{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:51:04Z","timestamp":1792259464755,"version":"4.4.0"},"reference-count":152,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Oxidative stress is a significant factor in male infertility, with increasing evidence evaluating the role of antioxidants in mitigating its detrimental effects on sperm function and quality. This review examines the mechanisms by which reactive oxygen species (ROS) impact male reproductive health. This article synthesizes the different mechanisms at play and highlights key clinical studies published in the literature that contribute to our understanding of antioxidants to treat male infertility. These studies suggest that supplementation with specific antioxidants may improve sperm parameters and increase fertility outcomes, although results vary depending on dosage, duration, and individual health conditions. Despite promising findings, there are inconsistencies across study methodologies and a lack of standardized treatment protocols, which underscore the need for more rigorous clinical trials. Antioxidant supplementation has the potential to serve as a supportive treatment for male infertility, but it should be approached cautiously and appropriately by carefully selecting patients who are deficient in the administered antioxidants. There is a need to better evaluate the long-term impact on reproductive outcomes and determine the optimal supplementation strategies and patient profiles that would benefit most from supplementation regimens.<\/jats:p>","DOI":"10.3390\/antiox14081013","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T07:56:06Z","timestamp":1755590166000},"page":"1013","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3716-3447","authenticated-orcid":false,"given":"David","family":"Bouhadana","sequence":"first","affiliation":[{"name":"Division of Urology, McGill University, Montreal, QC H4A 3J1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-6752","authenticated-orcid":false,"given":"Marie-H\u00e9l\u00e8ne","family":"Godin Pag\u00e9","sequence":"additional","affiliation":[{"name":"Fertilys Fertility Centers, Laval, QC H7S 1Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9776-7459","authenticated-orcid":false,"given":"Debbie","family":"Montjean","sequence":"additional","affiliation":[{"name":"Fertilys Fertility Centers, Laval, QC H7S 1Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-3913","authenticated-orcid":false,"given":"Marie-Claire","family":"B\u00e9langer","sequence":"additional","affiliation":[{"name":"Fertilys Fertility Centers, Laval, QC H7S 1Z5, Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), CHUM Research Center, Montreal, QC J1H 5N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Benkhalifa","sequence":"additional","affiliation":[{"name":"Fertilys Fertility Centers, Laval, QC H7S 1Z5, Canada"},{"name":"M\u00e9decine et Biologie de la Reproduction et Laboratoire PERITOX, Universit\u00e9 Picardie Jules Verne, CBH-CHU Amiens Picardie, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3509-2369","authenticated-orcid":false,"given":"Pierre","family":"Miron","sequence":"additional","affiliation":[{"name":"Fertilys Fertility Centers, Laval, QC H7S 1Z5, Canada"},{"name":"Institut National de Recherche Scientifique-Centre Armand-Frappier Sant\u00e9 Biotechnologie, Laval, QC H7V 1B7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0257-2008","authenticated-orcid":false,"given":"Francis","family":"Petrella","sequence":"additional","affiliation":[{"name":"Fertilys Fertility Centers, Laval, QC H7S 1Z5, Canada"},{"name":"H\u00f4pital Charles-Lemoyne, Department of Urology, Universit\u00e9 de Sherbrooke, Greenfield Park, QC J4K 0A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Agarwal, A., Mulgund, A., Hamada, A., and Chyatte, M.R. 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