{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:21:02Z","timestamp":1791562862641,"version":"4.3.4"},"reference-count":86,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Ischaemic stroke is the most prevalent stroke subtype, accounting for 80\u201390% of all cases worldwide, and remains a leading cause of morbidity and mortality. Its pathophysiology involves complex molecular cascades, with oxidative stress playing a central role. During cerebral ischaemia, reduced blood flow deprives neurons of essential oxygen and nutrients, triggering excitotoxicity, mitochondrial dysfunction, and excessive production of reactive oxygen and nitrogen species (RONS). Not only do these species damage cellular components, but they also activate inflammatory pathways, particularly those mediated by the transcription factor nuclear factor kappa-B (NF-\u03baB). The pro-inflammatory milieu intensifies neuronal damage, compromises blood\u2013brain barrier integrity, and exacerbates reperfusion-induced damage. Recent findings highlight the importance of the gut microbiota in modulating stroke outcomes, primarily through metabolic and immunological interactions along the gut\u2013brain axis. Dysbiosis, characterised by reduced microbial diversity and an imbalance between beneficial and harmful strains, has been linked to increased systemic inflammation, oxidative stress, and worse prognoses. Specific gut-derived metabolites, including short-chain fatty acids (SCFAs) and trimethylamine N-oxide (TMAO), appear to either mitigate or intensify neuronal injury. SCFAs may strengthen the blood\u2013brain barrier and temper inflammatory responses, whereas elevated TMAO levels may increase thrombotic risk. This narrative review consolidates both experimental and clinical data demonstrating the central role of oxidative stress in ischaemic stroke pathophysiology and explores the gut microbiota\u2019s ability to modulate these damaging processes. Therapeutic strategies targeting oxidative pathways or rebalancing gut microbial composition, such as antioxidant supplementation, dietary modulation, probiotics, and faecal microbiota transplantation, present promising paradigms for stroke intervention. However, their widespread clinical implementation is hindered by a lack of large-scale, randomised trials. Future efforts should employ a multidisciplinary approach to elucidate the intricate mechanisms linking oxidative stress and gut dysbiosis to ischaemic stroke, thereby paving the way for novel, mechanism-based therapies for improved patient outcomes.<\/jats:p>","DOI":"10.3390\/antiox14050542","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T03:50:43Z","timestamp":1746071443000},"page":"542","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Role of Oxidative Stress in Ischaemic Stroke and the Influence of Gut Microbiota"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-5253","authenticated-orcid":false,"given":"Aleksandra","family":"Golenia","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1984-1566","authenticated-orcid":false,"given":"Piotr","family":"Olejnik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/17474930241308142","article-title":"World Stroke Organization: Global Stroke Fact Sheet 2025","volume":"20","author":"Feigin","year":"2025","journal-title":"Int. J. Stroke"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S1474-4422(24)00369-7","article-title":"Global, Regional, and National Burden of Stroke and Its Risk Factors, 1990\u20132021: A Systematic Analysis for the Global Burden of Disease Study 2021","volume":"23","author":"Feigin","year":"2024","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Salaudeen, M.A., Bello, N., Danraka, R.N., and Ammani, M.L. (2024). Understanding the Pathophysiology of Ischemic Stroke: The Basis of Current Therapies and Opportunity for New Ones. Biomolecules, 14.","DOI":"10.3390\/biom14030305"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kuriakose, D., and Xiao, Z. (2020). Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207609"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1326-6-11","article-title":"Pathophysiology, Treatment, and Animal and Cellular Models of Human Ischemic Stroke","volume":"6","author":"Woodruff","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Pawluk, H., Tafelska-Kaczmarek, A., Sopo\u0144ska, M., Porzych, M., Modrzejewska, M., Pawluk, M., Kurhaluk, N., Tkaczenko, H., and Ko\u0142odziejska, R. (2024). The Influence of Oxidative Stress Markers in Patients with Ischemic Stroke. Biomolecules, 14.","DOI":"10.3390\/biom14091130"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","article-title":"Neuroprotection in Acute Stroke: Targeting Excitotoxicity, Oxidative and Nitrosative Stress, and Inflammation","volume":"15","author":"Chamorro","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Patil, S., Rossi, R., Jabrah, D., and Doyle, K. (2022). Detection, Diagnosis and Treatment of Acute Ischemic Stroke: Current and Future Perspectives. Front. Med. Technol., 4.","DOI":"10.3389\/fmedt.2022.748949"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.pharep.2014.02.021","article-title":"Catalase Activity in Blood Fractions of Patients with Sporadic ALS","volume":"66","author":"Golenia","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s42466-022-00222-8","article-title":"The Gut-Brain Axis in Ischemic Stroke: Its Relevance in Pathology and as a Therapeutic Target","volume":"4","author":"Benakis","year":"2022","journal-title":"Neurol. Res. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhang, H., He, J., and Xiong, X. (2022). The Role of the Gut Microbiota in the Development of Ischemic Stroke. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.845243"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0028-3908(01)00019-3","article-title":"Oxidative Stress Induced-Neurodegenerative Diseases: The Need for Antioxidants That Penetrate the Blood Brain Barrier","volume":"40","author":"Melamed","year":"2001","journal-title":"Neuropharmacology"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Anaya-Fern\u00e1ndez, R., Anaya-Prado, R., Anaya-Fernandez, M.M., Guerrero-Palomera, M.A., Garcia-Ramirez, I.F., Gonzalez-Martinez, D., Azcona-Ramirez, C.C., Guerrero-Palomera, C.S., Garcia-Perez, C., and Tenorio-Gonzalez, B. (2024). Oxidative Stress in Cerebral Ischemia\/Reperfusion Injury. OBM Neurobiol., 8.","DOI":"10.21926\/obm.neurobiol.2403239"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/biom5020472","article-title":"Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction","volume":"5","author":"Weidinger","year":"2015","journal-title":"Biomolecules"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Daraghmeh, D.N., and Karaman, R. (2024). The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants. Antioxidants, 14.","DOI":"10.3390\/antiox14010036"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free Radicals and Antioxidants in Normal Physiological Functions and Human Disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1042\/bj3530411","article-title":"Mitochondrial Respiratory Chain-Dependent Generation of Superoxide Anion and Its Release into the Intermembrane Space","volume":"353","author":"Han","year":"2001","journal-title":"Biochem. J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Reis, P.A., de Albuquerque, C.F.G., Maron-Gutierrez, T., Silva, A.R., and Neto, H.C.D.C.F. (2017). Role of Nitric Oxide Synthase in the Function of the Central Nervous System under Normal and Infectious Conditions. Nitric Oxide Synthase\u2014Simple Enzyme-Complex Roles, InTech.","DOI":"10.5772\/67816"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sies, H. (2020). Oxidative Stress: Concept and Some Practical Aspects. Antioxidants, 9.","DOI":"10.3390\/antiox9090852"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative Stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1747-4949.2009.00387.x","article-title":"Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke","volume":"4","author":"Allen","year":"2009","journal-title":"Int. J. Stroke"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00221-007-1050-9","article-title":"Some New Prospects in the Understanding of the Molecular Basis of the Pathogenesis of Stroke","volume":"182","author":"Saeed","year":"2007","journal-title":"Exp. Brain Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1756286418789340","DOI":"10.1177\/1756286418789340","article-title":"Inflammatory Molecules Might Become Both Biomarkers and Therapeutic Targets for Stroke Management","volume":"11","author":"Ramiro","year":"2018","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1089\/ars.2009.2463","article-title":"Redox Regulation of Nuclear Post-Translational Modifications During NF-\u039aB Activation","volume":"11","author":"Gloire","year":"2009","journal-title":"Antioxid. Redox Signal"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of Reactive Oxygen Species and NF-\u039aB Signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The Immunology of Stroke: From Mechanisms to Translation","volume":"17","author":"Iadecola","year":"2011","journal-title":"Nat. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.1109766","article-title":"Inflammatory Mechanisms in Ischemic Stroke: Role of Inflammatory Cells","volume":"87","author":"Jin","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","article-title":"The Science of Stroke: Mechanisms in Search of Treatments","volume":"67","author":"Moskowitz","year":"2010","journal-title":"Neuron"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","article-title":"Ischemia-Reperfusion Injury: Molecular Mechanisms and Therapeutic Targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/jsre.2002.6385","article-title":"Ischemia\/Reperfusion Injury","volume":"105","author":"Lentsch","year":"2002","journal-title":"J. Surg. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lin, L., Wang, X., and Yu, Z. (2016). Ischemia-Reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies. Biochem. Pharmacol., 5.","DOI":"10.4172\/2167-0501.1000213"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion Injury and Reactive Oxygen Species: The Evolution of a Concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.freeradbiomed.2003.09.013","article-title":"Application of in Vivo ESR Spectroscopy to Measurement of Cerebrovascular ROS Generation in Stroke","volume":"35","author":"Yamato","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s12035-010-8102-z","article-title":"Reperfusion and Neurovascular Dysfunction in Stroke: From Basic Mechanisms to Potential Strategies for Neuroprotection","volume":"41","author":"Jung","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12035-012-8344-z","article-title":"Molecular Mechanisms of Ischemia\u2013Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation","volume":"47","author":"Sanderson","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"103047","DOI":"10.1016\/j.redox.2024.103047","article-title":"Reactive Oxygen Species Generation by Reverse Electron Transfer at Mitochondrial Complex I Under Simulated Early Reperfusion Conditions","volume":"70","author":"Dancil","year":"2024","journal-title":"Redox Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00109-012-0963-3","article-title":"NADPH Oxidases as a Source of Oxidative Stress and Molecular Target in Ischemia\/Reperfusion Injury","volume":"90","author":"Kleikers","year":"2012","journal-title":"J. Mol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the Human Gut Microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1111\/j.1753-4887.2012.00493.x","article-title":"Defining the Human Microbiome","volume":"70","author":"Ursell","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in Health and Diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G., Gasbarrini, A., and Mele, M. (2019). What Is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms, 7.","DOI":"10.3390\/microorganisms7010014"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1097\/MIB.0000000000000750","article-title":"Current Understanding of Dysbiosis in Disease in Human and Animal Models","volume":"22","author":"DeGruttola","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000516398","article-title":"Role of the Gut Microbiota in Stroke Pathogenesis and Potential Therapeutic Implications","volume":"77","author":"Yamashiro","year":"2021","journal-title":"Ann. Nutr. Metab."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kasarello, K., Cudnoch-Jedrzejewska, A., and Czarzasta, K. (2023). Communication of Gut Microbiota and Brain via Immune and Neuroendocrine Signaling. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1118529"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota\u2013Gut\u2013Brain Axis and Its Therapeutic Applications in Neurodegenerative Diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Dicks, L.M.T. (2022). Gut Bacteria and Neurotransmitters. Microorganisms, 10.","DOI":"10.3390\/microorganisms10091838"},{"key":"ref_48","first-page":"1707","article-title":"Gut Microbiota Neurotransmitters: Influence on Risk and Outcome of Ischemic Stroke","volume":"18","author":"Pluta","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"114559","DOI":"10.1016\/j.biopha.2023.114559","article-title":"New Insight into Gut Microbiota and Their Metabolites in Ischemic Stroke: A Promising Therapeutic Target","volume":"162","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/STROKEAHA.121.036800","article-title":"Gut Microbiota and Their Metabolites in Stroke: A Double-Edged Sword","volume":"53","author":"Peh","year":"2022","journal-title":"Stroke"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/nep3.44","article-title":"Role of Gut Microbiota in Ischemic Stroke: A Narrative Review of Human and Animal Studies","volume":"2","author":"Chen","year":"2024","journal-title":"Neuroprotection"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12937-020-00592-2","article-title":"Gut Microbiota-Associated Metabolite Trimethylamine N-Oxide and the Risk of Stroke: A Systematic Review and Dose\u2013Response Meta-Analysis","volume":"19","author":"Farhangi","year":"2020","journal-title":"Nutr. J."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Liu, Y., Qu, J., Xu, J., Gu, A., Deng, D., Jia, X., and Wang, B. (2023). Trimethylamine-N-Oxide: A Potential Biomarker and Therapeutic Target in Ischemic Stroke. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1156879"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","article-title":"Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk","volume":"165","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10571-022-01209-4","article-title":"The Bridge Between Ischemic Stroke and Gut Microbes: Short-Chain Fatty Acids","volume":"43","author":"Fang","year":"2023","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Silva, Y.P., Bernardi, A., and Frozza, R.L. (2020). The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00025"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Chou, P.-S., Yang, I.-H., Kuo, C.-M., Wu, M.-N., Lin, T.-C., Fong, Y.-O., Juan, C.-H., and Lai, C.-L. (2023). The Prognostic Biomarkers of Plasma Trimethylamine N-Oxide and Short-Chain Fatty Acids for Recanalization Therapy in Acute Ischemic Stroke. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310796"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Henry, N., Frank, J., McLouth, C., Trout, A.L., Morris, A., Chen, J., Stowe, A.M., Fraser, J.F., and Pennypacker, K. (2022). Short Chain Fatty Acids Taken at Time of Thrombectomy in Acute Ischemic Stroke Patients Are Independent of Stroke Severity But Associated With Inflammatory Markers and Worse Symptoms at Discharge. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.797302"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10977","DOI":"10.1038\/s41598-021-90463-5","article-title":"Microbiota Dysbiosis and Functional Outcome in Acute Ischemic Stroke Patients","volume":"11","author":"Chang","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Fusco, W., Lorenzo, M.B., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M.C., Gasbarrini, A., and Collado, M.C. (2023). Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota. Nutrients, 15.","DOI":"10.3390\/nu15092211"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Sun, H., Gu, M., Li, Z., Chen, X., and Zhou, J. (2022). Gut Microbiota Dysbiosis in Acute Ischemic Stroke Associated With 3-Month Unfavorable Outcome. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.799222"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Yamashiro, K., Tanaka, R., Urabe, T., Ueno, Y., Yamashiro, Y., Nomoto, K., Takahashi, T., Tsuji, H., Asahara, T., and Hattori, N. (2017). Gut Dysbiosis Is Associated with Metabolism and Systemic Inflammation in Patients with Ischemic Stroke. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176062"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s40168-023-01648-1","article-title":"Gut Microbiota of Old Mice Worsens Neurological Outcome after Brain Ischemia via Increased Valeric Acid and IL-17 in the Blood","volume":"11","author":"Zeng","year":"2023","journal-title":"Microbiome"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"14086","DOI":"10.1038\/s41598-024-64819-6","article-title":"Identifying Gut Microbiota with High Specificity for Ischemic Stroke with Large Vessel Occlusion","volume":"14","author":"He","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zhang, J., Ling, L., Xiang, L., Li, W., Bao, P., and Yue, W. (2024). Role of the Gut Microbiota in Complications after Ischemic Stroke. Front. Cell Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1334581"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"106836","DOI":"10.1016\/j.nbd.2025.106836","article-title":"The Impact of Gut Microbiota on the Occurrence, Treatment, and Prognosis of Ischemic Stroke","volume":"207","author":"Chen","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Kunst, C., Schmid, S., Michalski, M., T\u00fcmen, D., Buttensch\u00f6n, J., M\u00fcller, M., and G\u00fclow, K. (2023). The Influence of Gut Microbiota on Oxidative Stress and the Immune System. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051388"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1801944","DOI":"10.1080\/19490976.2020.1801944","article-title":"Oxidative Stress Tolerance and Antioxidant Capacity of Lactic Acid Bacteria as Probiotic: A Systematic Review","volume":"12","author":"Feng","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e7172","DOI":"10.1590\/1414-431x20187172","article-title":"Protective Effect and Mechanism of Lactobacillus on Cerebral Ischemia Reperfusion Injury in Rats","volume":"51","author":"Wanchao","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wang, Q., Guo, M., Liu, Y., Xu, M., Shi, L., Li, X., Zhao, J., Zhang, H., Wang, G., and Chen, W. (2022). Bifidobacterium Breve and Bifidobacterium Longum Attenuate Choline-Induced Plasma Trimethylamine N-Oxide Production by Modulating Gut Microbiota in Mice. Nutrients, 14.","DOI":"10.3390\/nu14061222"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Long, J., Wang, J., Li, Y., and Chen, S. (2022). Gut Microbiota in Ischemic Stroke: Where We Stand and Challenges Ahead. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1008514"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"108725","DOI":"10.1016\/j.clineuro.2025.108725","article-title":"Progress of Research on Short-Chain Fatty Acids, Metabolites of Gut Microbiota, and Acute Ischemic Stroke","volume":"249","author":"Deng","year":"2025","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"122979","DOI":"10.1016\/j.lfs.2024.122979","article-title":"Short-Chain Fatty Acid on Blood-Brain Barrier and Glial Function in Ischemic Stroke","volume":"354","author":"Mathias","year":"2024","journal-title":"Life Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"114351","DOI":"10.1016\/j.expneurol.2023.114351","article-title":"Butyrate Promotes Post-Stroke Outcomes in Aged Mice via Interleukin-22","volume":"363","author":"Chen","year":"2023","journal-title":"Exp. Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.clnu.2008.11.002","article-title":"Butyrate Modulates Oxidative Stress in the Colonic Mucosa of Healthy Humans","volume":"28","author":"Hamer","year":"2009","journal-title":"Clin. Nutr."},{"key":"ref_76","first-page":"1762","article-title":"Sodium Butyrate Relieves Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting JNK\/STAT Pathway","volume":"23","author":"Wang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Zhou, S.-Y., Guo, Z.-N., Yang, Y., Qu, Y., and Jin, H. (2023). Gut-Brain Axis: Mechanisms and Potential Therapeutic Strategies for Ischemic Stroke through Immune Functions. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1081347"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Qu, D., Jiang, D., Xin, Y., Yang, G., Liang, H., and Wang, L. (2024). Gut Microbiota and Functional Outcome after Ischemic Stroke: A Mendelian Randomization Study. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1414653"},{"key":"ref_79","first-page":"e37324","article-title":"Connecting the Dots: The Interplay Between Stroke and the Gut-Brain Axis","volume":"15","author":"Murthy","year":"2023","journal-title":"Cureus"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41430-021-00986-3","article-title":"Effect of Early Enteral Nutrition Combined with Probiotics in Patients with Stroke: A Meta-Analysis of Randomized Controlled Trials","volume":"76","author":"Chen","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e37682","DOI":"10.1097\/MD.0000000000037682","article-title":"Bifidobacterium Bifidum Supplementation Improves Ischemic Stroke Outcomes in Elderly Patients: A Retrospective Study","volume":"103","author":"Xin","year":"2024","journal-title":"Medicine"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Savigamin, C., Samuthpongtorn, C., Mahakit, N., Nopsopon, T., Heath, J., and Pongpirul, K. (2022). Probiotic as a Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of In Vitro and In Vivo Studies. Nutrients, 14.","DOI":"10.20944\/preprints202207.0374.v1"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus Strain Regulates Emotional Behavior and Central GABA Receptor Expression in a Mouse via the Vagus Nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1365-2982.2011.01796.x","article-title":"The Anxiolytic Effect of Bifidobacterium Longum NCC3001 Involves Vagal Pathways for Gut-Brain Communication","volume":"23","author":"Bercik","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"106727","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106727","article-title":"The Effect of Fecal Microbiota Transplantation on Stroke Outcomes: A Systematic Review","volume":"31","author":"Pasokh","year":"2022","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Hediyal, T.A., Vichitra, C., Anand, N., Bhaskaran, M., Essa, S.M., Kumar, P., Qoronfleh, M.W., Akbar, M., Kaul-Ghanekar, R., and Mahalakshmi, A.M. (2024). Protective Effects of Fecal Microbiota Transplantation against Ischemic Stroke and Other Neurological Disorders: An Update. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1324018"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/5\/542\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:24:54Z","timestamp":1760030694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/5\/542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":86,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["antiox14050542"],"URL":"https:\/\/doi.org\/10.3390\/antiox14050542","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}