{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:03:18Z","timestamp":1777971798958,"version":"3.51.4"},"reference-count":74,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Wuxi Taihu Talent Project","award":["WXTTP 2021"],"award-info":[{"award-number":["WXTTP 2021"]}]},{"name":"the Wuxi Taihu Talent Project","award":["22520231069"],"award-info":[{"award-number":["22520231069"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["WXTTP 2021"],"award-info":[{"award-number":["WXTTP 2021"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["22520231069"],"award-info":[{"award-number":["22520231069"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Ulcerative colitis (UC) is a chronic immune disease that is difficult to cure. We recently found that chick early amniotic fluid (ceAF) has notable anti-inflammatory and antioxidative properties, through its active components. This study demonstrates the potential of ceAF as a protective agent against UC. UPLC-MS mass spectrometry identified key components of ceAF, including various fatty acids and nucleosides. In vitro, ceAF improved viability in DSS-induced Caco-2 cells, reduced pro-inflammatory cytokines IL-1\u03b2 and TNF-\u03b1, and increased the anti-inflammatory cytokine IL-10. It also upregulated the tight junction proteins ZO-1 and occludin. In DSS-induced UC mice, ceAF treatment alleviated weight loss, colon shortening, and disease activity, while improving histopathology, crypt depth, and colonic fibrosis. Mechanistically, ceAF\u2019s anti-inflammatory effects are mediated by inhibiting the overactivation of TCR signaling through the LCK\/ZAP70\/LAT pathway. Our findings suggest that ceAF could be a valuable nutritional intervention for UC, potentially enhancing existing functional foods aimed at managing this condition.<\/jats:p>","DOI":"10.3390\/antiox14010051","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T09:17:02Z","timestamp":1736155022000},"page":"51","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chick Early Amniotic Fluid Alleviates Dextran-Sulfate-Sodium-Induced Colitis in Mice via T-Cell Receptor Pathway"],"prefix":"10.3390","volume":"14","author":[{"given":"Fan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi 214151, China"},{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi 214082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yining","family":"Zhao","sequence":"additional","affiliation":[{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi 214082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfa","family":"Dai","sequence":"additional","affiliation":[{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi 214082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Sun","sequence":"additional","affiliation":[{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi 214082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuezheng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi 214151, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6778-1524","authenticated-orcid":false,"given":"Jiajun","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi 214151, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhe","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi 214151, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0809-5628","authenticated-orcid":false,"given":"Ke-jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi 214151, China"},{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi 214082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1053\/j.gastro.2021.07.042","article-title":"Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management","volume":"161","author":"Rogler","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000504092","article-title":"Treatment Algorithm for Mild and Moderate-to-Severe Ulcerative Colitis: An Update","volume":"101","author":"Burri","year":"2020","journal-title":"Digestion"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1080\/10408398.2014.903384","article-title":"Nutraceuticals and Functional Foods: The Foods for the Future World","volume":"56","author":"Gul","year":"2016","journal-title":"Crit. 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