{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:18:49Z","timestamp":1782249529470,"version":"3.54.5"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006347","name":"Babe\u0219-Bolyai University","doi-asserted-by":"publisher","award":["SEED"],"award-info":[{"award-number":["SEED"]}],"id":[{"id":"10.13039\/501100006347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The Caryophyllaceae family, commonly utilized in traditional medicine, exhibits various effects revealed by ethnopharmacological studies. Thus, the diuretic effect of the leaf and stem of three Gypsophila taxa endemic to T\u00fcrkiye was evaluated for the first time by comparing their bio-metabolic profiles, antioxidant capacities, carbonic anhydrase inhibition, and infrared spectra. The leaf and stem of Gypsophila taxa were macerated in 50% ethanol and 50% water, bio-metabolic profiles were performed by a new validated ultra-performance liquid chromatographic (UPLC) method and spectrophotometric methods, the antioxidant capacity was determined by DPPH and ABTS assays, and the in vitro diuretic activity was evaluated by carbonic anhydrase inhibition. The results show that the G. simonii leaf exhibited the highest quantity of rutin and total polyphenols content (TPC). On the other hand, the G. germanicopolitana leaf showed the highest quantity of rosmarinic acid, and the G. eriocalyx leaf contained the maximum total flavonoids content (TFC). The antioxidant results indicated that G. eriocalyx has the highest capacity. The G. germanicopolitana leaf strongly inhibited the enzyme activity. The ATR-FTIR spectra showed that the general chemical composition in the leaf and stem parts was preserved after the extraction process. Band intensity changes may be due to the extraction process and the amount of substances. In conclusion, the species of Gypsophila taxa show considerable potential for utilization in the pharmaceutical area.<\/jats:p>","DOI":"10.3390\/antiox14020219","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T11:14:41Z","timestamp":1739531681000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unveiling the Potential of Three Endemic Gypsophila L. (Caryophyllaceae) Taxa as Promising Carbonic Anhydrase Inhibitors\u2014Bio-Metabolic Profiles and In Vitro Evaluation of Enzyme Inhibition and Antioxidant Capacity"],"prefix":"10.3390","volume":"14","author":[{"given":"Eda","family":"B\u00fcker","sequence":"first","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Gazi University, 06330 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3555-4399","authenticated-orcid":false,"given":"Ay\u015fenur","family":"Kayaba\u015f Av\u015far","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, \u00c7ank\u0131r\u0131 Karatekin University, 18100 \u00c7ank\u0131r\u0131, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4083-3408","authenticated-orcid":false,"given":"Ertan","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Gazi University, 06500 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7056-8000","authenticated-orcid":false,"given":"Dorina","family":"Casoni","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babe\u015f-Bolyai University, 11 Arany J\u00e1nos, 400028 Cluj-Napoca, Romania"},{"name":"Research Centre for Advanced Chemical Analysis, Instrumentation and Chemometrics\u2013ANALYTICA, Babe\u015f-Bolyai University, 11 Arany Janos, 400028 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona Codru\u021ba Aurora","family":"Cobzac","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babe\u015f-Bolyai University, 11 Arany J\u00e1nos, 400028 Cluj-Napoca, Romania"},{"name":"Research Centre for Advanced Chemical Analysis, Instrumentation and Chemometrics\u2013ANALYTICA, Babe\u015f-Bolyai University, 11 Arany Janos, 400028 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cimpoiu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babe\u015f-Bolyai University, 11 Arany J\u00e1nos, 400028 Cluj-Napoca, Romania"},{"name":"Research Centre for Advanced Chemical Analysis, Instrumentation and Chemometrics\u2013ANALYTICA, Babe\u015f-Bolyai University, 11 Arany Janos, 400028 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref_1","first-page":"123","article-title":"Medicinal plants of the family Caryophyllaceae: A review of ethno-medicinal uses and pharmacological properties","volume":"43","author":"Chandra","year":"2015","journal-title":"Int. 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