{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:09:51Z","timestamp":1789153791206,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002848","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["ANID FONDECYT 11240910."],"award-info":[{"award-number":["ANID FONDECYT 11240910."]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["ANID Vinculaci\u00f3n Internacional PCI-FOVI240183,"],"award-info":[{"award-number":["ANID Vinculaci\u00f3n Internacional PCI-FOVI240183,"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032816","name":"Universidad San Sebasti\u00e1n","doi-asserted-by":"crossref","award":["VRIDFAPPE 22\/02"],"award-info":[{"award-number":["VRIDFAPPE 22\/02"]}],"id":[{"id":"10.13039\/100032816","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100032816","name":"Universidad San Sebasti\u00e1n","doi-asserted-by":"crossref","award":["USS-FIN-23- CNGI-16."],"award-info":[{"award-number":["USS-FIN-23- CNGI-16."]}],"id":[{"id":"10.13039\/100032816","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The demand for sustainable methods to extract bioactive compounds from native fruits is increasing. We evaluated the potential of natural deep eutectic solvents (NaDES) combined with ultrasound-assisted extraction (UAE) to recover phenolic compounds from Ugni molinae Turcz. (murta), a Chilean fruit with recognized ethnopharmacological and antioxidant value. Seven choline chloride-based NaDESs (M1\u2013M7) were assessed and compared with conventional methanol: formic acid extraction (M8). The choline chloride: 1,2-propanediol system (1:2, M2) achieved the highest recovery of total phenolics (64.87 mg GAE\/g) and flavonoids (35.38 mg QE\/g), together with strong antioxidant activity (DPPH IC50: 1.05 \u00b5g\/mL; ORAC: 40,291 \u00b5mol TE\/g). When comparing the different NaDES formulations (M1\u2013M8), M8 displayed superior FRAP and ORAC values, although its phenolic and flavonoid yields were lower, reflecting differences in solvent selectivity. HPLC-DAD analysis further revealed that NaDES, particularly M5 (choline chloride: oxalic acid, 1:1), favored the extraction of flavonoid and anthocyanin-type compounds. Multivariate and PCA analyses showed distinct chemical profiles in NaDES extracts, forming two clusters apart from M8. Pearson correlation analysis linked antioxidant capacity with major flavonoids. Overall, NaDES combined with UAE represents an efficient, green strategy for selectively recovering bioactives, supporting applications in foods, nutraceuticals, and health products from Chilean native fruits.<\/jats:p>","DOI":"10.3390\/antiox14101234","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:41:29Z","timestamp":1760449289000},"page":"1234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Natural Deep Eutectic Solvent (NaDES) Extraction, HPLC-DAD Analysis, and Antioxidant Activity of Chilean Ugni molinae Turcz. Fruits"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3110-3953","authenticated-orcid":false,"given":"Javier","family":"Antileo-Laurie","sequence":"first","affiliation":[{"name":"Escuela de Qu\u00edmica y Farmacia, Facultad de Ciencias, Universidad San Sebasti\u00e1n, General Lagos 1163, Valdivia 5090000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Olate-Olave","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica e Inmunohematolog\u00eda, Universidad de Talca, Avenida Lircay s\/n, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Fehrmann-Riquelme","sequence":"additional","affiliation":[{"name":"School of Nutrition and Dietetics, Faculty of Rehabilitation and Quality of Life Sciences, Universidad San Sebast\u00edan, General Lagos 1163, Valdivia 5090000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Anabal\u00f3n-Alvarez","sequence":"additional","affiliation":[{"name":"School of Nutrition and Dietetics, Faculty of Rehabilitation and Quality of Life Sciences, Universidad San Sebast\u00edan, General Lagos 1163, Valdivia 5090000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Cid-Carrillo","sequence":"additional","affiliation":[{"name":"School of Nutrition and Dietetics, Faculty of Rehabilitation and Quality of Life Sciences, Universidad San Sebast\u00edan, General Lagos 1163, Valdivia 5090000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-409X","authenticated-orcid":false,"given":"Javier","family":"Campanini-Salinas","sequence":"additional","affiliation":[{"name":"Escuela de Qu\u00edmica y Farmacia, Facultad de Ciencias, Universidad San Sebasti\u00e1n, Lago Panguipulli 1390, Puerto Montt 5501842, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4282-8853","authenticated-orcid":false,"given":"Carlos","family":"Fern\u00e1ndez-Galleguillos","sequence":"additional","affiliation":[{"name":"Departamento Biom\u00e9dico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta 1270300, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-4853","authenticated-orcid":false,"given":"Luisa","family":"Quesada-Romero","sequence":"additional","affiliation":[{"name":"School of Nutrition and Dietetics, Faculty of Rehabilitation and Quality of Life Sciences, Universidad San Sebast\u00edan, General Lagos 1163, Valdivia 5090000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhang, J.J., Xu, D.P., Zhou, T., Zhou, Y., Li, S., and Li, H. 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