{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:42Z","timestamp":1760060742622,"version":"build-2065373602"},"reference-count":82,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Ministry of Culture and Innovation, National Fund for Research, Development and Innovation","award":["EK\u00d6P-24-3-I-PTE-392","EK\u00d6P-24-3-I","K135457","NAP3.HUN-REN TKI14016","TKP2021-EGA-32"],"award-info":[{"award-number":["EK\u00d6P-24-3-I-PTE-392","EK\u00d6P-24-3-I","K135457","NAP3.HUN-REN TKI14016","TKP2021-EGA-32"]}]},{"DOI":"10.13039\/501100012550","name":"the National Research, Development and Innovation Fund","doi-asserted-by":"publisher","award":["EK\u00d6P-24-3-I-PTE-392","EK\u00d6P-24-3-I","K135457","NAP3.HUN-REN TKI14016","TKP2021-EGA-32"],"award-info":[{"award-number":["EK\u00d6P-24-3-I-PTE-392","EK\u00d6P-24-3-I","K135457","NAP3.HUN-REN TKI14016","TKP2021-EGA-32"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the National Brain Research Program","award":["EK\u00d6P-24-3-I-PTE-392","EK\u00d6P-24-3-I","K135457","NAP3.HUN-REN TKI14016","TKP2021-EGA-32"],"award-info":[{"award-number":["EK\u00d6P-24-3-I-PTE-392","EK\u00d6P-24-3-I","K135457","NAP3.HUN-REN TKI14016","TKP2021-EGA-32"]}]},{"name":"the National Academy of Scientist Education Program of the National Biomedical Foundation","award":["EK\u00d6P-24-3-I-PTE-392","EK\u00d6P-24-3-I","K135457","NAP3.HUN-REN TKI14016","TKP2021-EGA-32"],"award-info":[{"award-number":["EK\u00d6P-24-3-I-PTE-392","EK\u00d6P-24-3-I","K135457","NAP3.HUN-REN TKI14016","TKP2021-EGA-32"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The prevalence of hypoxia-caused eye diseases is increasing, but effective, non-invasive treatment options are not available. Abscisic acid (ABA) is a plant hormone with anti-inflammatory and antioxidant effects. ABA is also present in various mammalian tissues and plays an important role in metabolic processes. Therefore, we aimed to investigate the potential protective role of ABA eye drops in ischemic retinopathy. Retinal ischemia was induced by permanent unilateral common carotid artery occlusion (UCCAO) in mice. Half of the animals received ABA eye drops two times a day for two weeks. Optical coherence tomography (OCT) was used to follow the changes in retinal thickness. Moreover, immunohistochemistry and molecular biology methods were used to explore the morphological changes and the underlying mechanisms, respectively. Based on OCT measurements, ischemic retinopathy was successfully developed. The decrease in the thickness of numerous retinal layers could be prevented with ABA eye drops. The ganglion cell number decreased significantly after UCCAO in the central and peripheral regions of the retina. ABA treatment could moderate the damage in both regions. Furthermore, our apoptosis array results suggest that ABA regulates the apoptotic pathways under hypoxic conditions. In conclusion, ABA eye drops may represent a new potential therapeutic option for the treatment of ischemic retinopathy.<\/jats:p>","DOI":"10.3390\/antiox14091133","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:11:01Z","timestamp":1758269461000},"page":"1133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinoprotective Effects of Abscisic Acid in Ischemic Retinopathy Mouse Model"],"prefix":"10.3390","volume":"14","author":[{"given":"Inez","family":"Bosnyak","sequence":"first","affiliation":[{"name":"Department of Anatomy, HUN-REN-PTE PACAP Research Team, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6846-5301","authenticated-orcid":false,"given":"Agnes","family":"Nagy","sequence":"additional","affiliation":[{"name":"Center for Health Technology Assessment and Pharmacoeconomic Research, Faculty of Pharmacy, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorottya","family":"Molitor","sequence":"additional","affiliation":[{"name":"Department of Anatomy, HUN-REN-PTE PACAP Research Team, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"Meresz","sequence":"additional","affiliation":[{"name":"Department of Anatomy, HUN-REN-PTE PACAP Research Team, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edina","family":"Szabo","sequence":"additional","affiliation":[{"name":"Department of Anatomy, HUN-REN-PTE PACAP Research Team, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Reglodi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, HUN-REN-PTE PACAP Research Team, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8112-8633","authenticated-orcid":false,"given":"Tamas","family":"Atlasz","sequence":"additional","affiliation":[{"name":"Department of Anatomy, HUN-REN-PTE PACAP Research Team, Medical School, University of Pecs, 7624 Pecs, Hungary"},{"name":"Department of Sports Biology and Kinesiology, Faculty of Sciences, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Vaczy","sequence":"additional","affiliation":[{"name":"Department of Anatomy, HUN-REN-PTE PACAP Research Team, Medical School, University of Pecs, 7624 Pecs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","article-title":"Causes of Blindness and Vision Impairment in 2020 and Trends over 30 Years, and Prevalence of Avoidable Blindness in Relation to VISION 2020: The Right to Sight: An Analysis for the Global Burden of Disease Study","volume":"9","author":"Steinmetz","year":"2021","journal-title":"Lancet Glob. 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