{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:30:48Z","timestamp":1781926248086,"version":"3.54.5"},"reference-count":98,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Education, University and Research (MIUR)","award":["20152LFKAT"],"award-info":[{"award-number":["20152LFKAT"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This study aimed to evaluate the effects of brine enriched with an olive vegetation water (OVW) extract on the physico-chemical, oxidative, and sensory characteristics of cooked ham during storage, as a strategy to partially or totally replace nitrites. Four brines formulated with different concentrations of nitrites in combination with 200 mg of OVW extract\/kg product were tested; the cooked ham samples were sliced, placed in trays, packed in a protective atmosphere, and monitored for 30 days at 4 \u00b0C. The results showed that phenolic compounds derived from OVW effectively reduced lipid and protein oxidation, limiting the formation of secondary oxidation products such as thiobarbituric acid reactive substances, volatile aldehydes, and cholesterol oxides. Sensory analysis confirmed that the extract did not negatively affect the organoleptic properties of the ham, while also helping to preserve color stability. These findings suggest that brine enriched with OVW phenols can be a promising green strategy to reduce nitrites in cooked ham, which also promotes the sustainable valorization of olive oil by-products.<\/jats:p>","DOI":"10.3390\/antiox14091124","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T13:03:02Z","timestamp":1758114182000},"page":"1124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brine Enriched with Olive Wastewater Phenols: A Green Strategy to Reduce Nitrites in Cooked Ham"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-2661","authenticated-orcid":false,"given":"Dario","family":"Mercatante","sequence":"first","affiliation":[{"name":"Department of Agricultural and Food Sciences, Alma Mater Studiorum\u2014University of Bologna, 40127 Bologna, BO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-7665","authenticated-orcid":false,"given":"Stefania","family":"Balzan","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, PD, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-6212","authenticated-orcid":false,"given":"Sonia","family":"Esposto","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environmental Sciences, University of Perugia, 06126 Perugia, PG, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, Alma Mater Studiorum\u2014University of Bologna, 40127 Bologna, BO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Fontana","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, PD, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-1150","authenticated-orcid":false,"given":"Luca","family":"Fasolato","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, PD, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo De","family":"Rosa","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, Alma Mater Studiorum\u2014University of Bologna, 40127 Bologna, BO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8726-2075","authenticated-orcid":false,"given":"Maurizio","family":"Servili","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environmental Sciences, University of Perugia, 06126 Perugia, PG, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-1787","authenticated-orcid":false,"given":"Agnese","family":"Taticchi","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environmental Sciences, University of Perugia, 06126 Perugia, PG, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-5156","authenticated-orcid":false,"given":"Enrico","family":"Novelli","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, PD, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-4183","authenticated-orcid":false,"given":"Maria Teresa","family":"Rodriguez-Estrada","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, Alma Mater Studiorum\u2014University of Bologna, 40127 Bologna, BO, Italy"},{"name":"Interdepartmental Centre for Industrial Agrofood Research, Alma Mater Studiorum\u2014University of Bologna, 47521 Cesena, FC, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref_1","unstructured":"(2025, February 20). Statista. Available online: https:\/\/www.statista.com\/."},{"key":"ref_2","unstructured":"ASSICA (2025, February 20). Associazione Industriali delle Carni e dei Salumi. Available online: https:\/\/www.assica.it\/."},{"key":"ref_3","unstructured":"Ministerial Decree (2025, February 20). DECRETO 26 Maggio 2016 Modifiche al Decreto 21 Settembre 2005 Concernente la Disciplina della Produzione e della Vendita di Taluni Prodotti di Salumeria. (16A04808) (GU Serie Generale n.149 del 28-06-2016). Available online: https:\/\/www.gazzettaufficiale.it\/atto\/serie_generale\/caricaDettaglioAtto\/originario?atto.dataPubblicazioneGazzetta=2016-06-28&atto.codiceRedazionale=16A04808&elenco30giorni=true."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Toldr\u00e1, F. (2010). Cooked ham. Handbook of Meat Processing, Wiley-Blackwell.","DOI":"10.1002\/9780813820897"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S1470-2045(15)00444-1","article-title":"International Agency for Research on Cancer Monograph Working Group Carcinogenicity of Consumption of Red and Processed Meat","volume":"16","author":"Bouvard","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"108610","DOI":"10.1016\/j.meatsci.2021.108610","article-title":"Critical Overview of the Use of Plant Antioxidants in the Meat Industry: Opportunities, Innovative Applications and Future Perspectives","volume":"181","year":"2021","journal-title":"Meat Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"109451","DOI":"10.1016\/j.meatsci.2024.109451","article-title":"The Utilisation of Agricultural By-Products in Processed Meat Products: Effects on Physicochemical, Nutritional and Sensory Quality\u2013Invited Review","volume":"211","author":"Grasso","year":"2024","journal-title":"Meat Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zeb, A. (2020). Concept, Mechanism, and Applications of Phenolic Antioxidants in Foods. J. Food Biochem., 44.","DOI":"10.1111\/jfbc.13394"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Chen, J., Yang, J., Ma, L., Li, J., Shahzad, N., and Kim, C.K. (2020). Structure-Antioxidant Activity Relationship of Methoxy, Phenolic Hydroxyl, and Carboxylic Acid Groups of Phenolic Acids. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-59451-z"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1039\/C4FO00124A","article-title":"A Shortcut to Wide-Ranging Biological Actions of Dietary Polyphenols: Modulation of the Nitrate\u2013Nitrite\u2013Nitric Oxide Pathway in the Gut","volume":"5","author":"Rocha","year":"2014","journal-title":"Food Funct."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tak\u00f3, M., Kerekes, E.B., Zambrano, C., Kotog\u00e1n, A., Papp, T., Krisch, J., and V\u00e1gv\u00f6lgyi, C. (2020). Plant Phenolics and Phenolic-Enriched Extracts as Antimicrobial Agents against Food-Contaminating Microorganisms. Antioxidants, 9.","DOI":"10.3390\/antiox9020165"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1039\/D3FO02877A","article-title":"Inhibitory Effects and Reactions of Gallic Acid, Catechin, and Procyanidin B2 with Nitrosation under Stomach Simulating Conditions","volume":"15","author":"Ren","year":"2024","journal-title":"Food Funct."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Shakil, M.H., Trisha, A.T., Rahman, M., Talukdar, S., Kobun, R., Huda, N., and Zzaman, W. (2022). Nitrites in Cured Meats, Health Risk Issues, Alternatives to Nitrites: A Review. Foods, 11.","DOI":"10.3390\/foods11213355"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ferysiuk, K., and W\u00f3jciak, K.M. (2020). Reduction of Nitrite in Meat Products through the Application of Various Plant-Based Ingredients. Antioxidants, 9.","DOI":"10.3390\/antiox9080711"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mercatante, D., Ansorena, D., Taticchi, A., Astiasar\u00e1n, I., Servili, M., and Rodriguez-Estrada, M.T. (2023). Effects of In Vitro Digestion on the Antioxidant Activity of Three Phenolic Extracts from Olive Mill Wastewaters. Antioxidants, 12.","DOI":"10.3390\/antiox12010022"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1021\/acs.jafc.1c00296","article-title":"Potential of Olive Oil Mill Wastewater as a Source of Polyphenols for the Treatment of Skin Disorders: A Review","volume":"69","author":"Carrara","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.foodchem.2010.07.042","article-title":"Improvement of Bioactive Phenol Content in Virgin Olive Oil with an Olive-Vegetation Water Concentrate Produced by Membrane Treatment","volume":"124","author":"Servili","year":"2011","journal-title":"Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Benincasa, C., Pellegrino, M., Romano, E., Claps, S., Fallara, C., and Perri, E. (2022). Qualitative and Quantitative Analysis of Phenolic Compounds in Spray-Dried Olive Mill Wastewater. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.782693"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1080\/10408398.2017.1343797","article-title":"Use of Phenolic Compounds from Olive Mill Wastewater as Valuable Ingredients for Functional Foods","volume":"58","author":"Caporaso","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.tifs.2018.07.010","article-title":"Phenols Recovered from Olive Mill Wastewater as Additives in Meat Products","volume":"79","author":"Galanakis","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.meatsci.2013.06.001","article-title":"A Correlative Study on Data from Pork Carcass and Processed Meat (Bauernspeck) for Automatic Estimation of Chemical Parameters by Means of near-Infrared Spectroscopy","volume":"95","author":"Boschetti","year":"2013","journal-title":"Meat Sci."},{"key":"ref_22","unstructured":"AOAC (1990). Official Methods of Analysis, Association of Official Analytical Chemists. [15th ed.]."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijfoodmicro.2016.04.003","article-title":"Agricultural By-Products with Bioactive Effects: A Multivariate Approach to Evaluate Microbial and Physicochemical Changes in a Fresh Pork Sausage Enriched with Phenolic Compounds from Olive Vegetation Water","volume":"228","author":"Fasolato","year":"2016","journal-title":"Int. J. Food Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Miraglia, D., Castrica, M., Menchetti, L., Esposto, S., Branciari, R., Ranucci, D., Urbani, S., Sordini, B., Veneziani, G., and Servili, M. (2020). Effect of an Olive Vegetation Water Phenolic Extract on the Physico-Chemical, Microbiological and Sensory Traits of Shrimp (Parapenaeus longirostris) during the Shelf-Life. Foods, 9.","DOI":"10.3390\/foods9111647"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1021\/jf405753c","article-title":"Optimization of the Temperature and Oxygen Concentration Conditions in the Malaxation during the Oil Mechanical Extraction Process of Four Italian Olive Cultivars","volume":"62","author":"Selvaggini","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.meatsci.2007.10.030","article-title":"Effects of Oxygen Concentration on the Sensory Evaluation and Quality Indicators of Beef Muscle Packed under Modified Atmosphere","volume":"79","author":"Zakrys","year":"2008","journal-title":"Meat Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.foodchem.2008.09.030","article-title":"Oxidation of Lipid and Protein in Horse Mackerel (Trachurus trachurus) Mince and Washed Minces during Processing and Storage","volume":"114","author":"Eymard","year":"2009","journal-title":"Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbagen.2013.03.031","article-title":"Quantification of Thiols and Disulfides","volume":"1840","author":"Winther","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0021-9673(01)00688-4","article-title":"Pressurized Liquid Extraction of Lipids for the Determination of Oxysterols in Egg-Containing Food","volume":"917","author":"Boselli","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12911","DOI":"10.1021\/acs.jafc.8b03097","article-title":"Evaluation of Breed and Parity Order Effects on the Lipid Composition of Porcine Colostrum","volume":"66","author":"Luise","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.meatsci.2015.02.010","article-title":"Effect of Dietary Supplementation on Lipid Photooxidation in Beef Meat, during Storage under Commercial Retail Conditions","volume":"105","author":"Cardenia","year":"2015","journal-title":"Meat Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/BF02630824","article-title":"A Distillation Method for the Quantitative Determination of Malonaldehyde in Rancid Foods","volume":"37","author":"Tarladgis","year":"1960","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jssc.201100660","article-title":"Analysis of Cholesterol Oxidation Products by Fast Gas Chromatography\/Mass Spectrometry","volume":"35","author":"Cardenia","year":"2012","journal-title":"J. Sep. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Dottori, I., Urbani, S., Sordini, B., Servili, M., Selvaggini, R., Veneziani, G., Ranucci, D., Taticchi, A., and Esposto, S. (2023). Frozen Ready-to-(h)Eat Meals: Evolution of Their Quality during a Real-Time Short Shelf Life. Foods, 12.","DOI":"10.3390\/foods12051087"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.foodchem.2013.11.052","article-title":"HS-SPME GC\/MS Characterization of Volatiles in Raw and Dry-Roasted Almonds (Prunus dulcis)","volume":"151","author":"Xiao","year":"2014","journal-title":"Food Chem."},{"key":"ref_37","first-page":"c427","article-title":"Protein Oxidation in Frankfurters with Increasing Levels of Added Rosemary Essential Oil: Effect on Color and Texture Deterioration","volume":"70","author":"Ventanas","year":"2005","journal-title":"J. Food Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e00202","DOI":"10.1016\/j.heliyon.2016.e00202","article-title":"Sensory and Rapid Instrumental Methods as a Combined Tool for Quality Control of Cooked Ham","volume":"2","author":"Barbieri","year":"2016","journal-title":"Heliyon"},{"key":"ref_39","unstructured":"Meilgaard, M.C., Carr, B.T., and Civille, G.V. (2006). Sensory Evaluation Techniques, CRC Press. [4th ed.]."},{"key":"ref_40","unstructured":"(2007). Sensory Analysis\u2014Methodology\u2014Triangle Test (Standard No. BS EN ISO 4120:2007)."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Barbieri, S., Mercatante, D., Balzan, S., Esposto, S., Cardenia, V., Servili, M., Novelli, E., Taticchi, A., and Rodriguez-Estrada, M.T. (2021). Improved Oxidative Stability and Sensory Quality of Beef Hamburgers Enriched with a Phenolic Extract from Olive Vegetation Water. Antioxidants, 10.","DOI":"10.3390\/antiox10121969"},{"key":"ref_42","unstructured":"CREA (2025, February 07). Tabella di Composizione Degli Alimenti. Available online: https:\/\/www.alimentinutrizione.it\/sezioni\/tabelle-nutrizionali."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.foodchem.2012.10.020","article-title":"Micronutrients in Italian Ham: A Survey of Traditional Products","volume":"140","author":"Lucarini","year":"2013","journal-title":"Food Chem."},{"key":"ref_44","unstructured":"Griglio, B., Piovesan, F., Goi, R., Sattanino, G., Natangelo, U., and Civera, T. (2025, February 20). Indagine Preliminare per la Valutazione dei Parametri Chimico\/Fisici del Prosciutto Cotto nel Corso della vita Commerciale e in Fase di Rilavorazione a Seguito di Ritiro dal Mercato. AIVEMP 2012, 3 (Luglio). Available online: https:\/\/www.gazzettaufficiale.it\/eli\/gu\/2016\/06\/28\/149\/sg\/pdf."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"109090","DOI":"10.1016\/j.meatsci.2022.109090","article-title":"Effects of Natural Nitrite Sources from Arugula and Barberry Extract on Quality Characteristic of Heat-Treated Fermented Sausages","volume":"198","author":"Can","year":"2023","journal-title":"Meat Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijfoodmicro.2011.03.006","article-title":"Functional Milk Beverage Fortified with Phenolic Compounds Extracted from Olive Vegetation Water, and Fermented with Functional Lactic Acid Bacteria","volume":"147","author":"Servili","year":"2011","journal-title":"Int. J. Food Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.lwt.2017.07.001","article-title":"Effect of Phenols Extracted from a By-Product of the Oil Mill on the Shelf-Life of Raw and Cooked Fresh Pork Sausages in the Absence of Chemical Additives","volume":"85","author":"Balzan","year":"2017","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1039\/b719736e","article-title":"Biosynthesis and biotransformations of phenol-conjugated oleosidic secoiridoids from Olea europaea L","volume":"25","author":"Obied","year":"2008","journal-title":"Nat. Prod. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.1021\/jf0107860","article-title":"Acid Hydrolysis of Secoiridoid Aglycons during Storage of Virgin Olive Oil","volume":"49","author":"Brenes","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/aocs.12684","article-title":"A Review on Losses and Transformation Mechanisms of Common Antioxidants","volume":"100","author":"Li","year":"2023","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"111843","DOI":"10.1016\/j.foodres.2022.111843","article-title":"Effect of Olive Polyphenols on Lipid Oxidation of High-Fat Beef during Digestion","volume":"161","author":"Han","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"100317","DOI":"10.1016\/j.fochx.2022.100317","article-title":"Paradoxical Effects of Lipolysis on the Lipid Oxidation in Meat and Meat Products","volume":"14","author":"Tatiyaborworntham","year":"2022","journal-title":"Food Chem. X"},{"key":"ref_53","unstructured":"Ju\u015b, K., Jasnowska-Ma\u0142ecka, J., and Bi\u0144czak, O. (2015). Fatty acid composition of local, traditional and conventional pork meat products. Current Trends in Commodity Science: New Trends in Food Quality, Packaging and Consumer Behavior, Pozna\u0144 University of Economics and Business."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Parrini, S., Sirtori, F., Acciaioli, A., Becciolini, V., Crovetti, A., Franci, O., Romani, A., Scardigli, A., and Bozzi, R. (2019). Effect of Replacement of Synthetic vs. Natural Curing Agents on Quality Characteristics of Cinta Senese Frankfurter-Type Sausage. Animals, 10.","DOI":"10.3390\/ani10010014"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.biopha.2006.07.080","article-title":"Evolutionary Aspects of Diet, the Omega-6\/Omega-3 Ratio and Genetic Variation: Nutritional Implications for Chronic Diseases","volume":"60","author":"Simopoulos","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/ejlt.201000076","article-title":"Healthier Lipid Combination as Functional Ingredient Influencing Sensory and Technological Properties of Low-Fat Frankfurters","volume":"112","author":"Cofrades","year":"2010","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.meatsci.2011.04.025","article-title":"Protein Carbonyls in Meat Systems: A Review","volume":"89","year":"2011","journal-title":"Meat Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/1541-4337.12127","article-title":"Protein Oxidation in Processed Meat: Mechanisms and Potential Implications on Human Health","volume":"14","author":"Soladoye","year":"2015","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104689","DOI":"10.1016\/j.tifs.2024.104689","article-title":"Formation and Regulation Strategies for Volatile Off-Flavor Compounds in Livestock Meat, Poultry Meat, and Their Products: A Comprehensive Review","volume":"152","author":"Ren","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.meatsci.2016.02.027","article-title":"The Application of Natural Antioxidants via Brine Injection Protects Iberian Cooked Hams against Lipid and Protein Oxidation","volume":"116","author":"Armenteros","year":"2016","journal-title":"Meat Sci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Altomare, A., Baron, G., Gianazza, E., Banfi, C., Carini, M., and Aldini, G. (2021). Lipid Peroxidation Derived Reactive Carbonyl Species in Free and Conjugated Forms as an Index of Lipid Peroxidation: Limits and Perspectives. Redox Biol., 42.","DOI":"10.1016\/j.redox.2021.101899"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Farhoosh, R. (2022). Quantitative Criteria Characterizing the Time Change Pattern of Total Lipid-Peroxidation Carbonyls. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-27066-1"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Munekata, P.E.S., Pateiro, M., Dom\u00ednguez, R., Nieto, G., Kumar, M., Dhama, K., and Lorenzo, J.M. (2023). Bioactive Compounds from Fruits as Preservatives. Foods, 12.","DOI":"10.3390\/foods12020343"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"de Oliveira, I., Santos-Buelga, C., Aquino, Y., Barros, L., and Heleno, S.A. (2025). New Frontiers in the Exploration of Phenolic Compounds and Other Bioactives as Natural Preservatives. Food Biosci., 68.","DOI":"10.1016\/j.fbio.2025.106571"},{"key":"ref_65","first-page":"2","article-title":"Phenolic-Protein Interactions: Insight from in-Silico Analyses\u2014A Review","volume":"5","author":"Shahidi","year":"2023","journal-title":"FPPN"},{"key":"ref_66","unstructured":"Pearson, A.M., and Dutson, T.R. (1987). Rancidity and warmed-over flavor. Advances in Meat Research, Van Nostrand Reinhold Co., Ltd."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.foodchem.2005.01.037","article-title":"The Effect of Heat Treatment on the Cholesterol Oxides, Cholesterol, Total Lipid and Fatty Acid Contents of Processed Meat Products","volume":"95","author":"Baggio","year":"2006","journal-title":"Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0308-8146(02)00136-X","article-title":"Simultaneous Determination of Total Lipid, Cholesterol and Fatty Acids in Meat and Backfat of Suckling and Adult Pigs","volume":"79","author":"Bragagnolo","year":"2002","journal-title":"Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0024-3205(01)01218-8","article-title":"Effects of Virgin Olive Oil Phenolics on Scavenging of Reactive Nitrogen Species and upon Nitrergic Neurotransmission","volume":"69","author":"Flavill","year":"2001","journal-title":"Life Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.biochi.2012.07.012","article-title":"Cholesterol Photosensitized Oxidation in Food and Biological Systems","volume":"95","author":"Cardenia","year":"2013","journal-title":"Biochimie"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.1021\/acs.jpcb.8b03500","article-title":"Comprehensive Investigation of the Antioxidant and Pro-Oxidant Effects of Phenolic Compounds: A Double-Edged Sword in the Context of Oxidative Stress?","volume":"122","author":"Reina","year":"2018","journal-title":"J. Phys. Chem. B"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mam.2009.02.006","article-title":"Cytotoxic Effects of Oxysterols Associated with Human Diseases: Induction of Cell Death (Apoptosis and\/or Oncosis), Oxidative and Inflammatory Activities, and Phospholipidosis","volume":"30","author":"Vejux","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.bbrc.2014.02.098","article-title":"7-Ketocholesterol as Marker of Cholesterol Oxidation in Model and Food Systems: When and How","volume":"446","author":"Lagarda","year":"2014","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Canzoneri, F., Leoni, V., Rosso, G., Risso, D., Menta, R., and Poli, G. (2022). Oxysterols as Reliable Markers of Quality and Safety in Cholesterol Containing Food Ingredients and Products. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.853460"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.niox.2006.12.006","article-title":"Magnetic Resonance Study of the Transmembrane Nitrite Diffusion","volume":"16","author":"Samouilov","year":"2007","journal-title":"Nitric Oxide"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tifs.2023.02.003","article-title":"Underlying Mechanisms of Synergistic Antioxidant Interactions during Lipid Oxidation","volume":"133","author":"Bayram","year":"2023","journal-title":"Trends Food Sci. Technol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12944-015-0091-5","article-title":"Cooking, Storage, and Reheating Effect on the Formation of Cholesterol Oxidation Products in Processed Meat Products","volume":"14","author":"Khan","year":"2015","journal-title":"Lipids Health Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1700047","DOI":"10.1002\/ejlt.201700047","article-title":"Lipid Oxidation Derived Aldehydes and Oxysterols Between Health and Disease","volume":"121","author":"Sottero","year":"2019","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.cofs.2021.08.001","article-title":"Oxysterols\u2014How Much Do We Know about Food Occurrence, Dietary Intake and Absorption?","volume":"41","author":"Mercatante","year":"2021","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1365-2621.2011.02816.x","article-title":"Identification and Process Origin of Bacteria Responsible for Cavities and Volatile Off-Flavour Compounds in Artisan Cooked Ham","volume":"47","author":"Comi","year":"2012","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/jfq.12153","article-title":"Physical and Chemical Characteristics of Cooked Ham: Effect of Tumbling Time and Modifications during Storage","volume":"38","author":"Pancrazio","year":"2015","journal-title":"J. Food Qual."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1021\/jf026218h","article-title":"Analysis of Volatiles in Meat from Iberian Pigs and Lean Pigs after Refrigeration and Cooking by Using SPME-GC-MS","volume":"51","author":"Morcuende","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"108287","DOI":"10.1016\/j.meatsci.2020.108287","article-title":"Effects of Sous Vide vs. Grilling Methods on Lamb Meat Colour and Lipid Stability during Cooking and Heated Display","volume":"171","author":"Mateo","year":"2021","journal-title":"Meat Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1017\/S1751731116000392","article-title":"Use of Dietary Rosemary Diterpenes to Inhibit Rancid Volatiles in Lamb Meat Packed under Protective Atmosphere","volume":"10","author":"Serrano","year":"2016","journal-title":"Animal"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"108766","DOI":"10.1016\/j.meatsci.2022.108766","article-title":"Human Perception of Color Differences Using Computer Vision System Measurements of Raw Pork Loin","volume":"188","author":"Altmann","year":"2022","journal-title":"Meat Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.meatsci.2007.03.025","article-title":"Cured Meat Products without Direct Addition of Nitrate or Nitrite: What Are the Issues?","volume":"77","author":"Sebranek","year":"2007","journal-title":"Meat Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s13197-011-0352-x","article-title":"Effect of Light, Packaging Condition and Dark Storage Durations on Colour and Lipid Oxidative Stability of Cooked Ham","volume":"50","author":"Haile","year":"2013","journal-title":"J. Food Sci. Technol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Dirpan, A., Djalal, M., and Ainani, A.F. (2022). A Simple Combination of Active and Intelligent Packaging Based on Garlic Extract and Indicator Solution in Extending and Monitoring the Meat Quality Stored at Cold Temperature. Foods, 11.","DOI":"10.3390\/foods11101495"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.meatsci.2008.07.009","article-title":"Colour Calibration of a Laboratory Computer Vision System for Quality Evaluation of Pre-Sliced Hams","volume":"81","author":"Valous","year":"2009","journal-title":"Meat Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.meatsci.2009.09.016","article-title":"Classification of Pre-Sliced Pork and Turkey Ham Qualities Based on Image Colour and Textural Features and Their Relationships with Consumer Responses","volume":"84","author":"Iqbal","year":"2010","journal-title":"Meat Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.meatsci.2016.07.017","article-title":"Physicochemical, Microbiological and Sensory Evaluation of Beef Patties Incorporated with Destoned Olive Cake Powder","volume":"122","author":"Hawashin","year":"2016","journal-title":"Meat Sci."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Karwowska, M., Kononiuk, A., and W\u00f3jciak, K.M. (2019). Impact of Sodium Nitrite Reduction on Lipid Oxidation and Antioxidant Properties of Cooked Meat Products. Antioxidants, 9.","DOI":"10.3390\/antiox9010009"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ijfoodmicro.2018.09.017","article-title":"Microbiota of Sliced Cooked Ham Packaged in Modified Atmosphere throughout the Shelf Life: Microbiota of Sliced Cooked Ham in MAP","volume":"289","author":"Raimondi","year":"2019","journal-title":"Int. J. Food Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Spampinato, G., Candeliere, F., Amaretti, A., Licciardello, F., Rossi, M., and Raimondi, S. (2022). Microbiota Survey of Sliced Cooked Ham During the Secondary Shelf Life. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.842390"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1002\/jsfa.8240","article-title":"Hydroxytyrosol Extracts, Olive Oil and Walnuts as Functional Components in Chicken Sausages","volume":"97","author":"Nieto","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"ref_96","first-page":"171","article-title":"Effetto delle Tecniche di Zangolatura e di Cottura sulla Resa e sull\u2019Accettabilit\u00e0 del Prosciutto Cotto Ottenuto da Cosce di Diversa Qualit\u00e0","volume":"75","author":"Pizza","year":"2000","journal-title":"Ind. Conserve"},{"key":"ref_97","unstructured":"Colavita, G. (2023). Prodotti di salumeria. Igiene e Tecnologie degli Alimenti, Point Veterinaire Italie."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1365-2672.2009.04451.x","article-title":"Determination of the Shelf Life of Sliced Cooked Ham Based on the Growth of Lactic Acid Bacteria in Different Steps of the Chain","volume":"108","author":"Kreyenschmidt","year":"2010","journal-title":"J. Appl. Microbiol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/9\/1124\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:47:06Z","timestamp":1760035626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/9\/1124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":98,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["antiox14091124"],"URL":"https:\/\/doi.org\/10.3390\/antiox14091124","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]}}}