{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:35:16Z","timestamp":1793226916824,"version":"4.5.0"},"reference-count":137,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Bialystok"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Facial bone fractures represent a significant clinical challenge due to their impact on function, aesthetics, and quality of life. Despite advances in imaging and surgical techniques, early and accurate assessment of the healing process remains limited. Conventional diagnostic methods often detect complications, such as delayed union or non-union, too late for optimal intervention. Oxidative stress\u2014an imbalance between reactive oxygen species (ROS) and antioxidant defenses\u2014plays a critical role in bone regeneration. In this review, biomarkers are presented in two main categories: (1) oxidative damage biomarkers (lipid peroxidation products: malondialdehyde, 4-hydroxynonenal, and F2-isoprostanes) and (2) antioxidant biomarkers (glutathione, enzymatic antioxidants: SOD, GPx, CAT). Their potential as non-invasive diagnostic and prognostic tools in craniofacial fracture healing is evaluated, along with emerging therapeutic strategies. Monitoring their levels in blood samples may provide real-time insights into the dynamics of fracture repair, enabling earlier detection of healing disturbances and informing personalized treatment approaches.<\/jats:p>","DOI":"10.3390\/antiox14091070","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T08:28:15Z","timestamp":1756715295000},"page":"1070","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oxidative Stress and Biomarkers in Craniofacial Fractures Healing: From Lipid Peroxidation to Antioxidant Therapies"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6889-1012","authenticated-orcid":false,"given":"\u0141ukasz","family":"Wo\u017aniak","sequence":"first","affiliation":[{"name":"Department of Dental Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8363-9090","authenticated-orcid":false,"given":"\u017baneta Anna","family":"Mierzejewska","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, Faculty of Mechanical Department, Bialystok University of Technology, Wiejska 45C, 15-351 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Borys","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial and Plastic Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-0875","authenticated-orcid":false,"given":"Wioletta","family":"Ratajczak-Wrona","sequence":"additional","affiliation":[{"name":"Department of Immunology, Medical University of Bialystok, Jerzego Waszyngtona 15A, 15-269 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u017cena","family":"Antonowicz","sequence":"additional","affiliation":[{"name":"Department of Dental Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.emc.2018.09.012","article-title":"The diagnosis and management of facial bone fractures","volume":"37","author":"Chukwulebe","year":"2019","journal-title":"Emer. Med. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13244-020-00847-w","article-title":"Facial fractures: Classification and highlights for a useful report","volume":"11","year":"2020","journal-title":"Insights Into Imaging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1097\/SCS.0000000000004269","article-title":"Facial fractures","volume":"29","author":"Ghosh","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.bjoms.2019.08.020","article-title":"Patterns of facial fractures in children","volume":"57","author":"Khan","year":"2019","journal-title":"Br. Oral. Maxillofac. Surg."},{"key":"ref_5","first-page":"6279721","article-title":"Bone tissue regeneration in the oral and maxillofacial region: A review on the application of stem cells and new strategies to improve vascularization","volume":"1","author":"Wu","year":"2019","journal-title":"Stem Cells Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/s-0036-1584197","article-title":"Treatment of temporal bone fractures","volume":"77","author":"Diaz","year":"2016","journal-title":"J. Neurol. Surg. B Skull Base"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Dong, C., Tan, G., Zhang, G., Lin, W., and Wang, G. (2023). The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1133995"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ijom.2015.11.022","article-title":"Impact of trauma and surgical treatment on the quality of life of patients with facial fractures","volume":"45","author":"Conforte","year":"2016","journal-title":"Int. J. Oral. Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Merch\u00e1n, E.C. (2021). A review of recent developments in the molecular mechanisms of bone healing. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020767"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/10715762.2018.1563782","article-title":"Glutathione accelerates osteoclast differentiation and inflammatory bone destruction","volume":"53","author":"Fujita","year":"2019","journal-title":"Free Radic. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zhu, C., Shen, S., Zhang, S., Huang, M., Zhang, L., and Chen, X. (2022). Autophagy in bone remodeling: A regulator of oxidative stress. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.898634"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11914-020-00645-9","article-title":"Connexin gap junctions and hemichannels link oxidative stress to skeletal physiology and pathology","volume":"19","author":"Hua","year":"2021","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Dhama, K., Latheef, S.K., Dadar, M., Samad, H.A., Munjal, A., Khandia, R., and Joshi, S.K. (2019). Biomarkers in stress related diseases\/disorders: Diagnostic, prognostic, and therapeutic values. Front. Mol. Biosci., 6.","DOI":"10.3389\/fmolb.2019.00091"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103308","DOI":"10.1016\/j.autrev.2023.103308","article-title":"Oxidative stress, mitochondrial dysfunction, and respiratory chain enzyme defects in inflammatory myopathies","volume":"22","author":"Danieli","year":"2023","journal-title":"Autoimmun. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: Mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_16","first-page":"57","article-title":"Bone injury and fracture healing biology","volume":"28","author":"Oryan","year":"2015","journal-title":"Biomed. Environ. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/iwj.12231","article-title":"Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures","volume":"12","author":"Oryan","year":"2015","journal-title":"Int. Wound J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/13543784.2023.2263352","article-title":"Pharmacological agents for bone fracture healing: Talking points from recent clinical trials","volume":"32","author":"Migliorini","year":"2023","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Maruyama, M., Rhee, C., Utsunomiya, T., Zhang, N., Ueno, M., Yao, Z., and Goodman, S.B. (2020). Modulation of the inflammatory response and bone healing. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00386"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00441-011-1205-7","article-title":"Inflammatory phase of bone healing initiates the regenerative healing cascade","volume":"347","author":"Schell","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10456-017-9541-1","article-title":"The role of vasculature in bone development, regeneration and proper systemic functioning","volume":"20","author":"Filipowska","year":"2017","journal-title":"Angiogenesis"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e12874","DOI":"10.1111\/cpr.12874","article-title":"Motivating role of type H vessels in bone regeneration","volume":"53","author":"Zhang","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bl\u00e1zquez-Carmona, P., Mora-Mac\u00edas, J., Pajares, A., M\u00e1rmol, \u00c1., and Reina-Romo, E. (2024). On the influence of structural and chemical properties on the elastic modulus of woven bone under healing. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1476473"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"W\u00e4hnert, D., Greiner, J., Brianza, S., Kaltschmidt, C., Vordemvenne, T., and Kaltschmidt, B. (2021). Strategies to improve bone healing: Innovative surgical implants meet nano-\/micro-topography of bone scaffolds. Biomedicines, 9.","DOI":"10.3390\/biomedicines9070746"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bonr.2017.03.002","article-title":"Bone fracture healing in mechanobiological modeling: A review of principles and methods","volume":"6","author":"Ghiasi","year":"2017","journal-title":"Bone Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Terkawi, M.A., Matsumae, G., Shimizu, T., Takahashi, D., Kadoya, K., and Iwasaki, N. (2022). Interplay between inflammation and pathological bone resorption: Insights into recent mechanisms and pathways in related diseases for future perspectives. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031786"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"B\u0103dil\u0103, A.E., R\u0103dulescu, D.M., Ilie, A., Niculescu, A.G., Grumezescu, A.M., and R\u0103dulescu, A.R. (2022). Bone regeneration and oxidative stress: An updated overview. Antioxidants, 11.","DOI":"10.3390\/antiox11020318"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Li, M., Zhao, Z., and Yi, J. (2024). Biomaterials Designed to Modulate Reactive Oxygen Species for Enhanced Bone Regeneration in Diabetic Conditions. J. Funct. Biomater., 15.","DOI":"10.3390\/jfb15080220"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Agidigbi, T.S., and Kim, C. (2019). Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143576"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2201067","DOI":"10.1002\/adfm.202201067","article-title":"A multifunctional composite hydrogel that rescues the ROS microenvironment and guides the immune response for repair of osteoporotic bone defects","volume":"32","author":"Chen","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/bph.13828","article-title":"Reactive oxygen species: Key regulators in vascular health and diseases","volume":"175","author":"Chen","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-023-01512-7","article-title":"Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: From mechanism to therapy","volume":"16","author":"Liu","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"101619","DOI":"10.1016\/j.arr.2022.101619","article-title":"Oxidative stress: The core pathogenesis and mechanism of Alzheimer\u2019s disease","volume":"77","author":"Bai","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5152\/eurasianjmed.2018.17397","article-title":"Reactive oxygen species: The dual role in physiological and pathological conditions of the human body","volume":"50","author":"Bardaweel","year":"2018","journal-title":"Eurasian J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1083\/jcb.201708007","article-title":"Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling","volume":"217","author":"Wang","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Marcucci, G., Domazetovic, V., Nediani, C., Ruzzolini, J., Favre, C., and Brandi, M.L. (2023). Oxidative stress and natural antioxidants in osteoporosis: Novel preventive and therapeutic approaches. Antioxidants, 12.","DOI":"10.3390\/antiox12020373"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Lee, J.Y., Kim, M., Oh, S.B., Kim, H.Y., Kim, C., Kim, T.Y., and Park, Y.H. (2022). Superoxide dismutase 3 prevents early stage diabetic retinopathy in streptozotocin-induced diabetic rat model. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0262396"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.archoralbio.2018.04.018","article-title":"Sources of free radicals and oxidative stress in the oral cavity","volume":"92","author":"Maciejczyk","year":"2018","journal-title":"Arch. Oral. Biol."},{"key":"ref_40","first-page":"287","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alex. J. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/s13287-022-03125-2","article-title":"Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs","volume":"13","author":"Wang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhang, Y., Tang, Q., Zhang, Y., Yin, Y., and Chen, L. (2024). Application of antioxidant compounds in bone defect repair. Antioxidants, 13.","DOI":"10.3390\/antiox13070789"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lacina, L., Kol\u00e1\u0159, M., Pfeiferov\u00e1, L., Gal, P., and Smetana Jr, K. (2024). Wound healing: Insights into autoimmunity, ageing, and cancer ecosystems through inflammation and IL-6 modulation. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1403570"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1089\/ten.teb.2009.0687","article-title":"The early fracture hematoma and its potential role in fracture healing","volume":"16","author":"Kolar","year":"2010","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Leyane, T.S., Jere, S.W., and Houreld, N.N. (2022). Oxidative stress in ageing and chronic degenerative pathologies: Molecular mechanisms involved in counteracting oxidative stress and chronic inflammation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137273"},{"key":"ref_46","first-page":"209","article-title":"Oxidative stress in bone remodeling: Role of antioxidants","volume":"14","author":"Domazetovic","year":"2017","journal-title":"Clin. Cases Min. Bone Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12342","article-title":"Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way","volume":"84","author":"Sczepanik","year":"2020","journal-title":"Periodontology"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jitjumnong, M., Chalermkitpanit, P., Suantawee, T., Dechsupa, S., Vajarintarangoon, L., and Honsawek, S. (2022). Telomere shortening and increased oxidative stress in lumbar disc degeneration. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231710125"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Menzel, A., Samouda, H., Dohet, F., Loap, S., Ellulu, M.S., and Bohn, T. (2021). Common and novel markers for measuring inflammation and oxidative stress ex vivo in research and clinical practice\u2014Which to use regarding disease outcomes?. Antioxidants, 10.","DOI":"10.3390\/antiox10030414"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Viglianisi, G., Tartaglia, G.M., Santonocito, S., Amato, M., Polizzi, A., Mascitti, M., and Isola, G. (2023). The emerging role of salivary oxidative stress biomarkers as prognostic markers of periodontitis: New insights for a personalized approach in dentistry. J. Pers. Med., 13.","DOI":"10.3390\/jpm13020166"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Jing, W., Liu, C., Su, C., Liu, L., Chen, P., Li, X., and Du, X. (2023). Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1107670"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.7150\/thno.97412","article-title":"An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation","volume":"14","author":"Zhou","year":"2024","journal-title":"Theranostics"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Capuzzi, E., Ossola, P., Caldiroli, A., Auxilia, A.M., and Buoli, M. (2022). Malondialdehyde as a candidate biomarker for bipolar disorder: A meta-analysis. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 113.","DOI":"10.1016\/j.pnpbp.2021.110469"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Mas-Bargues, C., Escriva, C., Dromant, M., Borras, C., and Vina, J. (2021). Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Arch. Biochem. Biophys., 709.","DOI":"10.1016\/j.abb.2021.108941"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Valgimigli, L. (2023). Lipid peroxidation and antioxidant protection. Biomolecules, 13.","DOI":"10.3390\/biom13091291"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41420-023-01613-9","article-title":"Lipid peroxidation in osteoarthritis: Focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death discov."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/0960327110374203","article-title":"Oxidative stress and bone markers in plasma of patients with long-bone fixative surgery: Role of antioxidants","volume":"30","author":"Sandukji","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.joen.2006.12.001","article-title":"The role of cyclooxygenase-2 (COX-2) in inflammatory bone resorption","volume":"33","author":"Coon","year":"2007","journal-title":"J. Endod."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Huang, C., Xue, M., Chen, H., Jiao, J., Herschman, H.R., O\u2019Keefe, R.J., and Zhang, X. (2014). The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100079"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"156058","DOI":"10.1016\/j.cyto.2022.156058","article-title":"COX-2\/PGE2\/VEGF signaling promotes ERK-mediated BMSCs osteogenic differentiation under hypoxia by the paracrine action of ECs","volume":"161","author":"Wu","year":"2023","journal-title":"Cytokine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1007\/s10103-022-03638-5","article-title":"The effect of low-level laser irradiation on the proliferation, osteogenesis, inflammatory reaction, and oxidative stress of human periodontal ligament stem cells under inflammatory conditions","volume":"37","author":"Wang","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_62","first-page":"9","article-title":"Study of oxidant (MDA) and antioxidants (SOD & vitamin E) in hypertensive patients and normotensive individuals","volume":"2","author":"Singh","year":"2016","journal-title":"Int. J. Life Sci. Sci. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mrfmmm.2004.03.006","article-title":"Vitamins C and E: Acute interactive effects on biomarkers of antioxidant defence and oxidative stress","volume":"551","author":"Choi","year":"2004","journal-title":"Mutat. Res. Fund. Mol. Mech. Mutagen."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/jbmr.2709","article-title":"The roles and mechanisms of actions of vitamin C in bone: New developments","volume":"30","author":"Aghajanian","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Toto, A., Wild, P., Graille, M., Turcu, V., Cr\u00e9z\u00e9, C., Hemmendinger, M., and Hopf, N.B. (2022). Urinary malondialdehyde (MDA) concentrations in the general population\u2014A systematic literature review and meta-analysis. Toxics, 10.","DOI":"10.3390\/toxics10040160"},{"key":"ref_66","first-page":"1","article-title":"Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarker","volume":"50","author":"Ortega","year":"2022","journal-title":"J. Int. Med. Res."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Montecillo-Aguado, M., Tirado-Rodriguez, B., and Huerta-Yepez, S. (2023). The involvement of polyunsaturated fatty acids in apoptosis mechanisms and their implications in cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411691"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Stojkovic, L., Rankovic, S., Dincic, E., Boskovic, M., Kolakovic, A., Seke, M., and Zivkovic, M. (2025). The Erythrocyte Fatty Acid Profile in Multiple Sclerosis Is Linked to the Disease Course, Lipid Peroxidation, and Dietary Influence. Nutrients, 17.","DOI":"10.3390\/nu17060974"},{"key":"ref_69","first-page":"2233906","article-title":"Oxidative stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the pathogenesis and treatment of aging-related diseases","volume":"1","author":"Li","year":"2022","journal-title":"J. Immunol. Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Perkovic, M.N., Jaganjac, M., Milkovic, L., Horvat, T., Rojo, D., Zarkovic, K., and Zarkovic, N. (2023). Relationship between 4-hydroxynonenal (4-HNE) as systemic biomarker of lipid peroxidation and metabolomic profiling of patients with prostate cancer. Biomolecules, 13.","DOI":"10.3390\/biom13010145"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"\u017darkovi\u0107, N., G\u0119gotek, A., \u0141uczaj, W., Jaganjac, M., \u0160unji\u0107, S.B., \u017darkovi\u0107, K., and Skrzydlewska, E. (2024). Overview of the lipid peroxidation measurements in patients by the enzyme-linked immunosorbent assay specific for the 4-hydroxynonenal-protein adducts (4-HNE-ELISA). Front. Biosci.-Landmark, 29.","DOI":"10.31083\/j.fbl2904153"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Milkovic, L., Zarkovic, N., Marusic, Z., Zarkovic, K., and Jaganjac, M. (2023). The 4-hydroxynonenal\u2013protein adducts and their biological relevance: Are some proteins preferred targets?. Antioxidants, 12.","DOI":"10.3390\/antiox12040856"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1186\/s13018-023-04153-1","article-title":"Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head","volume":"18","author":"Xiao","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/ar2503","article-title":"4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: The protective role of glutathione-S-transferase","volume":"10","author":"Vaillancourt","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41467-025-55929-4","article-title":"Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41420-024-01969-6","article-title":"Unraveling ferroptosis in osteogenic lineages: Implications for dysregulated bone remodeling during periodontitis progression","volume":"10","author":"Tang","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"116215","DOI":"10.1016\/j.bone.2021.116215","article-title":"Damage associated molecular patterns in necrotic femoral head inhibit osteogenesis and promote fibrogenesis of mesenchymal stem cells","volume":"154","author":"Deng","year":"2022","journal-title":"Bone"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.1073\/pnas.87.23.9383","article-title":"A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism","volume":"87","author":"Morrow","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"156889","DOI":"10.1016\/j.cyto.2025.156889","article-title":"Are F2-isoprostanes a better marker of semen lipid peroxidation than MDA in reproductive pathologies with inflammatory basis?","volume":"188","author":"Moretti","year":"2025","journal-title":"Cytokine"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0891-5849(99)00264-6","article-title":"Measurement of F2-isoprostanes as an index of oxidative stress in vivo","volume":"28","author":"Morrow","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nprot.2006.375","article-title":"Quantification of F2-isoprostanes as a biomarker of oxidative stress","volume":"2","author":"Milne","year":"2007","journal-title":"Nat. Protoc."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3109\/10715762.2015.1014812","article-title":"Unresolved issues in the analysis of F2-isoprostanes, F4-neuroprostanes, isofurans, neurofurans, and F2-dihomo-isoprostanes in body fluids and tissue using gas chromatography\/negative-ion chemical-ionization mass spectrometry","volume":"49","author":"Yen","year":"2015","journal-title":"Free Radic. Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Jadoon, S., and Malik, A. (2018). A comprehensive review article on isoprostanes as biological markers. Biochem. Pharmacol., 7.","DOI":"10.4172\/2167-0501.1000246"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.redox.2017.04.028","article-title":"Classifying oxidative stress by F2-Isoprostane levels in human disease: The re-imagining of a biomarker","volume":"12","author":"Milne","year":"2017","journal-title":"Redox Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"101552","DOI":"10.1016\/j.arr.2021.101552","article-title":"Association of F2-isoprostane levels with Alzheimer\u2019s disease in observational studies: A systematic review and meta-analysis","volume":"74","author":"Trares","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000534258","article-title":"Association between F2-isoprostane metabolites and weight change in older women: A longitudinal analysis","volume":"70","author":"Zhao","year":"2024","journal-title":"Gerontology"},{"key":"ref_87","first-page":"91","article-title":"Systemic F2-isoprostane levels in predisposition to obesity and type 2 diabetes: Emphasis on racial differences","volume":"14","author":"Wong","year":"2017","journal-title":"Divers. Equal. Health Care"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Kumar, P., Osahon, O., Vides, D.B., Hanania, N., Minard, C.G., and Sekhar, R.V. (2021). Severe glutathione deficiency, oxidative stress and oxidant damage in adults hospitalized with COVID-19: Implications for GlyNAC (glycine and N-acetylcysteine) supplementation. Antioxidants, 11.","DOI":"10.3390\/antiox11010050"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.2174\/0929867033457115","article-title":"The isoprostanes: Unique products of arachidonic acid oxidation-a review","volume":"10","author":"Fam","year":"2023","journal-title":"Curr. Med. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Boldeanu, L., V\u0103duva, C.C., Caragea, D.C., Novac, M.B., Manasia, M., Silo\u0219i, I., and Dijm\u0103rescu, A.L. (2023). Association between serum 8-iso-prostaglandin F2\u03b1 as an oxidative stress marker and immunological markers in a cohort of preeclampsia patients. Life, 13.","DOI":"10.3390\/life13122242"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/toxics3010020","article-title":"Toxicity of glutathione-binding metals: A review of targets and mechanisms","volume":"3","author":"Rubino","year":"2015","journal-title":"Toxics"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Kalinina, E., and Novichkova, M. (2021). Glutathione in protein redox modulation through S-glutathionylation and S-nitrosylation. Molecules, 26.","DOI":"10.3390\/molecules26020435"},{"key":"ref_93","first-page":"177","article-title":"Oral delivery of glutathione: Antioxidant function, barriers and strategies","volume":"1","author":"Wei","year":"2022","journal-title":"Acta Mater. Med."},{"key":"ref_94","first-page":"4128152","article-title":"Oxidative stress indexes for diagnosis of health or disease in humans","volume":"1","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.freeradbiomed.2015.09.023","article-title":"Glutathione\u2013linking cell proliferation to oxidative stress","volume":"89","author":"Kiddle","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Vairetti, M., Di Pasqua, L.G., Cagna, M., Richelmi, P., Ferrigno, A., and Berardo, C. (2021). Changes in glutathione content in liver diseases: An update. Antioxidants, 10.","DOI":"10.3390\/antiox10030364"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"26739","DOI":"10.1074\/jbc.M116.749507","article-title":"Evolution of negative cooperativity in glutathione transferase enabled preservation of enzyme function","volume":"291","author":"Bocedi","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_98","first-page":"736837","article-title":"Glutathione homeostasis and functions: Potential targets for medical interventions","volume":"1","author":"Lushchak","year":"2012","journal-title":"J. Amino Acids"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1038\/s41467-024-49159-3","article-title":"Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption","volume":"15","author":"Ding","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e70299","DOI":"10.1111\/jcmm.70299","article-title":"Advances in osteoblast and mitochondrial dynamics and their transfer in osteoporosis","volume":"28","author":"Liu","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Rinaldi, C., Donato, L., Alibrandi, S., Scimone, C., D\u2019Angelo, R., and Sidoti, A. (2021). Oxidative stress and the neurovascular unit. Life, 11.","DOI":"10.3390\/life11080767"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1515\/cclm-2012-0605","article-title":"The role of homocysteine in bone remodeling","volume":"51","author":"Vacek","year":"2013","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1515\/CCLM.2008.302","article-title":"Oxidative stress, free radicals and bone remodeling","volume":"46","author":"Banfi","year":"2008","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Borys, J., Maciejczyk, M., Antonowicz, B., Kr\u0119towski, A., Sidun, J., Domel, E., and Zalewska, A. (2019). Glutathione metabolism, mitochondria activity, and nitrosative stress in patients treated for mandible fractures. J. Clin. Med., 8.","DOI":"10.3390\/jcm8010127"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Rosa, A.C., Corsi, D., Cavi, N., Bruni, N., and Dosio, F. (2021). Superoxide dismutase administration: A review of proposed human uses. Molecules, 26.","DOI":"10.3390\/molecules26071844"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1074\/jbc.TM117.000182","article-title":"Eukaryotic copper-only superoxide dismutases (SODs): A new class of SOD enzymes and SOD-like protein domains","volume":"293","author":"Robinett","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.molimm.2022.01.007","article-title":"Identification and functional characterization of interleukin-12 receptor beta 1 and 2 in grass carp (Ctenopharyngodon idella)","volume":"143","author":"Qiu","year":"2022","journal-title":"Mol. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Rajgarhia, A., Ayasolla, K.R., Zaghloul, N., Lopez Da Re, J.M., Miller, E.J., and Ahmed, M. (2021). Extracellular superoxide dismutase (EC-SOD) regulates gene methylation and cardiac fibrosis during chronic hypoxic stress. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.669975"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Grujicic, J., and Allen, A.R. (2024). MnSOD mimetics in therapy: Exploring their role in combating oxidative stress-related diseases. Antioxidants, 13.","DOI":"10.3390\/antiox13121444"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Dworza\u0144ski, J., Strycharz-Dudziak, M., Kliszczewska, E., Kie\u0142czykowska, M., Dworza\u0144ska, A., Drop, B., and Polz-Dacewicz, M. (2020). Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in patients with diabetes mellitus type 2 infected with Epstein-Barr virus. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0230374"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00198-018-4547-0","article-title":"Vitamin D3 contributes to enhanced osteogenic differentiation of MSCs under oxidative stress condition via activating the endogenous antioxidant system","volume":"29","author":"Zhou","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12011-018-1583-8","article-title":"The impact of trace minerals on bone metabolism","volume":"188","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12018-024-09302-6","article-title":"Antioxidant enzyme activities, total sialic acid, vitamin, and trace element status in the patient with osteoporosis and osteopenia","volume":"22","author":"Karakus","year":"2024","journal-title":"Clin. Transl. Metab."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Ciosek, \u017b., Kot, K., and Rotter, I. (2023). Iron, zinc, copper, cadmium, mercury, and bone tissue. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20032197"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.freeradbiomed.2022.05.003","article-title":"The glutathione peroxidase family: Discoveries and mechanism","volume":"187","author":"Toppo","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Cheff, D.M., Cheng, Q., Guo, H., Travers, J., Klumpp-Thomas, C., Shen, M., and Hall, M.D. (2023). Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4. Redox Biol., 63.","DOI":"10.1016\/j.redox.2023.102719"},{"key":"ref_117","first-page":"5594386","article-title":"A comprehensive review of free radicals, oxidative stress, and antioxidants: Overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds","volume":"1","author":"Tumilaar","year":"2024","journal-title":"J. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Zinellu, E., Zinellu, A., Pau, M.C., Piras, B., Fois, A.G., Mellino, S., and Pirina, P. (2021). Glutathione peroxidase in stable chronic obstructive pulmonary disease: A systematic review and meta-analysis. Antioxidants, 10.","DOI":"10.3390\/antiox10111745"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Pei, J., Pan, X., Wei, G., and Hua, Y. (2023). Research progress of glutathione peroxidase family (GPX) in redoxidation. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1147414"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Zhang, N., Liao, H., Lin, Z., and Tang, Q. (2024). Insights into the role of glutathione peroxidase 3 in non-neoplastic diseases. Biomolecules, 14.","DOI":"10.3390\/biom14060689"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1515\/hsz-2020-0286","article-title":"Emerging roles for non-selenium containing ER-resident glutathione peroxidases in cell signaling and disease","volume":"402","author":"Buday","year":"2021","journal-title":"Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Li, H., Zhang, Z., Liu, J., and Wang, H. (2025). Antioxidant scaffolds for enhanced bone regeneration: Recent advances and challenges. Biomed. Eng. OnLine, 24.","DOI":"10.1186\/s12938-025-01370-z"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.ijbiomac.2022.09.236","article-title":"3D printing of reduced glutathione grafted gelatine methacrylate hydrogel scaffold promotes diabetic bone regeneration by activating PI3K\/Akt signaling pathway","volume":"222","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Anwar, S., Alrumaihi, F., Sarwar, T., Babiker, A.Y., Khan, A.A., Prabhu, S.V., and Rahmani, A.H. (2024). Exploring therapeutic potential of catalase: Strategies in disease prevention and management. Biomolecules, 14.","DOI":"10.3390\/biom14060697"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/10242422.2021.1932838","article-title":"Catalase-mediated remediation of environmental pollutants and potential application\u2013A review","volume":"39","author":"Takio","year":"2021","journal-title":"Biocatal. Biotransform"},{"key":"ref_126","first-page":"9613090","article-title":"Role of catalase in oxidative stress-and age-associated degenerative diseases","volume":"1","author":"Nandi","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Hansberg, W. (2022). Monofunctional heme-catalases. Antioxidants, 11.","DOI":"10.3390\/antiox11112173"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"16931","DOI":"10.1074\/jbc.RA118.004641","article-title":"Hydrogen sulfide bypasses the rate-limiting oxygen activation of heme oxygenase","volume":"293","author":"Matsui","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Gebicka, L., and Krych-Madej, J. (2019). The role of catalases in the prevention\/promotion of oxidative stress. J. Inorg. Biochem., 197.","DOI":"10.1016\/j.jinorgbio.2019.110699"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/10715762.2019.1612059","article-title":"Oxidative stress in biological systems and its relation with pathophysiological functions: The effect of physical activity on cellular redox homeostasis","volume":"53","author":"Kruk","year":"2019","journal-title":"Free Radic. Res."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Balogh, E., T\u00f3th, A., Csiki, D.M., and Jeney, V. (2024). Zinc Ameliorates High Pi and Ca-Mediated Osteogenic Differentiation of Mesenchymal Stem Cells. Nutrients, 16.","DOI":"10.3390\/nu16234012"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Balogh, E., Paragh, G., and Jeney, V. (2018). Influence of iron on bone homeostasis. Pharmaceuticals, 11.","DOI":"10.3390\/ph11040107"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6501046","DOI":"10.1155\/2017\/6501046","article-title":"Measurement and clinical significance of biomarkers of oxidative stress in humans","volume":"1","author":"Marrocco","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Patel, T.A., Kevadiya, B.D., Bajwa, N., Singh, P.A., Zheng, H., Kirabo, A., and Patel, K.P. (2023). Role of nanoparticle-conjugates and nanotheranostics in abrogating oxidative stress and ameliorating neuroinflammation. Antioxidants, 12.","DOI":"10.3390\/antiox12101877"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jcmm.13295","article-title":"Striking a new path in reducing cartilage breakdown: Combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma","volume":"22","author":"Riegger","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"110","DOI":"10.22203\/eCM.v036a09","article-title":"The functional role of chondrogenic stem\/progenitor cells: Novel evidence for immunomodulatory properties and regenerative potential after cartilage injury","volume":"36","author":"Riegger","year":"2018","journal-title":"Eur. Cell Mater."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Riegger, J., Schoppa, A., Ruths, L., Haffner-Luntzer, M., and Ignatius, A. (2023). Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: A narrative review. Cell Mol. Biol. Lett., 28.","DOI":"10.1186\/s11658-023-00489-y"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/9\/1070\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:36:26Z","timestamp":1760034986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/9\/1070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":137,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["antiox14091070"],"URL":"https:\/\/doi.org\/10.3390\/antiox14091070","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,31]]}}}