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Dimethyl fumarate (DMF) and its primary active metabolite, monomethyl fumarate (MMF), are Nrf2 activators and have been recognized as strategic antioxidants. This study aimed to evaluate the potential of MMF and DMF to interfere with adipogenesis and obesity, and identify the molecular mechanisms involved. The 3T3-L1 preadipocytes were incubated with differentiation medium (MIX) and simultaneously treated with different concentrations of MMF. In addition, male C57BL\/6 mice were fed a standard diet or high-fat\/high-sucrose diet (HFHSD) for 16 weeks, during the last 4 of which, they received oral DMF treatment. Exposure to MMF prevented the development of MIX-induced adipogenesis by reducing the expression of transcription factors that drive adipocyte differentiation and by decreasing triglyceride levels. In addition, various antioxidant and anti-inflammatory effects were observed after treatment with MMF as evidenced by the modulation of transcription factor activities and reduction in reactive oxygen species, adipokine, proinflammatory cytokine and resistin levels. In vivo treatment with DMF reduced calorie intake, body weight, and visceral and subcutaneous fat mass in HFHSD mice. Furthermore, DMF administration led to a better glycemic response as well as lower leptin and adiponectin plasma levels in these animals. Our data demonstrate that DMF and its metabolite MMF interfere with adipogenesis and prevent the key features of diet-induced obesity. Considering DMF is already a commercial drug used to treat psoriasis and multiple sclerosis, its pharmacological application for the treatment of obesity and related metabolic disorders holds promise.<\/jats:p>","DOI":"10.3390\/antiox13121496","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:01:37Z","timestamp":1733716897000},"page":"1496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic Potential of Dimethyl Fumarate for the Treatment of High-Fat\/High-Sucrose Diet-Induced Obesity"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-3362","authenticated-orcid":false,"given":"Helber da Maia","family":"Valenca","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Avenida Carlos Chagas Filho 373, bloco F, 3\u00b0 floor, room 301, Cidade Universit\u00e1ria, 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4091-5865","authenticated-orcid":false,"given":"Alexsandro Tavares","family":"Figueiredo-Junior","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Avenida Carlos Chagas Filho 373, bloco F, 3\u00b0 floor, room 301, Cidade Universit\u00e1ria, Rio de Janeiro CEP 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Verdini","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Avenida Carlos Chagas Filho 373, bloco F, 3\u00b0 floor, room 301, Cidade Universit\u00e1ria, Rio de Janeiro CEP 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-8694","authenticated-orcid":false,"given":"Bruna","family":"Romana-Souza","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, State University of Rio de Janeiro (UERJ), Rua Professor Manoel de Abreu, 444, 3\u00b0 andar, Rio de Janeiro CEP 20550-170, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-5272","authenticated-orcid":false,"given":"Mariana","family":"Renovato-Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation and Metabolism, Biology Institute, Departament of Cellular and Molecular Biology, Fluminense Federal University (UFF), Rua Professor Marcos Waldemar de Freitas Reis, s\/n, Campus do Gragoat\u00e1, Bloco M, room 316, Niter\u00f3i CEP 24210-201, RJ, 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(2023). Distinct inflammatory signatures of upper and lower body adipose tissue and adipocytes in women with normal weight or obesity. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1205799"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Li, S., Zhang, W., Fu, Z., and Liu, H. (2023). Impact of obesity on all-cause and cause-specific mortality among critically ill men and women: A cohort study on the eicu database. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1143404"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1111\/dom.15114","article-title":"Inclusion of drugs on the world health organization\u2019s essential medicines list: A game-changer for obesity?","volume":"25","author":"Seetharaman","year":"2023","journal-title":"Diabetes Obes. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112821","DOI":"10.1016\/j.socscimed.2020.112821","article-title":"Annual transition probabilities of overweight and obesity in older adults: Evidence from world health organization study on global ageing and adult health","volume":"247","author":"Lartey","year":"2020","journal-title":"Soc. Sci. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Garcia-Sanchez, A., Gomez-Hermosillo, L., Casillas-Moreno, J., Pacheco-Moises, F., Campos-Bayardo, T.I., Roman-Rojas, D., and Miranda-Diaz, A.G. (2023). Prevalence of hypertension and obesity: Profile of mitochondrial function and markers of inflammation and oxidative stress. Antioxidants, 12.","DOI":"10.3390\/antiox12010165"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Di Pietro Fernandes, C., Santana, L.F., Dos Santos, J.R., Fernandes, D.S., Hiane, P.A., Pott, A., Freitas, K.C., Bogo, D., do Nascimento, V.A., and Filiu, W.F.O. (2023). Nutraceutical potential of grape (Vitis vinifera L.) seed oil in oxidative stress, inflammation, obesity and metabolic alterations. Molecules, 28.","DOI":"10.3390\/molecules28237811"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/oby.23734","article-title":"Metabolic dysfunction in obesity is related to impaired suppression of fatty acid release from adipose tissue by insulin","volume":"31","author":"Schleh","year":"2023","journal-title":"Obesity"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41418-022-01062-4","article-title":"Cell death and inflammation during obesity: \u201cKnow my methods, WAT (son)\u201d","volume":"30","author":"Hildebrandt","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e2303075120","DOI":"10.1073\/pnas.2303075120","article-title":"FAP expression in adipose tissue macrophages promotes obesity and metabolic inflammation","volume":"120","author":"Wu","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.biochi.2023.04.008","article-title":"Adipokines in obesity and metabolic-related-diseases","volume":"212","author":"Pestel","year":"2023","journal-title":"Biochimie"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wurfel, M., Bluher, M., Stumvoll, M., Ebert, T., Kovacs, P., Tonjes, A., and Breitfeld, J. (2023). Adipokines as clinically relevant therapeutic targets in obesity. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051427"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Artasensi, A., Mazzolari, A., Pedretti, A., Vistoli, G., and Fumagalli, L. (2023). Obesity and type 2 diabetes: Adiposopathy as a triggering factor and therapeutic options. Molecules, 28.","DOI":"10.3390\/molecules28073094"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s40200-023-01221-5","article-title":"Role of obesity related inflammation in pathogenesis of peripheral artery disease in patients of type 2 diabetes mellitus","volume":"22","author":"Yadav","year":"2023","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1136\/gutjnl-2023-330110","article-title":"Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: An updated systematic review and meta-analysis","volume":"72","author":"Ang","year":"2023","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Matteo, P., Federico, D., Emanuela, M., Giulia, R., Tommaso, B., Alfredo, G., Anna, C., and Annamaria, O. (2022). New and old horizons for an ancient drug: Pharmacokinetics, pharmacodynamics, and clinical perspectives of dimethyl fumarate. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14122732"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kourakis, S., Timpani, C.A., de Haan, J.B., Gueven, N., Fischer, D., and Rybalka, E. (2020). Dimethyl fumarate and its esters: A drug with broad clinical utility?. Pharmaceuticals, 13.","DOI":"10.20944\/preprints202009.0684.v1"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e00099-20","DOI":"10.1128\/MCB.00099-20","article-title":"The molecular mechanisms regulating the KEAP1-NRF2 pathway","volume":"40","author":"Baird","year":"2020","journal-title":"Mol. Cell. Biol."},{"key":"ref_18","unstructured":"National Institute of Child Health and Human Development (2006). Dimethyl fumarate. Drugs and Lactation Database (LactMed(R)), National Institute of Child Health and Human Development."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s40263-021-00799-9","article-title":"Pharmacokinetics and bioavailability of monomethyl fumarate Following a single oral dose of bafiertam (monomethyl fumarate) or tecfidera((R)) (dimethyl fumarate)","volume":"35","author":"Lategan","year":"2021","journal-title":"CNS Drugs"},{"key":"ref_20","first-page":"20552173221132469","article-title":"Progressive multifocal leukoencephalopathy outcomes in patients with multiple sclerosis treated with dimethyl fumarate","volume":"8","author":"Lyons","year":"2022","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bresciani, G., Manai, F., Davinelli, S., Tucci, P., Saso, L., and Amadio, M. (2023). Novel potential pharmacological applications of dimethyl fumarate-an overview and update. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1264842"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1185\/03007995.2013.849236","article-title":"BG-12 (dimethyl fumarate): A review of mechanism of action, efficacy, and safety","volume":"30","author":"Fox","year":"2014","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"175025","DOI":"10.1016\/j.ejphar.2022.175025","article-title":"Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases","volume":"926","author":"Majkutewicz","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2337\/diab.37.9.1163","article-title":"Diet-induced type II diabetes in C57BL\/6J mice","volume":"37","author":"Surwit","year":"1988","journal-title":"Diabetes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1507\/endocrj.EJ14-0262","article-title":"The role of estrogen in adipose tissue metabolism: Insights into glucose homeostasis regulation","volume":"61","author":"Kim","year":"2014","journal-title":"Endocr. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/ptr.7377","article-title":"Beneficial effects of Ilex paraguariensis in the prevention of obesity-associated metabolic disorders in mice","volume":"36","author":"Valenca","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1590\/S0074-02762006000900039","article-title":"Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet","volume":"101","author":"Neves","year":"2006","journal-title":"Mem\u00f3rias Inst. Oswaldo Cruz"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Al-Jaderi, Z., and Maghazachi, A.A. (2016). Utilization of dimethyl fumarate and related molecules for treatment of multiple sclerosis, cancer, and other diseases. Front. Immunol., 7.","DOI":"10.3389\/fimmu.2016.00278"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1089\/ars.2015.6571","article-title":"Control of oxidative stress and inflammation in sickle cell disease with the nrf2 activator dimethyl fumarate","volume":"26","author":"Belcher","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101306","DOI":"10.1016\/j.bjorl.2023.101306","article-title":"Effect of obesity, lipids and adipokines on allergic rhinitis risk: A mendelian randomization study","volume":"89","author":"Lin","year":"2023","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Mokgalaboni, K., and Phoswa, W.N. (2023). Corchorus olitorius extract exhibit anti-hyperglycemic and anti-inflammatory properties in rodent models of obesity and diabetes mellitus. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1099880"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.20463\/pan.2023.0035","article-title":"Effect of physical activity levels on blood lipids, insulin resistance, and adipokines in children with obesity","volume":"27","author":"Sohn","year":"2023","journal-title":"Phys. Act. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41574-021-00471-8","article-title":"Lipid and glucose metabolism in white adipocytes: Pathways, dysfunction and therapeutics","volume":"17","author":"Morigny","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"L312","DOI":"10.1152\/ajplung.00423.2019","article-title":"Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung","volume":"319","author":"Ahrendt","year":"2020","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molmet.2013.12.009","article-title":"Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice","volume":"3","author":"Kim","year":"2014","journal-title":"Mol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Li, X., Ren, Y., Chang, K., Wu, W., Griffiths, H.R., Lu, S., and Gao, D. (2023). Adipose tissue macrophages as potential targets for obesity and metabolic diseases. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1153915"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"108479","DOI":"10.1016\/j.jdiacomp.2023.108479","article-title":"PSTPIP2 alleviates obesity associated adipose tissue inflammation and insulin resistance in diabetes mice through promoting m2 macrophage polarization via activation of ppargamma","volume":"37","author":"Xu","year":"2023","journal-title":"J. Diabetes Complicat."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1002\/cbin.11417","article-title":"Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ros generation","volume":"44","author":"Kim","year":"2020","journal-title":"Cell Biol. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e13795","DOI":"10.1111\/apha.13795","article-title":"Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice","volume":"234","author":"Napso","year":"2022","journal-title":"Acta Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/bjd\/ljac107","article-title":"Adipokines as an important link between hidradenitis suppurativa and obesity: A narrative review","volume":"188","author":"Krajewski","year":"2023","journal-title":"Br. J. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1611338","DOI":"10.3389\/pore.2023.1611338","article-title":"Obesity as a risk factor for multiple myeloma: Insight on the role of adipokines","volume":"29","author":"Tie","year":"2023","journal-title":"Pathol. Oncol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1007\/s10787-023-01242-9","article-title":"Salsalate: A pleotropic anti-inflammatory drug in the treatment of diabetes, obesity, and metabolic diseases","volume":"31","author":"Hasan","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Rosito, M., Testi, C., Parisi, G., Cortese, B., Baiocco, P., and Di Angelantonio, S. (2020). Exploring the use of dimethyl fumarate as microglia modulator for neurodegenerative diseases treatment. Antioxidants, 9.","DOI":"10.3390\/antiox9080700"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Cazac, G.D., Lacatusu, C.M., Stefanescu, G., Mihai, C., Grigorescu, E.D., Onofriescu, A., and Mihai, B.M. (2023). Glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease\u2014Current background, hopes, and perspectives. Metabolites, 13.","DOI":"10.3390\/metabo13050581"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e000647","DOI":"10.20945\/2359-3997000000647","article-title":"Obesity, diabetes, and cancer: Epidemiology, pathophysiology, and potential interventions","volume":"67","author":"Wayerbacher","year":"2023","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Frankowski, R., Kobierecki, M., Wittczak, A., Rozycka-Kosmalska, M., Pietras, T., Sipowicz, K., and Kosmalski, M. (2023). Type 2 diabetes mellitus, non-alcoholic fatty liver disease, and metabolic repercussions: The vicious cycle and its interplay with inflammation. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119677"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1080\/13813455.2021.1874017","article-title":"Biochanin A attenuates obesity cardiomyopathy in rats by inhibiting oxidative stress and inflammation through the Nrf-2 pathway","volume":"129","author":"Jir","year":"2023","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/gerona\/glac021","article-title":"Relationship between adipokines, cognition, and brain structures in old age depending on obesity","volume":"78","author":"Ha","year":"2023","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1007\/s10620-023-08021-0","article-title":"Plasma exosomes aggravate acute pancreatitis by promoting m1 polarization of adipose tissue macrophages in obesity-related severe acute pancreatitis","volume":"68","author":"Han","year":"2023","journal-title":"Dig. Dis. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Luz, A.B.S., Dos Santos Figueredo, J.B., Salviano, B., Aguiar, A., Pinheiro, L., Krause, M.F.D., da Silva Camillo, C., Ladd, F.V.L., Bortolin, R.H., and Silbiger, V.N. (2018). Adipocytes and intestinal epithelium dysfunctions linking obesity to inflammation induced by high glycemic index pellet-diet in Wistar rats. Biosci. Rep., 38.","DOI":"10.1042\/BSR20180304"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ostrowska, L., Smarkusz-Zarzecka, J., Gornowicz, A., Lendzion, K., Zysk, B., and Pogodzinski, D. (2023). Analysis of selected salivary adipokines and cytokines in patients with obesity\u2014A pilot study. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24044145"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Turpin, T., Thouvenot, K., and Gonthier, M.P. (2023). Adipokines and bacterial metabolites: A pivotal molecular bridge linking obesity and gut microbiota dysbiosis to target. Biomolecules, 13.","DOI":"10.3390\/biom13121692"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"100582","DOI":"10.1016\/j.jaim.2022.100582","article-title":"Methanolic fruit extract of Myrica nagi protects the hypothalamus and attenuates inflammation associated with gold thioglucose- and high-fat diet-induced obesity via various adipokines","volume":"14","author":"Prashar","year":"2023","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ramineedu, K., Sankaran, K.R., Mallepogu, V., Rendedula, D.P., Gunturu, R., Gandham, S., Md, S.I., and Meriga, B. (2024). Thymoquinone mitigates obesity and diabetic parameters through regulation of major adipokines, key lipid metabolizing enzymes and AMPK\/p-AMPK in diet-induced obese rats. 3 Biotech, 14.","DOI":"10.1007\/s13205-023-03847-x"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s10020-023-00702-w","article-title":"Leptin\/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages","volume":"29","author":"Wang","year":"2023","journal-title":"Mol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Bica, I.C., Stoica, R.A., Salmen, T., Janez, A., Volcansek, S., Popovic, D., Muzurovic, E., Rizzo, M., and Stoian, A.P. (2023). The effects of sodium-glucose cotransporter 2-inhibitors on steatosis and fibrosis in patients with non-alcoholic fatty liver disease or steatohepatitis and type 2 diabetes: A systematic review of randomized controlled trials. Medicina, 59.","DOI":"10.3390\/medicina59061136"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Dwivedi, D.K., and Jena, G.B. (2023). Dimethyl fumarate-mediated nrf2\/are pathway activation and glibenclamide-mediated NLRP3 inflammasome cascade inhibition alleviate type ii diabetes-associated fatty liver in rats by mitigating oxidative stress and inflammation. J. Biochem. Mol. Toxicol., 37.","DOI":"10.1002\/jbt.23357"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Khaznadar, F., Petrovic, A., Khaznadar, O., Roguljic, H., Bojanic, K., Kuna Roguljic, L., Siber, S., Smolic, R., Bilic-Curcic, I., and Wu, G.Y. (2023). Biomarkers for assessing non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus on sodium-glucose cotransporter 2 inhibitor therapy. J. Clin. Med., 12.","DOI":"10.3390\/jcm12206561"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/10520295.2019.1589573","article-title":"The role of HMGB1 in liver inflammation in obese rats","volume":"94","author":"Erdal","year":"2019","journal-title":"Biotech. Histochem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/ana.24471","article-title":"Progressive neurologic dysfunction in a psoriasis patient treated with dimethyl fumarate","volume":"78","author":"Bartsch","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1756285614564152","article-title":"Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: An overview","volume":"8","author":"Bomprezzi","year":"2015","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"107710","DOI":"10.1016\/j.pharmthera.2020.107710","article-title":"Dimethyl fumarate induced lymphopenia in multiple sclerosis: A review of the literature","volume":"219","author":"Scott","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Schuhmann, M.K., Langhauser, F., Zimmermann, L., Bellut, M., Kleinschnitz, C., and Fluri, F. (2023). Dimethyl fumarate attenuates lymphocyte infiltration and reduces infarct size in experimental stroke. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115540"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/12\/1496\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:49:44Z","timestamp":1760114984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/12\/1496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,8]]},"references-count":63,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["antiox13121496"],"URL":"https:\/\/doi.org\/10.3390\/antiox13121496","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,8]]}}}