{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:12:54Z","timestamp":1788448374305,"version":"build-2803163510"},"reference-count":77,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Cat\u00f3lica de Valencia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Fucus vesiculosus is a brown seaweed known for its strong antioxidant properties, mainly attributed to its high polyphenolic content. This study aimed to evaluate the antioxidant protective effect of an optimised F. vesiculosus extract in an experimental model of intestinal ischemia\/reperfusion (I\/R) injury, considering the intestine as particularly vulnerable to this pathology. Seventy-two male Wistar albino rats were randomly divided into twelve groups: Sham, I\/R groups (3 and 24 h reperfusion), I\/R plus vehicle groups (three application times, 3 h reperfusion), and I\/R plus F. vesiculosus extract groups (three application times, 3 and 24 h reperfusion). Intestinal injury was assessed through biochemical markers (malondialdehyde [MDA], superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and mieloperoxidase [MPO]), inflammatory cytokines (interleukin 1 \u03b2 [IL-1\u03b2] and interleukin [IL-10]), and histological analysis. Results demonstrated that treatment with F. vesiculosus significantly reduced oxidative stress and inflammation caused by I\/R injury (p &lt; 0.05), restoring analysed parameters (MDA, SOD, CAT, IL-10) to levels comparable to the Sham group. Histological examination confirmed the preservation of intestinal mucosal integrity following F. vesiculosus administration. These findings suggest that the antioxidant extract from F. vesiculosus effectively protects against intestinal I\/R injury, highlighting its potential for clinical use in preventing and managing this pathological condition, particularly in surgical contexts.<\/jats:p>","DOI":"10.3390\/antiox14060624","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:35:09Z","timestamp":1747982109000},"page":"624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antioxidant Effect of a Fucus vesiculosus Extract on Intestinal Ischemia\/Reperfusion Injury in Rats: A Biochemical and Histological Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-8854","authenticated-orcid":false,"given":"Desir\u00e9e","family":"S\u00e1nchez-Bonet","sequence":"first","affiliation":[{"name":"Escuela de Doctorado, Universidad Cat\u00f3lica de Valencia \u201cSan Vicente M\u00e1rtir\u201d, Plaza de San Agust\u00edn, 3, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1237-8900","authenticated-orcid":false,"given":"Carolina","family":"Padr\u00f3n-Sanz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Traslacional San Alberto Magno, Universidad Cat\u00f3lica de Valencia \u201cSan Vicente M\u00e1rtir\u201d, C\/Quevedo, 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Lloris-Cejalvo","sequence":"additional","affiliation":[{"name":"Escuela de Doctorado, Universidad Cat\u00f3lica de Valencia \u201cSan Vicente M\u00e1rtir\u201d, Plaza de San Agust\u00edn, 3, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8685-5936","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Lloris-Cars\u00ed","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Departamento de Cirug\u00eda, Universidad de Valencia, Avda. Blasco Ib\u00e1\u00f1ez, 13, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4825-1856","authenticated-orcid":false,"given":"Dolores","family":"Cejalvo-Lape\u00f1a","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Traslacional San Alberto Magno, Universidad Cat\u00f3lica de Valencia \u201cSan Vicente M\u00e1rtir\u201d, C\/Quevedo, 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/oxygen2040030","article-title":"RONS and oxidative stress: An overview of basic concepts","volume":"2","year":"2022","journal-title":"Oxygen"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kotha, R.R., Tareq, F.S., Yildiz, E., and Luthria, D.L. (2022). Oxidative stress and antioxidants\u2014A critical review on in vitro antioxidant assays. Antioxidants, 11.","DOI":"10.3390\/antiox11122388"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.56499\/jppres24.1957_12.6.1111","article-title":"The effect of ethanol-based coriander (Coriandrum sativum L.) seed extract on oxidative stress, antioxidant level and cellular senescence in the heart of obese rat","volume":"12","author":"Namirah","year":"2024","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Di Meo, S., Napolitano, G., and Venditti, P. (2019). Physiological and pathological role of ROS: Benefits and limitations of antioxidant treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194810"},{"key":"ref_5","first-page":"715","article-title":"Oxidative stress","volume":"86","author":"Sies","year":"1985","journal-title":"Acad. Press"},{"key":"ref_6","first-page":"1","article-title":"Antioxidant and anti-inflammatory activities of Gallic acid in Japanese quails induced by oxidative stress","volume":"33","author":"Alasahan","year":"2023","journal-title":"Rev. Cient. Fac. Cienc. Vet."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wu, L., Xiong, X., Wu, X., Ye, Y., Jian, Z., Zhi, Z., and Gu, L. (2020). Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.00028"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/stresses2030019","article-title":"Chemistry of hydrogen peroxide formation and elimination in mammalian cells, and its role in various pathologies","volume":"2","author":"Juan","year":"2022","journal-title":"Stresses"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lin, L., Wang, X., and Yu, Z. (2016). Ischemia-reperfusion injury in the brain: Mechanisms and potential therapeutic strategies. Biochem. Pharmacol., 5.","DOI":"10.4172\/2167-0501.1000213"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Nieuwenhuijs-Moeke, G.J., Pischke, S.E., Berger, S.P., Sanders, J.S.F., Pol, R.A., Struys, M.M.R.F., Ploeg, R.J., and Leuvenink, H.G.D. (2020). Ischemia and reperfusion injury in kidney transplantation: Relevant mechanisms in injury and repair. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010253"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Afolabi, A.O., Akhigbe, T.M., Odetayo, A.F., Anyogu, D.C., Hamed, M.A., and Akhigbe, R.E. (2022). Restoration of hepatic and intestinal integrity by Phyllanthus amarus is dependent on Bax\/Caspase 3 modulation in intestinal ischemia\/reperfusion-induced injury. Molecules, 27.","DOI":"10.3390\/molecules27165073"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1096\/fj.201900817R","article-title":"HMGB1-associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia\/reperfusion in rats","volume":"34","author":"Wen","year":"2020","journal-title":"FASEB J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.drudis.2018.05.034","article-title":"Mesenteric ischemia-reperfusion: An overview of preclinical drug strategies","volume":"23","author":"Bertoni","year":"2018","journal-title":"Drug Discov. Today"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000503727","article-title":"Sevoflurane protects against intestinal ischemia-reperfusion injury by activating peroxisome proliferator-activated receptor gamma\/nuclear factor-kappaB pathway in rats","volume":"105","author":"Liu","year":"2020","journal-title":"Pharmacology"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Li, G., Wang, S., and Fan, Z. (2022). Oxidative stress in intestinal ischemia-reperfusion. Front. Med., 8.","DOI":"10.3389\/fmed.2021.750731"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Abo-Shady, A.M., Gheda, S.F., Ismail, G.A., Cotas, J., Pereira, L., and Abdel-Karim, O.H. (2023). Antioxidant and antidiabetic activity of algae. Life, 13.","DOI":"10.3390\/life13020460"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Anwar, H., Hussain, G., and Mustafa, I. (2018). Antioxidants from natural sources. Antioxidants in Foods and its Applications, InTech.","DOI":"10.5772\/intechopen.75961"},{"key":"ref_19","first-page":"21","article-title":"A review on marine algae and its applications","volume":"13","author":"Veluchamy","year":"2020","journal-title":"Asian J. Pharm. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.1021\/jf3003653","article-title":"Antioxidant capacities of phlorotannins extracted from the brown algae Fucus vesiculosus","volume":"60","author":"Wang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tziveleka, L.A., Tammam, M.A., Tzakou, O., Roussis, V., and Ioannou, E. (2021). Metabolites with antioxidant activity from marine macroalgae. Antioxidants, 10.","DOI":"10.3390\/antiox10091431"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10811-014-0291-9","article-title":"Phenolic content and antioxidant activity of fractions obtained from selected Irish macroalgae species (Laminaria digitata, Fucus serratus, Gracilaria gracilis and Codium fragile)","volume":"27","author":"Heffernan","year":"2015","journal-title":"J. Appl. Phycol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Cikos, A.M., Jokic, S., Subaric, D., and Jerkovic, I. (2018). Overview on the application of modern methods for the extraction of bioactive compounds from marine macroalgae. Mar. Drugs, 16.","DOI":"10.3390\/md16100348"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/A:1007935218120","article-title":"A comparison of screening methods for antioxidant activity in seaweeds","volume":"9","author":"Matsukawa","year":"1997","journal-title":"J. Appl. Phycol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Pereira, L., and Cotas, J. (2023). Therapeutic potential of polyphenols and other micronutrients of marine origin. Mar. Drugs, 21.","DOI":"10.3390\/md21060323"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"128262","DOI":"10.1016\/j.foodchem.2020.128262","article-title":"Main bioactive phenolic compounds in marine algae and their mechanisms of action supporting potential health benefits","volume":"341","author":"Pereira","year":"2021","journal-title":"Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.afnr.2016.12.004","article-title":"Phenolic compounds and its bioavailability: In vitro bioactive compounds or health promoters?","volume":"82","author":"Ferreira","year":"2017","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kumar, N., and Goel, N. (2019). Phenolic acids: Natural versatile molecules with promising therapeutic applications. Biotechnol. Rep., 24.","DOI":"10.1016\/j.btre.2019.e00370"},{"key":"ref_29","unstructured":"Segura Campos, M.R. (2019). Phenolic Compounds: Structure, Classification, and Antioxidant Power. Bioactive Compounds: Health Benefits and Potential Applications, Woodhead Publishing."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Rudrapal, M., Khairnar, S.J., Khan, J., Bin Dukhyil, A., Ansari, M.A., Alomary, M.N., Alshabrmi, F.M., Palai, S., Deb, P.K., and Devi, R. (2022). Dietary polyphenols and their role in oxidative stress-induced human diseases: Insights into protective effects, antioxidant potentials and mechanism(s) of action. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.806470"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.foodchem.2012.11.026","article-title":"In vitro antioxidant properties of crude extracts and compounds from brown algae: A review","volume":"138","author":"Balboa","year":"2013","journal-title":"Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Catarino, M.D., Silva, A.M.S., and Cardoso, S.M. (2017). Fucaceae: A source of bioactive phlorotannins. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061327"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Agreg\u00e1n, R., Munekata, P., Franco, D., Carballo, J., Barba, F.J., and Lorenzo, J.M. (2018). Antioxidant potential of extracts obtained from macro-algae (Ascophyllum nodosum, Fucus vesiculosus and Bifurcaria bifurcata) and micro-algae (Chlorella vulgaris and Spirulina platensis) assisted by ultrasound. Medicines, 5.","DOI":"10.3390\/medicines5020033"},{"key":"ref_34","first-page":"29","article-title":"Comparative assessment of antioxidant activity and biochemical composition of four seaweeds, Rocky Bay of Abu Qir in Alexandria, Egypt","volume":"41","author":"Bases","year":"2020","journal-title":"Food Sci. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Obluchinskaya, E.D., Pozharitskaya, O.N., Zakharov, D.V., Flisyuk, E.V., Terninko, I.I., Generalova, Y.E., Smekhova, I.E., and Shikov, A.N. (2022). The biochemical composition and antioxidant properties of Fucus vesiculosus from the Arctic region. Mar. Drugs, 20.","DOI":"10.3390\/md20030193"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.foodchem.2017.08.032","article-title":"Structure dependent antioxidant capacity of phlorotannins from Icelandic Fucus vesiculosus by UHPLC-DAD-ECD-QTOFMS","volume":"240","author":"Hermund","year":"2018","journal-title":"Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Mateos, R., P\u00e9rez-Correa, J.R., and Dom\u00ednguez, H. (2020). Bioactive properties of marine phenolics. Mar. Drugs, 18.","DOI":"10.3390\/md18100501"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.foodchem.2009.03.025","article-title":"Antioxidant and antitumoural activities of some Phaeophyta from Brittany coasts","volume":"116","author":"Zubia","year":"2009","journal-title":"Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.foodchem.2010.11.127","article-title":"In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland","volume":"126","author":"Queguineur","year":"2011","journal-title":"Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10811-019-01927-1","article-title":"Effect of extraction method and solvent system on the phenolic content and antioxidant activity of selected macro and microalgae extracts","volume":"32","author":"Monteiro","year":"2020","journal-title":"J. Appl. Phycol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1021\/jf00062a013","article-title":"Phenolic constituents on the leaves of northern willows: Methods for the analysis of certain phenolics","volume":"33","year":"1985","journal-title":"J. Agric. Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/(SICI)1097-0010(200004)80:5<561::AID-JSFA574>3.0.CO;2-#","article-title":"Flavonoid content of several vegetables and their antioxidant activity","volume":"80","author":"Chu","year":"2000","journal-title":"J. Sci. Food Agric."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.foodchem.2010.09.101","article-title":"The effects of solvents on the phenolic contents and antioxidant activity of Stypocaulon scoparium algae extracts","volume":"125","author":"Rico","year":"2011","journal-title":"Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"122978","DOI":"10.1016\/j.jchromb.2021.122978","article-title":"RP-HPLC-DAD determination of the differences in the polyphenol content of Fucus vesiculosus extracts with similar antioxidant activity","volume":"1184","year":"2021","journal-title":"J. Chromatogr. B"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1620\/tjem.218.251","article-title":"Resveratrol, a natural antioxidant, attenuates intestinal ischemia\/reperfusion injury in rats","volume":"218","author":"Ozkan","year":"2009","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states: I. A morphological, hemodynamic, and metabolic reappraisal","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhang, W., and Wu, G. (2021). Intestinal ischemic reperfusion injury: Recommended rats model and comprehensive review for protective strategies. Biomed. Pharmacother., 138.","DOI":"10.1016\/j.biopha.2021.111482"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"112891","DOI":"10.1016\/j.ejmech.2020.112891","article-title":"Oxidative stress mitigation by antioxidants\u2014An overview on their chemistry and influences on health status","volume":"209","author":"Pisoschi","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Mas-Bargues, C., Escriv\u00e1, C., Dromat, M., Borr\u00e1s, C., and Vi\u00f1a, J. (2021). Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Arch. Biochem. Biophys., 709.","DOI":"10.1016\/j.abb.2021.108941"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"476","DOI":"10.28982\/josam.1029203","article-title":"The healing effects of Gonoderma lucidum on intestinal ischemia-reperfusion damage in rats","volume":"6","author":"Ercan","year":"2022","journal-title":"J. Surg. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.surg.2017.04.017","article-title":"Antioxidant potential of Himanthalia elongata for protection against ischemia-reperfusion injury in the small bowel","volume":"162","year":"2017","journal-title":"Surgery"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zhou, T., Prather, E.R., Garrison, D.E., and Zuo, L. (2018). Interplay between ROS and antioxidants during ischemia-reperfusion injuries in cardiac and skeletal muscle. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020417"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1172\/JCI107816","article-title":"Superoxide dismutases in polymorphonuclear leukocytes","volume":"54","author":"Salin","year":"1974","journal-title":"J. Clin. Investig."},{"key":"ref_55","first-page":"287","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alex. J. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0009-9120(99)00075-2","article-title":"Antioxidant enzymes and human diseases","volume":"32","author":"Mates","year":"1999","journal-title":"Clin. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00436-005-1377-8","article-title":"Antioxidant potential of rat liver in experimental infection with Fasciola hepatica","volume":"96","author":"Kolodziejczyk","year":"2005","journal-title":"Parasitol. Res."},{"key":"ref_58","first-page":"501","article-title":"Alteration in antioxidant defense mechanisms in the small intestines of methotrexate treated rat may contribute to its gastrointestinal toxicity","volume":"5","author":"Kolli","year":"2007","journal-title":"Cancer Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3109\/19390211.2015.1103828","article-title":"Antioxidant potential of the methanol extract of Parquetina nigrescens mediates protection against intestinal ischemia-reperfusion injury in rats","volume":"13","author":"Akinrinmade","year":"2016","journal-title":"J. Diet. Suppl."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4103\/1319-3767.166203","article-title":"Protective effects of thymoquine and melatonin on intestinal ischemia-reperfusion injury","volume":"21","author":"Tas","year":"2015","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2182930","DOI":"10.1080\/08941939.2023.2182930","article-title":"The effect of antioxidant Astaxanthin on intestinal ischemia-reperfusion damage in rats","volume":"36","author":"Yilmaz","year":"2023","journal-title":"J. Investig. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"20","DOI":"10.31450\/ukrjnd.4(64).2019.04","article-title":"Evaluation of protective effects of melatonin on free radical metabolism in rat kidney during ischemia-reperfusion","volume":"4","author":"Nisari","year":"2019","journal-title":"Ukr. J. Nephrol. Dial."},{"key":"ref_63","first-page":"604","article-title":"The preventive effects of dex medetomidine against intestinal ischemia-reperfusion injury in Wistar rats","volume":"18","author":"Zhang","year":"2015","journal-title":"Iran J. Basic Med. Sci."},{"key":"ref_64","first-page":"39","article-title":"Enzimas que participan como barreras fisiol\u00f3gicas para eliminar los radicales libres: Catalasa","volume":"15","author":"Rodriguez","year":"1996","journal-title":"Rev. Cubana Investig. Biomed."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"26","DOI":"10.28982\/josam.858237","article-title":"Effect of rutin on experimentally induced small intestinal ischemia-reperfusion injury in rats: A biochemical and histopathological evaluation","volume":"5","author":"Altuner","year":"2021","journal-title":"J. Surg. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1124\/jpet.121.000587","article-title":"Anwulignan improves intestinal ischemia-reperfusion injury","volume":"378","author":"Lin","year":"2021","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"633","DOI":"10.5603\/FM.a2023.0034","article-title":"Gallic acid treatment protects intestinal tissue against ischaemia-reperfusion","volume":"82","author":"Durgun","year":"2023","journal-title":"Folia Morphol."},{"key":"ref_68","first-page":"1487","article-title":"Daidzein alleviated the pathologies in intestinal tissue against ischemia-reperfusion","volume":"27","author":"Durgun","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_69","first-page":"190","article-title":"Enzimas generadoras de especies reactivas del ox\u00edgeno: Mieloperoxidasa","volume":"17","author":"Pereira","year":"1998","journal-title":"Rev. Cubana Inv. Biom\u00e9d."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Chen, S., Chen, H., Du, Q., and Shen, J. (2020). Targeting myeloperoxidase (MPO)-mediated oxidative stress and inflammation for reducing brain ischemia injury: Potential application of natural compounds. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00433"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1159\/000494579","article-title":"Entire peroxidation reaction system of myeloperoxidase correlates with progressive low-density lipoprotein modifications via reactive aldehydes in atherosclerotic patients with hypertension","volume":"50","author":"Liu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"120901","DOI":"10.1016\/j.talanta.2020.120901","article-title":"A novel reaction-based fluorescence probe for rapid imaging of HClO in live cells, animals, and injured liver tissues","volume":"215","author":"Deng","year":"2020","journal-title":"Talanta"},{"key":"ref_73","first-page":"59","article-title":"The role of chlorogenic acid in alleviating intestinal ischemia\/reperfusion-induced lung injury","volume":"1","author":"Tanyeli","year":"2020","journal-title":"New Trend Med. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.4049\/jimmunol.172.4.2542","article-title":"Role of bradykinin B2 and B1 receptors in the local, remote, and systemic inflammatory responses that follow intestinal ischemia and reperfusion injury","volume":"172","author":"Souza","year":"2004","journal-title":"J. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejphar.2006.10.065","article-title":"Effects of the treatment with glibenclamide, an ATP-sensitive potassium channel blocker, on intestinal ischemia and reperfusion injury","volume":"556","author":"Pompermayer","year":"2007","journal-title":"Eur. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4149\/gpb_2014030","article-title":"Intestinal ischemia-reperfusion injury mediates expression of inflammatory cytokines in rats","volume":"34","author":"Urban","year":"2015","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ijsu.2020.08.061","article-title":"Effects of endothelin receptor blockade and COX inhibition on intestinal I\/R injury in a rat model: Experimental research","volume":"83","author":"Ucar","year":"2020","journal-title":"Int. J. Surg."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/6\/624\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:38:56Z","timestamp":1760031536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/6\/624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":77,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["antiox14060624"],"URL":"https:\/\/doi.org\/10.3390\/antiox14060624","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]}}}