{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:15:03Z","timestamp":1773152103541,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ayuda del Plan Regional de Investigaci\u00f3n de la Comunidad de Madrid","award":["08.1\/0013.1"],"award-info":[{"award-number":["08.1\/0013.1"]}]},{"name":"Ayuda del Plan Regional de Investigaci\u00f3n de la Comunidad de Madrid","award":["PR1\/03"],"award-info":[{"award-number":["PR1\/03"]}]},{"name":"Proyecto Investigaci\u00f3n Complutense","award":["08.1\/0013.1"],"award-info":[{"award-number":["08.1\/0013.1"]}]},{"name":"Proyecto Investigaci\u00f3n Complutense","award":["PR1\/03"],"award-info":[{"award-number":["PR1\/03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Alterations in the gastric mucosal barrier, one of whose fundamental components is phosphatidylcholine (PC), may play an important role in the pathophysiology of erosive gastritis secondary to sepsis. Pentoxifylline (PTX) has been shown to reduce tissue damage in various experimental models of sepsis. The aim of this study was to investigate the effect of PTX on gastric mucosa PC synthesis, leukocyte infiltration, arachidonic acid-related metabolites, inflammation, oxidative stress, NO, CO, and somatostatin in a rat model of LPS-induced sepsis. Rats were administered LPS (10 mg\/kg b.w.) intraperitoneally. After 30 min (early treatment group) or 120 min (late treatment group) of LPS administration, they were randomly divided into two groups that were intraperitoneally administered saline (5 mL\/kg; LPS + Saline group) or PTX (45 mg\/kg; 5 mL\/kg; LPS + PTX group). Control rats received only saline instead of LPS and\/or PTX. Two hours after saline or PTX administration (total of 150 or 240 min of procedure), animals were anesthetized, and then gastric lavage, gastric mucosa and plasma samples were obtained and kept frozen until determination. LPS-induced sepsis changed the gastric mucosal barrier by reducing its phospholipid content, PGI2, and somatostatin levels, as well as increasing MPO, TXB2, LTB4, PLA2, and MDA. Alterations may be mediated, at least in part, by modifications in the production of NO, CO, and cGMP content. PTX had a beneficial effect on gastric lesions secondary to sepsis by restoring PC production.<\/jats:p>","DOI":"10.3390\/antiox13121481","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T04:47:22Z","timestamp":1733287642000},"page":"1481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protective Effect of Pentoxifylline on the Development of Acute Gastric Mucosal Injury in a Model of LPS-Induced Sepsis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4646-4199","authenticated-orcid":false,"given":"Sergio D.","family":"Paredes","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Complutense University of Madrid, Avda. Complutense, s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Hern\u00e1ndez-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University of Madrid, Avda. Complutense, s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzin","family":"Falahat","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, Complutense University of Madrid, Avda. Complutense, s\/n, 28040 Madrid, Spain"},{"name":"Oral and Maxillofacial Surgery Service, Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-192X","authenticated-orcid":false,"given":"Lisa","family":"Rancan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University of Madrid, Avda. Complutense, s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3002-3305","authenticated-orcid":false,"given":"Javier","family":"Arias-D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, Complutense University of Madrid, Avda. Complutense, s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-5215","authenticated-orcid":false,"given":"Elena","family":"Vara","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University of Madrid, Avda. Complutense, s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.12968\/bjon.2022.31.8.422","article-title":"Shock: Aetiology, pathophysiology and management","volume":"31","author":"Blumlein","year":"2022","journal-title":"Br. J. 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