{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:25:41Z","timestamp":1787631941802,"version":"build-2736575974"},"reference-count":309,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research and Innovation Fund of Paracelsus Medical University (PMU-RIF)","award":["2022-Iif-004-DOSSENA"],"award-info":[{"award-number":["2022-Iif-004-DOSSENA"]}]},{"name":"Research and Innovation Fund of Paracelsus Medical University (PMU-RIF)","award":["042023"],"award-info":[{"award-number":["042023"]}]},{"name":"FIZ RM&amp;NT Talent Pool Senior Researcher","award":["2022-Iif-004-DOSSENA"],"award-info":[{"award-number":["2022-Iif-004-DOSSENA"]}]},{"name":"FIZ RM&amp;NT Talent Pool Senior Researcher","award":["042023"],"award-info":[{"award-number":["042023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Cisplatin is an established component of treatment protocols for various solid malignancies but carries a significant potential for serious adverse effects. Ototoxicity from cisplatin treatment is an important dose-limiting toxicity that manifests as bilateral, progressive, irreversible, dose-dependent sensorineural hearing loss, ear pain, tinnitus, and vestibular dysfunction. Despite the recent approval of sodium thiosulphate for the prevention of cisplatin-induced hearing loss (CIHL) in pediatric patients, structured prevention programs are not routinely implemented in most hospitals, and reducing platinum-induced ototoxicity in adults remains an important clinical problem without established treatment options. Cochlear oxidative stress plays a fundamental role in CIHL. Here, we review the molecular mechanisms leading to oxidative stress in CIHL and the clinical and preclinical studies testing antioxidants in CIHL to guide future clinical trials in assessing the efficacy and safety of candidate antioxidant compounds in this clinical setting.<\/jats:p>","DOI":"10.3390\/antiox13121578","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T04:33:29Z","timestamp":1734928409000},"page":"1578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cisplatin-Induced Hearing Loss, Oxidative Stress, and Antioxidants as a Therapeutic Strategy\u2014A State-of-the-Art Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1681-4909","authenticated-orcid":false,"given":"Olaf","family":"Rose","sequence":"first","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Center of Public Health and Health Services Research, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Croonenberg","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8788-9329","authenticated-orcid":false,"given":"Stephanie","family":"Clemens","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Center of Public Health and Health Services Research, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hinteregger","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Eppacher","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2919-6363","authenticated-orcid":false,"given":"Petra","family":"Huber-Cantonati","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garcia-Miralles","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Liuni","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6694-9249","authenticated-orcid":false,"given":"Silvia","family":"Dossena","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Research and Innovation Center Regenerative Medicine & Novel Therapies (FIZ RM&NT), Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","article-title":"The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. 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