{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:27:21Z","timestamp":1790890041491,"version":"4.1.0"},"reference-count":74,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the European Commission within the framework of the Erasmus+ FOOD4S Programme","award":["619864-EPP-1-2020-1-BE-EPPKA1-JMD-MOB"],"award-info":[{"award-number":["619864-EPP-1-2020-1-BE-EPPKA1-JMD-MOB"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Polyphenolic compounds, commonly found in Greek medicinal plants, exhibit promising antiviral and antioxidant properties, making them potential candidates for therapeutic purposes. This study aims to evaluate the antiviral activity of nine selected polyphenols against Dengue virus (DENV) and Yellow Fever virus (YFV) life cycles, alongside their antioxidant capacity determined by the DPPH method and the ABTS assay, and their ability to inhibit DNA strand scission induced by peroxyl radicals. Kaempferol and caffeic acid demonstrated the most potent inhibitory effects on DENV genome replication, while coumaric acid blocked viral entry more effectively. Notably, among the nine compounds, kaempferol exhibited the strongest anti-DENV effect, especially at the level of virus-released infectivity, showing the lowest EC50 (3.55 \u03bc\u039c) and the highest selectivity index (SI = 25.45). In contrast, none of the compounds showed significant antiviral activity against YFV genome replication. Concomitantly, caffeic acid and kaempferol had the highest radical scavenging activity (DPPH and ABTS assays), highlighting their dual properties. Moreover, DNA scission inhibition assays confirmed the strong antioxidant potential of all tested compounds, with caffeic acid and kaempferol achieving the highest inhibition rate of 98.98% and 97.34% respectively. These findings underscore the potential of specific polyphenols, particularly kaempferol and caffeic acid, as antiviral and antioxidant agents targeting DENV and oxidative stress-related damage.<\/jats:p>","DOI":"10.3390\/antiox14091103","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T14:14:55Z","timestamp":1757513695000},"page":"1103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of Polyphenolic Compounds Common in Greek Medicinal Plants for Their Antioxidant Effects and Antiviral Activity Against Dengue and Yellow Fever Viruses"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0764-6256","authenticated-orcid":false,"given":"Eirini","family":"Kyriakopoulou","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3278-7461","authenticated-orcid":false,"given":"Aliki","family":"Tsakni","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Food Sciences, University of West Attica, 12243 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1888-0798","authenticated-orcid":false,"given":"Evangelos","family":"Korakidis","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-7993","authenticated-orcid":false,"given":"George","family":"Mpekoulis","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5547-6864","authenticated-orcid":false,"given":"Katerina I.","family":"Kalliampakou","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Polanska","sequence":"additional","affiliation":[{"name":"BioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering, KU Leuven, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-1638","authenticated-orcid":false,"given":"Jan F. M.","family":"Van Impe","sequence":"additional","affiliation":[{"name":"BioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering, KU Leuven, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5630-1572","authenticated-orcid":false,"given":"Efstathia","family":"Tsakali","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Food Sciences, University of West Attica, 12243 Athens, Greece"},{"name":"BioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering, KU Leuven, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-2081","authenticated-orcid":false,"given":"Dimitra","family":"Houhoula","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Food Sciences, University of West Attica, 12243 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-3438","authenticated-orcid":false,"given":"Niki","family":"Vassilaki","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.annepidem.2005.02.004","article-title":"Medicinal plants: Historical and cross-cultural usage patterns","volume":"15","author":"Halberstein","year":"2005","journal-title":"Ann. 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