{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:25:32Z","timestamp":1770985532179,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Science and Technology Special Projects in Henan Province","award":["231100310200"],"award-info":[{"award-number":["231100310200"]}]},{"name":"Major Science and Technology Special Projects in Henan Province","award":["241111314200"],"award-info":[{"award-number":["241111314200"]}]},{"name":"Key R&amp;D Projects in Henan Province","award":["231100310200"],"award-info":[{"award-number":["231100310200"]}]},{"name":"Key R&amp;D Projects in Henan Province","award":["241111314200"],"award-info":[{"award-number":["241111314200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Excessive alcohol consumption is associated with various health complications, including liver damage and systemic inflammation. Probiotic interventions have emerged as promising strategies to mitigate alcohol-induced harm, yet their mechanisms of action remain incompletely understood. This randomized, double-blind, placebo-controlled clinical trial aimed to evaluate the protective effects of Weizmannia coagulans BC179 in chronic alcohol consumers. Seventy participants with a history of long-term alcohol intake were randomly assigned to receive either BC179 (3 g\/day, 1 \u00d7 1010 CFU) or a placebo for a 30-day intervention period. Following alcohol ingestion, dynamic monitoring of blood alcohol concentration (BAC), inflammatory and oxidative stress biomarkers, and serum metabolomic profiles was conducted. BC179 supplementation significantly reduced BAC and enhanced the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), while decreasing levels of alkaline phosphatase (ALP), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-\u03b1 (TNF-\u03b1), and interleukin-6 (IL-6). Conversely, the anti-inflammatory cytokine interleukin-10 (IL-10), superoxide dismutase (SOD), and glutathione (GSH) were significantly upregulated. Levels of cytochrome P4502E1 (CYP2E1) and malondialdehyde (MDA) were also markedly reduced. Metabolomic analysis revealed significant modulation of taurine and hypotaurine metabolism, as well as downregulation of caffeine-related pathways. Collectively, these findings indicate that W. coagulans BC179 alleviates alcohol-induced discomfort by enhancing alcohol metabolism, attenuating inflammation, reducing oxidative stress, and modulating key metabolic pathways. This probiotic strain may represent a promising adjunctive strategy for managing alcohol-related health issues.<\/jats:p>","DOI":"10.3390\/antiox14091038","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:09:32Z","timestamp":1756080572000},"page":"1038","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Weizmannia coagulans BC179 Alleviates Post-Alcohol Discomfort May via Taurine-Related Metabolism and Antioxidant Regulation: A Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.3390","volume":"14","author":[{"given":"Mengyao","family":"Duan","sequence":"first","affiliation":[{"name":"College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China"},{"name":"Henan Engineering Research Center of Food Material, Henan University of Science and Technology, Luoyang 471023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2206-5126","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China"},{"name":"Henan Engineering Research Center of Food Microbiology, Luoyang 471000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saman","family":"Azeem","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Dong","sequence":"additional","affiliation":[{"name":"Wecare Probiotics R&D Centers (WPC), Wecare Probiotics Co., Ltd., Suzhou 215200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghui","family":"Gai","sequence":"additional","affiliation":[{"name":"Wecare Probiotics R&D Centers (WPC), Wecare Probiotics Co., Ltd., Suzhou 215200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Wecare Probiotics R&D Centers (WPC), Wecare Probiotics Co., Ltd., Suzhou 215200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuguang","family":"Fang","sequence":"additional","affiliation":[{"name":"Wecare Probiotics R&D Centers (WPC), Wecare Probiotics Co., Ltd., Suzhou 215200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaobin","family":"Gu","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China"},{"name":"Henan Engineering Research Center of Food Material, Henan University of Science and Technology, Luoyang 471023, China"},{"name":"Henan Engineering Research Center of Food Microbiology, Luoyang 471000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Malnick, S.D.H., Alin, P., Somin, M., and Neuman, M.G. 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