{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:07:41Z","timestamp":1783030061031,"version":"3.54.6"},"reference-count":64,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Science Fund of the Republic of Serbia","award":["17797"],"award-info":[{"award-number":["17797"]}]},{"DOI":"10.13039\/501100023848","name":"Innovation Fund of the Republic of Serbia","doi-asserted-by":"crossref","award":["TTF 1078"],"award-info":[{"award-number":["TTF 1078"]}],"id":[{"id":"10.13039\/501100023848","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-137\/2025-03\/200125"],"award-info":[{"award-number":["451-03-137\/2025-03\/200125"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-136\/2025-03\/200125"],"award-info":[{"award-number":["451-03-136\/2025-03\/200125"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["101114443"],"award-info":[{"award-number":["101114443"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Iron deficiency anaemia (IDA) affects 25% of the global population, with detrimental effects on the health of women and children. Treatments with iron supplements offer temporary relief but often yield adverse effects, hindering patient adherence. Additionally, IDA is associated with oxidative stress, which becomes significantly exacerbated during iron supplementation. Our study aimed to address this challenge by developing a plant-based nutritional formula rich in bioavailable iron and antioxidants devoid of adverse effects. Chemical analysis of edible plants, focused on the content of iron and iron absorption inhibitors, guided formula development. In vivo studies on rats with IDA evaluated iron bioavailability from the formulated plant-based nutraceuticals. Results of animal studies showed significant improvements in IDA-associated blood parameters after 28 days of oral administration of the nutraceuticals. Additionally, the nutraceuticals did not impede the benefits of iron supplementation. These findings strongly indicate that plant-based nutraceuticals can serve as an effective source of bioavailable iron, potentially improving treatment adherence and at the same time aligning with ongoing WHO and UNICEF initiatives to enhance IDA management.<\/jats:p>","DOI":"10.3390\/antiox14111335","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T16:09:47Z","timestamp":1762358987000},"page":"1335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Innovative Plant-Based Nutraceuticals: Enhancing Iron Bioavailability to Address Iron Deficiency Anaemia"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7839-2815","authenticated-orcid":false,"given":"Nemanja","family":"\u017divanovi\u0107","sequence":"first","affiliation":[{"name":"Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-0676","authenticated-orcid":false,"given":"Vesna","family":"Mijatovi\u0107 Jovin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21137 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-9190","authenticated-orcid":false,"given":"Bojana","family":"Andreji\u0107 Vi\u0161nji\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21137 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0949-6092","authenticated-orcid":false,"given":"Diandra","family":"Pinta\u0107 \u0160arac","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21137 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-3850","authenticated-orcid":false,"given":"Danica","family":"\u0106uji\u0107","sequence":"additional","affiliation":[{"name":"Institute for the Application of Nuclear Energy, University of Belgrade, Banatska 31b, 11080 Zemun, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3837-453X","authenticated-orcid":false,"given":"Nata\u0161a","family":"Simin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9764-9903","authenticated-orcid":false,"given":"Marija","family":"Lesjak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"ref_1","unstructured":"WHO (2015). 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