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(2) Methods: The review adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We utilized PubMed and Web of Science databases to search for relevant studies on the use of phenolic acids in liver diseases from 2015 to 2025. (3) Results: Phenolic acids can improve different types of liver diseases, including drug-induced liver injury (DILI), alcoholic liver disease (ALD), metabolic dysfunction-associated steatotic liver disease, liver fibrosis, and liver cancer. Their beneficial effects are attributed to mechanisms such as anti-inflammatory properties, antioxidant activity, regulation of lipid metabolism, inhibition of cell apoptosis, and modulation of gut microbiota. (4) Conclusion: Phenolic acids exhibit a good protective effect against various liver diseases and are associated with multiple signaling pathways. However, the primary target cells and specific molecular targets of phenolic acids remain unclear, necessitating further research to elucidate their protective mechanisms in liver diseases.<\/jats:p>","DOI":"10.3390\/antiox14101247","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:39:34Z","timestamp":1760701174000},"page":"1247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Protective Effect of Phenolic Acids on Liver Disease: A Review of Possible Mechanisms"],"prefix":"10.3390","volume":"14","author":[{"given":"Xinyi","family":"Ma","sequence":"first","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhui","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-501X","authenticated-orcid":false,"given":"Yamei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-1797","authenticated-orcid":false,"given":"Limei","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchen","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. 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