{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:09:02Z","timestamp":1758931742891,"version":"3.44.0"},"reference-count":69,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009338","name":"National Marine Biodiversity Institute of Korea","doi-asserted-by":"publisher","award":["2025M00500"],"award-info":[{"award-number":["2025M00500"]}],"id":[{"id":"10.13039\/501100009338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Antioxidants"],"abstract":"<jats:p>In this study, the cosmeceutical potential of a 70% ethanol extract of Rosa lucieae was investigated as a multifunctional bioactive ingredient. The extract was systematically evaluated for its antioxidant, anti-melanogenic, and anti-aging properties, and was comprehensively phytochemically profiled using ultra-high-performance liquid chromatography\u2013quadrupole time-of-flight mass spectrometry. The analysis tentatively identified 21 metabolites, including phenolic acids (gallic acid, ellagic acid, and corilagin), flavonoids (catechin, rutin, quercetin, hyperoside, and quercitrin), and glycosidic derivatives (e.g., phlorizin), several of which are well-documented for their skin-protective effects. Quantitative measurements confirmed high polyphenol and flavonoid contents, correlating with strong radical-scavenging and reducing capacities in \u03b1-diphenyl-\u03b2-picrylhydrazyl, 2,2\u2032-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid, as well as ferric ion reducing antioxidant power assays. Moreover, the extract inhibited tyrosinase activity and 3,4-dihydroxyphenylalanine oxidation, thereby suppressing melanin biosynthesis. In addition, marked inhibitory effects against collagenase, elastase, and hyaluronidase were observed; these enzymes are critically involved in extracellular matrix degradation and skin aging. Taken together, these results indicate that the biological activities of R. lucieae are supported by a diverse polyphenol- and flavonoid-rich chemical profile, highlighting the potential of this plant as a natural multifunctional ingredient for cosmeceutical, nutraceutical, functional food, and preventive healthcare applications.<\/jats:p>","DOI":"10.3390\/antiox14101177","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:33:03Z","timestamp":1758889983000},"page":"1177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant, Anti-Melanogenic, and Anti-Aging Activities of the Aqueous\u2013Ethanolic Dry Extract of Rosa lucieae with Phytochemical Profiling"],"prefix":"10.3390","volume":"14","author":[{"given":"Yun Gyeong","family":"Park","sequence":"first","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Yul","family":"Kim","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok-Chun","family":"Ko","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-9249","authenticated-orcid":false,"given":"Kyung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongwoo","family":"Yang","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-1463","authenticated-orcid":false,"given":"Du-Min","family":"Jo","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Geun","family":"Lee","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Min","family":"Lee","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Jin","family":"Yim","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-1402","authenticated-orcid":false,"given":"Dae-Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Seafood Science and Technology, Institute of Marine Industry, Gyeongsang National University, Tongyeong 53064, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gun-Woo","family":"Oh","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, Seochun 33662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00606-007-0539-9","article-title":"Phylogeny and classification of Rosaceae","volume":"266","author":"Potter","year":"2007","journal-title":"Plant Syst. 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