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We previously identified protein complex formation between transient receptor potential canonical 3 (TRPC3) and NADPH oxidase 2 (Nox2) as a key driver of anthracycline-induced myocardial atrophy. Here, we investigated whether this complex also contributes to skeletal muscle wasting. In skeletal muscle from sciatic nerve transection model mice and Duchenne muscular dystrophy (mdx) mice, TRPC3-Nox2 complex formation was enhanced. TRPC3 deletion significantly attenuated denervation-induced soleus atrophy and reduced reactive oxygen species (ROS) production. TRPC3-Nox2 complex formation was upregulated in the soleus muscle (SM) of mdx mice. Pharmacological disruption of the TRPC3-Nox2 interaction improved muscle size and strength and reduced plasma creatine kinase in mdx mice. A recombinant adeno-associated virus (AAV) encoding a TRPC3 C-terminal peptide was used to suppress TRPC3-Nox2 complex formation in vivo. AAV-mediated expression of TRPC3 C-terminal peptide mitigated muscle wasting (CSA) in mdx mice, while muscle strength and plasma CK were not significantly improved. Thus, TRPC3-Nox2 complex formation may be a pivotal driver of oxidative stress-mediated skeletal muscle atrophy. Targeting this protein\u2013protein interaction represents a promising therapeutic strategy for Duchenne muscular dystrophy (DMD) and other intractable muscle-wasting disorders.<\/jats:p>","DOI":"10.3390\/antiox15010038","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:25:51Z","timestamp":1766989551000},"page":"38","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of TRPC3-Nox2 Complex Formation Ameliorates Skeletal Muscle Atrophy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-911X","authenticated-orcid":false,"given":"Yuri","family":"Kato","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1858-6009","authenticated-orcid":false,"given":"Tomoya","family":"Ito","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1232-7268","authenticated-orcid":false,"given":"Yara","family":"Atef","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ayukawa","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinya","family":"Mi","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-3562","authenticated-orcid":false,"given":"Kazuhiro","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"},{"name":"Laboratory of Prophylactic Pharmacology, Graduate School of Veterinary Science, Osaka Metropolitan University, Osaka 598-8531, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-3994","authenticated-orcid":false,"given":"Akiyuki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences & Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Department of Physiological Sciences, SOKENDAI (School of Life Science, The Graduate University for Advanced Studies), Okazaki 444-8787, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2587-5458","authenticated-orcid":false,"given":"Motohiro","family":"Nishida","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"},{"name":"Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences & Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Department of Physiological Sciences, SOKENDAI (School of Life Science, The Graduate University for Advanced Studies), Okazaki 444-8787, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1007\/s00018-016-2285-z","article-title":"Striated muscle function, regeneration, and repair","volume":"73","author":"Shadrin","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: Aging-Related Loss of Muscle Mass and Function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"105807","DOI":"10.1016\/j.phrs.2021.105807","article-title":"Skeletal muscle atrophy: From mechanisms to treatments","volume":"172","author":"Yin","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/S0140-6736(19)32910-1","article-title":"Muscular dystrophies","volume":"394","author":"Mercuri","year":"2019","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/aje\/kwh058","article-title":"Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women","volume":"159","author":"Janssen","year":"2004","journal-title":"Am. J. Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1532-5415.2004.52014.x","article-title":"The healthcare costs of sarcopenia in the United States","volume":"52","author":"Janssen","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000369343","article-title":"Prevalence of muscular dystrophies: A systematic literature review","volume":"43","author":"Theadom","year":"2014","journal-title":"Neuroepidemiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/335735a0","article-title":"Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice","volume":"335","author":"Turner","year":"1988","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1083\/jcb.115.6.1701","article-title":"Increased calcium influx in dystrophic muscle","volume":"115","author":"Turner","year":"1991","journal-title":"J. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1469-7793.1999.859ab.x","article-title":"Increased calcium entry into dystrophin-deficient muscle fibres of MDX and ADR-MDX mice is reduced by ion channel blockers","volume":"515","author":"Tutdibi","year":"1999","journal-title":"J. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s12079-018-0477-z","article-title":"Role of defective Ca2+ signaling in skeletal muscle weakness: Pharmacological implications","volume":"12","author":"Agrawal","year":"2018","journal-title":"J. Cell Commun. Signal."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1186\/s12967-021-03191-9","article-title":"TRPC3, but not TRPC1, as a good therapeutic target for standalone or complementary treatment of DMD","volume":"19","author":"Gazaille","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"E10763","DOI":"10.1073\/pnas.1712623114","article-title":"Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy","volume":"114","author":"Chung","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lopez, J.R., Uryash, A., Faury, G., Est\u00e8ve, E., and Adams, J.A. (2020). Contribution of TRPC Channels to Intracellular Ca2+ Dyshomeostasis in Smooth Muscle From mdx Mice. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00126"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"19023","DOI":"10.1073\/pnas.0906591106","article-title":"Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism","volume":"106","author":"Millay","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1440-1681.2006.04394.x","article-title":"Muscle damage in mdx (dystrophic) mice: Role of calcium and reactive oxygen species","volume":"33","author":"Whitehead","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Whitehead, N.P., Yeung, E.W., Froehner, S.C., and Allen, D.G. (2010). Skeletal muscle NADPH oxidase is increased and triggers stretch-induced damage in the mdx mouse. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015354"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1038\/ncomms5425","article-title":"Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy","volume":"5","author":"Pal","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.1202768","article-title":"X-ROS signaling: Rapid mechano-chemo transduction in heart","volume":"333","author":"Prosser","year":"2011","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.bpj.2015.09.031","article-title":"Modeling Local X-ROS and Calcium Signaling in the Heart","volume":"109","author":"Limbu","year":"2015","journal-title":"Biophys. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.yjmcc.2012.11.011","article-title":"X-ROS signaling in the heart and skeletal muscle: Stretch-dependent local ROS regulates [Ca2+]i","volume":"58","author":"Prosser","year":"2013","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37001","DOI":"10.1038\/srep37001","article-title":"TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling","volume":"6","author":"Kitajima","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e93358","DOI":"10.1172\/jci.insight.93358","article-title":"TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy","volume":"2","author":"Shimauchi","year":"2017","journal-title":"JCI Insight"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1073\/pnas.0808793106","article-title":"Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound","volume":"106","author":"Kiyonaka","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1111\/bph.14777","article-title":"Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes","volume":"176","author":"Nishiyama","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1002\/acn3.51450","article-title":"Transcriptome analysis of collagen VI-related muscular dystrophy muscle biopsies","volume":"8","author":"Guadagnin","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ralston, E., Gutierrez-Cruz, G., Kenea, A., and Brooks, S.R. (2021). Transcriptomic analysis of mdx mouse muscles reveals a signature of early human Duchenne muscular dystrophy. bioRxiv.","DOI":"10.1101\/2021.07.16.452553"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e202101215","DOI":"10.26508\/lsa.202101215","article-title":"miR-486 is essential for muscle function and suppresses a dystrophic transcriptome","volume":"5","author":"Samani","year":"2022","journal-title":"Life Sci. Alliance"},{"key":"ref_29","first-page":"e100115","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"4","author":"Hurst","year":"2020","journal-title":"BMJ Open Sci."},{"key":"ref_30","first-page":"51303","article-title":"Assessing functional performance in the mdx mouse model","volume":"85","year":"2014","journal-title":"J. Vis. Exp."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"13926","DOI":"10.1038\/s41598-020-70956-5","article-title":"Modulation of P2Y(6)R expression exacerbates pressure overload-induced cardiac remodeling in mice","volume":"10","author":"Shimoda","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"C317","DOI":"10.1152\/ajpcell.00174.2021","article-title":"Muscle-nerve communication and the molecular assessment of human skeletal muscle denervation with aging","volume":"321","author":"Soendenbroe","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41392-024-02049-y","article-title":"Neutrophil diversity and function in health and disease","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejphar.2006.02.053","article-title":"The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family","volume":"538","author":"Gibson","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jacbts.2021.11.004","article-title":"Cardiovascular Disease in Duchenne Muscular Dystrophy: Overview and Insight Into Novel Therapeutic Targets","volume":"7","author":"Schultz","year":"2022","journal-title":"JACC Basic. Transl. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jot.2025.03.004","article-title":"Extracellular matrix in skeletal muscle injury and atrophy: Mechanisms and therapeutic implications","volume":"52","author":"Ge","year":"2025","journal-title":"J. Orthop. Translat"},{"key":"ref_37","first-page":"5307","article-title":"Phosphodiesterase 4 inhibitor and phosphodiesterase 5 inhibitor combination therapy has antifibrotic and anti-inflammatory effects in mdx mice with Duchenne muscular dystrophy","volume":"31","author":"Nio","year":"2017","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"119563","DOI":"10.1016\/j.lfs.2021.119563","article-title":"Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC\/Akt effectors and inhibiting FoxO factors","volume":"278","author":"Arcaro","year":"2021","journal-title":"Life Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/wdev.230","article-title":"Skeletal muscle fiber type: Using insights from muscle developmental biology to dissect targets for susceptibility and resistance to muscle disease","volume":"5","author":"Talbot","year":"2016","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1242\/jcs.094060","article-title":"The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II","volume":"125","author":"Diebold","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1002\/jcp.22640","article-title":"Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia","volume":"226","author":"Yuan","year":"2011","journal-title":"J. Cell Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Nguyen, T.H., Conotte, S., Belayew, A., Decl\u00e8ves, A.E., Legrand, A., and Tassin, A. (2021). Hypoxia and Hypoxia-Inducible Factor Signaling in Muscular Dystrophies: Cause and Consequences. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137220"},{"key":"ref_43","first-page":"548","article-title":"The therapeutic potential of skeletal muscle plasticity in Duchenne muscular dystrophy: Phenotypic modifiers as pharmacologic targets","volume":"28","author":"Ljubicic","year":"2014","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"26473","DOI":"10.1074\/jbc.M600451200","article-title":"A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation","volume":"281","author":"Hidalgo","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3194917","DOI":"10.1155\/2018\/3194917","article-title":"Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy","volume":"2018","author":"Kadoguchi","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"10385","DOI":"10.1074\/jbc.M710231200","article-title":"TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells","volume":"283","author":"Tong","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.bbamcr.2010.12.022","article-title":"TRP expression pattern and the functional importance of TRPC3 in primary human T-cells","volume":"1813","author":"Wenning","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s12276-024-01270-7","article-title":"From inflammation to bone formation: The intricate role of neutrophils in skeletal muscle injury and traumatic heterotopic ossification","volume":"56","author":"Shu","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tcb.2011.11.002","article-title":"Redox regulation of cell migration and adhesion","volume":"22","author":"Hurd","year":"2012","journal-title":"Trends Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"108034","DOI":"10.1016\/j.isci.2023.108034","article-title":"Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase","volume":"26","author":"Song","year":"2023","journal-title":"iScience"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Leiding, J.W., Mathews, C.E., Arnold, D.E., and Chen, J. (2025). The Role of NADPH Oxidase 2 in Leukocytes. Antioxidants, 14.","DOI":"10.3390\/antiox14030309"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/1\/38\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T05:33:10Z","timestamp":1767072790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/1\/38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["antiox15010038"],"URL":"https:\/\/doi.org\/10.3390\/antiox15010038","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]}}}