{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:34:06Z","timestamp":1793043246318,"version":"4.5.0"},"reference-count":302,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Emerging evidence suggests that viral infections may contribute to the onset and progression of Alzheimer\u2019s disease (AD) and other forms of dementia. Understanding the mechanism of viral involvement in the pathogenesis of AD and related dementia (ADRD) could contribute to reducing the burden caused by these conditions, which affect a large portion of the aging population. Some studies indicate the link between AD and viral infections, notably coronaviruses and herpesviruses. In AD, excessive production of reactive oxygen species (ROS) results in the modifications of lipids, proteins, and nucleic acids, contributing to synaptic dysfunction and cognitive impairments. Experimental evidence suggests that viral infections linked to ADRD induce the cellular production of ROS, possibly contributing to the pathogenesis of these conditions. Despite significant advances in defining the roles of ROS in neurological disorders and viral infections, the specific roles of ROS in virus-associated ADRD have not been thoroughly investigated. The main objective of this review article is to comprehensively provide information on the experimental evidence for the production of ROS by viruses to help the readers investigate the role of ROS in the relationship between viral infections with ADRD.<\/jats:p>","DOI":"10.3390\/antiox15010066","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:28:57Z","timestamp":1767626937000},"page":"66","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Roles of Reactive Oxygen Species in Relationships Between Viral Infections and Alzheimer\u2019s Disease and Related Dementia"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4571-3189","authenticated-orcid":false,"given":"Gunel","family":"Ayyubova","sequence":"first","affiliation":[{"name":"Department of Cytology, Embryology and Histology, Azerbaijan Medical University, Baku AZ1022, Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariha E.","family":"Bablu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazrin","family":"Rahimli","sequence":"additional","affiliation":[{"name":"Department of Cytology, Embryology and Histology, Azerbaijan Medical University, Baku AZ1022, Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Aghayeva","sequence":"additional","affiliation":[{"name":"Department of Cytology, Embryology and Histology, Azerbaijan Medical University, Baku AZ1022, Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5089-2683","authenticated-orcid":false,"given":"Elijah M.","family":"Springer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fada A.","family":"Alghenaim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6689-0497","authenticated-orcid":false,"given":"Yuichiro J.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41582-023-00790-6","article-title":"Viral pathogens increase risk of neurodegenerative disease","volume":"19","author":"Blackhurst","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.neuron.2022.12.029","article-title":"Virus exposure and neurodegenerative disease risk across national biobanks","volume":"111","author":"Levine","year":"2023","journal-title":"Neuron"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rippee-Brooks, M.D., Wu, W., Dong, J., Pappolla, M., Fang, X., and Bao, X. (2024). Viral infections, are they a trigger and risk factor of Alzheimer\u2019s disease?. Pathogens, 13.","DOI":"10.20944\/preprints202402.0179.v1"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6547248","DOI":"10.1155\/2016\/6547248","article-title":"Redox imbalance and viral infections in neurodegenerative diseases","volume":"2016","author":"Limongi","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2174\/1570159X16666180419124508","article-title":"Viral induced oxidative and inflammatory response in Alzheimer\u2019s disease pathogenesis with identification of potential drug candidates: A systematic review using systems biology approach","volume":"17","author":"Talwar","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0074-7742(07)82016-2","article-title":"Oxidative stress and the pathogenesis of neurodegenerative disorders","volume":"82","author":"Reynolds","year":"2007","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mendon\u00e7a-Vieira, L.R., An\u00edbal-Silva, C.E., Menezes-Neto, A., Azevedo, E.A.N., Zanluqui, N.G., Peron, J.P.S., and Franca, R.F.O. (2021). Reactive oxygen species (ROS) are not a key determinant for Zika virus-induced apoptosis in SH-SY5Y neuroblastoma cells. Viruses, 13.","DOI":"10.3390\/v13112111"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"110267","DOI":"10.1016\/j.mehy.2020.110267","article-title":"The viral protein fragment theory of COVID-19 pathogenesis","volume":"144","author":"Suzuki","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ayyubova, G., Gychka, S.G., Nikolaienko, S.I., Alghenaim, F.A., Teramoto, T., Shults, N.V., and Suzuki, Y.J. (2024). The role of furin in the pathogenesis of COVID-19-associated neurological disorders. Life, 14.","DOI":"10.20944\/preprints202310.2100.v2"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Taylor, M.W. (2014). What Is a Virus?. Viruses and Man: A History of Interactions, Springer International Publishing.","DOI":"10.1007\/978-3-319-07758-1_2"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Louten, J. (2016). Virus Structure and Classification. Essential Human Virology, Academic Press.","DOI":"10.1016\/B978-0-12-800947-5.00002-8"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1128\/br.35.3.235-241.1971","article-title":"Expression of animal virus genomes","volume":"35","author":"Baltimore","year":"1971","journal-title":"Bacteriol. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e0005321","DOI":"10.1128\/MMBR.00053-21","article-title":"The Baltimore Classification of Viruses 50 years later: How does it stand in the light of virus evolution?","volume":"85","author":"Koonin","year":"2021","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102068","DOI":"10.1016\/j.arr.2023.102068","article-title":"Alzheimer\u2019s disease as a viral disease: Revisiting the infectious hypothesis","volume":"91","author":"Bruno","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41591-024-03426-4","article-title":"Plasma proteomic evidence for increased \u03b2-amyloid pathology after SARS-CoV-2 infection","volume":"31","author":"Duff","year":"2025","journal-title":"Nat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12993-022-00187-3","article-title":"The interplay between oxidative stress and autophagy: Focus on the development of neurological diseases","volume":"18","author":"Talebi","year":"2022","journal-title":"Behav. Brain Funct."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: Harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201102095","article-title":"Signal transduction by reactive oxygen species","volume":"194","author":"Finkel","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0891-5849(96)00275-4","article-title":"Oxidants as stimulators of signal transduction","volume":"22","author":"Suzuki","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.59566\/IJBS.2008.4089","article-title":"Free radicals, antioxidants in disease and health","volume":"4","author":"He","year":"2008","journal-title":"Int. J. Biomed. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","article-title":"Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine","volume":"115","author":"Radi","year":"2018","journal-title":"Proc. Natil. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free radicals: Properties, sources, targets, and their implication in various diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1042\/BST0351147","article-title":"Biochemistry of oxidative stress","volume":"35","author":"Halliwell","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Tirichen, H., Yaigoub, H., Xu, W., Wu, C., Li, R., and Li, Y. (2021). Mitochondrial reactive oxygen species and their contribution in chronic kidney disease progression through oxidative stress. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.627837"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1245049","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS sources in physiological and pathological conditions","volume":"2016","author":"Reed","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Teleanu, D.M., Niculescu, A.G., Lungu, I.I., Radu, C.I., Vlad\u00e2cenco, O., Roza, E., Cost\u0103chescu, B., Grumezescu, A.M., and Teleanu, R.I. (2022). An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115938"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1111\/jgs.17345","article-title":"Impact of dementia: Health disparities, population trends, care interventions, and economic costs","volume":"69","author":"Aranda","year":"2021","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s40120-022-00338-8","article-title":"Alzheimer\u2019s disease: Epidemiology and clinical progression","volume":"11","author":"Byrnes","year":"2022","journal-title":"Neurol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lagan\u00e0, V., Bruno, F., Altomari, N., Bruni, G., Smirne, N., Curcio, S., Mirabelli, M., Colao, R., Puccio, G., and Frangipane, F. (2022). Neuropsychiatric or behavioral and psychological symptoms of dementia (BPSD): Focus on prevalence and natural history in Alzheimer\u2019s disease and frontotemporal dementia. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.832199"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Murakami, S., and Lacayo, P. (2022). Biological and disease hallmarks of Alzheimer\u2019s disease defined by Alzheimer\u2019s disease genes. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.996030"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ratan, Y., Rajput, A., Maleysm, S., Pareek, A., Jain, V., Pareek, A., Kaur, R., and Singh, G. (2023). An insight into cellular and molecular mechanisms underlying the pathogenesis of neurodegeneration in Alzheimer\u2019s disease. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051398"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/s41591-024-02869-z","article-title":"Highly accurate blood test for Alzheimer\u2019s disease is similar or superior to clinical cerebrospinal fluid tests","volume":"30","author":"Schindler","year":"2024","journal-title":"Nat. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.4103\/NRR.NRR-D-24-00230","article-title":"The dopaminergic system and Alzheimer\u2019s disease","volume":"20","author":"Zhang","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0002-9440(10)64700-1","article-title":"Intraneuronal Abeta42 accumulation in human brain","volume":"156","author":"Gouras","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(02)00875-3","article-title":"Consistent immunohistochemical detection of intracellular beta-amyloid42 in pyramidal neurons of Alzheimer\u2019s disease entorhinal cortex","volume":"333","author":"Nagele","year":"2002","journal-title":"Neurosci. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/2051-5960-2-61","article-title":"Intracellular A\u03b2 pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: A multidimensional study","volume":"2","author":"Iulita","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","article-title":"Intraneuronal Abeta causes the onset of early Alzheimer\u2019s disease-related cognitive deficits in transgenic mice","volume":"45","author":"Billings","year":"2005","journal-title":"Neuron"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: Where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"12757","DOI":"10.1021\/acs.chemrev.0c00761","article-title":"Connecting the \u201cDots\u201d: From free radical lipid autoxidation to cell pathology and disease","volume":"120","author":"Foret","year":"2020","journal-title":"Chem. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1007\/s12035-017-0580-9","article-title":"Hippocampal proteomic analysis reveals distinct pathway deregulation profiles at early and late stages in a rat model of Alzheimer\u2019s-like amyloid pathology","volume":"55","author":"Crynen","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41582-020-0323-9","article-title":"Do infections have a role in the pathogenesis of Alzheimer disease?","volume":"16","author":"Itzhaki","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Naughton, S.X., Raval, U., and Pasinetti, G.M. (2020). The viral hypothesis in Alzheimer\u2019s disease: Novel insights and pathogen-based biomarkers. J. Pers. Med., 10.","DOI":"10.3390\/jpm10030074"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/rej.2009.0849","article-title":"Age-dependent down-regulation of mitochondrial 8-oxoguanine DNA glycosylase in SAM-P\/8 mouse brain and its effect on brain aging","volume":"12","author":"Tian","year":"2009","journal-title":"Rejuvenation Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"15918","DOI":"10.3390\/ijms160715918","article-title":"Mitochondrial oxidative stress, mitochondrial DNA damage and their role in age-related vascular dysfunction","volume":"16","author":"Mikhed","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.nbd.2007.12.007","article-title":"Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer\u2019s disease","volume":"30","author":"Reed","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.bbadis.2013.04.013","article-title":"Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer\u2019s disease neuropathology: Redox proteomics analysis of human brain","volume":"1832","author":"Coccia","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.freeradbiomed.2014.03.027","article-title":"Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: Clues for understanding the development of Alzheimer disease","volume":"71","author":"Pupo","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0098-2997(03)00025-6","article-title":"Hydroxynonenal, toxic carbonyls, and Alzheimer disease","volume":"24","author":"Liu","year":"2003","journal-title":"Mol. Aspects Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1016\/j.jprot.2011.06.015","article-title":"Proteomic identification of specifically carbonylated brain proteins in APPNLh\/APPNLh \u00d7 PS-1P264L\/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age","volume":"74","author":"Sultana","year":"2011","journal-title":"J. Proteomics"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.freeradbiomed.2008.03.012","article-title":"Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease","volume":"44","author":"Resende","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_55","first-page":"196","article-title":"Blood-based metabolic signatures in Alzheimer\u2019s disease","volume":"8","author":"Peeters","year":"2017","journal-title":"Alzheimers Dement."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"14244","DOI":"10.1038\/s41598-019-50837-2","article-title":"New screening approach for Alzheimer\u2019s disease risk assessment from urine lipid peroxidation compounds","volume":"9","author":"Vigor","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41591-020-0815-6","article-title":"Large-scale proteomic analysis of Alzheimer\u2019s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation","volume":"26","author":"Johnson","year":"2020","journal-title":"Nat. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.dnarep.2013.04.010","article-title":"The role of DNA repair in brain related disease pathology","volume":"12","author":"Canugovi","year":"2013","journal-title":"DNA Repair"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/NEN.0b013e318248e614","article-title":"The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons","volume":"71","author":"Nunomura","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0197-4580(02)00019-2","article-title":"Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases","volume":"23","author":"Floyd","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/jnc.13425","article-title":"Iron neurochemistry in Alzheimer\u2019s disease and Parkinson\u2019s disease: Targets for therapeutics","volume":"139","author":"Belaidi","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ding, Q., Shults, N.V., Gychka, S.G., Harris, B.T., and Suzuki, Y.J. (2021). Protein expression of angiotensin-converting enzyme 2 (ACE2) is upregulated in brains with Alzheimer\u2019s disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041687"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S128","DOI":"10.1093\/infdis\/jiae242","article-title":"From viral infections to Alzheimer\u2019s disease: Unveiling the mechanistic links through systems bioinformatics","volume":"230","author":"Onisiforou","year":"2024","journal-title":"J. Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.freeradbiomed.2009.10.035","article-title":"In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP","volume":"48","author":"Butterfield","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/hmg\/ddl066","article-title":"Mitochondria are a direct site of A beta accumulation in Alzheimer\u2019s disease neurons: Implications for free radical generation and oxidative damage in disease progression","volume":"15","author":"Manczak","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbadis.2011.10.011","article-title":"Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer\u2019s disease: Implications to mitochondria-targeted antioxidant therapeutics","volume":"1822","author":"Reddy","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"780179","DOI":"10.1155\/2014\/780179","article-title":"Mitochondrial dysfunction: Different routes to Alzheimer\u2019s disease therapy","volume":"2014","author":"Picone","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Tamagno, E., Guglielmotto, M., Vasciaveo, V., and Tabaton, M. (2021). Oxidative stress and beta amyloid in Alzheimer\u2019s disease. Which comes first: The chicken or the egg?. Antioxidants, 10.","DOI":"10.3390\/antiox10091479"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/382685a0","article-title":"RAGE and amyloid-beta peptide neurotoxicity in Alzheimer\u2019s disease","volume":"382","author":"Yan","year":"1996","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s40478-019-0723-5","article-title":"Early neuronal accumulation of DNA double strand breaks in Alzheimer\u2019s disease","volume":"7","author":"Shanbhag","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrn.2016.141","article-title":"Network abnormalities and interneuron dysfunction in Alzheimer disease","volume":"17","author":"Palop","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1476-5381.2012.02057.x","article-title":"Alzheimer\u2019s disease, \u03b2-amyloid, glutamate, NMDA receptors and memantine\u2014Searching for the connections","volume":"167","author":"Danysz","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/nn.3537","article-title":"Maintaining genome stability in the nervous system","volume":"16","author":"McKinnon","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev.genet.38.072902.092448","article-title":"Repair and genetic consequences of endogenous DNA base damage in mammalian cells","volume":"38","author":"Barnes","year":"2004","journal-title":"Annu. Rev. Genet."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s42003-024-06552-4","article-title":"Early oxidative stress and DNA damage in A\u03b2-burdened hippocampal neurons in an Alzheimer\u2019s-like transgenic rat model","volume":"7","author":"Foret","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.dnarep.2006.10.017","article-title":"The mechanics of base excision repair, and its relationship to aging and disease","volume":"6","author":"Wilsoniii","year":"2007","journal-title":"DNA Repair"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2008.09.001","article-title":"Oxidative stress hypothesis in Alzheimer\u2019s disease: A reappraisal","volume":"29","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0891-5849(96)00629-6","article-title":"Oxidative stress hypothesis in Alzheimer\u2019s disease","volume":"23","author":"Markesbery","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MOH.0000000000000502","article-title":"Emerging molecular mechanisms of vascular dementia","volume":"26","author":"Romay","year":"2019","journal-title":"Curr. Opin. Hematol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/jmv.1890330403","article-title":"Latent herpes simplex virus type 1 in normal and Alzheimer\u2019s disease brains","volume":"33","author":"Jamieson","year":"1991","journal-title":"J. Med. Virol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"200286","DOI":"10.1098\/rsob.200286","article-title":"Alzheimer\u2019s disease-like perturbations in HIV-mediated neuronal dysfunctions: Understanding mechanisms and developing therapeutic strategies","volume":"10","author":"Jha","year":"2020","journal-title":"Open Biol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Filgueira, L., Larionov, A., and Lannes, N. (2021). The influence of virus infection on microglia and accelerated brain aging. Cells, 10.","DOI":"10.3390\/cells10071836"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"17114","DOI":"10.1074\/jbc.RA120.015165","article-title":"Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains","volume":"295","author":"Lingel","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/jnen\/nlac040","article-title":"Neuropathologic findings in elderly HIV-positive individuals","volume":"81","author":"Magaki","year":"2022","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12974-022-02439-5","article-title":"Proteomic landscape subtype and clinical prognosis of patients with the cognitive impairment by Japanese encephalitis infection","volume":"19","author":"Yin","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Uddin, M.S., Stachowiak, A., Mamun, A.A., Tzvetkov, N.T., Takeda, S., Atanasov, A.G., Bergantin, L.B., Abdel-Daim, M.M., and Stankiewicz, A.M. (2018). Autophagy and Alzheimer\u2019s disease: From molecular mechanisms to therapeutic implications. Front. Aging Neurosci., 10.","DOI":"10.3389\/fnagi.2018.00004"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.jalz.2018.06.3040","article-title":"The antimicrobial protection hypothesis of Alzheimer\u2019s disease","volume":"14","author":"Moir","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuron.2018.06.030","article-title":"Alzheimer\u2019s disease-associated \u03b2-amyloid is rapidly seeded by herpesviridae to protect against brain infection","volume":"99","author":"Eimer","year":"2018","journal-title":"Neuron"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.2449","article-title":"Herpes simplex virus type 1 DNA is located within Alzheimer\u2019s disease amyloid plaques","volume":"217","author":"Wozniak","year":"2009","journal-title":"J. Pathol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3233\/JAD-160152","article-title":"Microbes and Alzheimer\u2019s disease","volume":"51","author":"Itzhaki","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuron.2018.05.023","article-title":"Multiscale analysis of independent Alzheimer\u2019s cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus","volume":"99","author":"Readhead","year":"2018","journal-title":"Neuron"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(00)04638-9","article-title":"Herpes simplex virus infections","volume":"357","author":"Whitley","year":"2001","journal-title":"Lancet"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0140-6736(96)10149-5","article-title":"Herpes simplex virus type 1 in brain and risk of Alzheimer\u2019s disease","volume":"349","author":"Itzhaki","year":"1997","journal-title":"Lancet"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2990.1990.tb01158.x","article-title":"Human herpes virus infections and Alzheimer\u2019s disease","volume":"16","author":"Deatly","year":"1990","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1096\/fj.201700359","article-title":"Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer\u2019s disease: Inseparable partners in a multifactorial disease","volume":"31","author":"Nixon","year":"2017","journal-title":"FASEB J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"15444","DOI":"10.1038\/srep15444","article-title":"Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-\u03b2 protein accumulation","volume":"5","author":"Piacentini","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3233\/JAD-220287","article-title":"Potential involvement of Varicella Zoster Virus in Alzheimer\u2019s disease via reactivation of quiescent Herpes Simplex Virus Type 1","volume":"88","author":"Cairns","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-009-0612-2","article-title":"Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: An update","volume":"119","author":"Mackenzie","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e088632","DOI":"10.1136\/bmjopen-2024-088632","article-title":"Association between herpes simplex virus 1 and dementia: A systematic review protocol","volume":"15","author":"Hong","year":"2025","journal-title":"BMJ Open"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"De Francesco, M.A. (2024). Herpesviridae, neurodegenerative disorders and autoimmune diseases: What is the relationship between them?. Viruses, 16.","DOI":"10.3390\/v16010133"},{"key":"ref_101","first-page":"140539","article-title":"Alzheimer\u2019s disease: A pathogenetic autoimmune disorder caused by herpes simplex in a gene-dependent manner","volume":"2010","author":"Carter","year":"2010","journal-title":"Int. J. Alzheimers Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s13311-018-0611-x","article-title":"Anti-herpetic medications and reduced risk of dementia in patients with herpes simplex virus infections-a nationwide, population-based cohort study in Taiwan","volume":"15","author":"Tzeng","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10072-023-07038-7","article-title":"The association between varicella zoster virus and dementia: A systematic review and meta-analysis of observational studies","volume":"45","author":"Gao","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e660","DOI":"10.1212\/WNL.0000000000200709","article-title":"Incident herpes zoster and risk of dementia: A population-based Danish cohort study","volume":"99","author":"Schmidt","year":"2022","journal-title":"Neurology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e1103","DOI":"10.1212\/NXI.0000000000001103","article-title":"Targeted RNA sequencing of VZV-infected brain vascular adventitial fibroblasts indicates that amyloid may be involved in VZV vasculopathy","volume":"9","author":"Bubak","year":"2022","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_106","first-page":"e12119","article-title":"Herpesvirus infections, antiviral treatment, and the risk of dementia-a registry-based cohort study in Sweden","volume":"7","author":"Hemmingsson","year":"2021","journal-title":"Alzheimers Dement."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Tomas-Ojer, P., Puthenparampil, M., Cruciani, C., Docampo, M.J., Martin, R., and Sospedra, M. (2022). Characterization of antigen-induced CD4+ T-cell senescence in multiple sclerosis. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.790884"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"422","DOI":"10.14283\/jpad.2023.126","article-title":"Cytomegalovirus infection and Alzheimer\u2019s disease: A meta-analysis","volume":"11","author":"Ji","year":"2024","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41586-019-1895-7","article-title":"Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer\u2019s disease","volume":"577","author":"Gate","year":"2020","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.1002\/alz.13136","article-title":"Early \u03b2-amyloid accumulation in the brain is associated with peripheral T cell alterations","volume":"19","author":"Gericke","year":"2023","journal-title":"Alzheimers Dement."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/alz.12488","article-title":"Impact of COVID-19 on the onset and progression of Alzheimer\u2019s disease and related dementias: A roadmap for future research","volume":"18","author":"Gordon","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"106408","DOI":"10.1016\/j.isci.2023.106408","article-title":"Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer\u2019s and coronary disease pathways","volume":"26","author":"Wang","year":"2023","journal-title":"iScience"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tim.2016.03.003","article-title":"Epidemiology, genetic recombination, and pathogenesis of coronaviruses","volume":"24","author":"Su","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1196\/annals.1408.002","article-title":"The molecular biology of SARS coronavirus","volume":"1102","author":"Satija","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.abb2762","article-title":"Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2","volume":"367","author":"Yan","year":"2020","journal-title":"Science"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41423-020-0400-4","article-title":"Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: Implication for development of RBD protein as a viral attachment inhibitor and vaccine","volume":"17","author":"Tai","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00392-020-01626-9","article-title":"Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China","volume":"109","author":"Li","year":"2020","journal-title":"Clin. Res. Cardiol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Seeherman, S., and Suzuki, Y.J. (2021). Viral infection and cardiovascular disease: Implications for the molecular basis of COVID-19 pathogenesis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041659"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","article-title":"Mechanisms of SARS-CoV-2 entry into cells","volume":"23","author":"Jackson","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1093\/clinchem\/hvaa213","article-title":"Ultra-sensitive serial profiling of SARS-CoV-2 antigens and antibodies in plasma to understand disease progression in COVID-19 patients with severe disease","volume":"66","author":"Ogata","year":"2020","journal-title":"Clin. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/cid\/ciab465","article-title":"Circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine antigen detected in the plasma of mRNA-1273 vaccine recipients","volume":"74","author":"Ogata","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1161\/CIRCULATIONAHA.122.061025","article-title":"Circulating spike protein detected in post-COVID-19 mRNA vaccine myocarditis","volume":"147","author":"Yonker","year":"2023","journal-title":"Circulation"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk factors associated with acute respiratory distress syndrome and death in patients with Coronavirus Disease 2019 pneumonia in Wuhan, China","volume":"180","author":"Wu","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathological findings of COVID-19 associated with acute respiratory distress syndrome","volume":"8","author":"Xu","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijid.2020.03.017","article-title":"Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: A systematic review and meta-analysis","volume":"94","author":"Yang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurological manifestations of hospitalized patients with Coronavirus Disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1056\/NEJMc2008597","article-title":"Neurologic features in severe SARS-CoV-2 infection","volume":"382","author":"Helms","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41586-022-04569-5","article-title":"SARS-CoV-2 is associated with changes in brain structure in UK Biobank","volume":"604","author":"Douaud","year":"2022","journal-title":"Nature"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/alz.12556","article-title":"Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer\u2019s dementia","volume":"18","author":"Frontera","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e2200960119","DOI":"10.1073\/pnas.2200960119","article-title":"Morphological, cellular, and molecular basis of brain infection in COVID-19 patients","volume":"119","author":"Crunfli","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1093\/gerona\/glaa183","article-title":"Preexisting comorbidities predicting COVID-19 and mortality in the UK Biobank Community Cohort","volume":"75","author":"Atkins","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40035-022-00316-y","article-title":"The COVID-19 pandemic and Alzheimer\u2019s disease: Mutual risks and mechanisms","volume":"11","author":"Chen","year":"2022","journal-title":"Transl. Neurodegener"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41582-020-00450-z","article-title":"The effects of the COVID-19 pandemic on people with dementia","volume":"17","author":"Numbers","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/alz.12296","article-title":"COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US","volume":"17","author":"Wang","year":"2021","journal-title":"Alzheimers Dement."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s12603-020-1389-1","article-title":"Clinical presentation of COVID19 in dementia patients","volume":"24","author":"Bianchetti","year":"2020","journal-title":"J. Nutr. Health Aging"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1056\/NEJMoa2311330","article-title":"Cognition and memory after Covid-19 in a large community sample","volume":"390","author":"Hampshire","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41593-024-01573-y","article-title":"Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19","volume":"27","author":"Radke","year":"2024","journal-title":"Nat. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-220800","article-title":"COVID-19 as a risk factor for Alzheimer\u2019s disease","volume":"91","author":"Weaver","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3233\/JAD-220717","article-title":"Association of COVID-19 with new-onset Alzheimer\u2019s disease","volume":"89","author":"Wang","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/alz.12558","article-title":"Alzheimer\u2019s-like signaling in brains of COVID-19 patients","volume":"18","author":"Reiken","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1093\/brain\/awab337","article-title":"A genetic link between risk for Alzheimer\u2019s disease and severe COVID-19 outcomes via the OAS1 gene","volume":"144","author":"Magusali","year":"2021","journal-title":"Brain"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00702-022-02499-0","article-title":"The relationship of early- and late-onset Alzheimer\u2019s disease genes with COVID-19","volume":"129","author":"Sirin","year":"2022","journal-title":"J. Neural. Transm."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1093\/gerona\/glaa131","article-title":"APOE e4 genotype predicts severe COVID-19 in the UK Biobank Community Cohort","volume":"75","author":"Kuo","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"7296","DOI":"10.1002\/alz.14089","article-title":"Parallel electrophysiological abnormalities due to COVID-19 infection and to Alzheimer\u2019s disease and related dementia","volume":"20","author":"Jiang","year":"2024","journal-title":"Alzheimers Dement."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Shan, D., Wang, C., Crawford, T., and Holland, C. (2024). Association between COVID-19 infection and new-onset dementia in older adults: A systematic review and meta-analysis. BMC Geriatr., 24.","DOI":"10.1186\/s12877-024-05538-5"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1038\/s41591-022-02001-z","article-title":"Long-term neurologic outcomes of COVID-19","volume":"28","author":"Xu","year":"2022","journal-title":"Nat. Med."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"\u00c1vila-P\u00e9rez, G., Nogales, A., Mart\u00edn, V., Almaz\u00e1n, F., and Mart\u00ednez-Sobrido, L. (2018). Reverse genetic approaches for the generation of recombinant zika virus. Viruses, 10.","DOI":"10.3390\/v10110597"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e00350-17","DOI":"10.1128\/mBio.00350-17","article-title":"N-Methyl-d-Aspartate (NMDA) receptor blockade prevents neuronal death induced by Zika virus infection","volume":"8","author":"Costa","year":"2017","journal-title":"mBio"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41420-022-00958-x","article-title":"Zika virus infection accelerates Alzheimer\u2019s disease phenotypes in brain organoids","volume":"8","author":"Lee","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_152","first-page":"1615","article-title":"Enteroviruses: Classification, diseases they cause, and approaches to development of antiviral drugs","volume":"82","author":"Nikonov","year":"2018","journal-title":"Biochemistry"},{"key":"ref_153","unstructured":"Sinclair, W., and Omar, M. (2025). Enterovirus, StatPearls Publishing."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.virol.2010.12.014","article-title":"Enterovirus infections of the central nervous system","volume":"411","author":"Rhoades","year":"2011","journal-title":"Virology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e220252","DOI":"10.1590\/0074-02760220252","article-title":"Enterovirus infection and its relationship with neurodegenerative diseases","volume":"118","author":"Sousa","year":"2023","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Grizer, C.S., Messacar, K., and Mattapallil, J.J. (2024). Enterovirus-D68\u2014A reemerging non-polio enterovirus that causes severe respiratory and neurological disease in children. Front. Virol., 4.","DOI":"10.3389\/fviro.2024.1328457"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Cheng, M.L., Weng, S.F., Kuo, C.H., and Ho, H.Y. (2014). Enterovirus 71 induces mitochondrial reactive oxygen species generation that is required for efficient replication. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113234"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1073\/pnas.94.5.1931","article-title":"Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40\u2013CD40 ligand signaling in\u2009atherosclerosis","volume":"94","author":"Mach","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"10142","DOI":"10.1073\/pnas.181328798","article-title":"HIV envelope gp120 activates human arterial smooth muscle cells","volume":"98","author":"Schecter","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/COH.0b013e328324bbec","article-title":"The biology of CCR5 and CXCR4","volume":"4","author":"Alkhatib","year":"2009","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/360358a0","article-title":"Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160","volume":"360","author":"Hallenberger","year":"1992","journal-title":"Nature"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ebiom.2015.12.004","article-title":"Small CD4 mimetics prevent HIV-1 uninfected bystander CD4 + T cell killing mediated by antibody-dependent cell-mediated cytotoxicity","volume":"3","author":"Richard","year":"2015","journal-title":"EBioMedicine"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1086\/651434","article-title":"How much gp120 is there?","volume":"201","author":"Cummins","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00126334-199203000-00005","article-title":"Identification of HIV-1 envelope glycoprotein in the serum of AIDS and ARC patients","volume":"5","author":"Oh","year":"1992","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"11045","DOI":"10.1128\/JVI.00307-14","article-title":"HIV-1 gp120 activates the STAT3\/interleukin-6 axis in primary human monocyte-derived dendritic cells","volume":"88","author":"Donninelli","year":"2014","journal-title":"J. Virol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"L372","DOI":"10.1152\/ajplung.00193.2013","article-title":"HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3","volume":"306","author":"Green","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Hioe, C.E., Tuen, M., Vasiliver-Shamis, G., Alvarez, Y., Prins, K.C., Banerjee, S., N\u00e1das, A., Cho, M.W., Dustin, M.L., and Kachlany, S.C. (2011). HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA). PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023202"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mvr.2008.11.003","article-title":"HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: Modulatory effects of STAT1 signaling","volume":"77","author":"Yang","year":"2009","journal-title":"Microvasc. Res."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Davis, K., Perez-Guzman, P., Hoyer, A., Brinks, R., Gregg, E., Althoff, K.N., Justice, A.C., Reiss, P., Gregson, S., and Smit, M. (2021). Association between HIV infection and hypertension: A global systematic review and meta-analysis of cross-sectional studies. BMC Med., 19.","DOI":"10.1186\/s12916-021-01978-7"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/COH.0000000000000298","article-title":"Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe: Comparisons with general population","volume":"11","author":"Wandeler","year":"2016","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1742-4690-3-28","article-title":"HIV-1 associated dementia: Symptoms and causes","volume":"3","author":"Ghafouri","year":"2006","journal-title":"Retrovirology"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1097\/QAD.0000000000001888","article-title":"Noncommunicable diseases among HIV-infected persons in low-income and middle-income countries: A systematic review and meta-analysis","volume":"32","author":"Patel","year":"2018","journal-title":"AIDS"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.2147\/IJGM.S295859","article-title":"HIV-associated neurocognitive disorder (HAND): Obstacles to early neuropsychological diagnosis","volume":"15","author":"Vastag","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Zenebe, Y., Necho, M., Yimam, W., and Akele, B. (2022). Worldwide occurrence of HIV-associated neurocognitive disorders and its associated factors: A systematic review and meta-analysis. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.814362"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"e2610","DOI":"10.1212\/WNL.0000000000010752","article-title":"Global prevalence and burden of HIV-associated neurocognitive disorder: A meta-analysis","volume":"95","author":"Wang","year":"2020","journal-title":"Neurology"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/jnen\/61.11.992","article-title":"HIV-1 gp120 proteins and gp160 peptides are toxic to brain endothelial cells and neurons: Possible pathway for HIV entry into the brain and HIV-associated dementia","volume":"61","author":"Kanmogne","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Avdoshina, V., and Mocchetti, I. (2022). Recent Advances in the molecular and cellular mechanisms of gp120-mediated neurotoxicity. Cells, 11.","DOI":"10.3390\/cells11101599"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S1474-4422(12)70205-3","article-title":"HIV infection and stroke: Current perspectives and future directions","volume":"11","author":"Benjamin","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Ismael, S., Moshahid Khan, M., Kumar, P., Kodidela, S., Mirzahosseini, G., Kumar, S., and Ishrat, T. (2020). HIV associated risk factors for ischemic stroke and future perspectives. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155306"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Spagnolo-Allende, A., and Gutierrez, J. (2021). Role of brain arterial remodeling in HIV-associated cerebrovascular outcomes. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.593605"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics\u20142019 update: A report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbadis.2016.01.015","article-title":"Stroke injury, cognitive impairment and vascular dementia","volume":"1862","author":"Kalaria","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1212\/WNL.0b013e318206ca1e","article-title":"Three-month stroke outcome: The European Registers of Stroke (EROS) investigators","volume":"76","author":"Heuschmann","year":"2011","journal-title":"Neurology"},{"key":"ref_184","first-page":"e8296","article-title":"Frequency of human immunodeficiency virus in patients admitted with acute stroke","volume":"12","author":"Ali","year":"2020","journal-title":"Cureus"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"e904","DOI":"10.1212\/WNL.0000000000200780","article-title":"Prevalence and characteristics of HIV-associated stroke in a tertiary hospital setting in South Africa","volume":"99","author":"Corbett","year":"2022","journal-title":"Neurology"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/QAI.0000000000002598","article-title":"Types of stroke among people living with HIV in the United States","volume":"86","author":"Crane","year":"2021","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Lin, H.L., Muo, C.H., Lin, C.Y., Chen, H.J., and Chen, P.C. (2019). Incidence of stroke in patients with HIV infection: A population-based study in Taiwan. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217147"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1097\/QAD.0b013e3283493fb0","article-title":"Risk of cerebrovascular events in persons with and without HIV: A Danish nationwide population-based cohort study","volume":"25","author":"Rasmussen","year":"2011","journal-title":"AIDS"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1017\/S1355617720001022","article-title":"HIV, vascular risk factors, and cognition in the combination antiretroviral therapy era: A systematic review and meta-analysis","volume":"27","author":"McIntosh","year":"2021","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s44400-024-00001-z","article-title":"A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer\u2019s disease (ART-AD)","volume":"1","author":"Sullivan","year":"2025","journal-title":"NPJ Dement."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1099\/0022-1317-75-12-3337","article-title":"Effects of herpes simplex virus type 1 infection on the plasma membrane and related functions of HeLa S3 cells","volume":"75","author":"Biasolo","year":"1994","journal-title":"J. Gen. Virol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/13550280701460573","article-title":"Herpes simplex virus type 1 infection induces oxidative stress and the release of bioactive lipid peroxidation by-products in mouse P19N neural cell cultures","volume":"13","author":"Kavouras","year":"2007","journal-title":"J. Neurovirol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/JVI.01341-07","article-title":"The antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation","volume":"82","author":"Aubert","year":"2008","journal-title":"J. Virol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1134\/S0026893308030096","article-title":"Herpes simplex virus type 1 ICP27 induces apoptotic cell death by increasing intracellular reactive oxygen species","volume":"42","author":"Kim","year":"2008","journal-title":"Mol. Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1142\/S0192415X21500099","article-title":"Mori ramulus and its major component morusin inhibit herpes simplex virus type 1 replication and the virus-induced reactive oxygen species","volume":"49","author":"Kim","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Elias, T., Lee, L.H., Rossi, M., Caruso, F., and Adams, S.D. (2021). In vitro analysis of the antioxidant and antiviral activity of embelin against herpes simplex virus-1. Microorganisms, 9.","DOI":"10.3390\/microorganisms9020434"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/13550280802093927","article-title":"Microglia are the major cellular source of inducible nitric oxide synthase during experimental herpes encephalitis","volume":"14","author":"Marques","year":"2008","journal-title":"J. Neurovirol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/jn\/138.1.130","article-title":"The immune response to herpes simplex virus encephalitis in mice is modulated by dietary vitamin E","volume":"138","author":"Sheridan","year":"2008","journal-title":"J. Nutr."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-2094-7-35","article-title":"Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2","volume":"7","author":"Schachtele","year":"2010","journal-title":"J. Neuroinflamm."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.4049\/jimmunol.174.4.2235","article-title":"A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions","volume":"174","author":"Bellner","year":"2005","journal-title":"J. Immunol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.4049\/jimmunol.179.9.6080","article-title":"A monocyte-specific peptide from herpes simplex virus type 2 glycoprotein G activates the NADPH-oxidase but not chemotaxis through a G-protein-coupled receptor distinct from the members of the formyl peptide receptor family","volume":"179","author":"Bellner","year":"2007","journal-title":"J. Immunol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1742-2094-8-123","article-title":"Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia","volume":"8","author":"Hu","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Gonzalez-Dosal, R., Horan, K.A., Rahbek, S.H., Ichijo, H., Chen, Z.J., Mieyal, J.J., Hartmann, R., and Paludan, S.R. (2011). HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: Role for S-glutathionylation of TRAF3 and 6. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002250"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Marino-Merlo, F., Papaianni, E., Frezza, C., Pedatella, S., De Nisco, M., Macchi, B., Grelli, S., and Mastino, A. (2019). NF-\u03baB-dependent production of ROS and restriction of HSV-1 infection in U937 monocytic cells. Viruses, 11.","DOI":"10.3390\/v11050428"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Kwon, E.B., Kim, Y.S., Kim, B., Kim, S.G., Na, S.J., Go, Y., Choi, H.M., Lee, H.J., Han, S.M., and Choi, J.G. (2023). Korean chestnut honey suppresses HSV-1 infection by regulating the ROS-NLRP3 inflammasome pathway. Antioxidants, 12.","DOI":"10.3390\/antiox12111935"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Tarbeeva, D.V., Pislyagin, E.A., Menchinskaya, E.S., Berdyshev, D.V., Krylova, N.V., Iunikhina, O.V., Kalinovskiy, A.I., Shchelkanov, M.Y., Mishchenko, N.P., and Aminin, D.L. (2024). Polyphenols from Maackia amurensis heartwood protect neuronal cells from oxidative stress and prevent herpetic infection. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084142"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"e0237022","DOI":"10.1128\/mbio.02370-22","article-title":"Herpes simplex virus 1-induced ferroptosis contributes to viral encephalitis","volume":"14","author":"Xu","year":"2023","journal-title":"mBio"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13567-016-0332-2","article-title":"BHV-1 induced oxidative stress contributes to mitochondrial dysfunction in MDBK cells","volume":"47","author":"Zhu","year":"2016","journal-title":"Vet. Res."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"7072917","DOI":"10.1155\/2019\/7072917","article-title":"The differential expression of mitochondrial function-associated proteins and antioxidant enzymes during bovine herpesvirus 1 infection: A potential mechanism for virus infection-induced oxidative mitochondrial dysfunction","volume":"2019","author":"Fu","year":"2019","journal-title":"Mediators Inflamm."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4149\/av_2016_03_328","article-title":"The synergistic antiviral effects of GSH in combination with acyclovir against BoHV-1 infection in vitro","volume":"60","author":"Yuan","year":"2016","journal-title":"Acta Virol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13567-016-0377-2","article-title":"The activation of p38MAPK and JNK pathways in bovine herpesvirus 1 infected MDBK cells","volume":"47","author":"Zhu","year":"2016","journal-title":"Vet. Res."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Zhu, L., Fu, X., Yuan, C., Jiang, X., and Zhang, G. (2018). Induction of oxidative DNA damage in bovine herpesvirus 1 infected bovine kidney cells (MDBK cells) and human tumor cells (A549 cells and U2OS cells). Viruses, 10.","DOI":"10.3390\/v10080393"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"4957878","DOI":"10.1155\/2019\/4957878","article-title":"Bovine herpesvirus 1 productive infection led to inactivation of Nrf2 signaling through diverse approaches","volume":"2019","author":"Fu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s13365-016-0444-5","article-title":"Bovine herpesviruses induce different cell death forms in neuronal and glial-derived tumor cell cultures","volume":"22","author":"Cardoso","year":"2016","journal-title":"J. Neurovirol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"639","DOI":"10.24425\/124300","article-title":"Reactive oxygen metabolites in alpha-herpesvirus-seropositive Mediterranean buffaloes (Bubalus bubalis): A preliminary study","volume":"21","author":"Tafuri","year":"2018","journal-title":"Pol. J. Vet. Sci."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"309","DOI":"10.24425\/pjvs.2020.133646","article-title":"Equine herpesvirus type 1 affects mitochondrial network morphology and reactive oxygen species generation in equine dermal cell line","volume":"23","author":"Bartak","year":"2020","journal-title":"Pol. J. Vet. Sci."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Chodkowski, M., S\u0142o\u0144ska, A., Gregorczyk-Zboroch, K., Nowak-Zyczynska, Z., Golke, A., Krzy\u017cowska, M., Ba\u0144bura, M.W., and Cymerys, J. (2022). Equid Alphaherpesvirus 1 (EHV-1) influences morphology and function of neuronal mitochondria in vitro. Pathogens, 11.","DOI":"10.3390\/pathogens11080876"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0928-0197(94)90047-7","article-title":"Generation of hydrogen peroxide by varicella-zoster virus-stimulated polymorphonuclear leukocytes","volume":"2","author":"Fujiwara","year":"1994","journal-title":"Clin. Diagn. Virol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1442-200X.1994.tb03198.x","article-title":"Effect of varicella zoster virus antigen-antibody complexes on hydrogen peroxide generation by human polymorphonuclear leukocytes","volume":"36","author":"Fujiwara","year":"1994","journal-title":"Acta Paediatr. Jpn."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/jmv.25204","article-title":"Impaired oxidative status as a potential predictor in clinical manifestations of herpes zoster","volume":"90","author":"Khazan","year":"2018","journal-title":"J. Med. Virol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF01309571","article-title":"Pathogenesis of cytomegalovirus-associated pneumonitis in ICR mice: Possible involvement of superoxide radicals","volume":"127","author":"Ikeda","year":"1992","journal-title":"Arch. Virol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1161\/01.RES.79.6.1143","article-title":"Role of reactive oxygen intermediates in cytomegalovirus gene expression and in the response of human smooth muscle cells to viral infection","volume":"79","author":"Speir","year":"1996","journal-title":"Circ. Res."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1161\/01.CIR.102.24.2990","article-title":"Antioxidant effect of estrogen on cytomegalovirus-induced gene expression in coronary artery smooth muscle cells","volume":"102","author":"Speir","year":"2000","journal-title":"Circulation"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/1348-0421.12575","article-title":"Reactive oxygen species-induced parthanatos of immunocytes by human cytomegalovirus-associated substance","volume":"62","author":"Kim","year":"2018","journal-title":"Microbiol. Immunol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"e01183-19","DOI":"10.1128\/JVI.01183-19","article-title":"Human cytomegalovirus alters host cell mitochondrial function during acute infection","volume":"94","author":"Combs","year":"2020","journal-title":"J. Virol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12985-022-01954-4","article-title":"Suppressive effects of pterostilbene on human cytomegalovirus (HCMV) infection and HCMV-induced cellular senescence","volume":"19","author":"Wang","year":"2022","journal-title":"Virol. J."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Khomich, O.A., Kochetkov, S.N., Bartosch, B., and Ivanov, A.V. (2018). Redox biology of respiratory viral infections. Viruses, 10.","DOI":"10.3390\/v10080392"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"25754","DOI":"10.1038\/srep25754","article-title":"SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-\u03b21 via ROS\/p38 MAPK\/STAT3 pathway","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1574-695X.2006.00045.x","article-title":"Severe acute respiratory syndrome coronavirus 3C-like protease-induced apoptosis","volume":"46","author":"Lin","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1086\/519166","article-title":"Open reading frame 8a of the human severe acute respiratory syndrome coronavirus not only promotes viral replication but also induces apoptosis","volume":"196","author":"Chen","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10731190601188422","article-title":"SARS-CoV nucleocapsid protein induced apoptosis of COS-1 mediated by the mitochondrial pathway","volume":"35","author":"Zhang","year":"2007","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/sji.12386","article-title":"The plasma level of proprotein convertase FURIN in patients with suspected infection in the emergency room: A prospective cohort study","volume":"82","author":"Ranta","year":"2015","journal-title":"Scand. J. Immunol."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Liu, Z.W., Ma, Q., Liu, J., Li, J.W., and Chen, Y.D. (2021). The association between plasma furin and cardiovascular events after acute myocardial infarction. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-02029-y"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1161\/ATVBAHA.120.315698","article-title":"Platelet activation and plasma levels of furin are associated with prognosis of patients with coronary artery disease and COVID-19","volume":"41","author":"Langnau","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s11481-021-10015-6","article-title":"Mitochondrial dynamics in SARS-COV2 spike protein treated human microglia: Implications for Neuro-COVID","volume":"16","author":"Clough","year":"2021","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s10522-023-10019-0","article-title":"SARS-COV-2 spike protein promotes RPE cell senescence via the ROS\/P53\/P21 pathway","volume":"24","author":"Zhang","year":"2023","journal-title":"Biogerontology"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1007\/s11064-023-03949-1","article-title":"SARS-CoV-2 spike protein S1 exposure increases susceptibility to angiotensin II-induced hypertension in rats by promoting central neuroinflammation and oxidative stress","volume":"48","author":"Sun","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.1007\/s11033-023-08504-3","article-title":"Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells","volume":"50","author":"Zhang","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"e0079421","DOI":"10.1128\/JVI.00794-21","article-title":"SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells","volume":"95","author":"Meyer","year":"2021","journal-title":"J. Virol."},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Wang, R., Chen, Y., Tian, Z., Zhu, M., Zhang, B., Du, S., Li, Y., Liu, Z., Hou, S., and Yang, Y. (2022). Coenzyme Q10 attenuates human platelet aggregation induced by SARS-CoV-2 spike protein via reducing oxidative stress in vitro. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012345"},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Lesi\u00f3w, M.K., Witwicki, M., Tan, N.K., Graziotto, M.E., and New, E.J. (2023). Unravelling the mystery of COVID-19 pathogenesis: Spike protein and Cu can synergize to trigger ROS production. Chemistry, 29.","DOI":"10.1002\/chem.202301530"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.21873\/invivo.13605","article-title":"SARS-CoV-2 spike protein induces oxidative stress and senescence in mouse and human lung","volume":"38","author":"Greenberger","year":"2024","journal-title":"In Vivo"},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Huynh, T.V., Rethi, L., Lee, T.W., Higa, S., Kao, Y.H., and Chen, Y.J. (2023). Spike protein impairs mitochondrial function in human cardiomyocytes: Mechanisms underlying cardiac injury in COVID-19. Cells, 12.","DOI":"10.3390\/cells12060877"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Van Tin, H., Rethi, L., Higa, S., Kao, Y.H., and Chen, Y.J. (2024). Spike protein of SARS-CoV-2 activates cardiac fibrogenesis through NLRP3 inflammasomes and NF-\u03baB signaling. Cells, 13.","DOI":"10.3390\/cells13161331"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1093\/cvr\/cvaa267","article-title":"SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes","volume":"116","author":"Bojkova","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Ahn, W., Burnett, F.N., Pandey, A., Ghoshal, P., Singla, B., Simon, A.B., Derella, C.C., Addo, S.A., Harris, R.A., and Lucas, R. (2024). SARS-CoV-2 spike protein stimulates macropinocytosis in murine and human macrophages via PKC-NADPH oxidase signaling. Antioxidants, 13.","DOI":"10.3390\/antiox13020175"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Almeida, N.B.F., Fantone, K.M., Sarr, D., Ashtiwi, N.M., Channell, S., Grenfell, R.F.Q., Martins-Filho, O.A., and Rada, B. (2023). Variant-dependent oxidative and cytokine responses of human neutrophils to SARS-CoV-2 spike protein and anti-spike IgG1 antibodies. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1255003"},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Maeda, Y., Toyoda, M., Kuwata, T., Terasawa, H., Tokugawa, U., Monde, K., Sawa, T., Ueno, T., and Matsushita, S. (2024). Differential ability of spike protein of SARS-CoV-2 variants to downregulate ACE2. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021353"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jinf.2022.06.030","article-title":"Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection","volume":"85","author":"Gao","year":"2022","journal-title":"J. Infect."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"ar147","DOI":"10.1091\/mbc.E22-02-0045","article-title":"SARS-CoV-2 down-regulates ACE2 through lysosomal degradation","volume":"33","author":"Lu","year":"2022","journal-title":"Mol. Biol. Cell."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1161\/CIRCRESAHA.121.318902","article-title":"SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE 2","volume":"128","author":"Lei","year":"2021","journal-title":"Circ. Res."},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Sui, Y., Li, J., Venzon, D.J., and Berzofsky, J.A. (2021). SARS-CoV-2 spike protein suppresses ACE2 and Type I interferon expression in primary cells from macaque lung bronchoalveolar lavage. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.658428"},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Camargo, R.L., Bombassaro, B., Monfort-Pires, M., Mansour, E., Palma, A.C., Ribeiro, L.C., Ulaf, R.G., Bernardes, A.F., Nunes, T.A., and Agrela, M.V. (2022). Plasma angiotensin II is increased in critical coronavirus disease 2019. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.847809"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"20117","DOI":"10.1038\/s41598-022-24628-1","article-title":"The systemic renin-angiotensin system in COVID-19","volume":"12","author":"Domenig","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s13054-020-03015-0","article-title":"Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients","volume":"24","author":"Wu","year":"2020","journal-title":"Crit. Care"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s10096-020-04138-6","article-title":"COVID-19: Angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection","volume":"40","author":"Beyerstedt","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/HYPERTENSIONAHA.114.03743","article-title":"Angiotensin II mediates angiotensin converting enzyme type 2 internalization and degradation through an angiotensin II type I receptor-dependent mechanism","volume":"64","author":"Deshotels","year":"2014","journal-title":"Hypertension"},{"key":"ref_258","doi-asserted-by":"crossref","unstructured":"Cojocaru, E., Cojocaru, C., Vlad, C.E., and Eva, L. (2023). Role of the renin-angiotensin system in long COVID\u2019s cardiovascular injuries. Biomedicines, 11.","DOI":"10.3390\/biomedicines11072004"},{"key":"ref_259","doi-asserted-by":"crossref","unstructured":"El-Arif, G., Farhat, A., Khazaal, S., Annweiler, C., Kovacic, H., Wu, Y., Cao, Z., Fajloun, Z., Khattar, Z.A., and Sabatier, J.M. (2021). The renin-angiotensin system: A key role in SARS-CoV-2-induced COVID-19. Molecules, 26.","DOI":"10.3390\/molecules26226945"},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Georgieva, E., Ananiev, J., Yovchev, Y., Arabadzhiev, G., Abrashev, H., Abrasheva, D., Atanasov, V., Kostandieva, R., Mitev, M., and Petkova-Parlapanska, K. (2023). COVID-19 complications: Oxidative stress, inflammation, and mitochondrial and endothelial dysfunction. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914876"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"166260","DOI":"10.1016\/j.bbadis.2021.166260","article-title":"SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K\/AKT\/mTOR signaling","volume":"1867","author":"Li","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s11658-024-00659-6","article-title":"The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death","volume":"29","author":"Xie","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1080\/21505594.2021.1964329","article-title":"The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells","volume":"12","author":"Kelesidis","year":"2021","journal-title":"Virulence"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"e29270","DOI":"10.1002\/jmv.29270","article-title":"SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species","volume":"95","author":"Yu","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Chen, I.Y., Moriyama, M., Chang, M.F., and Ichinohe, T. (2019). Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.00050"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.freeradbiomed.2023.08.011","article-title":"Excess iron aggravates the severity of COVID-19 infection","volume":"208","author":"Chaubey","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"5397733","DOI":"10.1155\/2022\/5397733","article-title":"Superoxide dismutase prevents SARS-CoV-2-induced plasma cell apoptosis and stabilizes specific antibody induction","volume":"2022","author":"Mo","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Simanjuntak, Y., Liang, J.J., Chen, S.Y., Li, J.K., Lee, Y.L., Wu, H.C., and Lin, Y.L. (2018). Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1006854"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"198084","DOI":"10.1016\/j.virusres.2020.198084","article-title":"Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo","volume":"286","author":"Almeida","year":"2020","journal-title":"Virus Res."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"2417864","DOI":"10.1080\/22221751.2024.2417864","article-title":"Erp57 facilitates ZIKV-induced DNA damage via NS2B\/NS3 complex formation","volume":"13","author":"Wang","year":"2024","journal-title":"Emerg. Microbes Infect."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1002\/jcp.22677","article-title":"Enterovirus 71 induces integrin beta1\/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells: Role of HO-1\/CO in viral replication","volume":"226","author":"Tung","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.intimp.2018.04.050","article-title":"Harmine, a small molecule derived from natural sources, inhibits enterovirus 71 replication by targeting NF-kappaB pathway","volume":"60","author":"Chen","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Cheng, M.L., Wu, C.H., Chien, K.Y., Lai, C.H., Li, G.J., Liu, Y.Y., Lin, G., and Ho, H.Y. (2022). Enteroviral 2B interacts with VDAC3 to regulate reactive oxygen species generation that is essential to viral replication. Viruses, 14.","DOI":"10.3390\/v14081717"},{"key":"ref_274","doi-asserted-by":"crossref","unstructured":"Cui, G., Wang, H., Yang, C., Zhou, X., Wang, J., Wang, T., and Ma, T. (2022). Berberine prevents lethal EV71 neurological infection in newborn mice. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1027566"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"199267","DOI":"10.1016\/j.virusres.2023.199267","article-title":"Enterovirus 71 leads to abnormal mitochondrial dynamics in human neuroblastoma SK-N-SH cells","volume":"339","author":"Zhang","year":"2024","journal-title":"Virus Res."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"116866","DOI":"10.1016\/j.biopha.2024.116866","article-title":"Magnolol against enterovirus 71 by targeting Nrf2-SLC7A11-GSH pathway","volume":"176","author":"Zhao","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1002\/jcb.29628","article-title":"EV71 infection induces cell apoptosis through ROS generation and SIRT1 activation","volume":"121","author":"Li","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1080\/21505594.2020.1766790","article-title":"Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation","volume":"11","author":"You","year":"2020","journal-title":"Virulence"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1007\/s11033-022-08116-3","article-title":"Ebselen inhibits enterovirus A71-induced apoptosis through reactive oxygen species-mediated signaling pathway","volume":"50","author":"Chen","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000356649","article-title":"Heme oxygenase-1 mediates oxidative stress and apoptosis in coxsackievirus B3-induced myocarditis","volume":"33","author":"Ursu","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.bbrc.2018.07.093","article-title":"Nox4-dependent ROS production is involved in CVB3-induced myocardial apoptosis","volume":"503","author":"Chi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/02648725.2023.2194074","article-title":"LncRNA XIST knockdown reduces myocardial damage in myocarditis by targeting the miR-140-3p\/RIPK1 axis","volume":"40","author":"Zhang","year":"2024","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"117396","DOI":"10.1016\/j.jep.2023.117396","article-title":"Jingfang Granule mitigates coxsackievirus B3-induced myocardial damage by modulating mucolipin 1 expression","volume":"320","author":"Sun","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4049\/jimmunol.1700478","article-title":"Superoxide production by NADPH oxidase intensifies macrophage antiviral responses during diabetogenic coxsackievirus infection","volume":"200","author":"Burg","year":"2018","journal-title":"J. Immunol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4014\/jmb.2210.10027","article-title":"Stress granules inhibit Coxsackievirus B3-mediated cell death via reduction of mitochondrial reactive oxygen species and viral extracellular release","volume":"33","author":"Park","year":"2023","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1631\/jzus.B2300077","article-title":"Exosomal let-7a-5p derived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2\/ZFP36 signal axis","volume":"25","author":"Li","year":"2024","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/j.1460-2075.1991.tb07761.x","article-title":"Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1","volume":"10","author":"Schreck","year":"1991","journal-title":"EMBO J."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/00365548809032453","article-title":"Increased production of malondialdehyde in patients with HIV infection","volume":"20","author":"Carlin","year":"1988","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1515\/bchm3.1989.370.1.101","article-title":"Low concentrations of acid-soluble thiol (cysteine) in the blood plasma of HIV-1 infected patients","volume":"370","author":"Eck","year":"1989","journal-title":"Biol. Chem. Hoppe Seyler"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1006\/exnr.2000.7619","article-title":"Mechanisms of estrogenic protection against gp120-induced neurotoxicity","volume":"168","author":"Howard","year":"2001","journal-title":"Exp. Neurol."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1089\/aid.1996.12.1209","article-title":"HIV type 1 glycoprotein amplifies tumor necrosis factor-induced NF-kappa B activation in Jurkat cells","volume":"12","author":"Shatrov","year":"1996","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00042560-199712010-00001","article-title":"Antioxidants and dipyridamole inhibit HIV-1 gp120-induced free radical-based oxidative damage to human monocytoid cells","volume":"16","author":"Foga","year":"1997","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1530-0277.1998.tb03676.x","article-title":"Chronic alcohol intoxication attenuates human immunodeficiency virus-1 glycoprotein 120-induced superoxide anion release by isolated Kupffer cells","volume":"22","author":"Bautista","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0306-4522(01)00332-3","article-title":"Reactive oxygen species generated by glia are responsible for neuron death induced by human immunodeficiency virus-glycoprotein 120 in vitro","volume":"107","author":"Viviani","year":"2001","journal-title":"Neuroscience"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1471-4159.2002.00825.x","article-title":"Effect of GP120 on glutathione peroxidase activity in cortical cultures and the interaction with steroid hormones","volume":"81","author":"Brooke","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-2094-1-8","article-title":"Antioxidant protection from HIV-1 gp120-induced neuroglial toxicity","volume":"1","author":"Walsh","year":"2004","journal-title":"J. Neuroinflamm."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"9531","DOI":"10.1523\/JNEUROSCI.3085-04.2004","article-title":"Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase","volume":"24","author":"Jana","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.expneurol.2006.03.030","article-title":"A novel antioxidant N-acetylcysteine amide prevents gp120- and Tat-induced oxidative stress in brain endothelial cells","volume":"201","author":"Price","year":"2006","journal-title":"Exp. Neurol."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.freeradbiomed.2007.03.022","article-title":"Differential regulation of Mn-superoxide dismutase in neurons and astroglia by HIV-1 gp120: Implications for HIV-associated dementia","volume":"42","author":"Saha","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1080\/13550280902755375","article-title":"Cocaine and human immunodeficiency virus type 1 gp120 mediate neurotoxicity through overlapping signaling pathways","volume":"15","author":"Yao","year":"2009","journal-title":"J. Neurovirol"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"8852","DOI":"10.3390\/cimb46080523","article-title":"ROS chronicles in HIV infection: Genesis of oxidative stress, associated pathologies, and therapeutic strategies","volume":"46","author":"Harshithkumar","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"100235","DOI":"10.1016\/j.bbih.2021.100235","article-title":"The role of oxidative stress in HIV-associated neurocognitive disorders","volume":"13","author":"Buckley","year":"2021","journal-title":"Brain Behav. Immun. Health"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/1\/66\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:44:04Z","timestamp":1767627844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/1\/66"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,3]]},"references-count":302,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["antiox15010066"],"URL":"https:\/\/doi.org\/10.3390\/antiox15010066","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,3]]}}}