{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:02:42Z","timestamp":1790928162022,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Public Health Three-Year Action Plan (2023\u20132025) Key Discipline Project","award":["GWVI-11.1-41 and 42"],"award-info":[{"award-number":["GWVI-11.1-41 and 42"]}]},{"name":"Shanghai Public Health Three-Year Action Plan (2023\u20132025) Key Discipline Project","award":["GWVI-4"],"award-info":[{"award-number":["GWVI-4"]}]},{"name":"Shanghai Public Health Three-Year Action Plan (2023\u20132025) Project","award":["GWVI-11.1-41 and 42"],"award-info":[{"award-number":["GWVI-11.1-41 and 42"]}]},{"name":"Shanghai Public Health Three-Year Action Plan (2023\u20132025) Project","award":["GWVI-4"],"award-info":[{"award-number":["GWVI-4"]}]},{"name":"The Institute of Chemical Safety Evaluation\/State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants at the Shanghai Municipal Center for Disease Control and Prevention","award":["GWVI-11.1-41 and 42"],"award-info":[{"award-number":["GWVI-11.1-41 and 42"]}]},{"name":"The Institute of Chemical Safety Evaluation\/State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants at the Shanghai Municipal Center for Disease Control and Prevention","award":["GWVI-4"],"award-info":[{"award-number":["GWVI-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Ferroptosis, a form of regulated cell death driven by lipid peroxidation, has been implicated in the pathogenesis of liver diseases. This study investigates the role of circRNA_1156 in neodymium nitrate (Nd(NO3)3)-induced hepatocyte ferroptosis. Our in vitro experiments revealed that exposure to Nd(NO3)3 (1.2 \u00b5M) significantly reduced the viability of AML12 hepatocytes (p &lt; 0.01), increased levels of reactive oxygen species (ROS) and malondialdehyde (MDA) (p &lt; 0.001), and depleted glutathione (GSH) (p &lt; 0.001). However, overexpression of circRNA_1156 effectively reversed these effects and suppressed the expression of ACSL4 and PKC\u03b2II (p &lt; 0.01). In our in vivo experiments, chronic exposure to Nd(NO3)3 (7\u201355 mg\/kg for 180 days) induced hepatic iron deposition, mitochondrial damage, and activation of the ACSL4\/PKC\u03b2II pathway (p &lt; 0.01). These adverse effects were significantly ameliorated by circRNA_1156 overexpression (p &lt; 0.05). Our findings identify circRNA_1156 as a novel inhibitor of Nd(NO3)3-induced ferroptosis via downregulation of the ACSL4\/PKC\u03b2II pathway, providing valuable therapeutic insights for hepatotoxicity caused by rare earth element compounds.<\/jats:p>","DOI":"10.3390\/antiox14060700","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T08:22:34Z","timestamp":1749457354000},"page":"700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CircRNA_1156 Attenuates Neodymium Nitrate-Induced Hepatocyte Ferroptosis by Inhibiting the ACSL4\/PKC\u03b2II Signaling Pathway"],"prefix":"10.3390","volume":"14","author":[{"given":"Ning","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Chemical Safety Evaluation, State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Leng","sequence":"additional","affiliation":[{"name":"Institute of Chemical Safety Evaluation, State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Chemical Safety Evaluation, State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelei","family":"Qian","sequence":"additional","affiliation":[{"name":"Institute of Chemical Safety Evaluation, State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Chemical Safety Evaluation, State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonghua","family":"Tao","sequence":"additional","affiliation":[{"name":"Institute of Chemical Safety Evaluation, State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xiao","sequence":"additional","affiliation":[{"name":"Institute of Chemical Safety Evaluation, State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Hong","sequence":"additional","affiliation":[{"name":"Institute of Chemical Safety Evaluation, State Environmental Protection Key Laboratory of Health Impact Assessment on New Environmental Pollutants, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"ref_1","first-page":"12","article-title":"Ferroptosis and cancer: Interlinkages and potential applications","volume":"1","author":"Hu","year":"2023","journal-title":"Clin. 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