{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:01:32Z","timestamp":1791925292725,"version":"4.3.4"},"reference-count":182,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Background: Endometriosis is a chronic inflammatory disorder that affects approximately 10% of women of reproductive age and exhibits tumor-like characteristics such as invasion, recurrence, and hormone-dependent proliferation despite its benign nature. Its pathogenesis is thought to involve hormonal imbalance, oxidative stress, hypoxia, immune dysregulation, and epigenetic alterations. This review summarizes how these factors contribute to lesion formation through intracellular signaling pathways, with a particular focus on the role of the stress-responsive transcription factor Forkhead box O (FOXO1). Methods: A comprehensive literature search was conducted using PubMed and Google Scholar without temporal restriction. Results: FOXO1 is a transcription factor that integratively regulates decidualization, cellular senescence, autophagy, and apoptosis. In the normal endometrium, under mild stress or hormonal stimulation, FOXO1 induces decidualization-associated genes (PRL, IGFBP1) and antioxidant enzymes, thereby promoting differentiation and survival. In contrast, in endometriosis, activation of the PI3K\/AKT signaling pathway and an estrogen-dominant environment suppress the nuclear activity of FOXO1, leading to apoptosis resistance, accumulation of senescent cells, and chronic inflammation through the senescence-associated secretory phenotype (SASP). Moreover, depending on the intensity and duration of oxidative, metabolic, and environmental stress, FOXO1 drives distinct cellular fates\u2014including decidualization, senescence, and apoptosis\u2014thus contributing to the persistence and progression of endometriotic lesions. Conclusion: Dysregulation of the FOXO1-dependent cellular fate\u2013control network plays a central role in the development of endometriosis. Elucidating the molecular mechanisms governing FOXO1 activity and its nuclear dynamics will be crucial for a comprehensive understanding of disease progression and for the development of novel therapeutic strategies.<\/jats:p>","DOI":"10.3390\/antiox15010003","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T12:05:35Z","timestamp":1766145935000},"page":"3","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Molecular Regulation of FOXO1 and Its Pathophysiological Significance in Endometriosis: A Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-6269","authenticated-orcid":false,"given":"Hiroshi","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, 871-1 Shijo-cho, Kashihara 634-0813, Japan"},{"name":"Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shigetomi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan"},{"name":"Department of Gynecology and Reproductive Medicine, Aska Ladies Clinic, 3-3-17 Kitatomigaoka-cho, Nara 634-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, 871-1 Shijo-cho, Kashihara 634-0813, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Umetani","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, 871-1 Shijo-cho, Kashihara 634-0813, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Imanaka","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, 871-1 Shijo-cho, Kashihara 634-0813, Japan"},{"name":"Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiratsugu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, 871-1 Shijo-cho, Kashihara 634-0813, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-018-0008-5","article-title":"Endometriosis","volume":"4","author":"Zondervan","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Adilbayeva, A., and Kunz, J. (2024). Pathogenesis of Endometriosis and Endometriosis-Associated Cancers. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147624"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7265238","DOI":"10.1155\/2017\/7265238","article-title":"Oxidative Stress and Endometriosis: A Systematic Review of the Literature","volume":"2017","author":"Scutiero","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1210\/er.2018-00242","article-title":"Endometriosis","volume":"40","author":"Bulun","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/jog.15918","article-title":"Cellular senescence in the pathogenesis of ovarian dysfunction","volume":"50","author":"Harada","year":"2024","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1111\/jog.16089","article-title":"Rethinking the pathogenesis of endometriosis: Complex interactions of genomic, epigenetic, and environmental factors","volume":"50","author":"Kobayashi","year":"2024","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"103205","DOI":"10.1016\/j.redox.2024.103205","article-title":"Hypoxia and the endometrium: An indispensable role for HIF-1alpha as therapeutic strategies","volume":"73","author":"Dai","year":"2024","journal-title":"Redox Biol."},{"key":"ref_9","first-page":"100070","article-title":"A Systematic Review of Epigenetics of Endometriosis","volume":"5","author":"Bedrick","year":"2024","journal-title":"F S Rev."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Shigetomi, H., Nishio, M., Umetani, M., Imanaka, S., Hashimoto, H., and Kobayashi, H. (2025). Balancing Decidualization, Autophagy, and Cellular Senescence for Reproductive Success in Endometriosis Biology. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26189125"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e12663","DOI":"10.1002\/rmb2.12663","article-title":"Mechanisms of Decidual Dysfunction and Infertility in Endometriosis: Roles of Prostaglandins and SASP","volume":"24","author":"Tamura","year":"2025","journal-title":"Reprod. Med. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0092-8674(04)00452-0","article-title":"FoxOs at the crossroads of cellular metabolism, differentiation, and transformation","volume":"117","author":"Accili","year":"2004","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/onc.2008.21","article-title":"The FoxO code","volume":"27","author":"Calnan","year":"2008","journal-title":"Oncogene"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7842","DOI":"10.1128\/MCB.22.22.7842-7852.2002","article-title":"Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin, D","volume":"22","author":"Schmidt","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41419-023-06177-1","article-title":"FOXO family isoforms","volume":"14","author":"Santos","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E35","DOI":"10.1210\/jc.2011-1527","article-title":"Increased activation of the PI3K\/AKT pathway compromises decidualization of stromal cells from endometriosis","volume":"97","author":"Yin","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ujvari, D., Jakson, I., Babayeva, S., Salamon, D., Rethi, B., Gidl\u00f6f, S., and Hirschberg, A.L. (2017). Dysregulation of In Vitro Decidualization of Human Endometrial Stromal Cells by Insulin via Transcriptional Inhibition of Forkhead Box Protein O1. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0171004"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/humrep\/deab234","article-title":"Scribble downregulation in adenomyosis compromises endometrial stromal decidualization by decreasing FOXO1 expression","volume":"37","author":"Peng","year":"2021","journal-title":"Hum. Reprod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.bbamcr.2011.06.002","article-title":"FoxO transcription factors; Regulation by AKT and 14-3-3 proteins","volume":"1813","author":"Tzivion","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Li, B., Yan, Y.P., Liang, C., He, Y.Y., Wang, Y., Li, M.Y., Chen, S.T., Li, Y., Liu, A.X., and Yan, G.J. (2022). Primary Cilia Restrain PI3K-AKT Signaling to Orchestrate Human Decidualization. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415573"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00018-024-05270-8","article-title":"NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1","volume":"81","author":"Wang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"22van der Heide, L.P., and Smidt, M.P. (2005). Regulation of FoxO activity by CBP\/p300-mediated acetylation. Trends Biochem. Sci., 30, 81\u201386.","DOI":"10.1016\/j.tibs.2004.12.002"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1074\/jbc.M110.163667","article-title":"FoxO1 mediates an autofeedback loop regulating SIRT1 expression","volume":"286","author":"Xiong","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.lfs.2017.11.030","article-title":"The regulation of FOXO1 and its role in disease progression","volume":"193","author":"Xing","year":"2018","journal-title":"Life Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1038\/sj.emboj.7600476","article-title":"FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK","volume":"23","author":"Essers","year":"2004","journal-title":"EMBO J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.bbapap.2010.05.002","article-title":"SIRT1 and p53, effect on cancer, senescence and beyond","volume":"1804","author":"Yi","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1210\/me.2006-0118","article-title":"Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization","volume":"20","author":"Kajihara","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000336633","article-title":"FOXO1 expression and regulation in endometrial tissue during the menstrual cycle and in early pregnancy decidua","volume":"74","author":"Fan","year":"2012","journal-title":"Gynecol. Obstet. Invest."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1210\/me.2005-0275","article-title":"Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium","volume":"20","author":"Labied","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e31274","DOI":"10.7554\/eLife.31274","article-title":"Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium","volume":"6","author":"Brighton","year":"2017","journal-title":"eLife"},{"key":"ref_31","first-page":"570","article-title":"FoxO1 is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy","volume":"27","author":"Adiguzel","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Tsuru, A., Yoshie, M., Kojima, J., Yonekawa, R., Azumi, M., Kusama, K., Nishi, H., and Tamura, K. (2022). PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells. Biomolecules, 12.","DOI":"10.3390\/biom12081046"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00795-013-0018-z","article-title":"The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy","volume":"46","author":"Kajihara","year":"2013","journal-title":"Med. Mol. Morphol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/1933719111414209","article-title":"Cyclic changes in the expression of p57(kip2) in human endometrium and its regulation by steroid hormones in endometrial stromal cells in vitro","volume":"19","author":"Kim","year":"2012","journal-title":"Reprod. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"100672","DOI":"10.1016\/j.repbio.2022.100672","article-title":"SIRT1 suppresses in vitro decidualization of human endometrial stromal cells through the downregulation of forkhead box O1 expression","volume":"22","author":"Yu","year":"2022","journal-title":"Reprod Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e69603","DOI":"10.7554\/eLife.69603","article-title":"Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids","volume":"10","author":"Rawlings","year":"2021","journal-title":"eLife"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12958-023-01151-0","article-title":"METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility","volume":"21","author":"Li","year":"2023","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e72073","DOI":"10.7554\/eLife.72073","article-title":"SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization","volume":"11","author":"Huang","year":"2022","journal-title":"eLife"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1210\/jc.2014-3720","article-title":"Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization","volume":"100","author":"Su","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/biolre\/ioac041","article-title":"Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1","volume":"106","author":"Kang","year":"2022","journal-title":"Biol. Reprod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/1933719113492208","article-title":"Expression patterns of progesterone receptor membrane components 1 and 2 in endometria from women with and without endometriosis","volume":"21","author":"Bunch","year":"2014","journal-title":"Reprod. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1210\/clinem\/dgab753","article-title":"Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium","volume":"107","author":"Kim","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1038\/s41598-017-04577-w","article-title":"KRAS Activation and over-expression of SIRT1\/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance","volume":"7","author":"Yoo","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"12302","DOI":"10.1038\/s41598-022-16629-x","article-title":"SIRT1 upregulation promotes epithelial-mesenchymal transition by inducing senescence escape in endometriosis","volume":"12","author":"Wang","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1186\/s12967-023-04209-0","article-title":"METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing","volume":"21","author":"Wang","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB Signaling: Navigating the Network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K Pathway in Human Disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR Signaling in Growth, Metabolism, and Disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/med.21802","article-title":"Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review","volume":"41","author":"Hung","year":"2021","journal-title":"Med. Res. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1007\/s10815-022-02638-2","article-title":"LncRNA IGF2-AS promotes endometriosis progression through targeting miR-370-3p\/IGF2 axis and activating PI3K\/AKT\/mTOR signaling pathway","volume":"39","author":"Jin","year":"2022","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/humupd\/dmv060","article-title":"Kinase signalling pathways in endometriosis: Potential targets for non-hormonal therapeutics","volume":"22","author":"McKinnon","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/molehr\/gam001","article-title":"PI3K\/Akt and ERK1\/2 signalling pathways are involved in endometrial cell migration induced by 17beta-estradiol and growth factors","volume":"13","author":"Gentilini","year":"2007","journal-title":"Mol. Hum. Reprod."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Marquardt, R.M., Kim, T.H., Shin, J.H., and Jeong, J.W. (2019). Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153822"},{"key":"ref_54","first-page":"449","article-title":"Pharmacological insights into targeting PI3K\/Akt and NF-kappaB pathways for treating endometriosis-associated infertility","volume":"38","author":"Xu","year":"2025","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_55","first-page":"3547","article-title":"PI3K\/Akt and HIF-1 signaling pathway in hypoxia-ischemia (Review)","volume":"18","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Hashimoto, Y., Tsuzuki-Nakao, T., Kida, N., Matsuo, Y., Maruyama, T., Okada, H., and Hirota, K. (2023). Inflammatory Cytokine-Induced HIF-1 Activation Promotes Epithelial-Mesenchymal Transition in Endometrial Epithelial Cells. Biomedicines, 11.","DOI":"10.3390\/biomedicines11010210"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"114909","DOI":"10.1016\/j.biopha.2023.114909","article-title":"Research advances in endometriosis-related signaling pathways: A review","volume":"164","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12958-018-0391-5","article-title":"A novel and compact review on the role of oxidative stress in female reproduction","volume":"16","author":"Lu","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Yue, J., and L\u00f3pez, J.M. (2020). Understanding MAPK Signaling Pathways in Apoptosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072346"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.redox.2015.06.019","article-title":"Redox regulation of FoxO transcription factors","volume":"6","author":"Klotz","year":"2015","journal-title":"Redox Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.cellsig.2006.08.015","article-title":"Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1","volume":"19","author":"Asada","year":"2007","journal-title":"Cell. Signal."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)00116-1","article-title":"Signal transduction by the JNK group of MAP kinases","volume":"103","author":"Davis","year":"2000","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/emboj.2011.69","article-title":"p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype","volume":"30","author":"Freund","year":"2011","journal-title":"EMBO J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2443.2003.00620.x","article-title":"Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway","volume":"8","author":"Iwasa","year":"2003","journal-title":"Genes Cells"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1111\/jog.14710","article-title":"The role of mitogen-activated protein kinase signaling pathway in endometriosis","volume":"47","author":"Bora","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Malvezzi, H., Cestari, B.A., Meola, J., and Podgaec, S. (2023). Higher Oxidative Stress in Endometriotic Lesions Upregulates Senescence-Associated p16(ink4a) and beta-Galactosidase in Stromal Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24020914"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/molehr\/gah119","article-title":"FOXO1 and c-jun transcription factors mRNA are modulated in endometriosis","volume":"10","author":"Shazand","year":"2004","journal-title":"Mol. Hum. Reprod."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3892\/mmr.2025.13654","article-title":"How transcription factors regulate apoptosis in endometriosis (Review)","volume":"32","author":"Ouyang","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/1933719117725828","article-title":"p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival","volume":"25","author":"Cakmak","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Kobayashi, H., Umetani, M., Nishio, M., Shigetomi, H., Imanaka, S., and Hashimoto, H. (2025). Molecular Mechanisms of Cellular Senescence in Age-Related Endometrial Dysfunction. Cells, 14.","DOI":"10.3390\/cells14120858"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: Many therapeutic avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Genes Dev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cellsig.2011.12.006","article-title":"Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP)","volume":"24","author":"Salminen","year":"2012","journal-title":"Cell. Signal."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s12964-024-01740-5","article-title":"Endometrial senescence is mediated by interleukin 17 receptor B signaling","volume":"22","author":"Kawamura","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.7150\/ijbs.72707","article-title":"An Update on the Multifaceted Role of NF-kappaB in Endometriosis","volume":"18","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.fertnstert.2010.01.013","article-title":"Involvement of the nuclear factor-kappaB pathway in the pathogenesis of endometriosis","volume":"94","author":"Lousse","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Zdrojkowski, \u0141., Jasi\u0144ski, T., Ferreira-Dias, G., Pawli\u0144ski, B., and Domino, M. (2023). The Role of NF-kappaB in Endometrial Diseases in Humans and Animals: A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032901"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e70202","DOI":"10.1111\/1751-7915.70202","article-title":"Gut Microbiota-Derived Acetate Ameliorates Endometriosis via JAK1\/STAT3-Mediated M1 Macrophage Polarisation","volume":"18","author":"Xu","year":"2025","journal-title":"Microb. Biotechnol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1210\/en.2019-00442","article-title":"Genomic Function of Estrogen Receptor beta in Endometriosis","volume":"160","author":"Han","year":"2019","journal-title":"Endocrinology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"gaab016","DOI":"10.1093\/molehr\/gaab016","article-title":"Tofacitinib alters STAT3 signaling and leads to endometriosis lesion regression","volume":"27","author":"Kotlyar","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s13238-013-2084-3","article-title":"NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer","volume":"4","author":"Fan","year":"2013","journal-title":"Protein Cell."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.fertnstert.2012.06.021","article-title":"Nuclear factor-kappaB: A main regulator of inflammation and cell survival in endometriosis pathophysiology","volume":"98","author":"Devoto","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/humrep\/deac098","article-title":"Persistent activation of signal transducer and activator of transcription 3 via interleukin-6 trans-signaling is involved in fibrosis of endometriosis","volume":"37","author":"Matsuzaki","year":"2022","journal-title":"Hum. Reprod."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1600-0897.2004.00231.x","article-title":"Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis","volume":"52","author":"Yoshino","year":"2004","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"109644","DOI":"10.1016\/j.intimp.2022.109644","article-title":"The cGAS-STING pathway promotes endometriosis by up-regulating autophagy","volume":"117","author":"Zhu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12958-024-01273-z","article-title":"Molecular regulation of DNA damage and repair in female infertility: A systematic review","volume":"22","author":"Xu","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1038\/s12276-022-00863-4","article-title":"DNA damage response revisited: The p53 family and its regulators provide endless cancer therapy opportunities","volume":"54","author":"Abuetabh","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1535-6108(02)00102-2","article-title":"The RB and p53 pathways in cancer","volume":"2","author":"Sherr","year":"2002","journal-title":"Cancer Cell."},{"key":"ref_88","first-page":"160","article-title":"Endometrial DNA damage response is modulated in endometriosis","volume":"36","author":"Bane","year":"2021","journal-title":"Hum. Reprod."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e14776","DOI":"10.1097\/MD.0000000000014776","article-title":"A research on the protein expression of p53, p16, and MDM2 in endometriosis","volume":"98","author":"Sang","year":"2019","journal-title":"Medicine"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.fertnstert.2015.02.007","article-title":"Autophagy is upregulated in ovarian endometriosis: A possible interplay with p53 and heme oxygenase-1","volume":"103","author":"Allavena","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_91","first-page":"1024","article-title":"Expression of nm23-H1, p53, and integrin beta1 in endometriosis and their clinical significance","volume":"13","author":"Duan","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.fertnstert.2003.11.048","article-title":"Reduction of apoptosis and proliferation in endometriosis","volume":"82","author":"Foidart","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jsgi.2005.01.028","article-title":"Immunohistochemical expression of p53, MDM2, and p21Waf1 oncoproteins in endometriomas but not adenomyosis","volume":"12","author":"Goumenou","year":"2005","journal-title":"J. Soc. Gynecol. Investig."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e128846","DOI":"10.1172\/jci.insight.128846","article-title":"Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature","volume":"4","author":"Khalaj","year":"2019","journal-title":"JCI Insight"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"107209","DOI":"10.1016\/j.jbc.2024.107209","article-title":"FOXO1 promotes cancer cell growth through MDM2-mediated p53 degradation","volume":"300","author":"Tomiyasu","year":"2024","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Malvezzi, H., Dobo, C., Filippi, R.Z., Mendes do Nascimento, H., Palmieri da Silva E Sousa, L., Meola, J., Piccinato, C.A., and Podgaec, S. (2022). Altered p16(Ink4a), IL-1beta, and Lamin b1 Protein Expression Suggest Cellular Senescence in Deep Endometriotic Lesions. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052476"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.fertnstert.2005.11.032","article-title":"p16, retinoblastoma (pRb), and cyclin D1 protein expression in human endometriotic and adenomyotic lesions","volume":"85","author":"Goumenou","year":"2006","journal-title":"Fertil. Steril."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00404-018-4691-y","article-title":"Depleted lamin B1: A possible marker of the involvement of senescence in endometriosis?","volume":"297","author":"Malvezzi","year":"2018","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"12245","DOI":"10.1073\/pnas.0813088106","article-title":"Cell fate decision mediated by p53 pulses","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.15252\/embr.201439245","article-title":"Senescence and apoptosis: Dueling or complementary cell fates?","volume":"15","author":"Childs","year":"2014","journal-title":"EMBO Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1517\/14728222.2012.648926","article-title":"SIRT1: New avenues of discovery for disorders of oxidative stress","volume":"16","author":"Chong","year":"2012","journal-title":"Expert. Opin. Ther. Targets"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.bbamcr.2011.03.001","article-title":"Regulation of FoxO transcription factors by acetylation and protein-protein interactions","volume":"1813","author":"Daitoku","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.110.227371","article-title":"Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes","volume":"107","author":"Hariharan","year":"2010","journal-title":"Circ. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ncrna.2021.02.002","article-title":"MiRNA 34-a regulate SIRT-1 and Foxo-1 expression in endometriosis","volume":"6","author":"Rezk","year":"2021","journal-title":"Noncoding RNA Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1101\/gad.17276711","article-title":"Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity","volume":"25","author":"Chien","year":"2011","journal-title":"Genes Dev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"110752","DOI":"10.1016\/j.exger.2019.110752","article-title":"Regulation of senescence and the SASP by the transcription factor C\/EBPbeta","volume":"128","author":"Salotti","year":"2019","journal-title":"Exp. Gerontol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e00512-20","DOI":"10.1128\/MCB.00512-20","article-title":"Translational Control during Cellular Senescence","volume":"41","author":"Payea","year":"2021","journal-title":"Mol. Cell. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ncb3195","article-title":"MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation","volume":"17","author":"Laberge","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/ncb3225","article-title":"mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype","volume":"17","author":"Herranz","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.devcel.2010.03.008","article-title":"FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor","volume":"18","author":"Chen","year":"2010","journal-title":"Dev. Cell."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/CIRCRESAHA.122.321542","article-title":"Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1beta Signaling","volume":"133","author":"Zhang","year":"2023","journal-title":"Circ. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1111\/jcmm.17319","article-title":"Targeted regulation of FoxO1 in chondrocytes prevents age-related osteoarthritis via autophagy mechanism","volume":"26","author":"Yue","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_113","first-page":"1","article-title":"Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization","volume":"50","author":"Baek","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Driva, T.S., Schatz, C., Sobo\u010dan, M., and Haybaeck, J. (2022). The Role of mTOR and eIF Signaling in Benign Endometrial Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073416"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.steroids.2007.03.001","article-title":"Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus","volume":"72","author":"Lengyel","year":"2007","journal-title":"Steroids"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1095\/biolreprod.104.027235","article-title":"In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent","volume":"71","author":"Kayisli","year":"2004","journal-title":"Biol. Reprod."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e13762","DOI":"10.1111\/aji.13762","article-title":"Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis","volume":"90","author":"Shan","year":"2023","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1096\/fj.05-4376com","article-title":"Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice","volume":"20","author":"Hsieh","year":"2006","journal-title":"FASEB J."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biocel.2015.02.015","article-title":"Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle","volume":"62","author":"Tan","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/15548627.2015.1023981","article-title":"Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways","volume":"11","author":"Zhang","year":"2015","journal-title":"Autophagy"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1210\/en.2010-0899","article-title":"NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling","volume":"152","author":"Fusi","year":"2011","journal-title":"Endocrinology"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Bouchez, C., and Devin, A. (2019). Mitochondrial Biogenesis and Mitochondrial Reactive Oxygen Species (ROS): A Complex Relationship Regulated by the cAMP\/PKA Signaling Pathway. Cells, 8.","DOI":"10.3390\/cells8040287"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e202402627","DOI":"10.26508\/lsa.202402627","article-title":"Mitochondria remodeling during endometrial stromal cell decidualization","volume":"7","author":"Pittari","year":"2024","journal-title":"Life Sci. Alliance"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-1-4419-1599-3_17","article-title":"FOXO transcription factors: From cell fate decisions to regulation of human female reproduction","volume":"665","author":"Brosens","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.fertnstert.2016.07.1075","article-title":"Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis","volume":"106","author":"Donnez","year":"2016","journal-title":"Fertil. Steril."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Chen, S., Liu, Y., Zhong, Z., Wei, C., Liu, Y., and Zhu, X. (2023). Peritoneal immune microenvironment of endometriosis: Role and therapeutic perspectives. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1134663"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Capobianco, A., and Rovere-Querini, P. (2013). Endometriosis, a disease of the macrophage. Front. Immunol., 4.","DOI":"10.3389\/fimmu.2013.00009"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3892\/ijmm.2025.5513","article-title":"Oxidative stress in endometriosis: Sources, mechanisms and therapeutic potential of antioxidants (Review)","volume":"55","author":"Huang","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e37421","DOI":"10.1097\/MD.0000000000037421","article-title":"Ferroptosis and oxidative stress in endometriosis: A systematic review of the literature","volume":"103","author":"Ni","year":"2024","journal-title":"Medicine"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s12276-022-00829-6","article-title":"The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights","volume":"54","author":"Xiang","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature01036","article-title":"Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress","volume":"419","author":"Kops","year":"2002","journal-title":"Nature"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/s41418-023-01141-0","article-title":"A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner","volume":"30","author":"Ragu","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1111\/cmi.12459","article-title":"FOXO responses to Porphyromonas gingivalis in epithelial cells","volume":"17","author":"Wang","year":"2015","journal-title":"Cell Microbiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3892\/ijo.2014.2269","article-title":"FOXO1-dependent DNA damage repair is regulated by JNK in lung cancer cells","volume":"44","author":"Ju","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"116277","DOI":"10.1016\/j.jep.2023.116277","article-title":"Bushen Wenyang Huayu Decoction inhibits autophagy by regulating the SIRT1-FoXO-1 pathway in endometriosis rats","volume":"308","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/molehr\/6.2.178","article-title":"Induction of superoxide dismutase by decidualization in human endometrial stromal cells","volume":"6","author":"Sugino","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2017.04.362","article-title":"Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis","volume":"110","author":"Marcellin","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"45","DOI":"10.20517\/2394-4722.2017.03","article-title":"DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression","volume":"3","author":"Wang","year":"2017","journal-title":"J. Cancer Metastasis Treat."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"8403","DOI":"10.1093\/nar\/gkt635","article-title":"Transcriptional regulation of human DNA repair genes following genotoxic stress: Trigger mechanisms, inducible responses and genotoxic adaptation","volume":"41","author":"Christmann","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1600-0749.2007.00414.x","article-title":"ATF2 on the double\u2014Activating transcription factor and DNA damage response protein","volume":"20","author":"Bhoumik","year":"2007","journal-title":"Pigment Cell Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1126\/science.1068712","article-title":"DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein","volume":"296","author":"Tran","year":"2002","journal-title":"Science"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Inci, G., Warkad, M.S., Kang, B.G., Lee, N.K., Suh, H.W., Lim, S.S., Kim, J., Kim, S.C., and Lee, J.Y. (2022). FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50. Molecules, 27.","DOI":"10.3390\/molecules27238623"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neulet.2018.06.052","article-title":"Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging","volume":"684","author":"Miki","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metab."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1242\/jcs.166132","article-title":"Akt-mediated phosphorylation increases the binding affinity of hTERT for importin alpha to promote nuclear translocation","volume":"128","author":"Jeong","year":"2015","journal-title":"J. Cell Sci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1196\/annals.1338.021","article-title":"Oxidative damage and mitochondrial DNA mutations with endometriosis","volume":"1042","author":"Kao","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Choi, Y.S., Park, J.H., Lee, J.H., Yoon, J.K., Yun, B.H., Park, J.H., Seo, S.K., Sung, H.J., Kim, H.S., and Cho, S. (2018). Association Between Impairment of DNA Double Strand Break Repair and Decreased Ovarian Reserve in Patients with Endometriosis. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00772"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1210\/me.2007-0058","article-title":"Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells","volume":"21","author":"Takano","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1074\/jbc.RA117.000234","article-title":"The distal upstream region of insulin-like growth factor-binding protein-1 enhances its expression in endometrial stromal cells during decidualization","volume":"293","author":"Tamura","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Lynch, V.J., Brayer, K., Gellersen, B., and Wagner, G.P. (2009). HoxA-11 and FOXO1A cooperate to regulate decidual prolactin expression: Towards inferring the core transcriptional regulators of decidual genes. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006845"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"13735","DOI":"10.1038\/srep13735","article-title":"FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization","volume":"5","author":"Jiang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"106153","DOI":"10.1016\/j.jsbmb.2022.106153","article-title":"Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis","volume":"223","author":"Thieffry","year":"2022","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jphs.2023.09.006","article-title":"Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells","volume":"153","author":"Tsuru","year":"2023","journal-title":"J. Pharmacol. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Vasquez, Y.M., Wang, X., Wetendorf, M., Franco, H.L., Mo, Q., Wang, T., Lanz, R.B., Young, S.L., Lessey, B.A., and Spencer, T.E. (2018). FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007787"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s42003-024-05898-z","article-title":"Impaired bone morphogenetic protein (BMP) signaling pathways disrupt decidualization in endometriosis","volume":"7","author":"Liao","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41420-022-01196-x","article-title":"Endometrial stromal PRMT5 plays a crucial role in decidualization by regulating NF-kappaB signaling in endometriosis","volume":"8","author":"Cai","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"28319","DOI":"10.1074\/jbc.M109.024406","article-title":"FoxO transcription factors promote autophagy in cardiomyocytes","volume":"284","author":"Sengupta","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.4161\/auto.21830","article-title":"FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway","volume":"8","author":"Zhou","year":"2012","journal-title":"Autophagy"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1172273","DOI":"10.1155\/2021\/1172273","article-title":"FOXO1 Is a Critical Switch Molecule for Autophagy and Apoptosis of Sow Endometrial Epithelial Cells Caused by Oxidative Stress","volume":"2021","author":"Lu","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41420-024-02048-6","article-title":"Interleukin-1beta induces and accelerates human endometrial stromal cell senescence and impairs decidualization via the c-Jun N-terminal kinase pathway","volume":"10","author":"Taylor","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Kong, Z., and Yao, T. (2022). Role for autophagy-related markers Beclin-1 and LC3 in endometriosis. BMC Womens Health, 22.","DOI":"10.1186\/s12905-022-01850-7"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Pizzimenti, C., Fiorentino, V., Ruggeri, C., Franchina, M., Ercoli, A., Tuccari, G., and Ieni, A. (2024). Autophagy Involvement in Non-Neoplastic and Neoplastic Endometrial Pathology: The State of the Art with a Focus on Carcinoma. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252212118"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e12577","DOI":"10.1002\/rmb2.12577","article-title":"Molecular mechanism of autophagy and apoptosis in endometriosis: Current understanding and future research directions","volume":"23","author":"Kobayashi","year":"2024","journal-title":"Reprod. Med. Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2017.10.145","article-title":"Autophagy in endometriosis: Friend or foe?","volume":"495","author":"Zhan","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S0015-0282(98)00073-9","article-title":"Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis","volume":"69","author":"Gebel","year":"1998","journal-title":"Fertil. Steril."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-2003-41323","article-title":"Apoptosis and the pathogenesis of endometriosis","volume":"21","author":"Arici","year":"2003","journal-title":"Semin. Reprod. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jri.2011.08.005","article-title":"Dysregulation of the Fas\/FasL system in mononuclear cells recovered from peritoneal fluid of women with endometriosis","volume":"92","author":"Sturlese","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2015.10.034","article-title":"Estrogen Receptor beta Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis","volume":"163","author":"Han","year":"2015","journal-title":"Cell"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00018-019-03374-0","article-title":"The link between endometrial stromal cell senescence and decidualization in female fertility: The art of balance","volume":"77","author":"Deryabin","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Konrad, L., Dietze, R., Riaz, M.A., Scheiner-Bobis, G., Behnke, J., Horn\u00e9, F., Hoerscher, A., Reising, C., and Meinhold-Heerlein, I. (2020). Epithelial-Mesenchymal Transition in Endometriosis-When Does It Happen?. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061915"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Hogg, C., Horne, A.W., and Greaves, E. (2020). Endometriosis-Associated Macrophages: Origin, Phenotype, and Function. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00007"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"hoae034","DOI":"10.1093\/hropen\/hoae034","article-title":"Endometriosis: From iron and macrophages to exosomes. Is the sky clearing?","volume":"2024","author":"Donnez","year":"2024","journal-title":"Hum. Reprod. Open."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1210\/en.2006-0167","article-title":"FOXO1A differentially regulates genes of decidualization","volume":"147","author":"Buzzio","year":"2006","journal-title":"Endocrinology"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"ar21","DOI":"10.1091\/mbc.E22-05-0193","article-title":"FOXO nuclear shuttling dynamics are stimulus-dependent and correspond with cell fate","volume":"34","author":"Lasick","year":"2023","journal-title":"Mol. Biol. Cell."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Weng, Q., Liu, Z., Li, B., Liu, K., Wu, W., and Liu, H. (2016). Oxidative Stress Induces Mouse Follicular Granulosa Cells Apoptosis via JNK\/FoxO1 Pathway. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167869"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.freeradbiomed.2014.07.039","article-title":"FoxO proteins\u2019 nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells","volume":"76","author":"Shukla","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"23058","DOI":"10.18632\/oncotarget.5492","article-title":"Regulation of Bim in Health and Disease","volume":"6","author":"Sionov","year":"2015","journal-title":"Oncotarget"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"27396","DOI":"10.1074\/jbc.M110.140228","article-title":"Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization","volume":"285","author":"Qiang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"R239","DOI":"10.1530\/JME-18-0178","article-title":"Molecular mechanisms of FOXO1 in adipocyte differentiation","volume":"62","author":"Chen","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"189083","DOI":"10.1016\/j.bbcan.2024.189083","article-title":"Mechanistic regulation of FOXO transcription factors in the nucleus","volume":"1879","author":"Guo","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"25727","DOI":"10.1074\/jbc.M112.349902","article-title":"Involvement of the up-regulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stress","volume":"287","author":"Shen","year":"2012","journal-title":"J. Biol. Chem."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/1\/3\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T12:12:32Z","timestamp":1766146352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/1\/3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":182,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["antiox15010003"],"URL":"https:\/\/doi.org\/10.3390\/antiox15010003","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]}}}