{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:56:51Z","timestamp":1765961811044,"version":"3.48.0"},"reference-count":58,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260852"],"award-info":[{"award-number":["32260852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32060760"],"award-info":[{"award-number":["32060760"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate Student Innovation Special Fund project of Jiangxi Province","award":["YC2024-B120"],"award-info":[{"award-number":["YC2024-B120"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This study examined the protective impact of tributyrin on heat-stressed Taihe silky fowls, providing insight into oxidative status, inflammatory response, and mucosal barrier function. Three hundred chicks were randomly assigned to 6 treatments: control (CON, 24 \u00b1 1 \u00b0C) fed with basal diet and 5 heat stress (HS) treatments (34 \u00b1 1 \u00b0C for 8 h\/d) fed with basal diet containing 0, 0.04, 0.08, 0.16, and 0.32% tributyrin. Heat stress elevated serum malondialdehyde (MDA), tumor necrosis factor \u03b1 (TNF-\u03b1), interleukin 1\u03b2 (IL-1\u03b2), D-lactate, and diamine oxidase levels, and decreased total antioxidant capacity (T-AOC) and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), interleukin 4 (IL-4), interleukin 10 (IL-10), and immunoglobulin G (IgG) levels (p &lt; 0.05). Compared with HS treatment, tributyrin reversed these serum changes (p &lt; 0.05). Moreover, HS elevated jejunal and ileal MDA content and IL-1\u03b2 mRNA abundance, decreased GSH-Px activity, villus height (VH), VH: crypt depth ratio, and mRNA abundance of IL-10, occludin, and zonula occludens-1 (ZO-1), and decreased cecal butyrate content (p &lt; 0.05). Compared with HS treatment, tributyrin reduced jejunal and ileal MDA content and IL-1\u03b2 mRNA abundance, increased GSH-Px activity, VH, and mRNA abundance of IL-4, IL-10, occludin, and ZO-1, and increased cecal butyrate content (p &lt; 0.05). In conclusion, tributyrin enhanced antioxidant capacity, attenuated inflammatory responses, increased cecal butyrate content, and improved intestinal morphology and mucosal barrier function in cyclic heat-stressed Taihe silky fowls.<\/jats:p>","DOI":"10.3390\/antiox14121511","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:32:27Z","timestamp":1765960347000},"page":"1511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of Tributyrin on Cyclic Heat-Stressed Taihe Silky Fowls: Insights into Oxidative Status, Inflammatory Response, and Mucosal Barrier Function"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7548-9133","authenticated-orcid":false,"given":"Chuanbin","family":"Chen","sequence":"first","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingren","family":"Qu","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-9023","authenticated-orcid":false,"given":"Guanhong","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Wan","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6664-2194","authenticated-orcid":false,"given":"Lanjiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Animal Nutrition and Feed, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"skaa090","DOI":"10.1093\/jas\/skaa090","article-title":"Effects of heat stress on the gut health of poultry","volume":"98","author":"Rostagno","year":"2020","journal-title":"J. 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