{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:42:35Z","timestamp":1768902155797,"version":"3.49.0"},"reference-count":83,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Reductive stress (RS) results from the overactivity of the enzymatic and non-enzymatic antioxidant systems and from excess antioxidant agents that neutralize reactive oxygen species. Hibiscus sabdariffa Linnaeus (HSL) is a natural source of antioxidant molecules that can overload the antioxidant system. Twenty-one Wistar rats were divided into three groups: group 1 (G) G1: rats that consumed a 6% HSL infusion for one month (HSL + 6%), G2: rats that consumed a 6% HSL infusion for one month and were then given natural water for another month (HSL \u00b1 6%), and G3: rats with natural drinking water. Renal vascular resistance (RVR) was evaluated through their responses to norepinephrine (Ne), acetylcholine (Ach), super oxide (O2\u2212), hydrogen peroxide (H2O2), and peroxynitrite (ONOO\u2212). The activity of antioxidant enzymes and oxidative stress markers was evaluated. RVR was increased by Ne and H2O2 (p = 0.03), but it was decreased by Ach, O2\u2212, and ONOO\u2212 (p = 0.01). The reduced glutathione \/ oxidized glutathione (GSH\/GSSG) ratio and nitrates\/nitrites ratio, the total antioxidant capacity, the activities of superoxide dismutase, catalase, peroxidases, glutathione peroxidase, glutathione reductase, glucose-6-phosphate, and the expression of phosphorylated NrF2 were increased (p \u2264 0.04). However, the thiol groups, adenochrome, and glutathione-S-transferase were decreased (p = 0.01) in G1 vs. G2 and G3. The excessive consumption of antioxidants provided by a 6% HSL infusion results in RS contributing to a decrease in ROS.<\/jats:p>","DOI":"10.3390\/antiox14080984","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T17:22:07Z","timestamp":1754932927000},"page":"984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impaired Renal Function Due to Reductive Stress Is Associated with Excessive Consumption of Hibiscus sabdariffa Linnaeus"],"prefix":"10.3390","volume":"14","author":[{"given":"Linaloe","family":"Manzano-Pech","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology UNAM, Facultad de Medicina y Veterinaria y Zootecnia, Av. 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Universidad 3000, Coyoac\u00e1n 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-047X","authenticated-orcid":false,"given":"Sara","family":"Caballero-Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology UNAM, Facultad de Medicina y Veterinaria y Zootecnia, Av. Universidad 3000, Coyoac\u00e1n 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1767-9908","authenticated-orcid":false,"given":"Ra\u00fal","family":"Mart\u00ednez-Memije","sequence":"additional","affiliation":[{"name":"Department de Electromechanical Instrumentation, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8844-2078","authenticated-orcid":false,"given":"Mar\u00eda Esther","family":"Rubio-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Juan Badiano 1, Secci\u00f3n XVI, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix Leao","family":"Rodr\u00edguez-Fierros","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Veterinaria, Facultad de Ciencias Naturales, Universidad Aut\u00f3noma de Quer\u00e9taro, Santiago de Quer\u00e9taro 76230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-7482","authenticated-orcid":false,"given":"Juan Carlos","family":"Torres-Narv\u00e1ez","sequence":"additional","affiliation":[{"name":"Department de Pharmacology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Juan Badiano 1, Secci\u00f3n XVI, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5106-5117","authenticated-orcid":false,"given":"Luz","family":"Ibarra-Lara","sequence":"additional","affiliation":[{"name":"Department de Pharmacology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Juan Badiano 1, Secci\u00f3n XVI, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-2954","authenticated-orcid":false,"given":"Israel","family":"P\u00e9rez-Torres","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biomedicine, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/CIRCRESAHA.111.300496","article-title":"Oxidative stress and sarcomeric proteins","volume":"112","author":"Singh","year":"2013","journal-title":"Cir. 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