{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:37:04Z","timestamp":1787510224743,"version":"build-2736575974"},"reference-count":240,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Council","award":["2021 DBA.AD005.225"],"award-info":[{"award-number":["2021 DBA.AD005.225"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Inflammatory bowel disease (IBD) is a multifactorial and complex condition of the gastrointestinal tract shaped by host genetics, immune dysregulation, gut microbiota and environmental determinants, with a steadily rising global prevalence. Although the etiology of IBD remains incompletely understood, chronic inflammation accompanied by oxidative stress, immune dysregulation, and gut dysbiosis is widely recognized as a hallmark of the condition. Given the frequent occurrence of undernutrition in IBD patients, the role of vitamins and micronutrients in modulating disease activity has been recently explored. Selenium (Se) is universally recognized as an essential trace element due to its diverse physiological functions, including potent antioxidant activity, anti-inflammatory effects, immunomodulatory properties, and the ability to influence gut microbial composition and diversity. This comprehensive review examines current evidence on the relationship between Se status and IBD, integrating epidemiological and experimental findings, elucidating the underlying biological mechanisms, and introducing Se nanoparticles, a viable therapeutic option using Se in IBD management.<\/jats:p>","DOI":"10.3390\/antiox14111299","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:16:24Z","timestamp":1761729384000},"page":"1299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Selenium: A Key Element in Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4619-6227","authenticated-orcid":false,"given":"Francesca","family":"Gorini","sequence":"first","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8335-5541","authenticated-orcid":false,"given":"Alessandro","family":"Tonacci","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Aleksandrova, K., Romero-Mosquera, B., and Hernandez, V. (2017). Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention. Nutrients, 9.","DOI":"10.20944\/preprints201707.0039.v1"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Wu, T., Cheng, H., Zhuang, J., Liu, X., Ouyang, Z., and Qian, R. (2025). Risk factors for inflammatory bowel disease: An umbrella review. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1410506"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/ueg2.12319","article-title":"Environmental risk factors for inflammatory bowel disease","volume":"10","author":"Singh","year":"2022","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.mayocp.2017.04.010","article-title":"Crohn Disease: Epidemiology, Diagnosis, and Management","volume":"92","author":"Feuerstein","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.mayocp.2014.07.002","article-title":"Ulcerative colitis: Epidemiology, diagnosis, and management","volume":"89","author":"Feuerstein","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lungaro, L., Costanzini, A., Manza, F., Barbalinardo, M., Gentili, D., Guarino, M., Caputo, F., Zoli, G., De Giorgio, R., and Caio, G. (2023). Impact of Female Gender in Inflammatory Bowel Diseases: A Narrative Review. J. Pers. Med., 13.","DOI":"10.3390\/jpm13020165"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Salem, D.A., El-Ijla, R., AbuMusameh, R.R., Zakout, K.A., Abu Halima, A.Y., Abudiab, M.T., Banat, Y.M., Alqeeq, B.F., Al-Tawil, M., and Matar, K. (2024). Sex-related differences in profiles and clinical outcomes of Inflammatory bowel disease: A systematic review and meta-analysis. BMC Gastroenterol., 24.","DOI":"10.1186\/s12876-024-03514-2"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Cai, Z., Wang, S., and Li, J. (2021). Treatment of Inflammatory Bowel Disease: A Comprehensive Review. Front. Med., 8.","DOI":"10.3389\/fmed.2021.765474"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1093\/ecco-jcc\/jjae082","article-title":"Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies","volume":"18","author":"Caron","year":"2024","journal-title":"J. Crohns Colitis"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zhou, J.L., Bao, J.C., Liao, X.Y., Chen, Y.J., Wang, L.W., Fan, Y.Y., Xu, Q.Y., Hao, L.X., Li, K.J., and Liang, M.X. (2023). Trends and projections of inflammatory bowel disease at the global, regional and national levels, 1990\u20132050: A bayesian age-period-cohort modeling study. BMC Public Health, 23.","DOI":"10.1186\/s12889-023-17431-8"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"17562848231218615","DOI":"10.1177\/17562848231218615","article-title":"Crossing barriers: The burden of inflammatory bowel disease across Western Europe","volume":"16","author":"Kumar","year":"2023","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cgh.2024.06.049","article-title":"The Cost of Inflammatory Bowel Disease Care: How to Make it Sustainable","volume":"23","author":"Burisch","year":"2025","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/ecco-jcc\/jjab029","article-title":"The Burden of Inflammatory Bowel Disease in Europe in 2020","volume":"15","author":"Zhao","year":"2021","journal-title":"J. Crohns Colitis"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-025-08940-0","article-title":"Global evolution of inflammatory bowel disease across epidemiologic stages","volume":"642","author":"Hracs","year":"2025","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.molmed.2020.06.006","article-title":"Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease","volume":"26","author":"Bourgonje","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1007\/s12011-024-04074-y","article-title":"The Role of the Trace Element Selenium in Inflammatory Bowel Disease","volume":"202","author":"Hu","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/ibd\/izad174","article-title":"Micronutrient Status and Prediction of Disease Outcome in Adults with Inflammatory Bowel Disease Receiving Biologic Therapy","volume":"30","author":"Brownson","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1097\/MEG.0000000000002130","article-title":"The dietary practices and beliefs of people living with older-onset inflammatory bowel disease","volume":"33","author":"Crooks","year":"2021","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2015.09.003","article-title":"Importance of selenium and SEPP1rotein for brain function: From antioxidant protection to neuronal signalling","volume":"153","author":"Solovyev","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gorini, F., Sabatino, L., Pingitore, A., and Vassalle, C. (2021). Selenium: An Element of Life Essential for Thyroid Function. Molecules, 26.","DOI":"10.3390\/molecules26237084"},{"key":"ref_23","first-page":"CD005195","article-title":"Selenium for preventing cancer","volume":"1","author":"Vinceti","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Meng, S., Yu, Y., Bi, L., Tian, J., and Zhang, L. (2024). Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1363299"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e34975","DOI":"10.1016\/j.heliyon.2024.e34975","article-title":"A comprehensive review on potential role of selenium, SEPP1roteins and selenium nanoparticles in male fertility","volume":"10","author":"Yuan","year":"2024","journal-title":"Heliyon"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Gorini, F., and Vassalle, C. (2022). Selenium and SEPP1roteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology. Antioxidants, 11.","DOI":"10.3390\/antiox11061188"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Nettleford, S.K., and Prabhu, K.S. (2018). Selenium and SEPP1roteins in Gut Inflammation-A Review. Antioxidants, 7.","DOI":"10.3390\/antiox7030036"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e40139","DOI":"10.1016\/j.heliyon.2024.e40139","article-title":"Selenium deficiency in inflammatory bowel disease: A comprehensive meta-analysis","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Sousa, J.A., McKay, D.M., and Raman, M. (2024). Selenium, Immunity, and Inflammatory Bowel Disease. Nutrients, 16.","DOI":"10.3390\/nu16213620"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Calvez, V., Puca, P., Di Vincenzo, F., Del Gaudio, A., Bartocci, B., Murgiano, M., Iaccarino, J., Parand, E., Napolitano, D., and Pugliese, D. (2025). Novel Insights into the Pathogenesis of Inflammatory Bowel Diseases. Biomedicines, 13.","DOI":"10.3390\/biomedicines13020305"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41579-019-0213-6","article-title":"Microbial genes and pathways in inflammatory bowel disease","volume":"17","author":"Schirmer","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7247238","DOI":"10.1155\/2019\/7247238","article-title":"A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease","volume":"2019","author":"Guan","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S2468-1253(24)00390-X","article-title":"The intestinal barrier: A pivotal role in health, inflammation, and cancer","volume":"10","author":"Neurath","year":"2025","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Bai, X., Liu, W., Chen, H., Zuo, T., and Wu, X. (2022). Immune Cell Landscaping Reveals Distinct Immune Signatures of Inflammatory Bowel Disease. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.861790"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/s12964-023-01386-9","article-title":"Macrophage polarization in inflammatory bowel disease","volume":"21","author":"Zhang","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3109\/08820139.2014.909456","article-title":"Disequilibrium of M1 and M2 macrophages correlates with the development of experimental inflammatory bowel diseases","volume":"43","author":"Zhu","year":"2014","journal-title":"Immunol. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2147\/JIR.S353038","article-title":"Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics","volume":"15","author":"Lu","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Baumgart, D. (2012). The Th1, Th2, and Th17 Paradigm in Inflammatory Bowel Disease. Crohn\u2019s Disease and Ulcerative Colitis, Springer.","DOI":"10.1007\/978-1-4614-0998-4"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cytogfr.2022.07.005","article-title":"The involvement of TH17 cells in the pathogenesis of IBD","volume":"6","author":"Jiang","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.3748\/wjg.v22.i7.2195","article-title":"Role of regulatory T cell in the pathogenesis of inflammatory bowel disease","volume":"22","author":"Yamada","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.coph.2020.10.002","article-title":"Targeting B cells for inflammatory bowel disease treatment: Back to the future","volume":"55","author":"Colombel","year":"2020","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1097\/MIB.0000000000001199","article-title":"Understanding the Cautions and Contraindications of Immunomodulator and Biologic Therapies for Use in Inflammatory Bowel Disease","volume":"23","author":"Cohn","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000535647","article-title":"Inflammatory Bowel Disease: From Conventional Immunosuppression to Biologic Therapy","volume":"42","author":"Milosavljevic","year":"2024","journal-title":"Dig. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Qiu, P., Ishimoto, T., Fu, L., Zhang, J., Zhang, Z., and Liu, Y. (2022). The Gut Microbiota in Inflammatory Bowel Disease. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.733992"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1038\/ncomms7734","article-title":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome","volume":"6","author":"Macia","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Cassol, I., Iba\u00f1ez, M., and Bustamante, J.P. (2025). Key features and guidelines for the application of microbial alpha diversity metrics. Sci. Rep., 15.","DOI":"10.1038\/s41598-024-77864-y"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/ibd\/izac194","article-title":"Searching for a Consensus Among Inflammatory Bowel Disease Studies: A Systematic Meta-Analysis","volume":"29","author":"Morgan","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1093\/ibd\/izy182","article-title":"Faecalibacterium prausnitzii Produces Butyrate to Maintain Th17\/Treg Balance and to Ameliorate Colorectal Colitis by Inhibiting Histone Deacetylase 1","volume":"24","author":"Zhou","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nie, K., Ma, K., Luo, W., Shen, Z., Yang, Z., Xiao, M., Tong, T., Yang, Y., and Wang, X. (2021). Roseburia intestinalis: A Beneficial Gut Organism from the Discoveries in Genus and Species. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.757718"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Baxter, N.T., Schmidt, A.W., Venkataraman, A., Kim, K.S., Waldron, C., and Schmidt, T.M. (2019). Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers. mBio, 10.","DOI":"10.1128\/mBio.02566-18"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases","volume":"569","author":"Arze","year":"2019","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"eaap8914","DOI":"10.1126\/scitranslmed.aap8914","article-title":"Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome","volume":"10","author":"Imhann","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1053\/j.gastro.2019.11.294","article-title":"Differences in Gut Microbiota in Patients With vs. Without Inflammatory Bowel Diseases: A Systematic Review","volume":"158","author":"Pittayanon","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1136\/gutjnl-2016-313235","article-title":"A microbial signature for Crohn\u2019s disease","volume":"66","author":"Pascal","year":"2017","journal-title":"Gut"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nri3535","article-title":"Microbiota-mediated colonization resistance against intestinal pathogens","volume":"13","author":"Buffie","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Anderson, M., Sansonetti, P.J., and Marteyn, B.S. (2016). Shigella Diversity and Changing Landscape: Insights for the Twenty-First Century. Front. Cell. Infect. Microbiol., 6.","DOI":"10.3389\/fcimb.2016.00045"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"115018","DOI":"10.1016\/j.celrep.2024.115018","article-title":"Genomic features and prevalence of Ruminococcus species in humans are associated with age, lifestyle, and disease","volume":"43","author":"Valentino","year":"2024","journal-title":"Cell Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13073-017-0490-5","article-title":"A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients","volume":"9","author":"Hall","year":"2017","journal-title":"Genome Med."},{"key":"ref_59","first-page":"129","article-title":"A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology Advances","volume":"16","author":"Abdulla","year":"2022","journal-title":"Biologics"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lee, G.R. (2018). The Balance of Th17 versus Treg Cells in Autoimmunity. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030730"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism","volume":"24","author":"Sayin","year":"2016","journal-title":"Cell Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-019-1785-z","article-title":"Bile acid metabolites control TH17 and Treg cell differentiation","volume":"576","author":"Hang","year":"2019","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41586-020-2193-0","article-title":"Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells","volume":"581","author":"Campbell","year":"2020","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/gutjnl-2015-310283","article-title":"Microbiota-induced obesity requires farnesoid X receptor","volume":"66","author":"Sommer","year":"2017","journal-title":"Gut"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Langan, D., Perkins, D.J., Vogel, S.N., and Moudgil, K.D. (2021). Microbiota-Derived Metabolites, Indole-3-aldehyde and Indole-3-acetic Acid, Differentially Modulate Innate Cytokines and Stromal Remodeling Processes Associated with Autoimmune Arthritis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042017"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1053\/j.gastro.2017.08.028","article-title":"Increased Tryptophan Metabolism Is Associated with Activity of Inflammatory Bowel Diseases","volume":"153","author":"Nikolaus","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/ajg.2015.50","article-title":"Familial risk of inflammatory bowel disease: A population-based cohort study 1977\u20132011","volume":"110","author":"Moller","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1080\/003655200451207","article-title":"Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study","volume":"35","author":"Orholm","year":"2000","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/ibd.20380","article-title":"Epidemiology of inflammatory bowel disease in a German twin cohort: Results of a nationwide study","volume":"14","author":"Spehlmann","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Al Nabhani, Z., Dietrich, G., Hugot, J.P., and Barreau, F. (2017). Nod2: The intestinal gate keeper. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006177"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/ibd\/izy085","article-title":"Determinants of IBD Heritability: Genes, Bugs, and More","volume":"24","author":"Turpin","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Jarmakiewicz-Czaja, S., Zieli\u0144ska, M., Sokal, A., and Filip, R. (2022). Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update. Genes, 13.","DOI":"10.1155\/2022\/4344905"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Alula, K.M., and Theiss, A.L. (2023). Autophagy in Crohn\u2019s Disease: Converging on Dysfunctional Innate Immunity. Cells, 12.","DOI":"10.3390\/cells12131779"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e39982","DOI":"10.7554\/eLife.39982","article-title":"The Crohn\u2019s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1\/Th17 response","volume":"8","author":"Lavoie","year":"2019","journal-title":"elife"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/jcmm.14770","article-title":"The multifaceted role of CARD9 in inflammatory bowel disease","volume":"24","author":"Luo","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nat. Med."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Valatas, V., Kolios, G., and Bamias, G. (2019). TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines with Diverse Functions in Gut Mucosal Immunity. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00583"},{"key":"ref_78","first-page":"2441","article-title":"Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: Important New Factors in Mucosal Homeostasis and Inflammation","volume":"21","author":"Siakavellas","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3109\/08916934.2014.930735","article-title":"Associations between TNFSF15 polymorphisms and susceptibility to ulcerative colitis and Crohn\u2019s disease: A meta-analysis","volume":"47","author":"Zhang","year":"2014","journal-title":"Autoimmunity"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1159\/000475439","article-title":"Identification of Two Additional Susceptibility Loci for Inflammatory Bowel Disease in a Chinese Population","volume":"41","author":"Lan","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/ibd.20223","article-title":"TNFSF15 is an ethnic-specific IBD gene","volume":"13","author":"Picornell","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"300060520961675","DOI":"10.1177\/0300060520961675","article-title":"Polymorphism rs6478109 in the TNFSF15 gene contributes to the susceptibility to Crohn\u2019s disease but not ulcerative colitis: A meta-analysis","volume":"48","author":"Zhou","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Loddo, I., and Romano, C. (2015). Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis. Front. Immunol., 6.","DOI":"10.3389\/fimmu.2015.00551"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1016\/j.cgh.2021.03.021","article-title":"A Systematic Review of Monogenic Inflammatory Bowel Disease","volume":"20","author":"Nambu","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Demirtas Guner, D., Bildik, H.N., Demir, H., Cagdas, D., Saltik Temizel, I.N., Ozgul, R.K., Hizarcioglu Gulsen, H., Tan, C., Cicek, B., and Ozen, H. (2025). Genetic Variants in Early-Onset Inflammatory Bowel Disease: Monogenic Causes and Clinical Implications. Children, 12.","DOI":"10.3390\/children12050536"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00439-022-02464-7","article-title":"Monogenic inflammatory bowel disease-genetic variants, functional mechanisms and personalised medicine in clinical practice","volume":"142","author":"Azabdaftari","year":"2023","journal-title":"Hum. Genet."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1080\/15592294.2020.1748916","article-title":"The DNA methylome of inflammatory bowel disease (IBD) reflects intrinsic and extrinsic factors in intestinal mucosal cells","volume":"15","author":"Agliata","year":"2020","journal-title":"Epigenetics"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/ecco-jcc\/jjac119","article-title":"Systematic Review and Meta-analysis of Peripheral Blood DNA Methylation Studies in Inflammatory Bowel Disease","volume":"17","author":"Joustra","year":"2023","journal-title":"J. Crohns Colitis"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1002\/mef2.63","article-title":"Role of epigenetic modifications and aging in inflammatory bowel disease","volume":"2","author":"Du","year":"2023","journal-title":"MedComm Future Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6142","DOI":"10.1074\/jbc.M113.517599","article-title":"Histone deacetylase inhibitors modulate interleukin 6-dependent CD4+ T cell polarization in vitro and in vivo","volume":"289","author":"Glauben","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/bph.15695","article-title":"Protein arginine methyltransferase 2 (PRMT2) promotes dextran sulfate sodium-induced colitis by inhibiting the SOCS3 promoter via histone H3R8 asymmetric dimethylation","volume":"179","author":"Li","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_93","first-page":"60","article-title":"The role of diet in the prevention and treatment of Inflammatory Bowel Diseases","volume":"89","author":"Reddavide","year":"2018","journal-title":"Acta Biomed."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000495214","article-title":"A multicentre Study of Nutrition Risk Assessment in Adult Patients with Inflammatory Bowel Disease Attending Outpatient Clinics","volume":"74","author":"Lomer","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5493\/wjem.v11.i1.1","article-title":"Role of diet and nutrition in inflammatory bowel disease","volume":"11","author":"Pascoal","year":"2021","journal-title":"World J. Exp. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.clnu.2022.12.004","article-title":"ESPEN guideline on Clinical Nutrition in inflammatory bowel disease","volume":"42","author":"Bischoff","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/j.gastro.2023.11.303","article-title":"AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients with Inflammatory Bowel Disease: Expert Review","volume":"166","author":"Hashash","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Statovci, D., Aguilera, M., MacSharry, J., and Melgar, S. (2017). The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00838"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"111153","DOI":"10.1016\/j.nut.2021.111153","article-title":"The rationale for selenium supplementation in inflammatory bowel disease: A mechanism-based point of view","volume":"85","author":"Ala","year":"2021","journal-title":"Nutrition"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Tokarczyk, J., and Koch, W. (2025). Dietary Zn\u2014Recent Advances in Studies on Its Bioaccessibility and Bioavailability. Molecules, 30.","DOI":"10.3390\/molecules30132742"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10534-022-00373-w","article-title":"Regulation of zinc-dependent enzymes by metal carrier proteins","volume":"35","author":"Thompson","year":"2022","journal-title":"Biometals"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Devarshi, P.P., Mao, Q., Grant, R.W., and Hazels Mitmesser, S. (2024). Comparative Absorption and Bioavailability of Various Chemical Forms of Zinc in Humans: A Narrative Review. Nutrients, 16.","DOI":"10.3390\/nu16244269"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2119\/2008-00033.Prasad","article-title":"Zinc in human health: Effect of zinc on immune cells","volume":"14","author":"Prasad","year":"2008","journal-title":"Mol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Jarmakiewicz-Czaja, S., Ferenc, K., Sokal-Dembowska, A., and Filip, R. (2024). Nutritional Support: The Use of Antioxidants in Inflammatory Bowel Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084390"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/ajcn\/87.5.1336","article-title":"Adaptation in human zinc absorption as influenced by dietary zinc and bioavailability","volume":"87","author":"Hunt","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1378S","DOI":"10.1093\/jn\/130.5.1378S","article-title":"Dietary factors influencing zinc absorption","volume":"130","year":"2000","journal-title":"J. Nutr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jtemb.2014.08.011","article-title":"Dietary phytate, zinc and hidden zinc deficiency","volume":"28","author":"Sandstead","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1007\/s12011-020-02433-z","article-title":"The Influence of Iron and Zinc Supplementation on Iron Apparent Absorption in Rats Fed Vitamins and Minerals Reduced Diets","volume":"199","author":"Rolf","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"100181","DOI":"10.1016\/j.advnut.2024.100181","article-title":"Preventing and Controlling Zinc Deficiency Across the Life Course: A Call to Action","volume":"15","author":"Lowe","year":"2024","journal-title":"Adv. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Wan, Y., and Zhang, B. (2022). The Impact of Zinc and Zinc Homeostasis on the Intestinal Mucosal Barrier and Intestinal Diseases. Biomolecules, 12.","DOI":"10.3390\/biom12070900"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Zupo, R., Sila, A., Castellana, F., Bringiotti, R., Curlo, M., De Pergola, G., De Nucci, S., Giannelli, G., Mastronardi, M., and Sardone, R. (2022). Prevalence of Zinc Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Nutrients, 14.","DOI":"10.3390\/nu14194052"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/MIB.0000000000000989","article-title":"Zinc Deficiency is Associated with Poor Clinical Outcomes in Patients with Inflammatory Bowel Disease","volume":"23","author":"Siva","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Henriksen, C., and Arnesen, E.K. (2023). Copper\u2014A scoping review for Nordic Nutrition Recommendations 2023. Food Nutr. Res., 67.","DOI":"10.29219\/fnr.v67.10322"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e724","DOI":"10.1002\/mco2.724","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"5","author":"Yang","year":"2024","journal-title":"MedComm"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1079\/BJN2002558","article-title":"The immune system as a physiological indicator of marginal copper status?","volume":"87","author":"Bonham","year":"2002","journal-title":"Br. J. Nutr."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"otaa001","DOI":"10.1093\/crocol\/otaa001","article-title":"The Copper\/Zinc Ratio Correlates with Markers of Disease Activity in Patients With Inflammatory Bowel Disease","volume":"2","author":"Schneider","year":"2020","journal-title":"Crohns Colitis 360"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Amerikanou, C., Karavoltsos, S., Gioxari, A., Tagkouli, D., Sakellari, A., Papada, E., Kalogeropoulos, N., Forbes, A., and Kaliora, A.C. (2022). Clinical and inflammatory biomarkers of inflammatory bowel diseases are linked to plasma trace elements and toxic metals; new insights into an old concept. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.997356"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: Mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1074\/jbc.M008922200","article-title":"Hepcidin, a urinary antimicrobial peptide synthesized in the liver","volume":"276","author":"Park","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1056\/NEJMra1004967","article-title":"Iron overload in human disease","volume":"366","author":"Fleming","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Res\u00e1l, T., Farkas, K., and Moln\u00e1r, T. (2021). Iron Deficiency Anemia in Inflammatory Bowel Disease: What Do We Know?. Front. Med., 8.","DOI":"10.3389\/fmed.2021.686778"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/MEG.0000000000002740","article-title":"Iron therapy supplementation in inflammatory bowel disease patients with iron deficiency anemia: Findings from a real-world analysis in Italy","volume":"36","author":"Fiorino","year":"2024","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"17562848231177153","DOI":"10.1177\/17562848231177153","article-title":"Iron deficiency anemia impacts disease progression and healthcare resource consumption in patients with inflammatory bowel disease: A real-world evidence study","volume":"16","author":"Fiorino","year":"2023","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Ye, R., Huang, J., Wang, Z., Chen, Y., and Dong, Y. (2021). Trace Element Selenium Effectively Alleviates Intestinal Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111708"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Bai, S., Zhang, M., Tang, S., Li, M., Wu, R., Wan, S., Chen, L., Wei, X., and Feng, S. (2024). Effects and Impact of Selenium on Human Health, A Review. Molecules, 30.","DOI":"10.20944\/preprints202411.0435.v1"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Zhang, F., Li, X., and Wei, Y. (2023). Selenium and SEPP1roteins in Health. Biomolecules, 13.","DOI":"10.3390\/biom13050799"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3390\/agriculture5041277","article-title":"Selenium Biochemistry and Bioavailability: Implications for Animal Agriculture","volume":"5","author":"Shini","year":"2015","journal-title":"Agriculture"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Mutonhodza, B., Chagumaira, C., Dembedza, M.P., Joy, E.J.M., Manzeke-Kangara, M.G., Njovo, H., Nyadzayo, T.K., Lark, R.M., Kalimbira, A.A., and Bailey, E.H. (2023). A pilot survey of selenium status and its geospatial variation among children and women in three rural districts of Zimbabwe. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1235113"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"He, N., Su, Y., Huang, F., Yu, D., Han, C., Li, X., Zhao, Z., and Sun, X. (2025). Health Assessment of Natural Selenium-Rich Soil in Yuanzhou District Based on Selenium\u2013Cadmium Principal Factors and the Accumulation of Selenium and Cadmium in the Area Crops. Agriculture, 15.","DOI":"10.3390\/agriculture15111149"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.foodres.2018.11.029","article-title":"Designing selenium functional foods and beverages: A review","volume":"12","author":"Adadi","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Ferreira, R.L.U., Sena-Evangelista, K.C.M., de Azevedo, E.P., Pinheiro, F.I., Cobucci, R.N., and Pedrosa, L.F.C. (2021). Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship with Diseases. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.685317"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Dobrzy\u0144ska, M., Drzyma\u0142a-Czy\u017c, S., Wo\u017aniak, D., Drzyma\u0142a, S., and Przys\u0142awski, J. (2023). Natural Sources of Selenium as Functional Food Products for Chemoprevention. Foods, 12.","DOI":"10.3390\/foods12061247"},{"key":"ref_134","first-page":"S168","article-title":"Selenium Metabolism and Biosynthesis of SEPP1roteins in the Human Body","volume":"87","author":"Minich","year":"2022","journal-title":"Biochemistry"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s12276-020-0408-y","article-title":"The role of selenium metabolism and SEPP1roteins in cartilage homeostasis and arthropathies","volume":"52","author":"Kang","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Shimada, B.K., Swanson, S., Toh, P., and Seale, L.A. (2022). Metabolism of Selenium, Selenocysteine, and SEPP1roteins in Ferroptosis in Solid Tumor Cancers. Biomolecules, 12.","DOI":"10.3390\/biom12111581"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"105218","DOI":"10.1016\/j.envint.2019.105218","article-title":"Urine selenium concentration is a useful biomarker for assessing population level selenium status","volume":"134","author":"Phiri","year":"2020","journal-title":"Environ. Int."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ijheh.2014.04.005","article-title":"Study of selenium intake and disposition in various matrices based on mathematical algorithms derived from pooled biomonitoring data","volume":"217","author":"Noisel","year":"2014","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"108787","DOI":"10.1016\/j.envres.2019.108787","article-title":"Toenails as biomarker of exposure to essential trace metals: A review","volume":"179","author":"Lope","year":"2019","journal-title":"Environ. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.3892\/mmr.2017.6388","article-title":"Toenail selenium as an indicator of environmental exposure: A cross-sectional study","volume":"15","author":"Filippini","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3390\/nu7031494","article-title":"A review of dietary selenium intake and selenium status in Europe and the Middle East","volume":"7","author":"Stoffaneller","year":"2015","journal-title":"Nutrients"},{"key":"ref_142","unstructured":"WHO, World Health Organization (2025, September 03). Trace Elements in Human Nutrition and Health, Available online: https:\/\/iris.who.int\/handle\/10665\/37931."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"EFSA, European Food Safety Authority (2014). Scientific Opinion on Dietary Reference Values for selenium. EFSA J., 12, 3846.","DOI":"10.2903\/j.efsa.2014.3846"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3945\/ajcn.2009.28169","article-title":"Establishing optimal selenium status: Results of a randomized, double-blind, placebo-controlled trial","volume":"91","author":"Hurst","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck, D., Bohn, T., Castenmiller, J., de Henauw, S., Hirsch-Ernst, K.I., Knutsen, H.K., Maciuk, A., Mangelsdorf, I., and McArdle, H.J. (2023). Scientific opinion on the tolerable upper intake level for selenium. EFSA J., 21, e07704.","DOI":"10.2903\/j.efsa.2023.7704"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jnutbio.2019.03.020","article-title":"Dietary selenium deficiency or selenomethionine excess drastically alters organ selenium contents without altering the expression of most SEPP1roteins in mice","volume":"69","author":"Akahoshi","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"134541","DOI":"10.1016\/j.scitotenv.2019.134541","article-title":"Exposure to a high selenium environment in Punjab, India: Biomarkers and health conditions","volume":"719","author":"Chawla","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s40572-018-0213-0","article-title":"Environmental Selenium and Human Health: An Update","volume":"5","author":"Vinceti","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jama.2008.864","article-title":"Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)","volume":"301","author":"Lippman","year":"2009","journal-title":"JAMA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S2468-1253(23)00011-0","article-title":"Inflammation and malnutrition in inflammatory bowel disease","volume":"8","author":"Massironi","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"8646495","DOI":"10.1155\/2017\/8646495","article-title":"Nutrition and IBD: Malnutrition and\/or Sarcopenia? A Practical Guide","volume":"2017","author":"Scaldaferri","year":"2017","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.clnesp.2024.12.010","article-title":"Exclusion diet and fasting practices in patients with inflammatory bowel disease: Impact on nutritional status","volume":"65","author":"Quilliot","year":"2025","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"363","DOI":"10.5009\/gnl16333","article-title":"Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease","volume":"11","author":"Han","year":"2017","journal-title":"Gut Liver"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.clinthera.2022.03.005","article-title":"Correlation Between Crohn\u2019s Disease Activity and Serum Selenium Concentration","volume":"44","author":"Yan","year":"2022","journal-title":"Clin. Ther."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"McDonnell, M., Sartain, S., Westoby, C., Katarachia, V., Wootton, S.A., and Cummings, J.R.F. (2023). Micronutrient Status in Adult Crohn\u2019s Disease during Clinical Remission: A Systematic Review. Nutrients, 15.","DOI":"10.3390\/nu15224777"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Chalcarz, M., Grabarek, B.O., Sirek, T., Sirek, A., Ossowski, P., Wilk, M., Kr\u00f3l-Jatr\u0119ga, K., Dziobek, K., Gajdeczka, J., and Madowicz, J. (2024). Evaluation of Selenium Concentrations in Patients with Crohn\u2019s Disease and Ulcerative Colitis. Biomedicines, 12.","DOI":"10.3390\/biomedicines12102167"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Wang, Y., Lin, Y., Feng, J., Lin, L., Liu, L., Su, J., Xie, C., and Shi, H. (2025). Correlation of serum trace elements with clinical features and gut microbiota in patients with Crohn\u2019s disease. J. Nutr. Biochem., 142.","DOI":"10.1016\/j.jnutbio.2025.109917"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Muro, P., Zhang, L., Li, S., Zhao, Z., Jin, T., Mao, F., and Mao, Z. (2024). The emerging role of oxidative stress in inflammatory bowel disease. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1390351"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Guan, G., and Lan, S. (2018). Implications of Antioxidant Systems in Inflammatory Bowel Disease. Biomed. Res. Int., 2018.","DOI":"10.1155\/2018\/1290179"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1074\/jbc.M113.490920","article-title":"Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: A novel mechanism of cellular adaption to inflammatory stress","volume":"289","author":"Stachel","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Fanizza, J., Bencardino, S., Allocca, M., Furfaro, F., Zilli, A., Parigi, T.L., Fiorino, G., Peyrin-Biroulet, L., Danese, S., and D\u2019Amico, F. (2024). Inflammatory Bowel Disease and Colorectal Cancer. Cancers, 16.","DOI":"10.20944\/preprints202407.2568.v1"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"goae053","DOI":"10.1093\/gastro\/goae053","article-title":"Global patterns in the epidemiology, cancer risk, and surgical implications of inflammatory bowel disease","volume":"12","author":"Zhang","year":"2024","journal-title":"Gastroenterol. Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e141676","DOI":"10.1172\/JCI141676","article-title":"DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk","volume":"13","author":"Grasberger","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1136\/gutjnl-2024-334346","article-title":"DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis","volume":"74","author":"Hazime","year":"2025","journal-title":"Gut"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4535194","DOI":"10.1155\/2017\/4535194","article-title":"Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies","volume":"2017","author":"Tian","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.freeradbiomed.2018.05.066","article-title":"Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease","volume":"127","author":"Short","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Costa Pereira, C., Dur\u00e3es, C., Coelho, R., Gr\u00e1cio, D., Silva, M., Peixoto, A., Lago, P., Pereira, M., Catarino, T., and Pinho, S. (2017). Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169102"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"109332","DOI":"10.18632\/oncotarget.22675","article-title":"Association between SOD1, CAT, GSHPX1 polymorphisms and the risk of inflammatory bowel disease in the Polish population","volume":"8","author":"Mrowicka","year":"2017","journal-title":"Oncotarget"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1097\/MIB.0000000000000464","article-title":"GPx2 Induction Is Mediated Through STAT Transcription Factors During Acute Colitis","volume":"21","author":"Hiller","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/MEG.0b013e3282f45751","article-title":"Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: An important role for H2O2?","volume":"20","author":"Pronk","year":"2008","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"G71","DOI":"10.1152\/ajpgi.00379.2014","article-title":"Selenium and inflammatory bowel disease","volume":"309","author":"Kudva","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"G848","DOI":"10.1152\/ajpgi.2001.281.3.G848","article-title":"Mice with combined disruption of Gpx1 and Gpx2 genes have colitis","volume":"281","author":"Esworthy","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.it.2022.04.013","article-title":"Targeting Th17 cells in HIV-1 remission\/cure interventions","volume":"43","author":"Fert","year":"2022","journal-title":"Trends Immunol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.med.53.082901.103952","article-title":"Cyclooxygenase-2: A therapeutic target","volume":"53","author":"Turini","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1089\/ars.2008.2047","article-title":"GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells","volume":"10","author":"Banning","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1158\/0008-5472.CAN-08-1321","article-title":"Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice","volume":"68","author":"Banning","year":"2008","journal-title":"Cancer Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/carcin\/bgr288","article-title":"Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply","volume":"33","author":"Krehl","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"M\u00fcller, M.F., Florian, S., Pommer, S., Osterhoff, M., Esworthy, R.S., Chu, F.F., Brigelius-Floh\u00e9, R., and Kipp, A.P. (2013). Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072055"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"6717","DOI":"10.1158\/0008-5472.CAN-14-1645","article-title":"GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer","volume":"74","author":"Emmink","year":"2014","journal-title":"Cancer Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1158\/0008-5472.CAN-12-3150","article-title":"Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma","volume":"73","author":"Barrett","year":"2013","journal-title":"Cancer Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1038\/s41467-020-15646-6","article-title":"Dietary lipids fuel GPX4-restricted enteritis resembling Crohn\u2019s disease","volume":"11","author":"Mayr","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/carcin\/bgq076","article-title":"Genetic variants in selenoprotein genes increase risk of colorectal cancer","volume":"31","author":"Hughes","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.nut.2004.08.025","article-title":"Serum SEPP1rotein-P levels in patients with inflammatory bowel disease","volume":"21","author":"Andoh","year":"2005","journal-title":"Nutrition"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"41254","DOI":"10.1074\/jbc.M202773200","article-title":"A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and SEPP1rotein P","volume":"277","author":"Takebe","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.freeradbiomed.2014.01.010","article-title":"Sepp1(UF) forms are N-terminal SEPP1rotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1","volume":"69","author":"Kurokawa","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.freeradbiomed.2010.05.035","article-title":"Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction","volume":"49","author":"Speckmann","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1172\/JCI76099","article-title":"SEPP1rotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage","volume":"125","author":"Barrett","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"102335","DOI":"10.1016\/j.psj.2022.102335","article-title":"Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent chromium in broilers","volume":"102","author":"Wang","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41392-025-02142-w","article-title":"Wnt signaling pathways in biology and disease: Mechanisms and therapeutic advances","volume":"10","author":"Xue","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.nut.2007.08.019","article-title":"High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colon","volume":"23","author":"Tirosh","year":"2007","journal-title":"Nutrition"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Carlson, B.A., Yoo, M.H., Sano, Y., Sengupta, A., Kim, J.Y., Irons, R., Gladyshev, V.N., Hatfield, D.L., and Park, J.M. (2009). Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunol., 10.","DOI":"10.1186\/1471-2172-10-57"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s12011-019-01775-7","article-title":"Impact of Selenium Deficiency on Inflammation, Oxidative Stress, and Phagocytosis in Mouse Macrophages","volume":"194","author":"Xu","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Palmieri, E.M., McGinity, C., Wink, D.A., and McVicar, D.W. (2020). Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight. Metabolites, 10.","DOI":"10.3390\/metabo10110429"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.3945\/jn.111.141176","article-title":"Selenium levels affect the IL-4-induced expression of alternative activation markers in murine macrophages","volume":"141","author":"Nelson","year":"2011","journal-title":"J. Nutr."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1007\/s12011-020-02444-w","article-title":"Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?","volume":"199","author":"Sadeghsoltani","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_197","first-page":"60","article-title":"Plasma and mucosal prostaglandin E2 as a surrogate marker of ulcerative colitis activity","volume":"46","author":"Flisiak","year":"2001","journal-title":"Rocz. Akad. Med. Bialymst."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"27471","DOI":"10.1074\/jbc.M111.260547","article-title":"Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma","volume":"286","author":"Gandhi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.4049\/jimmunol.1400347","article-title":"Crucial role of macrophage selenoproteins in experimental colitis","volume":"193","author":"Kaushal","year":"2014","journal-title":"J. Immunol."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Kim, W., Jang, J.H., Zhong, X., Seo, H., and Surh, Y.J. (2021). 15-Deoxy-\u25b312,14-Prostaglandin J2 Promotes Resolution of Experimentally Induced Colitis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.615803"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/andr.13308","article-title":"Pharmacological perturbation of peroxisome-proliferator-activated receptor gamma alters motility and mitochondrial function of bovine sperm","volume":"11","author":"Losano","year":"2023","journal-title":"Andrology"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3892\/ol.2015.3397","article-title":"Peroxisome proliferator-activated receptor-\u03b3 is downregulated in ulcerative colitis and is involved in experimental colitis-associated neoplasia","volume":"10","author":"Dou","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Guri, A.J., Mohapatra, S.K., Horne, W.T., Hontecillas, R., and Bassaganya-Riera, J. (2010). The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease. BMC Gastroenterol., 10.","DOI":"10.1186\/1471-230X-10-60"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/mi.2010.75","article-title":"Immunoregulatory mechanisms of macrophage PPAR-\u03b3 in mice with experimental inflammatory bowel disease","volume":"4","author":"Hontecillas","year":"2011","journal-title":"Mucosal Immunol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ibd.21322","article-title":"Peroxisome proliferator-activated receptor-gamma (PPAR-\u03b3) expression is downregulated in patients with active ulcerative colitis","volume":"17","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Posta, E., Fekete, I., Varkonyi, I., Zold, E., and Barta, Z. (2024). The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases. Cells, 13.","DOI":"10.3390\/cells13201688"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Koeberle, S.C., Gollowitzer, A., Laoukili, J., Kranenburg, O., Werz, O., Koeberle, A., and Kipp, A.P. (2020). Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-\u03baB-driven inflammation through redox-active mechanisms. Redox Biol., 28.","DOI":"10.1016\/j.redox.2019.101388"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"eadh1641","DOI":"10.1126\/scisignal.adh1641","article-title":"The NF-\u03baB signaling system in the immunopathogenesis of inflammatory bowel disease","volume":"17","author":"Mukherjee","year":"2024","journal-title":"Sci. Signal."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.biopha.2017.06.036","article-title":"Inducible nitric oxide synthase: Good or bad?","volume":"93","author":"Lind","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3892\/ijo.2022.5347","article-title":"Role of macrophages in tumor progression and therapy (Review)","volume":"60","author":"Xu","year":"2022","journal-title":"Int. J. Oncol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"20181","DOI":"10.1074\/jbc.M802559200","article-title":"Selenoproteins mediate T cell immunity through an antioxidant mechanism","volume":"283","author":"Shrimali","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1089\/ars.2009.2989","article-title":"Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development","volume":"13","author":"Won","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s41467-018-04274-w","article-title":"The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation","volume":"9","author":"Muri","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/eji.202048851","article-title":"The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion","volume":"51","author":"Muri","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.immuni.2021.07.004","article-title":"Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn\u2019s disease","volume":"54","author":"Huang","year":"2021","journal-title":"Immunity"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-Carbon Metabolism in Health and Disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12011-019-01877-2","article-title":"Role of Selenoproteins in Bacterial Pathogenesis","volume":"192","author":"Sumner","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1096\/fj.11-181990","article-title":"Dietary selenium affects host selenoproteome expression by influencing the gut microbiota","volume":"25","author":"Kasaikina","year":"2011","journal-title":"FASEB J."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/acs.estlett.8b00563","article-title":"Effects of Dietary Selenium Supplementation on Intestinal Barrier and Immune Responses Associated with Its Modulation of Gut Microbiota","volume":"5","author":"Zhai","year":"2018","journal-title":"Environ. Sci. Technol. Lett."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2157697","DOI":"10.1080\/19490976.2022.2157697","article-title":"Gut microbiome signatures reflect different subtypes of irritable bowel syndrome","volume":"15","author":"Su","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/19490976.2017.1349041","article-title":"Gut microbiome in multiple sclerosis: The players involved and the roles they play","volume":"8","author":"Shahi","year":"2017","journal-title":"Gut Microbes"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Lin, T.C., Soorneedi, A., Guan, Y., Tang, Y., Shi, E., Moore, M.D., and Liu, Z. (2023). Turicibacter fermentation enhances the inhibitory effects of Antrodia camphorata supplementation on tumorigenic serotonin and Wnt pathways and promotes ROS-mediated apoptosis of Caco-2 cells. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1203087"},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Gao, F., Cheng, C., Li, R., Chen, Z., Tang, K., and Du, G. (2025). The role of Akkermansia muciniphila in maintaining health: A bibliometric study. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1484656"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jnutbio.2008.06.009","article-title":"The gastrointestinal microbiota affects the selenium status and selenoprotein expression in mice","volume":"20","author":"Hrdina","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/1751-2980.12795","article-title":"Correlation of diet, microbiota and metabolite networks in inflammatory bowel disease","volume":"20","author":"Weng","year":"2019","journal-title":"J. Dig. Dis."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/ismej.2014.3","article-title":"Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission","volume":"8","author":"Rooks","year":"2014","journal-title":"ISME J."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrgastro.2012.14","article-title":"IBD-what role do Proteobacteria play?","volume":"9","author":"Mukhopadhya","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Rajni, E., Purohit, S., Priyadarshini, R., and Agarwal, G. (2025). Silent escalation: The journey of Shigella from gut to blood. Indian J. Med. Microbiol., 54.","DOI":"10.1016\/j.ijmmb.2025.100815"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"He, D., Liu, L., Zhang, Z., Yang, X., Jia, Y., Wen, Y., Cheng, S., Meng, P., Li, C., and Zhang, H. (2022). Association between gut microbiota and longevity: A genetic correlation and mendelian randomization study. BMC Microbiol., 22.","DOI":"10.1186\/s12866-022-02703-x"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Yang, H., Wang, Z., Li, L., Wang, X., Wei, X., Gou, S., Ding, Z., Cai, Z., Ling, Q., and Hoffmann, P.R. (2024). Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-\u03baB activation and enhancing glutathione peroxidase expression. J. Nanobiotechnol., 22.","DOI":"10.1186\/s12951-024-02861-2"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Au, A., Mojadadi, A., Shao, J.Y., Ahmad, G., and Witting, P.K. (2023). Physiological Benefits of Novel Selenium Delivery via Nanoparticles. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076068"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/1061186X.2024.2412142","article-title":"A comprehensive review on recent advancements in drug delivery via selenium nanoparticles","volume":"33","author":"Waqar","year":"2025","journal-title":"J. Drug Target."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"12360","DOI":"10.1080\/10408398.2022.2101093","article-title":"Selenium nanoparticles: Enhanced nutrition and beyond","volume":"63","author":"Chen","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12957-020-01850-7","article-title":"Selenium nanoparticles (SeNPs) have potent antitumor activity against prostate cancer cells through the upregulation of miR-16","volume":"18","author":"Liao","year":"2020","journal-title":"World J. Surg. Oncol."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Chen, W., Cheng, H., and Xia, W. (2022). Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy. Antioxidants, 11.","DOI":"10.3390\/antiox11101965"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Ye, R., Guo, Q., Huang, J., Wang, Z., Chen, Y., and Dong, Y. (2023). Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity. J. Nanobiotechnol., 21.","DOI":"10.1186\/s12951-023-01965-5"},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Peng, S.J., Ye, D.T., Zheng, J., Xue, Y.R., Lin, L., Zhao, Y.D., Miao, W.H., Song, Y., Wen, Z.S., and Zheng, B. (2022). Synthesis, Characterization of Low Molecular Weight Chitosan Selenium Nanoparticles and Its Effect on DSS-Induced Ulcerative Colitis in Mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415527"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.2147\/IJN.S157541","article-title":"Nano-selenium and its nanomedicine applications: A critical review","volume":"13","author":"Hosnedlova","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1007\/s00394-023-03214-9","article-title":"The effect of selenium supplementation on disease activity and immune-inflammatory biomarkers in patients with mild-to-moderate ulcerative colitis: A randomized, double-blind, placebo-controlled clinical trial","volume":"62","author":"Khazdouz","year":"2023","journal-title":"Eur. J. Nutr."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"e2300052","DOI":"10.1002\/pmic.202300052","article-title":"Omics insights into the responses to dietary selenium","volume":"23","author":"Collado","year":"2023","journal-title":"Proteomics"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/11\/1299\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:25:56Z","timestamp":1761888356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/14\/11\/1299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":240,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["antiox14111299"],"URL":"https:\/\/doi.org\/10.3390\/antiox14111299","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]}}}