTT and OP-AA in the fine fraction, with adjusted OR = 5.66; 95%CI (1.46 to 21.92) and 3.32; 95%CI (1.07 to 10.35), respectively, along with statistically significant dose\u2013response patterns when restricting to asthma and adjusted also for clinical variables (adjusted p-trend = 0.029 and 0.01). Similar or stronger associations and dose\u2013response patterns were found for the IL-6\/IL-10 ratio. In conclusion, our findings on the effect of PM-OP on systemic inflammation support that asthma is a heterogeneous disease at the molecular level, with PM-OP potentially playing an important role.<\/jats:p>","DOI":"10.3390\/antiox13121464","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T02:57:08Z","timestamp":1732849028000},"page":"1464","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Oxidative Potential of Particulate Matter Collected by Personal Samplers and Systemic Inflammation Among Asthmatic and Non-Asthmatic Adults"],"prefix":"10.3390","volume":"13","author":[{"given":"Miguel","family":"Santib\u00e1\u00f1ez","sequence":"first","affiliation":[{"name":"Global Health Research Group, Faculty of Nursing, Universidad de Cantabria-Valdecilla Research Institute (IDIVAL), Avenida Valdecilla, s\/n, 39008 Santander, Cantabria, 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-2728","authenticated-orcid":false,"given":"Laura","family":"Ruiz-Azcona","sequence":"additional","affiliation":[{"name":"Global Health Research Group, Faculty of Nursing, Universidad de Cantabria-Valdecilla Research Institute (IDIVAL), Avenida Valdecilla, s\/n, 39008 Santander, Cantabria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0562-427X","authenticated-orcid":false,"given":"Marcos","family":"Lopez-Hoyos","sequence":"additional","affiliation":[{"name":"Division of Immunology, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, 39008 Santander, Cantabria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-8671","authenticated-orcid":false,"given":"Juan","family":"Irure","sequence":"additional","affiliation":[{"name":"Division of Immunology, Hospital 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