{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:37:24Z","timestamp":1791380244927,"version":"4.3.3"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["KYCX20_1843"],"award-info":[{"award-number":["KYCX20_1843"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Hypertriglyceridemic acute pancreatitis (HTGAP) is characterized by frequent severe complications and poor clinical prognosis. Recent evidence suggests that gut dysbiosis is correlated with pancreatic injury in HTGAP, although the precise mechanisms remain to be elucidated. Here, we found that experimental HTGAP mice exhibited gut dysbiosis and intestinal barrier dysfunction, accompanied by an abnormal increase in Allobaculum mucilyticum (A. mucilyticum) and a decrease in Akkermansia muciniphila (A. muciniphila). Administration of A. mucilyticum aggravated oxidative stress-associated intestinal barrier dysfunction, promoted bacterial translocation to the pancreas, and ultimately exacerbated pancreatic injury. Conversely, supplementation with A. muciniphila alleviated the severity of HTGAP by restoring mucus layer thickness and reducing intestinal pro-inflammatory macrophage polarization. These findings highlight the critical role of gut dysbiosis in HTGAP progression, mediated through the pro-inflammatory mucolytic pathobiont A. mucilyticum, and suggest that modulating gut microbiota may represent a novel therapeutic strategy for HTGAP.<\/jats:p>","DOI":"10.3390\/antiox14111284","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:16:07Z","timestamp":1761642967000},"page":"1284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Allobaculum mucilyticum-Mediated Gut Barrier Dysfunction Exacerbates the Severity of Hypertriglyceridemic Acute Pancreatitis in Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Ping","family":"Yang","sequence":"first","affiliation":[{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"},{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"},{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"},{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Sun","sequence":"additional","affiliation":[{"name":"MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-7248","authenticated-orcid":false,"given":"Li-Long","family":"Pan","sequence":"additional","affiliation":[{"name":"MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"},{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China"},{"name":"MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New Insights into Acute Pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat. 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