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Each compound demonstrated metal-chelating properties, particularly in sequestering copper ions, with quantitative analysis revealing approximately 40% chelating activity across all the compounds. In cellular models, these hybrid compounds exhibited strong antioxidant and cytoprotective effects, countering reactive oxygen species (ROS) generated by the A\u03b2(25\u201335) peptide and its oxidative byproduct, hydrogen peroxide, as demonstrated by quantitative analysis showing on average a 25% increase in cell viability and a reduction in ROS levels to basal states. Further analysis using thioflavin T fluorescence assays, circular dichroism, and computational studies indicated that the synthesized derivatives effectively promoted the self-disaggregation of the A\u03b2(25\u201335) fragment. Taken together, these findings suggest a unique profile of neuroprotective actions for indole\u2013phenolic derivatives, combining chelating, antioxidant, and anti-aggregation properties, which position them as promising compounds for the development of multifunctional agents in Alzheimer\u2019s disease therapy. The methods used provide reliable in vitro data, although further in vivo validation and assessment of blood\u2013brain barrier penetration are needed to confirm therapeutic efficacy and safety.<\/jats:p>","DOI":"10.3390\/antiox13121585","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:58:27Z","timestamp":1734933507000},"page":"1585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Neuroprotective Potential of Indole-Based Compounds: A Biochemical Study on Antioxidant Properties and Amyloid Disaggregation in Neuroblastoma Cells"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-4373","authenticated-orcid":false,"given":"Tania","family":"Ciaglia","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Salerno, Via G. 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