{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:14:26Z","timestamp":1787318066743,"version":"build-2736575974"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Belgian Telethon (ABMM)","award":["PDR\/T.0026.21"],"award-info":[{"award-number":["PDR\/T.0026.21"]}]},{"name":"French Association against Myopathies (AFM T\u00e9l\u00e9thon)","award":["PDR\/T.0026.21"],"award-info":[{"award-number":["PDR\/T.0026.21"]}]},{"name":"Fund for Scientific Research\u2014FNRS","award":["PDR\/T.0026.21"],"award-info":[{"award-number":["PDR\/T.0026.21"]}]},{"name":"fund Cremers\u2013Opdebeeck managed by the King Baudouin Foundation","award":["PDR\/T.0026.21"],"award-info":[{"award-number":["PDR\/T.0026.21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Adiponectin (ApN) is a hormone with potent effects on various tissues. We previously demonstrated its ability to counteract Duchenne muscular dystrophy (DMD), a severe muscle disorder. However, its therapeutic use is limited. AdipoRon, an orally active ApN mimic, offers a promising alternative. While cardiomyopathy is the primary cause of mortality in DMD, the effects of ApN or AdipoRon on dystrophic hearts have not been investigated. Our recent findings demonstrated the significant protective effects of AdipoRon on dystrophic skeletal muscle. In this study, we investigated whether AdipoRon effects could be extended to dystrophic hearts. As cardiomyopathy develops late in mdx mice (DMD mouse model), 14-month-old mdx mice were orally treated for two months with AdipoRon at a dose of 50 mg\/kg\/day and then compared with untreated mdx and wild-type (WT) controls. Echocardiography revealed cardiac dysfunction and ventricular hypertrophy in mdx mice, which were fully reversed in AdipoRon-treated mice. AdipoRon also reduced markers of cardiac inflammation, oxidative stress, hypertrophy, and fibrosis while enhancing mitochondrial biogenesis via ApN receptor-1 and CAMKK2\/AMPK pathways. Remarkably, treated mice also showed improved skeletal muscle strength and endurance. By offering protection to both cardiac and skeletal muscles, AdipoRon holds potential as a comprehensive therapeutic strategy for better managing DMD.<\/jats:p>","DOI":"10.3390\/antiox13121551","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T03:40:56Z","timestamp":1734493256000},"page":"1551","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Striking Cardioprotective Effects of an Adiponectin Receptor Agonist in an Aged Mouse Model of Duchenne Muscular Dystrophy"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-7998","authenticated-orcid":false,"given":"Michel","family":"Abou-Samra","sequence":"first","affiliation":[{"name":"Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research (IREC), Medical Sector, Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-0579","authenticated-orcid":false,"given":"Nicolas","family":"Dubuisson","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research (IREC), Medical Sector, Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"},{"name":"Neuromuscular Reference Center, Department of Neurology, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-6576","authenticated-orcid":false,"given":"Alice","family":"Marino","sequence":"additional","affiliation":[{"name":"Pole of Cardiovascular Research, Institute of Experimental and Clinical Research (IREC), Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille M.","family":"Selvais","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research (IREC), Medical Sector, Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-3122","authenticated-orcid":false,"given":"Versele","family":"Romain","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research (IREC), Medical Sector, Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-3115","authenticated-orcid":false,"given":"Maria A.","family":"Davis-L\u00f3pez de Carrizosa","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research (IREC), Medical Sector, Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"},{"name":"Departamento de Fisiolog\u00eda, Facultad de Biolog\u00eda, Universidad de Sevilla, 41012 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Noel","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research (IREC), Medical Sector, Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Beauloye","sequence":"additional","affiliation":[{"name":"Pole of Cardiovascular Research, Institute of Experimental and Clinical Research (IREC), Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"},{"name":"Department of Cardiovascular Intensive Care, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia M.","family":"Brichard","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research (IREC), Medical Sector, Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Horman","sequence":"additional","affiliation":[{"name":"Pole of Cardiovascular Research, Institute of Experimental and Clinical Research (IREC), Universit\u00e9 Catholique de Louvain (UCLouvain), Avenue Hippocrate 55, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-021-00248-3","article-title":"Duchenne Muscular Dystrophy","volume":"7","author":"Duan","year":"2021","journal-title":"Nat. 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