{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:30:28Z","timestamp":1791379828753,"version":"4.3.3"},"reference-count":65,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32273074"],"award-info":[{"award-number":["32273074"]}]},{"name":"National Natural Science Foundation of China","award":["31972746"],"award-info":[{"award-number":["31972746"]}]},{"name":"National Natural Science Foundation of China","award":["31772809"],"award-info":[{"award-number":["31772809"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Fumonisin B1 (FB1) is an important toxin which poses global concerns in terms of food safety. Curcumin (Cur), a natural polyphenolic compound, has strong antioxidant and anti-inflammatory effects. Meanwhile, the mechanisms underlying the mitigation of FB1-induced toxicity by Cur are not fully understood, limiting its potential application as a novel feed additive to prevent FB1 toxicity. In this study, porcine kidney cells (PK-15) were used as an experimental model, utilizing mRNA and miRNA transcriptome technologies. The results revealed that Cur upregulated miR-1249 and inhibited the target gene Ern1 in the PK-15 cells, thereby suppressing the IRE1\/MKK7\/JNK\/CASPASE3 endoplasmic reticulum (ER) stress pathway and alleviating FB1-induced cell apoptosis. Cell transfection experiments confirmed that Cur effectively attenuated the apoptosis induced by ER stress following transfection with a miR-1249 inhibitor. Similarly, transfection with a miR-1249 mimic alleviated the ER stress and FB1-induced PK-15 cell apoptosis. These findings reveal that Cur mitigates FB1-induced ER stress and significantly reduces apoptotic damage in porcine kidney cells.<\/jats:p>","DOI":"10.3390\/antiox14020168","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:08:23Z","timestamp":1738235303000},"page":"168","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Curcumin Attenuates Fumonisin B1-Induced PK-15 Cell Apoptosis by Upregulating miR-1249 Expression to Inhibit the IRE1\/MKK7\/JNK\/CASPASE3 Signaling Pathway"],"prefix":"10.3390","volume":"14","author":[{"given":"Jia","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China"},{"name":"College of Laboratory Animal Medicine, Liaoning University of Traditional Chinese Medicine, 79 Chongshan Road, Shenyang 110847, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-1956","authenticated-orcid":false,"given":"Miao","family":"Long","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chen, J., Wen, J., Tang, Y., Shi, J., Mu, G., Yan, R., Cai, J., and Long, M. (2021). Research Progress on Fumonisin B1 Contamination and Toxicity: A Review. Molecules, 26.","DOI":"10.3390\/molecules26175238"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"121065","DOI":"10.1016\/j.envpol.2023.121065","article-title":"The natural occurrence, toxicity mechanisms and management strategies of Fumonisin B1: A review","volume":"320","author":"Gao","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Alvito, P., Assun\u00e7\u00e3o, R.M., Bajard, L., Martins, C., Mengelers, M.J.B., Mol, H., Namorado, S., van den Brand, A.D., Vasco, E., and Viegas, S. (2022). Current Advances, Research Needs and Gaps in Mycotoxins Biomonitoring under the HBM4EU\u2014Lessons Learned and Future Trends. Toxins, 14.","DOI":"10.3390\/toxins14120826"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"111977","DOI":"10.1016\/j.fct.2021.111977","article-title":"Fumonisin B(1): Mechanisms of toxicity and biological detoxification progress in animals","volume":"149","author":"Chen","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"112251","DOI":"10.1016\/j.fct.2021.112251","article-title":"Multidimensional analysis of the epigenetic alterations in toxicities induced by mycotoxins","volume":"153","author":"Zhu","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxicon.2020.06.024","article-title":"Lactobacillus paracasei alleviates genotoxicity, oxidative stress status and histopathological damage induced by Fumonisin B1 in BALB\/c mice","volume":"185","author":"Ezdini","year":"2020","journal-title":"Toxicon"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.tcb.2020.09.002","article-title":"When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response","volume":"30","author":"Blondel","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Pontisso, I., Ornelas-Guevara, R., Combettes, L., and Dupont, G. (2023). A journey in UPR modelling. Biol. Cell, 115.","DOI":"10.1111\/boc.202200111"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1080\/10408398.2016.1260526","article-title":"Mechanisms of cell death induction by food-borne mycotoxins","volume":"58","author":"Yin","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zhu, F., and Wang, Y. (2022). Fumonisin B(1) Induces Immunotoxicity and Apoptosis of Chicken Splenic Lymphocytes. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.898121"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Li, H., He, W., Yue, D., Wang, M., Yuan, X., and Huang, K. (2023). Low doses of fumonisin B1 exacerbate ochratoxin A-induced renal injury in mice and the protective roles of heat shock protein 70. Chem. Biol. Interact., 369.","DOI":"10.1016\/j.cbi.2022.110240"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0009-2797(03)00026-7","article-title":"Increased susceptibility of renal epithelial cells to TNFalpha-induced apoptosis following treatment with fumonisin B1","volume":"145","author":"Johnson","year":"2003","journal-title":"Chem. Biol. Interact."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kim, S.H., Singh, M.P., Sharma, C., and Kang, S.C. (2018). Fumonisin B1 actuates oxidative stress-associated colonic damage via apoptosis and autophagy activation in murine model. J. Biochem. Mol. Toxicol., 32.","DOI":"10.1002\/jbt.22161"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111274","DOI":"10.1016\/j.fct.2020.111274","article-title":"Transcriptome study reveals apoptosis of porcine kidney cells induced by fumonisin B1 via TNF signalling pathway","volume":"139","author":"Chen","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"116343","DOI":"10.1016\/j.ecoenv.2024.116343","article-title":"Curcumin alleviates zearalenone-induced liver injury in mice by scavenging reactive oxygen species and inhibiting mitochondrial apoptosis pathway","volume":"277","author":"Yang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/ptr.7360","article-title":"An overview of the therapeutic effects of curcumin in reproductive disorders with a focus on the antiinflammatory and immunomodulatory activities","volume":"36","author":"Saifi","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Fu, Y.S., Chen, T.H., Weng, L., Huang, L., Lai, D., and Weng, C.F. (2021). Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential. Biomed. Pharmacother., 141.","DOI":"10.1016\/j.biopha.2021.111888"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"119125","DOI":"10.1016\/j.lfs.2021.119125","article-title":"Curcumin reduces apoptosis and promotes osteogenesis of human periodontal ligament stem cells under oxidative stress in vitro and in vivo","volume":"270","author":"Tan","year":"2021","journal-title":"Life Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Liang, J., Chen, J., Yang, L., Wu, D., Xiong, L., Guo, X., Cao, H., Zhang, C., Hu, G., and Zhuang, Y. (2024). Curcumin alleviates atrazine-induced cardiotoxicity by inhibiting endoplasmic reticulum stress-mediated apoptosis in mice through ATF6\/Chop\/Bcl-2 signaling pathway. Biomed. Pharmacother., 171.","DOI":"10.1016\/j.biopha.2024.116205"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/ptr.8035","article-title":"The protective effects of curcumin against cigarette smoke-induced toxicity: A comprehensive review","volume":"38","author":"Fanoudi","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41419-022-04547-9","article-title":"Correction to: HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3\u03b2 via PI3K\/Akt\/c-Jun signaling to promote malignant progression and chemoresistance in gliomas","volume":"13","author":"Que","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.colsurfb.2017.02.023","article-title":"Relief of oxidative stress and cardiomyocyte apoptosis by using curcumin nanoparticles","volume":"153","author":"Li","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1177\/0300060519869459","article-title":"Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model","volume":"47","author":"Tang","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1007\/s00210-024-03121-8","article-title":"The role of natural products versus miRNA in renal cell carcinoma: Implications for disease mechanisms and diagnostic markers","volume":"397","author":"Ayed","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Smolarz, B., Durczy\u0144ski, A., Romanowicz, H., Szy\u0142\u0142o, K., and Hogendorf, P. (2022). miRNAs in Cancer (Review of Literature). Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052805"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"121340","DOI":"10.1016\/j.lfs.2022.121340","article-title":"The role of microRNA-21 (miR-21) in pathogenesis, diagnosis, and prognosis of gastrointestinal cancers: A review","volume":"316","author":"Vakili","year":"2023","journal-title":"Life Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e13338","DOI":"10.1111\/1541-4337.13338","article-title":"Toxicodynamic of combined mycotoxins: MicroRNAs and acute-phase proteins as diagnostic biomarkers","volume":"23","author":"Murtaza","year":"2024","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"113130","DOI":"10.1016\/j.ecoenv.2021.113130","article-title":"MicroRNA target-based network predicts androgen receptor-linked mycotoxin stress","volume":"230","author":"Moon","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/mnfr.201200456","article-title":"Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells","volume":"57","author":"Stachurska","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.toxlet.2020.05.009","article-title":"Zearalenone exposure triggered porcine granulosa cells apoptosis via microRNAs-mediated focal adhesion pathway","volume":"330","author":"Tian","year":"2020","journal-title":"Toxicol. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: Molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.molcel.2022.03.025","article-title":"Reshaping endoplasmic reticulum quality control through the unfolded protein response","volume":"82","author":"Wiseman","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3892\/ijmm.2021.4892","article-title":"5-Nitro-2-(3-phenylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway","volume":"47","author":"Niu","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1007\/s10695-020-00845-1","article-title":"Short-term effects of deoxynivalenol, T-2 toxin, fumonisin B1 or ochratoxin on lipid peroxidation and glutathione redox system and its regulatory genes in common carp (Cyprinus carpio L.) liver","volume":"46","author":"Balogh","year":"2020","journal-title":"Fish. Physiol. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kulcs\u00e1r, S., K\u00f6vesi, B., Balogh, K., Z\u00e1ndoki, E., Ancsin, Z., M\u00e1rta, B.E., and M\u00e9zes, M. (2021). Effects of Fusarium Mycotoxin Exposure on Lipid Peroxidation and Glutathione Redox System in the Liver of Laying Hens. Antioxidants, 10.","DOI":"10.3390\/antiox10081313"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12550-018-0335-0","article-title":"Fumonisin B(1)-induced oxidative stress triggers Nrf2-mediated antioxidant response in human hepatocellular carcinoma (HepG2) cells","volume":"35","author":"Arumugam","year":"2019","journal-title":"Mycotoxin Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1007\/s00253-021-11380-1","article-title":"Integrated signaling system under endoplasmic reticulum stress in eukaryotic microorganisms","volume":"105","author":"Cao","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1073\/pnas.1915311117","article-title":"Quantitative microscopy reveals dynamics and fate of clustered IRE1\u03b1","volume":"117","author":"Belyy","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/met.2024.0013","article-title":"The Role of Endoplasmic Reticulum Stress in Metabolic Diseases","volume":"22","author":"Sak","year":"2024","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/jcp.30913","article-title":"Polystyrene nanoplastics aggravates lipopolysaccharide-induced apoptosis in mouse kidney cells by regulating IRE1\/XBP1 endoplasmic reticulum stress pathway via oxidative stress","volume":"238","author":"Li","year":"2023","journal-title":"J. Cell. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e30700","DOI":"10.7554\/eLife.30700","article-title":"An unfolded protein-induced conformational switch activates mammalian IRE1","volume":"6","author":"Nguyen","year":"2017","journal-title":"Elife"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Fu, W., Im, Y.G., Kim, B., Kim, O.S., Yang, Y., Song, J., Liu, D., Zhu, S., Kang, J.S., and Kim, O. (2023). 625 nm Light Irradiation Prevented MC3T3-E1 Cells from Accumulation of Misfolded Proteins via ROS and ATP Production. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119257"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e143737","DOI":"10.1172\/JCI143737","article-title":"IRE1\u03b1 regulates skeletal muscle regeneration through Myostatin mRNA decay","volume":"131","author":"He","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_44","first-page":"440","article-title":"The endoplasmic reticulum and its signaling pathways\u2014A novel target for multiple myeloma treatment","volume":"37","year":"2023","journal-title":"Klin. Onkol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e52291","DOI":"10.7554\/eLife.52291","article-title":"Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress","volume":"9","author":"Lam","year":"2020","journal-title":"Elife"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Sisinni, L., Pietrafesa, M., Lepore, S., Maddalena, F., Condelli, V., Esposito, F., and Landriscina, M. (2019). Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040857"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41419-022-05444-x","article-title":"Endoplasmic reticulum stress-mediated cell death in liver injury","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e13826","DOI":"10.1111\/aji.13826","article-title":"Inhibition of the endoplasmic reticulum stress-associated IRE-1 pathway alleviates preterm birth","volume":"91","author":"Qiu","year":"2024","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/tox.23423","article-title":"Surfactin induces ER stress-mediated apoptosis via IRE1-ASK1-JNK signaling in human osteosarcoma","volume":"37","author":"Wang","year":"2022","journal-title":"Environ. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"115782","DOI":"10.1016\/j.ecoenv.2023.115782","article-title":"Hesperetin protects hippocampal neurons from the neurotoxicity of Aflatoxin B1 in mice","volume":"269","author":"Song","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/jat.3655","article-title":"Endoplasmic reticulum stress is involved in the T-2 toxin-induced apoptosis in goat endometrium epithelial cells","volume":"38","author":"Yi","year":"2018","journal-title":"J. Appl. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1080\/15384101.2021.1966199","article-title":"Ketamine enhances autophagy and endoplasmic reticulum stress in rats and SV-HUC-1 cells via activating IRE1-TRAF2-ASK1-JNK pathway","volume":"20","author":"Yu","year":"2021","journal-title":"Cell Cycle"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Chang, C.Y., Pan, P.H., Wu, C.C., Liao, S.L., Chen, W.Y., Kuan, Y.H., Wang, W.Y., and Chen, C.J. (2021). Endoplasmic Reticulum Stress Contributes to Gefitinib-Induced Apoptosis in Glioma. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083934"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s12291-021-01001-z","article-title":"Assessment of Role and Efficacy of Curcumin and Quercetin in Preventing Lead-Induced Oxidative Stress in Rats","volume":"37","author":"Zahid","year":"2022","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"114438","DOI":"10.1007\/s11356-023-30291-4","article-title":"A preliminary study on the pathology and molecular mechanism of fumonisin B(1) nephrotoxicity in young quails","volume":"30","author":"Li","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1080\/10408398.2017.1379000","article-title":"The more effective treatment of atrial fibrillation applying the natural compounds; as NADPH oxidase and ion channel inhibitors","volume":"58","author":"Barangi","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"112394","DOI":"10.1016\/j.ecoenv.2021.112394","article-title":"Arsenic (III) and\/or Antimony (III) induced disruption of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in mice heart","volume":"220","author":"Jiang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Khoder-Agha, F., and Kietzmann, T. (2021). The glyco-redox interplay: Principles and consequences on the role of reactive oxygen species during protein glycosylation. Redox Biol., 42.","DOI":"10.1016\/j.redox.2021.101888"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Cort\u00e9s, A., Pejenaute, \u00c1., Marqu\u00e9s, J., Izal, \u00cd., Cenoz, S., Ansorena, E., Mart\u00ednez-Irujo, J.J., de Miguel, C., and Zalba, G. (2021). NADPH Oxidase 5 Induces Changes in the Unfolded Protein Response in Human Aortic Endothelial Cells and in Endothelial-Specific Knock-in Mice. Antioxidants, 10.","DOI":"10.3390\/antiox10020194"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.cjca.2023.10.012","article-title":"Oxidative Stress and Endoplasmic Reticular Stress Interplay in the Vasculopathy of Hypertension","volume":"39","author":"Camargo","year":"2023","journal-title":"Can. J. Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/1541-4337.12412","article-title":"The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin-Induced Toxicity","volume":"18","author":"Rong","year":"2019","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.toxlet.2014.02.026","article-title":"Fumonisin B\u2081 modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b","volume":"227","author":"Chuturgoon","year":"2014","journal-title":"Toxicol. Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.tiv.2015.10.011","article-title":"MiR-122 partly mediates the ochratoxin A-induced GC-2 cell apoptosis","volume":"30","author":"Chen","year":"2015","journal-title":"Toxicol In Vitro"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Zhu, L., Gao, J., Huang, K., Luo, Y., Zhang, B., and Xu, W. (2015). miR-34a screened by miRNA profiling negatively regulates Wnt\/\u03b2-catenin signaling pathway in Aflatoxin B1 induced hepatotoxicity. Sci. Rep., 5.","DOI":"10.1038\/srep16732"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Chen, J., Yang, S., Li, P., Wu, A., Nepovimova, E., Long, M., Wu, W., and Kuca, K. (2022). MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro. J. Anim. Sci. Biotechnol., 13.","DOI":"10.1186\/s40104-021-00653-4"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/2\/168\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:38:53Z","timestamp":1759919933000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/2\/168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["antiox14020168"],"URL":"https:\/\/doi.org\/10.3390\/antiox14020168","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]}}}