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Thus, the search for alternative therapeutic strategies for CRC continues. In the present work, the antitumor potential of a hybrid compound, which contains fragments derived from resveratrol and curcumin, was evaluated. These natural compounds are known by their antioxidant, chemopreventive, and chemotherapeutic properties. Different methodologic approaches were used to investigate cytotoxic, genotoxic, antiproliferative, and antioxidant effects of a hybrid compound, named PQM-162, on HCT-8 colorectal cancer cells. The results showed that PQM-162 displays radical scavenging capacity as demonstrated by DPPH assay. Furthermore, this substance reduced cell viability and inhibited cell cycle progression at G2\/M in HCT-8 cells. Antiproliferative activity of PQM-162 was associated with its ability to modulate the expression of critical regulators of G2\/M transition and mitosis progression such as PLK1, AURKB, and CDKN1A. Taken together, our data indicate that PQM-162 is a promising antitumor agent due to its disruption of the redox balance in cancer cells and its modulation of the expression of regulators of the cell cycle and mitotic apparatus.<\/jats:p>","DOI":"10.3390\/antiox14111367","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:04:07Z","timestamp":1763388247000},"page":"1367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resveratrol\u2013Curcumin Hybrid Selectively Induces Chromosomal Abnormalities and Apoptosis in Colon Adenocarcinoma Cells"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9535-5204","authenticated-orcid":false,"given":"Mariane Minussi","family":"Baptistella","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u00e9xia Polo","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e2maris Lizia Santos","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Zavan","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-2210","authenticated-orcid":false,"given":"Carolina Sales","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-2758","authenticated-orcid":false,"given":"Matheus","family":"de Freitas Silva","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Tardelli","family":"Falleiros Lima","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7799-992X","authenticated-orcid":false,"suffix":"Jr.","given":"Cla\u00fadio","family":"Viegas","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-4796","authenticated-orcid":false,"given":"Bruno Martins","family":"Dala-Paula","sequence":"additional","affiliation":[{"name":"Faculdade de Nutri\u00e7\u00e3o, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Siqueira","family":"Caixeta","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Ionta","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-0277","authenticated-orcid":false,"given":"Pollyanna Francielli","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas, Alfenas 37130-001, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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