{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:59:44Z","timestamp":1792166384346,"version":"4.4.0"},"reference-count":176,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Health Technology R&amp;D Project through the Korea Health Industry Development Institute (KHIDI)","award":["RS-2024-00437643"],"award-info":[{"award-number":["RS-2024-00437643"]}]},{"DOI":"10.13039\/501100003710","name":"Ministry of Health &amp; Welfare, Republic of Korea","doi-asserted-by":"publisher","award":["RS-2024-00437643"],"award-info":[{"award-number":["RS-2024-00437643"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Advanced glycation end-products (AGEs) cause blood vessel damage and induce diabetic complications in various organs, such as the eyes, kidneys, nerves, and skin. As glycation stress causes aesthetic, physical, and functional changes in the skin, glycation-targeting skin anti-aging strategies are attracting attention in cosmetology and dermatology. The primary goal of this review is to understand the significance of glycation-induced skin aging and to examine the therapeutic potential of glycation-targeting strategies. This study covers experimental and clinical studies exploring various interventions to attenuate glycation-induced skin aging. Glycation stress decreases the viability of cells in culture media, the cell-mediated contraction of collagen lattices in reconstructed skin models, and the expression of fibrillin-1 at the dermo-epidermal junction in the skin explants. It also increases cross-links in tail tendon collagen in animals, prolonging its breakdown time. However, these changes are attenuated by several synthetic and natural agents. Animal and clinical studies have shown that dietary or topical administration of agents with antiglycation or antioxidant activity can attenuate changes in AGE levels (measured by skin autofluorescence) and skin aging parameters (e.g., skin color, wrinkles, elasticity, hydration, dermal density) induced by chronological aging, diabetes, high-carbohydrate diets, ultraviolet radiation, or oxidative stress. Therefore, the accumulating experimental and clinical evidence supports that dietary supplements or topical formulations containing one or more synthetic and natural antiglycation agents may help mitigate skin aging induced by AGEs.<\/jats:p>","DOI":"10.3390\/antiox14040498","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T20:31:36Z","timestamp":1745181096000},"page":"498","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Synthetic and Natural Agents Targeting Advanced Glycation End-Products for Skin Anti-Aging: A Comprehensive Review of Experimental and Clinical Studies"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9810-8107","authenticated-orcid":false,"given":"Joon Yong","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, The Graduate School, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea"},{"name":"BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Gyoung","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyungpook National University Hospital, Daegu 41944, Republic of Korea"},{"name":"Bio-Medical Research Institute, Kyungpook National University Hospital, Daegu 41944, Republic of Korea"},{"name":"Department of Dermatology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5708-1305","authenticated-orcid":false,"given":"Weon Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyungpook National University Hospital, Daegu 41944, Republic of Korea"},{"name":"Bio-Medical Research Institute, Kyungpook National University Hospital, Daegu 41944, Republic of Korea"},{"name":"Department of Dermatology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-2066","authenticated-orcid":false,"given":"Yong Chool","family":"Boo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, The Graduate School, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea"},{"name":"BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu 41944, Republic of Korea"},{"name":"Department of Dermatology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"},{"name":"Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"},{"name":"Cell and Matrix Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e16688","DOI":"10.1111\/jocd.16688","article-title":"Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights","volume":"24","author":"Hussein","year":"2025","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jtv.2016.03.002","article-title":"Introduction to skin aging","volume":"26","author":"Tobin","year":"2017","journal-title":"J. Tissue Viability"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-981-13-3681-2_10","article-title":"Skin Changes During Ageing","volume":"91","author":"Girard","year":"2019","journal-title":"Subcell. Biochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.ajpath.2020.03.007","article-title":"The Pathobiology of Skin Aging: New Insights into an Old Dilemma","volume":"190","author":"Murphy","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wong, Q.Y.A., and Chew, F.T. (2021). Defining skin aging and its risk factors: A systematic review and meta-analysis. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-01573-z"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1468-2494.2007.00415.x","article-title":"Intrinsic and extrinsic factors in skin ageing: A review","volume":"30","author":"Farage","year":"2008","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.jid.2020.12.011","article-title":"Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms","volume":"141","author":"Krutmann","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Boo, Y.C. (2020). Emerging Strategies to Protect the Skin from Ultraviolet Rays Using Plant-Derived Materials. Antioxidants, 9.","DOI":"10.3390\/antiox9070637"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Boo, Y.C. (2019). Can Plant Phenolic Compounds Protect the Skin from Airborne Particulate Matter?. Antioxidants, 8.","DOI":"10.3390\/antiox8090379"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"He, X., Gao, X., and Xie, W. (2023). Research Progress in Skin Aging, Metabolism, and Related Products. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115930"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Grenier, A., Morissette, M.C., Rochette, P.J., and Pouliot, R. (2023). The combination of cigarette smoke and solar rays causes effects similar to skin aging in a bilayer skin model. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-44868-z"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kierans, S.J., and Taylor, C.T. (2024). Glycolysis: A multifaceted metabolic pathway and signaling hub. J. Biol. Chem., 300.","DOI":"10.1016\/j.jbc.2024.107906"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbagen.2011.03.014","article-title":"Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes","volume":"1820","author":"Yamagishi","year":"2012","journal-title":"Biochim. Biophys. Acta."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4196\/kjpp.2014.18.1.1","article-title":"Advanced glycation end products and diabetic complications","volume":"18","author":"Singh","year":"2014","journal-title":"Korean J. Physiol. Pharmacol. Off. J. Korean Physiol. Soc. Korean Soc. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12551-024-01188-4","article-title":"An overview on glycation: Molecular mechanisms, impact on proteins, pathogenesis, and inhibition","volume":"16","author":"Uceda","year":"2024","journal-title":"Biophys. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Crisan, M., Taulescu, M., Crisan, D., Cosgarea, R., Parvu, A., C\u00e3toi, C., and Drugan, T. (2013). Expression of advanced glycation end-products on sun-exposed and non-exposed cutaneous sites during the ageing process in humans. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075003"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1177\/0300060517736914","article-title":"Association of advanced glycation end products, evaluated by skin autofluorescence, with lifestyle habits in a general Japanese population","volume":"46","author":"Isami","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jshs.2020.09.007","article-title":"A physically active lifestyle is related to a lower level of skin autofluorescence in a large population with chronic disease (LifeLines cohort)","volume":"11","author":"Zwerver","year":"2022","journal-title":"J. Sport. Health Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e15065","DOI":"10.1111\/exd.15065","article-title":"The effects of advanced glycation end-products on skin and potential anti-glycation strategies","volume":"33","author":"Wang","year":"2024","journal-title":"Exp. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1006\/bbrc.1997.6780","article-title":"Generation of active oxygen species from advanced glycation end-products (AGE) under ultraviolet light A (UVA) irradiation","volume":"235","author":"Masaki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Twarda-Clapa, A., Olczak, A., Bia\u0142kowska, A.M., and Kozio\u0142kiewicz, M. (2022). Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs. Cells, 11.","DOI":"10.3390\/cells11081312"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1021\/pr800858h","article-title":"A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: Probing the pathogenesis of chronic disease","volume":"8","author":"Zhang","year":"2009","journal-title":"J. Proteome Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1074\/jbc.M008626200","article-title":"Early glycation products produce pentosidine cross-links on native proteins. novel mechanism of pentosidine formation and propagation of glycation","volume":"276","author":"Chellan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.abb.2013.12.007","article-title":"Degradation of oxidized and glycoxidized collagen: Role of collagen cross-linking","volume":"542","author":"Nowotny","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9073451","DOI":"10.1155\/2019\/9073451","article-title":"N(\u03c9)-(Carboxymethyl)arginine Is One of the Dominant Advanced Glycation End Products in Glycated Collagens and Mouse Tissues","volume":"2019","author":"Kinoshita","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"B337","DOI":"10.1093\/gerona\/50A.6.B337","article-title":"Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen","volume":"50","author":"Cefalu","year":"1995","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.jid.5700070","article-title":"The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha","volume":"126","author":"Lohwasser","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Lee, E.J., Kim, J.Y., and Oh, S.H. (2016). Advanced glycation end products (AGEs) promote melanogenesis through receptor for AGEs. Sci. Rep., 6.","DOI":"10.1038\/srep27848"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Serban, A.I., Stanca, L., Geicu, O.I., Munteanu, M.C., and Dinischiotu, A. (2016). RAGE and TGF-\u03b21 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152376"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3818196","DOI":"10.1155\/2020\/3818196","article-title":"Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects","volume":"2020","author":"Perrone","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E685","DOI":"10.1152\/ajpendo.2001.280.5.E685","article-title":"Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE","volume":"280","author":"Wautier","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"19891","DOI":"10.3390\/ijms141019891","article-title":"Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond","volume":"14","author":"Daffu","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/BF00401835","article-title":"Secondary intervention with aminoguanidine retards the progression of diabetic retinopathy in the rat model","volume":"38","author":"Hammes","year":"1995","journal-title":"Diabetologia"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s007020050108","article-title":"Cytotoxicity of advanced glycation endproducts is mediated by oxidative stress","volume":"105","author":"Loske","year":"1998","journal-title":"J. Neural Transm."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kuzan, A. (2021). Toxicity of advanced glycation end products (Review). Biomed. Rep., 14.","DOI":"10.3892\/br.2021.1422"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.abb.2003.08.016","article-title":"Therapeutic potential of breakers of advanced glycation end product-protein crosslinks","volume":"419","author":"Vasan","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0003-9861(03)00015-8","article-title":"AGE-breakers cleave model compounds, but do not break Maillard crosslinks in skin and tail collagen from diabetic rats","volume":"412","author":"Yang","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/j.1745-7254.2005.00240.x","article-title":"C16, a novel advanced glycation endproduct breaker, restores cardiovascular dysfunction in experimental diabetic rats","volume":"26","author":"Cheng","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"23S","DOI":"10.1016\/j.amjhyper.2004.08.022","article-title":"Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process","volume":"17","author":"Bakris","year":"2004","journal-title":"Am. J. Hypertens."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Song, Q., Liu, J., Dong, L., Wang, X., and Zhang, X. (2021). Novel advances in inhibiting advanced glycation end product formation using natural compounds. Biomed. Pharmacother., 140.","DOI":"10.1016\/j.biopha.2021.111750"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Chen, C.Y., Zhang, J.Q., Li, L., Guo, M.M., He, Y.F., Dong, Y.M., Meng, H., and Yi, F. (2022). Advanced Glycation End Products in the Skin: Molecular Mechanisms, Methods of Measurement, and Inhibitory Pathways. Front. Med., 9.","DOI":"10.3389\/fmed.2022.837222"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/bbrc.1995.1935","article-title":"Histones from diabetic rats contain increased levels of advanced glycation end products","volume":"212","author":"Gugliucci","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/jn\/128.9.1442","article-title":"Long-term fructose consumption accelerates glycation and several age-related variables in male rats","volume":"128","author":"Levi","year":"1998","journal-title":"J. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.2337\/diabetes.52.11.2805","article-title":"Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice","volume":"52","author":"Peppa","year":"2003","journal-title":"Diabetes"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"12087","DOI":"10.1074\/jbc.M406313200","article-title":"Advanced Glycation End Products Enhance Expression of Pro-apoptotic Genes and Stimulate Fibroblast Apoptosis through Cytoplasmic and Mitochondrial Pathways","volume":"280","author":"Alikhani","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1600-0625.2011.01364.x","article-title":"A long-standing hyperglycaemic condition impairs skin barrier by accelerating skin ageing process","volume":"20","author":"Park","year":"2011","journal-title":"Exp. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/gerona\/glr208","article-title":"Advanced glycation end-products as markers of aging and longevity in the long-lived Ansell\u2019s mole-rat (Fukomys anselli)","volume":"67","author":"Dammann","year":"2012","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3164\/jcbn.15-132","article-title":"Non-invasive measurement of skin autofluorescence to evaluate diabetic complications","volume":"58","author":"Yamanaka","year":"2016","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10522-017-9733-5","article-title":"Accumulation of glycated proteins suggesting premature ageing in lamin B receptor deficient mice","volume":"19","author":"Hause","year":"2018","journal-title":"Biogerontology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.freeradbiomed.2018.03.022","article-title":"Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts","volume":"120","author":"Nowotny","year":"2018","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Nicolas, C., Jaisson, S., Gorisse, L., Tessier, F.J., Niquet-L\u00e9ridon, C., Jacolot, P., Pietrement, C., and Gillery, P. (2019). Carbamylation and glycation compete for collagen molecular aging in vivo. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-54817-4"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"12143","DOI":"10.18632\/aging.202924","article-title":"Effects of advanced glycation end products on neutrophil migration and aggregation in diabetic wounds","volume":"13","author":"Kang","year":"2021","journal-title":"Aging"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Hiramoto, K., Imai, M., Tanaka, S., and Ooi, K. (2023). Changes in the AGE\/Macrophage\/TNF-\u03b1 Pathway Affect Skin Dryness during KK-Ay\/Tajcl Mice Aging. Life, 13.","DOI":"10.3390\/life13061339"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1111\/jocd.16295","article-title":"Unveiling the mechanism of high sugar diet induced advanced glycosylation end products damage skin structure via extracellular matrix\u2013receptor interaction pathway","volume":"23","author":"Li","year":"2024","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1006\/bbrc.2001.5322","article-title":"Identification of N\u03c9-Carboxymethylarginine, a New Advanced Glycation Endproduct in Serum Proteins of Diabetic Patients: Possibility of a New Marker of Aging and Diabetes","volume":"285","author":"Odani","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2133.2005.06756.x","article-title":"Functional properties of the stratum corneum in patients with diabetes mellitus: Similarities to senile xerosis","volume":"153","author":"Sakai","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1600-0846.2009.00396.x","article-title":"Melanin and facial skin fluorescence as markers of yellowish discoloration with aging","volume":"15","author":"Ohshima","year":"2009","journal-title":"Skin. Res. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s00421-010-1779-x","article-title":"Skin advanced glycation end product accumulation and muscle strength among adult men","volume":"111","author":"Momma","year":"2011","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1089\/dia.2012.0316","article-title":"Clinical and technical factors associated with skin intrinsic fluorescence in subjects with type 1 diabetes from the Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications Study","volume":"15","author":"Cleary","year":"2013","journal-title":"Diabetes Technol. Ther."},{"key":"ref_60","first-page":"574","article-title":"An immunohistochemical panel to assess ultraviolet radiation-associated oxidative skin injury","volume":"13","author":"Mamalis","year":"2014","journal-title":"J. Drugs Dermatol."},{"key":"ref_61","first-page":"251","article-title":"Detection of galectin-3 and localization of advanced glycation end products (AGE) in human chronic skin wounds","volume":"29","author":"Pepe","year":"2014","journal-title":"Histol. Histopathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1210\/jc.2014-2754","article-title":"Associations of advanced glycation end-products with cognitive functions in individuals with and without type 2 diabetes: The maastricht study","volume":"100","author":"Spauwen","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10654-018-0444-2","article-title":"Serum 25-hydroxyvitamin D(3) is associated with advanced glycation end products (AGEs) measured as skin autofluorescence: The Rotterdam Study","volume":"34","author":"Chen","year":"2019","journal-title":"Eur. J. Epidemiol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Shirakami, T., Yamanaka, M., Fujihara, J., Matsuoka, Y., Gohto, Y., Obana, A., and Tanito, M. (2020). Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation. Antioxidants, 9.","DOI":"10.3390\/antiox9080755"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/jid.2011.298","article-title":"N(\u03b5)-(carboxymethyl)lysine modification of elastin alters its biological properties: Implications for the accumulation of abnormal elastic fibers in actinic elastosis","volume":"132","author":"Yoshinaga","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Mooldijk, S.S., Lu, T., Waqas, K., Chen, J., Vernooij, M.W., Ikram, M.K., Zillikens, M.C., and Ikram, M.A. (2024). Skin autofluorescence, reflecting accumulation of advanced glycation end products, and the risk of dementia in a population-based cohort. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-51703-6"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1172\/JCI32559","article-title":"Regulation of erythrocyte lifespan: Do reactive oxygen species set the clock?","volume":"117","author":"Hattangadi","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1096\/fj.04-2031fje","article-title":"Galectin-3\/AGE-receptor 3 knockout mice show accelerated AGE-induced glomerular injury: Evidence for a protective role of galectin-3 as an AGE receptor","volume":"18","author":"Iacobini","year":"2004","journal-title":"Faseb J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/01.LAB.0000018826.59648.07","article-title":"Conversion of Amadori products of the Maillard reaction to N(\u03b5)-(carboxymethyl) lysine by short-term heating: Possible detection of artifacts by immunohistochemistry","volume":"82","author":"Hayashi","year":"2002","journal-title":"Lab. Investig."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.archger.2007.08.019","article-title":"Effect of cellular aging on collagen biosynthesis: I. Methodological considerations and pharmacological applications","volume":"47","author":"Molinari","year":"2008","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.exger.2008.04.004","article-title":"Reconstructed skin modified by glycation of the dermal equivalent as a model for skin aging and its potential use to evaluate anti-glycation molecules","volume":"43","author":"Pageon","year":"2008","journal-title":"Exp. Gerontol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.archger.2007.12.004","article-title":"Expression of senescence-associated beta-galactosidase (SA-beta-Gal) by human skin fibroblasts, effect of advanced glycation end-products and fucose or rhamnose-rich polysaccharides","volume":"48","author":"Ravelojaona","year":"2009","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1248\/bpb.35.260","article-title":"Anti-glycation effect of gold nanoparticles on collagen","volume":"35","author":"Kim","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1515\/cclm-2013-0091","article-title":"Skin aging by glycation: Lessons from the reconstructed skin model","volume":"52","author":"Pageon","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1515\/cclm-2012-0828","article-title":"How to help the skin cope with glycoxidation","volume":"52","author":"Danoux","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.3390\/molecules20033549","article-title":"Anti-glycation activities of phenolic constituents from Silybum marianum (Milk Thistle) flower in vitro and on human explants","volume":"20","author":"Shin","year":"2015","journal-title":"Molecules"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.3390\/nu7115478","article-title":"Ameliorating Effect of Akebia quinata Fruit Extracts on Skin Aging Induced by Advanced Glycation End Products","volume":"7","author":"Shin","year":"2015","journal-title":"Nutrients"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1089\/ten.tea.2015.0009","article-title":"Glycated Reconstructed Human Skin as a Platform to Study the Pathogenesis of Skin Aging","volume":"21","author":"Pennacchi","year":"2015","journal-title":"Tissue Eng. Part. A"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/php.12615","article-title":"Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF-kappaB Pathways in HaCaT Cells","volume":"92","author":"Han","year":"2016","journal-title":"Photochem. Photobiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.foodchem.2016.11.056","article-title":"Effect of rosmarinic acid and carnosic acid on AGEs formation in vitro","volume":"221","author":"Ou","year":"2017","journal-title":"Food Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"8263934","DOI":"10.1155\/2019\/8263934","article-title":"Cecropia pachystachya Leaves Present Potential to Be Used as New Ingredient for Antiaging Dermocosmetics","volume":"2019","author":"Fernandes","year":"2019","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Orfanoudaki, M., Hartmann, A., Alilou, M., Gelbrich, T., Planchenault, P., Derbr\u00e9, S., Schinkovitz, A., Richomme, P., Hensel, A., and Ganzera, M. (2019). Absolute Configuration of Mycosporine-Like Amino Acids, Their Wound Healing Properties and In Vitro Anti-Aging Effects. Mar. Drugs, 18.","DOI":"10.3390\/md18010035"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Drouet, S., Leclerc, E.A., Garros, L., Tungmunnithum, D., Kabra, A., Abbasi, B.H., Lain\u00e9, \u00c9., and Hano, C. (2019). A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-Aging Flavonolignans from Milk Thistle Silybum marianum (L.) Gaertn. Fruits for Cosmetic Applications. Antioxidants, 8.","DOI":"10.20944\/preprints201907.0252.v1"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Li, H., DaSilva, N.A., Liu, W., Xu, J., Dombi, G.W., Dain, J.A., Li, D., Chamcheu, J.C., Seeram, N.P., and Ma, H. (2020). Thymocid(\u00ae), a Standardized Black Cumin (Nigella sativa) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells. Nutrients, 12.","DOI":"10.3390\/nu12072146"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1021\/acs.jnatprod.9b01083","article-title":"Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacabensis for the Prevention of Skin Aging","volume":"83","author":"Freitas","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Spagnuolo, L., Della Posta, S., Fanali, C., Dugo, L., and De Gara, L. (2021). Antioxidant and Antiglycation Effects of Polyphenol Compounds Extracted from Hazelnut Skin on Advanced Glycation End-Products (AGEs) Formation. Antioxidants, 10.","DOI":"10.3390\/antiox10030424"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Waditee-Sirisattha, R., and Kageyama, H. (2021). Protective effects of mycosporine-like amino acid-containing emulsions on UV-treated mouse ear tissue from the viewpoints of antioxidation and antiglycation. J. Photochem. Photobiol. B., 223.","DOI":"10.1016\/j.jphotobiol.2021.112296"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Lin, H., Lin, T.Y., Lin, J.A., Cheng, K.C., Santoso, S.P., Chou, C.H., and Hsieh, C.W. (2021). Effect of Pholiota nameko Polysaccharides Inhibiting Methylglyoxal-Induced Glycation Damage In Vitro. Antioxidants, 10.","DOI":"10.3390\/antiox10101589"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1111\/jocd.14406","article-title":"Anti-glycation activities of methyl gallate in vitro and in human explants","volume":"21","author":"Shin","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Yoon, S., Kim, M., Shin, S., Woo, J., Son, D., Ryu, D., Yoo, J., Park, D., and Jung, E. (2022). Effect of Cirsium japonicum Flower Extract on Skin Aging Induced by Glycation. Molecules, 27.","DOI":"10.3390\/molecules27072093"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"8789903","DOI":"10.1155\/2022\/8789903","article-title":"Inhibitory Effects of Parachlorella Beijerinckii Extracts on the Formation of Advanced Glycation End Products and Glycative Stress-Induced Inflammation in an In Vitro Skin Dermis-Like Model","volume":"2022","author":"Imai","year":"2022","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"7119256","DOI":"10.1155\/2022\/7119256","article-title":"Vanillic Acid Inhibited the Induced Glycation Using In Vitro and In Vivo Models","volume":"2022","author":"Alhadid","year":"2022","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1021\/acs.jafc.2c06502","article-title":"Cranberry Juice Polyphenols Inhibited the Formation of Advanced Glycation End Products in Collagens, Inhibited Advanced Glycation End Product-Induced Collagen Crosslinking, and Cleaved the Formed Crosslinks","volume":"70","author":"Chang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Spagnuolo, L., Della Posta, S., Fanali, C., Dugo, L., and De Gara, L. (2023). Chemical Composition of Hazelnut Skin Food Waste and Protective Role against Advanced Glycation End-Products (AGEs) Damage in THP-1-Derived Macrophages. Molecules, 28.","DOI":"10.3390\/molecules28062680"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/ics.12930","article-title":"N-acetyl-L-hydroxyproline\u2014A potent skin anti-ageing active preventing advanced glycation end-product formation in vitro and ex vivo","volume":"46","author":"Knoblich","year":"2024","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Sultana, R., Parveen, A., Kang, M.-C., Hong, S.-M., and Kim, S.Y. (2024). Glyoxal-derived advanced glycation end products (GO-AGEs) with UVB critically induce skin inflammaging: In vitro and in silico approaches. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-52037-z"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000448121","article-title":"The Effect of Glycation on Epidermal Lipid Content, Its Metabolism and Change in Barrier Function","volume":"29","author":"Yokota","year":"2016","journal-title":"Skin. Pharmacol. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1196\/annals.1333.060","article-title":"An in vitro approach to the chronological aging of skin by glycation of the collagen: The biological effect of glycation on the reconstructed skin model","volume":"1043","author":"Pageon","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1089\/biores.2014.0053","article-title":"Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging","volume":"4","author":"Pageon","year":"2015","journal-title":"BioResearch Open Access"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.archger.2009.05.006","article-title":"Age- and passage-dependent upregulation of fibroblast elastase-type endopeptidase activity. Role of advanced glycation endproducts, inhibition by fucose- and rhamnose-rich oligosaccharides","volume":"50","author":"Robert","year":"2010","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.biomaterials.2015.01.066","article-title":"In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules","volume":"51","author":"Cadau","year":"2015","journal-title":"Biomaterials"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Balansin Rigon, R., Kaessmeyer, S., Wolff, C., Hausmann, C., Zhang, N., Sochorov\u00e1, M., Kov\u00e1\u010dik, A., Haag, R., V\u00e1vrov\u00e1, K., and Ulrich, M. (2018). Ultrastructural and Molecular Analysis of Ribose-Induced Glycated Reconstructed Human Skin. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113521"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Li, X., Yang, K., Gao, S., Zhao, J., Liu, G., Chen, Y., Lin, H., Zhao, W., Hu, Z., and Xu, N. (2020). Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.593832"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Lee, Y.I., Lee, S.G., Jung, I., Suk, J., Lee, M.H., Kim, D.U., and Lee, J.H. (2022). Effect of a Topical Collagen Tripeptide on Antiaging and Inhibition of Glycation of the Skin: A Pilot Study. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031101"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Lyu, J.L., Liu, Y.J., Wen, K.C., Chiu, C.Y., Lin, Y.H., and Chiang, H.M. (2022). Protective Effect of Djulis (Chenopodium formosanum) Extract against UV- and AGEs-Induced Skin Aging via Alleviating Oxidative Stress and Collagen Degradation. Molecules, 27.","DOI":"10.3390\/molecules27072332"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1111\/jocd.15248","article-title":"A case study investigating the short-term efficacy and tolerability of a daily serum composed from a unique sunflower sprout extract","volume":"21","author":"Barua","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2147\/CCID.S364538","article-title":"Anti-Glycation and Anti-Aging Properties of Resveratrol Derivatives in the in-vitro 3D Models of Human Skin","volume":"15","author":"Markiewicz","year":"2022","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Ceccacci, S., Lucia, A., Tortora, A., Colantuono, A., Carotenuto, G., Tito, A., and Monti, M.C. (2022). Jasminum sambac Cell Extract as Antioxidant Booster against Skin Aging. Antioxidants, 11.","DOI":"10.3390\/antiox11122409"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3746\/pnf.2023.28.3.235","article-title":"Unripe Carica papaya Fresh Fruit Extract Protects against Methylglyoxal-Mediated Aging in Human Dermal Skin Fibroblasts","volume":"28","author":"Wattanapitayakul","year":"2023","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e2401960","DOI":"10.1002\/adhm.202401960","article-title":"Topical Transdermal Administration of Supramolecular Self-Assembled Carnosine for Anti-Melanin and Anti-Aging","volume":"13","author":"Bai","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Augello, F.R., Lombardi, F., Ciafarone, A., Ciummo, V., Altamura, S., Giuliani, M., Cinque, B., and Palumbo, P. (2024). Efficacy of an Innovative Poly-Component Formulation in Counteracting Human Dermal Fibroblast Aging by Influencing Oxidative and Inflammatory Pathways. Biomedicines, 12.","DOI":"10.3390\/biomedicines12092030"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.patbio.2009.09.009","article-title":"Reaction of glycation and human skin: The effects on the skin and its components, reconstructed skin as a model","volume":"58","author":"Pageon","year":"2010","journal-title":"Pathologie Biologie"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1159\/000492276","article-title":"Novel Facial Cream Containing Carnosine Inhibits Formation of Advanced Glycation End-Products in Human Skin","volume":"31","author":"Narda","year":"2018","journal-title":"Ski. Pharmacol. Physiol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Havas, F., Krispin, S., Cohen, M., Loing, E., Farge, M., Suere, T., and Attia-Vigneau, J. (2022). A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties. Mar. Drugs, 20.","DOI":"10.3390\/md20020104"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"De Decker, I., Notebaert, M., Speeckaert, M.M., Claes, K.E.Y., Blondeel, P., Van Aken, E., Van Dorpe, J., De Somer, F., Heintz, M., and Monstrey, S. (2023). Enzymatic Deglycation of Damaged Skin by Means of Combined Treatment of Fructosamine-3-Kinase and Fructosyl-Amino Acid Oxidase. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108981"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1369\/00221554221145998","article-title":"Long Hanging Structure of Collagen VII Connects the Elastic Fibers and the Basement Membrane in Young Skin Tissue","volume":"70","author":"Tohgasaki","year":"2022","journal-title":"J. Histochem. Cytochem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"796","DOI":"10.2337\/diab.39.7.796","article-title":"Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin","volume":"39","author":"Odetti","year":"1990","journal-title":"Diabetes"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0047-6374(94)01541-S","article-title":"Dietary calorie restriction in the Emory mouse: Effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen breaktime, DNA and RNA oxidation, skin integrity, fecundity, and cancer","volume":"79","author":"Taylor","year":"1995","journal-title":"Mech. Ageing Dev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0047-6374(97)01863-0","article-title":"Ageing promotes the increase of early glycation Amadori product as assessed by epsilon-N-(2-furoylmethyl)-L-lysine (furosine) levels in rodent skin collagen. The relationship to dietary restriction and glycoxidation","volume":"95","author":"Sell","year":"1997","journal-title":"Mech. Ageing Dev."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"B94","DOI":"10.1093\/gerona\/53A.2.B94","article-title":"Protein glycation in the aging male Sprague-Dawley rat: Effects of antiaging diet restrictions","volume":"53","author":"Novelli","year":"1998","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/713773927","article-title":"The influence of frequent and excessive intake of glucose on microvascular aging in healthy mice","volume":"6","author":"Yamada","year":"1999","journal-title":"Microcirculation"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"B171","DOI":"10.1093\/gerona\/54.4.B171","article-title":"Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: An avian solution?","volume":"54","author":"Iqbal","year":"1999","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0047-6374(99)00022-6","article-title":"Advanced glycation in D-galactose induced mouse aging model","volume":"108","author":"Song","year":"1999","journal-title":"Mech. Ageing Dev."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/jn\/130.5.1247","article-title":"Accumulation of Advanced Glycation Endproducts in Aging Male Fischer 344 Rats during Long-Term Feeding of Various Dietary Carbohydrates","volume":"130","author":"Lingelbach","year":"2000","journal-title":"J. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1532-0456(01)00186-7","article-title":"Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol","volume":"129","author":"Klandorf","year":"2001","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"B405","DOI":"10.1093\/gerona\/56.9.B405","article-title":"Effect of chronic aminoguanidine treatment on age-related glycation, glycoxidation, and collagen cross-linking in the Fischer 344 rat","volume":"56","author":"Sell","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_127","first-page":"453","article-title":"Green Tea Extract Suppresses the Age-Related Increase in Collagen Crosslinking and Fluorescent Products in C57BL\/6 Mice","volume":"73","author":"Rutter","year":"2003","journal-title":"IJVNR"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"B508","DOI":"10.1093\/gerona\/58.6.B508","article-title":"The Effect of Caloric Restriction on Glycation and Glycoxidation in Skin Collagen of Nonhuman Primates","volume":"58","author":"Sell","year":"2003","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Zhang, S., Dong, Z., Peng, Z., and Lu, F. (2014). Anti-aging effect of adipose-derived stem cells in a mouse model of skin aging induced by D-galactose. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097573"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1177\/0394632016634348","article-title":"Adipose stem cells\u2019 antagonism in glycosylation of D-galactose-induced skin aging of nude mice and its skin recovery function","volume":"29","author":"Wang","year":"2016","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"8999","DOI":"10.1002\/ece3.3388","article-title":"Using pentosidine and hydroxyproline to predict age and sex in an avian species","volume":"7","author":"Dorr","year":"2017","journal-title":"Ecol. Evol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Zhou, X., Du, H.-h., Jiang, M., Zhou, C., Deng, Y., Long, X., and Zhao, X. (2021). Antioxidant Effect of Lactobacillus fermentum CQPC04-Fermented Soy Milk on D-Galactose-Induced Oxidative Aging Mice. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.727467"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Gu, M.J., Lee, H.W., Yoo, G., Kim, D., Choi, I.W., Kim, Y., and Ha, S.K. (2023). Protective effect of Schizonepeta tenuifolia Briq. ethanolic extract against UVB-induced skin aging and photodamage in hairless mice. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1176073"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Xie, Y., Ye, J., Ouyang, Y., Gong, J., Li, C., Deng, Y., Mai, Y., Liu, Y., and Deng, W. (2023). Microneedle-Assisted Topical Delivery of Idebenone-Loaded Bioadhesive Nanoparticles Protect against UV-Induced Skin Damage. Biomedicines, 11.","DOI":"10.3390\/biomedicines11061649"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3746\/pnf.2023.28.2.134","article-title":"AGEs Blocker\u2122 (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice","volume":"28","author":"Yoo","year":"2023","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"157","DOI":"10.25122\/jml-2023-0343","article-title":"Dapagliflozin mitigates oxidative stress, inflammatory, and histopathological markers of aging in mice","volume":"17","author":"Shihab","year":"2024","journal-title":"J. Med. Life."},{"key":"ref_137","first-page":"81","article-title":"Measurement feasability of advanced glycated end-products from skin samples after antioxidant vitamin supplementation in patients with type 2 diabetes","volume":"4","author":"Konen","year":"2000","journal-title":"J. Nutr. Health Aging."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1524-4725.2005.31731","article-title":"Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin","volume":"31","author":"Chiu","year":"2005","journal-title":"Dermatol. Surg."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1473-2165.2009.00428.x","article-title":"An evaluation of the effect of a topical product containing C-xyloside and blueberry extract on the appearance of type II diabetic skin","volume":"8","author":"Draelos","year":"2009","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/09546634.2010.521812","article-title":"Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging","volume":"23","author":"Babizhayev","year":"2012","journal-title":"J. Dermatolog Treat."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Yoshikata, R., Myint, K.Z.Y., Ohta, H., and Ishigaki, Y. (2021). Effects of an equol-containing supplement on advanced glycation end products, visceral fat and climacteric symptoms in postmenopausal women: A randomized controlled trial. PLoS ONE, 16.","DOI":"10.21203\/rs.3.rs-265906\/v3"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/bbb\/zbad065","article-title":"Ingestion of a collagen peptide containing high concentrations of prolyl-hydroxyproline and hydroxyprolyl-glycine reduces advanced glycation end products levels in the skin and subcutaneous blood vessel walls: A randomized, double-blind, placebo-controlled study","volume":"87","author":"Koizumi","year":"2023","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Cheng, D., and Wang, F. (2025). Facial assessment methods for inhibiting glycation and aging effects and the correlation between glycation and aging parameters. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-86467-0"},{"key":"ref_144","first-page":"34","article-title":"Reversing Oxinflammation Associated with Glycative Stress and Formation of Advanced Glycation End Products with a Dietary Supplement Containing Rosemary Extract","volume":"18","author":"Guiotto","year":"2025","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Papaccio, F., Caputo, S., and Bellei, B. (2022). Focus on the Contribution of Oxidative Stress in Skin Aging. Antioxidants, 11.","DOI":"10.3390\/antiox11061121"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11010-019-03550-7","article-title":"Acceleration of protein glycation by oxidative stress and comparative role of antioxidant and protein glycation inhibitor","volume":"459","author":"Bavkar","year":"2019","journal-title":"Mol. Cell Biochem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.biopha.2016.05.023","article-title":"Genistein as antioxidant and antibrowning agents in vivo and in vitro: A review","volume":"82","author":"Mazumder","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Geng, R., Kang, S.G., Huang, K., and Tong, T. (2021). Boosting the Photoaged Skin: The Potential Role of Dietary Components. Nutrients, 13.","DOI":"10.3390\/nu13051691"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"7145656","DOI":"10.1155\/2020\/7145656","article-title":"Galactose-Induced Skin Aging: The Role of Oxidative Stress","volume":"2020","author":"Umbayev","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.2147\/CCID.S476362","article-title":"Mitigating Glycation and Oxidative Stress in Aesthetic Medicine: Hyaluronic Acid and Trehalose Synergy for Anti-AGEs Action in Skin Aging Treatment","volume":"17","author":"Chmielewski","year":"2024","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.36849\/JDD.SF378083","article-title":"INDIVIDUAL ARTICLE: Sugar Sag: What Is Skin Glycation and How Do You Combat It?","volume":"23","author":"Draelos","year":"2024","journal-title":"J. Drugs Dermatol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"100320","DOI":"10.1016\/j.clinsp.2023.100320","article-title":"Advanced glycation end products consumption and the decline of functional capacity in patients with Parkinson\u2019s disease: Cross-sectional study","volume":"79","author":"Almeida","year":"2024","journal-title":"Clinics"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/gerona\/gly108","article-title":"Advanced Glycation End Products Are Associated with Physical Activity and Physical Functioning in the Older Population","volume":"73","author":"Drenth","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.abb.2003.08.013","article-title":"Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts","volume":"419","author":"Thornalley","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Harper, E.I., Siroky, M.D., Hilliard, T.S., Dominique, G.M., Hammond, C., Liu, Y., Yang, J., Hubble, V.B., Walsh, D.J., and Melander, R.J. (2023). Advanced Glycation End Products as a Potential Target for Restructuring the Ovarian Cancer Microenvironment: A Pilot Study. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24129804"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Martinovic, D., Tokic, D., Usljebrka, M., Lupi-Ferandin, S., Cigic, L., Vanjaka Rogosic, L., Ercegovic, S., Kontic, M., Kumri\u0107, M., and Rusic, D. (2023). The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters. Life, 13.","DOI":"10.3390\/life13020256"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.freeradbiomed.2010.06.003","article-title":"Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis","volume":"49","author":"Fan","year":"2010","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/diab.43.5.676","article-title":"Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stages of the Maillard reaction","volume":"43","author":"Fu","year":"1994","journal-title":"Diabetes"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2133.2005.06949.x","article-title":"Facial skin fluorescence as a marker of the skin\u2019s response to chronic environmental insults and its dependence on age","volume":"154","author":"Stamatas","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"ref_160","first-page":"195","article-title":"Noninvasive measurement of advanced glycation end-products in the facial skin: New data for skin aging studies","volume":"68","author":"Qu","year":"2017","journal-title":"J. Cosmet. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/jocd.13452","article-title":"Correlation analysis between advanced glycation end products detected noninvasively and skin aging factors","volume":"20","author":"Xin","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"101194","DOI":"10.1016\/j.eclinm.2021.101194","article-title":"Clinical significance of non-invasive skin autofluorescence measurement in patients with diabetes: A systematic review and meta-analysis","volume":"42","author":"Hosseini","year":"2021","journal-title":"Eclinicalmedicine"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/dia.2011.0108","article-title":"Two fluorescent wavelengths, 440(ex)\/520(em) nm and 370(ex)\/440(em) nm, reflect advanced glycation and oxidation end products in human skin without diabetes","volume":"14","author":"Beisswenger","year":"2012","journal-title":"Diabetes Technol. Ther."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Delanghe, J.R., Beeckman, J., Beerens, K., Himpe, J., Bostan, N., Speeckaert, M.M., Notebaert, M., Huizing, M., and Van Aken, E. (2023). Topical Application of Deglycating Enzymes as an Alternative Non-Invasive Treatment for Presbyopia. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087343"},{"key":"ref_165","first-page":"102","article-title":"Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase","volume":"1478","author":"Fujino","year":"2000","journal-title":"Biochim. Et. Biophys. Acta BBA-Protein Struct. Mol. Enzymology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1248\/bpb.32.1632","article-title":"Increased oxidized protein hydrolase activity in serum and urine of diabetic rat models","volume":"32","author":"Shimizu","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4161\/derm.22804","article-title":"Skin anti-aging strategies","volume":"4","author":"Ganceviciene","year":"2012","journal-title":"Dermatoendocrinol"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e13391","DOI":"10.1111\/srt.13391","article-title":"Reverse skin aging signs by red light photobiomodulation","volume":"29","author":"Couturaud","year":"2023","journal-title":"Skin. Res. Technol."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Oh, S., Rho, N.K., Byun, K.A., Yang, J.Y., Sun, H.J., Jang, M., Kang, D., Son, K.H., and Byun, K. (2022). Combined Treatment of Monopolar and Bipolar Radiofrequency Increases Skin Elasticity by Decreasing the Accumulation of Advanced Glycated End Products in Aged Animal Skin. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23062993"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12974-020-01981-4","article-title":"Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE\/NF-\u03baB signaling pathway in vivo and in vitro","volume":"17","author":"Ding","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-med-041316-085215","article-title":"Targeting RAGE Signaling in Inflammatory Disease","volume":"69","author":"Hudson","year":"2018","journal-title":"Annu. Rev. Med."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Hoang, H.T., Moon, J.-Y., and Lee, Y.-C. (2021). Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives. Cosmetics, 8.","DOI":"10.3390\/cosmetics8040106"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Boo, Y.C. (2020). Natural Nrf2 Modulators for Skin Protection. Antioxidants, 9.","DOI":"10.3390\/antiox9090812"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e70075","DOI":"10.1111\/jocd.70075","article-title":"Conditions to Consider When Choosing Fillers","volume":"24","author":"Hong","year":"2025","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1055\/a-2366-3436","article-title":"Injectable Skin Boosters in Aging Skin Rejuvenation: A Current Overview","volume":"51","author":"Rho","year":"2024","journal-title":"Arch. Plast. Surg."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"14123","DOI":"10.1021\/acsnano.3c04726","article-title":"Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products","volume":"17","author":"Han","year":"2023","journal-title":"ACS Nano."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/4\/498\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:18:23Z","timestamp":1760030303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/4\/498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,20]]},"references-count":176,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["antiox14040498"],"URL":"https:\/\/doi.org\/10.3390\/antiox14040498","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,20]]}}}