{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:32:27Z","timestamp":1763389947130,"version":"build-2065373602"},"reference-count":79,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Food Research Center","doi-asserted-by":"publisher","award":["2013\/07914-8","2013\/12402-6"],"award-info":[{"award-number":["2013\/07914-8","2013\/12402-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2013\/07914-8","2013\/12402-6"],"award-info":[{"award-number":["2013\/07914-8","2013\/12402-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Dietary polyphenols\u2019 role in early life is not clear. While accumulating studies show both beneficial and deleterious effects of maternal consumption of these bioactive compounds on offspring\u2019s adult health, very few studies have focused on the impact of paternal consumption. In addition, the potential interaction of combined parental polyphenol consumption is still not known. Thus, the aim of the present study was to investigate the effects of maternal (gestation\/lactation) and\/or paternal (preconception) blackberry polyphenol (anthocyanins, ellagitannins, and quercetin) methanolic extract consumption on C57BL\/6 female mice offspring. Blackberry polyphenol consumption by fathers improved their sperm production and increased fertility. Blackberry polyphenol consumption by fathers, but not mothers, increased their plasma antioxidant capacity. All parental interventions decreased offspring perinatal mortality, with combined fathers\u2019 and mothers\u2019 polyphenol consumption exerting the most pronounced effects. Paternal or maternal polyphenol consumption decreased plasma total antioxidant capacity in the female offspring. On the other hand, combined parental consumption had opposing effects on the offspring. Only maternal polyphenol interventions increased glucose tolerance in the female offspring. These data only partially confirm our hypothesis that combined paternal and maternal polyphenol intervention would lead to better outcomes in the offspring. These results further show that blackberry polyphenols\u2019 effects on offspring health depend on whether their consumption occurred through the father, mother, or both. This suggests that in order to promote long-term health in descendants, nutritional interventions, including those with polyphenols, should target not only the mother but also the future father.<\/jats:p>","DOI":"10.3390\/antiox14070779","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:53:02Z","timestamp":1750823582000},"page":"779","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Paternal and\/or Maternal Blackberry (Rubus spp.) Polyphenolic Extract Consumption Improved Paternal Fertility and Differentially Affected Female Offspring Antioxidant Capacity and Metabolic Programming in a Mouse Model"],"prefix":"10.3390","volume":"14","author":[{"given":"Vanessa Cardoso","family":"Pires","sequence":"first","affiliation":[{"name":"Department of Food Science, School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Lima","family":"Anacleto","sequence":"additional","affiliation":[{"name":"Department of Food Science, School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"Matt\u00e9","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Fundamental Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Odair","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Institute of Health and Society, Federal University of S\u00e3o Paulo, Santos 11050-020, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3958-5934","authenticated-orcid":false,"given":"Franco Maria","family":"Lajolo","sequence":"additional","affiliation":[{"name":"Department of Food Science, School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"},{"name":"Food Research Center (FoRC), S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5576-7693","authenticated-orcid":false,"given":"Neuza Mariko Aymoto","family":"Hassimotto","sequence":"additional","affiliation":[{"name":"Department of Food Science, School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"},{"name":"Food Research Center (FoRC), S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Prates","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Food Science, School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"},{"name":"Food Research Center (FoRC), S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1021\/jf8026149","article-title":"Antioxidant status in humans after consumption of blackberry (Rubus fruticosus L.) juices with and without defatted milk","volume":"56","author":"Hassimotto","year":"2008","journal-title":"J. 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