{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:10:08Z","timestamp":1787062208127,"version":"build-2736575974"},"reference-count":82,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08280"],"award-info":[{"award-number":["22K08280"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"2022 Suzuken Memorial Foundation","award":["22K08280"],"award-info":[{"award-number":["22K08280"]}]},{"name":"2022 Yokoyama Foundation for Clinical Pharmacology","award":["22K08280"],"award-info":[{"award-number":["22K08280"]}]},{"name":"2022 Japan Diabetes Foundation\/Novo Nordisk Pharma Ltd.","award":["22K08280"],"award-info":[{"award-number":["22K08280"]}]},{"name":"2022 Takeda Science Foundation","award":["22K08280"],"award-info":[{"award-number":["22K08280"]}]},{"name":"2023 Takeda Science Foundation","award":["22K08280"],"award-info":[{"award-number":["22K08280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Preterm birth and low birth weight remain major contributors to neonatal morbidity and mortality, yet the underlying mechanisms are not fully understood. Maternal microbiota has been implicated in adverse pregnancy outcomes, but key mediators remain unidentified. We previously showed that the microbiota-derived peptide corisin induces epithelial apoptosis via mitochondrial membrane depolarization and reactive oxygen species accumulation. In this retrospective preliminary study, we evaluated the association between maternal serum corisin levels and pregnancy outcomes in 84 eligible women. Among them, 10 experienced preterm birth, and 22 delivered low-birth-weight infants. Corisin levels were significantly elevated in these groups compared with women with full-term, normal-weight deliveries. Preterm birth was associated with increased tissue factor, while low birth weight correlated with higher thrombin\u2013antithrombin complex and soluble thrombomodulin and lower fibrinogen levels. Corisin concentrations showed negative correlations with maternal BMI, birth weight and length, and estimated fetal weight. Positive correlations were observed between corisin, myeloperoxidase, and several coagulation markers. These preliminary findings suggest that elevated maternal corisin levels are associated with adverse pregnancy outcomes and may reflect underlying mechanisms involving oxidative stress and coagulation activation. Further investigation is warranted to clarify its potential role as a microbiota-derived biomarker in pregnancy complications.<\/jats:p>","DOI":"10.3390\/antiox14060670","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T12:27:09Z","timestamp":1748867229000},"page":"670","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploratory Evaluation of Circulating Microbiota-Derived Corisin Levels in Women with Adverse Pregnancy Outcomes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7335-1755","authenticated-orcid":false,"given":"Maya","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University, Mie University Hospital, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5270-5182","authenticated-orcid":false,"given":"Masafumi","family":"Nii","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University, Mie University Hospital, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9372-1808","authenticated-orcid":false,"given":"Kuniaki","family":"Toriyabe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University, Mie University Hospital, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Tamaishi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University, Mie University Hospital, Mie 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School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"},{"name":"Microbiome Research Center, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"},{"name":"Department of Diabetes, Endocrinology and Metabolism, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina N.","family":"D\u2019Alessandro-Gabazza","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department Pulmonary and Critical Care Medicine, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Cann","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department Pulmonary and Critical Care Medicine, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"},{"name":"Microbiome Research Center, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5748-1499","authenticated-orcid":false,"given":"Esteban C.","family":"Gabazza","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"},{"name":"Department Pulmonary and Critical Care Medicine, Faculty and Graduate School of Medicine, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"},{"name":"Microbiome Research Center, Mie University, Edobashi 2-174, Tsu, Mie 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University, Mie University Hospital, Mie 514-8507, 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