{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:19:29Z","timestamp":1791515969174,"version":"4.3.4"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund of the European Union","award":["\u03a42\u0395\u0394\u039a- 02465"],"award-info":[{"award-number":["\u03a42\u0395\u0394\u039a- 02465"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Marine by-products represent an important source of bioactive lipids with potential applications in nutraceuticals and functional foods. This study provides a biochemical and lipidomic characterization of oils derived from sardine, monkfish, grey mullet roe, squid, and anchovy by-products, assessing how the extraction method influences their lipid and antioxidant profiles. Fatty acids were quantified by GC-FID, antioxidant compounds by HPLC-DAD, and untargeted lipidomics by TIMS-HRMS. A total of 228 lipid species were identified, predominantly triglycerides (TGs) and diglycerides (DGs), accounting for approximately 69% of the annotated lipidome. Grey mullet roe oils exhibited the highest levels of long-chain PUFAs (EPA, DHA) and antioxidants (\u03b1-tocopherol 205\u2013469 mg\/Kg, lutein 10\u2013125 mg\/Kg, and squalene 1004\u20136049 mg\/Kg), whereas squid oils showed high n-3\/n-6 proportions. The extraction method strongly affected lipid integrity. Supercritical CO2 extraction with ethanol (SFE\u2013SE) preserved the greatest proportion of PUFA-rich TGs, yielding ~27\u201328 g EPA + DHA per 100 g oil, while wet reduction and mechanical pressing produced lower PUFA levels (~22 g\/100 g) and increased hydrolysis\/oxidation-associated lipids. PCA and PLS-DA revealed clear clustering driven by species and extraction class, with PUFA-containing TGs and DGs identified as major discriminating lipids. These results highlight the critical role of extraction conditions in determining the nutritional and functional value of marine oils and support the valorization of marine by-products in high-value applications.<\/jats:p>","DOI":"10.3390\/antiox15010095","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:44:44Z","timestamp":1768221884000},"page":"95","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lipidomic Characterization of Marine By-Product Oils: Impact of Species and Extraction Methods on Lipid Profile and Antioxidant Potential"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-1748","authenticated-orcid":false,"given":"Ioannis C.","family":"Martakos","sequence":"first","affiliation":[{"name":"Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-8001","authenticated-orcid":false,"given":"Paraskeui","family":"Tzika","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, International Hellenic University, 57400 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-4547","authenticated-orcid":false,"given":"Marilena E.","family":"Dasenaki","sequence":"additional","affiliation":[{"name":"Laboratory of Food Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9664-8455","authenticated-orcid":false,"given":"Eleni P.","family":"Kalogianni","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, International Hellenic University, 57400 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-4735","authenticated-orcid":false,"given":"Nikolaos S.","family":"Thomaidis","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zographou, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.3390\/nu15245118","article-title":"Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms","volume":"15","author":"Liu","year":"2023","journal-title":"Nutrients"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.1080\/10408398.2021.1893643","article-title":"Functional Foods and Bioactive Ingredients Harnessed from the Ocean: Current Status and Future Perspectives","volume":"62","author":"Lobine","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mutalipassi, M., Esposito, R., Ruocco, N., Viel, T., Costantini, M., and Zupo, V. (2021). Bioactive Compounds of Nutraceutical Value from Fishery and Aquaculture Discards. Foods, 10.","DOI":"10.3390\/foods10071495"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"129451","DOI":"10.1016\/j.foodchem.2021.129451","article-title":"Omega-3 Phospholipids in Pacific Blue Mackerel (Scomber Australasicus) Processing by-Products","volume":"353","author":"Ahmmed","year":"2021","journal-title":"Food Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/mnfr.201100710","article-title":"The Role of Marine Omega-3 (n-3) Fatty Acids in Inflammatory Processes, Atherosclerosis and Plaque Stability","volume":"56","author":"Calder","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1039\/C9FO01742A","article-title":"Inflammation and Cardiovascular Disease: Are Marine Phospholipids the Answer?","volume":"11","author":"Lordan","year":"2020","journal-title":"Food Funct."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1111\/ijfs.16768","article-title":"Optimised Extraction of Phospholipids and Omega-3 Fatty Acids from Patagonian Squid Waste with Low-Toxicity Solvents","volume":"58","author":"Trigo","year":"2023","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_8","first-page":"93","article-title":"Carotenoids in Aquatic Ecosystems and Aquaculture: A Colorful Business with Implications for Human Health","volume":"4","author":"Caramujo","year":"2017","journal-title":"Front. Mar. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nakano, T., and Wiegertjes, G. (2020). Properties of Carotenoids in Fish Fitness: A Review. Mar. Drugs, 18.","DOI":"10.3390\/md18110568"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/10408398.2012.694920","article-title":"Tocopherols in Seafood and Aquaculture Products","volume":"56","author":"Afonso","year":"2013","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2095.2010.00806.x","article-title":"Metabolism, Interactions, Requirements and Functions of Vitamin E in Fish","volume":"17","author":"Hamre","year":"2010","journal-title":"Aquac. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/B978-0-12-416003-3.00014-7","article-title":"Biological Importance and Applications of Squalene and Squalane","volume":"Volume 65","author":"Kim","year":"2012","journal-title":"Advances in Food and Nutrition Research"},{"key":"ref_13","first-page":"1","article-title":"Therapeutic Applications of Squalene\u2014A review","volume":"49","author":"Gopakumar","year":"2012","journal-title":"Fish. Technol."},{"key":"ref_14","first-page":"209","article-title":"A Comprehensive Review of Omega-3 Fatty Acids: Sources, Industrial Applications, and Health Benefits","volume":"13","author":"Saidaiah","year":"2024","journal-title":"Ann. Phytomedicine Int. J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Fonseca, S., Amaral, M.N., Reis, C.P., and Cust\u00f3dio, L. (2023). Marine Natural Products as Innovative Cosmetic Ingredients. Mar. Drugs, 21.","DOI":"10.3390\/md21030170"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Alves, A., Sousa, E., Sousa, E., Kijjoa, A., Pinto, M., and Pinto, M. (2020). Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics. Molecules, 25.","DOI":"10.3390\/molecules25112536"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Gim\u00e9nez Mart\u00ednez, R.J., Rivas Garc\u00eda, F., March Cerd\u00e1, J.C., Hern\u00e1ndez-Ru\u00edz, \u00c1., Gonz\u00e1lez Castro, M.I., Valverde-Merino, M.-I., Huertas Camarasa, F.J., Lloris Meseguer, F., and L\u00f3pez-Viota Gallardo, M. (2025). Bioactive Substances and Skin Health: An Integrative Review from a Pharmacy and Nutrition Perspective. Pharmaceuticals, 18.","DOI":"10.3390\/ph18030373"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2300008","DOI":"10.1002\/ejlt.202300008","article-title":"Effect of Extraction Method on the Yield and Quality of Mullet Roe Oil","volume":"125","author":"Georgiou","year":"2023","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/aocs.12681","article-title":"Valorization of Mullet Roe By-Products for the Production of Polyunsaturated Fatty Acids Rich Oils","volume":"100","author":"Kalogianni","year":"2023","journal-title":"JAOCS J. Am. Oil Chem. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tsamesidis, I., Tzika, P., Georgiou, D., Charisis, A., Hans, S., Lordan, R., Zabetakis, I., and Kalogianni, E.P. (2023). Oil from Mullet Roe Byproducts: Effect of Oil Extraction Method on Human Erythrocytes and Platelets. Foods, 13.","DOI":"10.3390\/foods13010079"},{"key":"ref_21","unstructured":"Food and Agriculture Organization of the United Nation (1986). The Production of Fish Meal and Oil, Food and Agriculture Organization of the United Nation."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.egypro.2017.09.033","article-title":"Extraction of Fish Oil Using Green Extraction Methods: A Short Review","volume":"128","author":"Ivanovs","year":"2017","journal-title":"Energy Procedia"},{"key":"ref_23","first-page":"2942","article-title":"Green Technologies for Production of Oils Rich in N-3 Polyunsaturated Fatty Acids from Aquatic Sources","volume":"62","author":"Aitta","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102712","DOI":"10.1016\/j.ifset.2021.102712","article-title":"Supercritical CO2 Extraction of Oil from Arctic Charr Side Streams from Filleting Processing","volume":"71","author":"Semenoglou","year":"2021","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_25","first-page":"12","article-title":"Supercritical CO2 Extraction of Fish Roe","volume":"28","author":"Luksta","year":"2024","journal-title":"Environ. Clim. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9073","DOI":"10.1111\/1750-3841.17508","article-title":"Extraction of High-Quality Antarctic Krill (Euphausia Superba) Oil Using Low-Temperature Continuous Phase-Transition Extraction Equipment","volume":"89","author":"Liu","year":"2024","journal-title":"J. Food Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"112829","DOI":"10.1016\/j.jfoodeng.2025.112829","article-title":"Enzyme Assisted Oil Extraction from Fishery by Products: Insight Gained from Interfacial Phenomena","volume":"407","author":"Kalogianni","year":"2025","journal-title":"J. Food Eng."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Martakos, I., Kostakis, M., Dasenaki, M., Pentogennis, M., and Thomaidis, N. (2019). Simultaneous Determination of Pigments, Tocopherols, and Squalene in Greek Olive Oils: A Study of the Influence of Cultivation and Oil-Production Parameters. Foods, 9.","DOI":"10.3390\/foods9010031"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"106232","DOI":"10.1016\/j.jfca.2024.106232","article-title":"Food Lipidomics: Development and Application of a Cutting-Edge Untargeted 4D HRMS Workflow for the Lipid Profiling of Food of Animal Origin","volume":"131","author":"Martakos","year":"2024","journal-title":"J. Food Compos. Anal."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cofs.2020.09.008","article-title":"Data Mining\/Machine Learning Methods in Foodomics","volume":"37","year":"2021","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nmeth.2551","article-title":"LipidBlast in Silico Tandem Mass Spectrometry Database for Lipid Identification","volume":"10","author":"Kind","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: Towards a Unified Platform for Metabolomics Data Processing, Analysis and Interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/ac051632c","article-title":"Probabilistic Quotient Normalization as Robust Method to Account for Dilution of Complex Biological Mixtures. Application in 1H NMR Metabonomics","volume":"78","author":"Dieterle","year":"2006","journal-title":"Anal. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/1541-4337.12510","article-title":"Marine Omega-3 (n-3) Phospholipids: A Comprehensive Review of Their Properties, Sources, Bioavailability, and Relation to Brain Health","volume":"19","author":"Ahmmed","year":"2019","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"220034","DOI":"10.4491\/eer.2022.034","article-title":"Fatty Acid Composition and Nutritional Analysis of Waste Crude Fish Oil Obtained by Optimized Milder Extraction Methods","volume":"28","author":"Zheng","year":"2022","journal-title":"Environ. Eng. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1590\/fst.21318","article-title":"Fish Oil for Human Health: Omega-3 Fatty Acid Profiles of Marine Seafood Species","volume":"39","year":"2019","journal-title":"Food Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Richter, C.K., Skulas-Ray, A.C., and Kris-Etherton, P.M. (2016). Recommended Intake of Fish and Fish Oils Worldwide. Fish and Fish Oil in Health and Disease Prevention, Elsevier Inc.","DOI":"10.1016\/B978-0-12-802844-5.00003-8"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"106161","DOI":"10.1016\/j.supflu.2023.106161","article-title":"Supercritical CO2 for Efficient Extraction of High-Quality Starfish (Asterias rubens) Oil","volume":"206","author":"Getachew","year":"2023","journal-title":"J. Supercrit. Fluids"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"133880","DOI":"10.1016\/j.foodchem.2022.133880","article-title":"Physicochemical, Biochemical and Microbiological Changes of Jeotgal-like Fermented Chinook Salmon (Oncorhynchus tshawytscha) Roe","volume":"398","author":"Bunga","year":"2022","journal-title":"Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.1021\/jf8003543","article-title":"Chemical Composition of Greek Avgotaracho Prepared from Mullet (Mugil cephalus): Nutritional and Health Benefits","volume":"56","author":"Kalogeropoulos","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1444-2906.2007.01380.x","article-title":"Oxidative Stability of Salmon and Herring Roe Lipids and Their Dietary Effect on Plasma Cholesterol Levels of Rats","volume":"73","author":"Moriya","year":"2007","journal-title":"Fish. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"129780","DOI":"10.1016\/j.foodchem.2021.129780","article-title":"Effect of Salted-Drying on Bioactive Compounds and Microbiological Changes during the Processing of Karasumi-like Chinook Salmon (Oncorhynchus tshawytscha) Roe Product","volume":"357","author":"Bunga","year":"2021","journal-title":"Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Galasso, C., Corinaldesi, C., and Sansone, C. (2017). Carotenoids from Marine Organisms: Biological Functions and Industrial Applications. Antioxidants, 6.","DOI":"10.3390\/antiox6040096"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Puebla, S., Arias-Sant\u00e9, M.F., Romero, J., Costa de Camargo, A., and Rinc\u00f3n-Cervera, M.\u00c1. (2025). Analysis of Fatty Acid Profile, \u03b1-Tocopherol, Squalene and Cholesterol Content in Edible Parts and By-Products of South Pacific Wild Fishes. Mar. Drugs, 23.","DOI":"10.3390\/md23030104"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"112100","DOI":"10.1016\/j.foodres.2022.112100","article-title":"Lipidomic Analysis and Triglyceride Profiles of Fish Oil: Preparation through Silica Gel Column and Enzymatic Treatment","volume":"162","author":"Song","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10337-024-04312-4","article-title":"Lipidomics Analysis of Different Marine Fish Oils Using Untargeted Liquid Chromatography\u2013Orbitrap High-Resolution Mass Spectrometry and Chemometrics","volume":"87","author":"Windarsih","year":"2024","journal-title":"Chromatographia"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Vazquez, J.A., Meduina, A., Duran, A.I., Nogueira, M., Fernandez-Compas, A., Perez-Martin, R.I., and Rodriguez-Amado, I. (2019). Production of Valuable Compounds and Bioactive Metabolites from By-Products of Fish Discards Using Chemical Processing, Enzymatic Hydrolysis, and Bacterial Fermentation. Mar. Drugs, 17.","DOI":"10.3390\/md17030139"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.tifs.2021.02.015","article-title":"Caviar and Fish Roe Substitutes: Current Status of Their Nutritive Value, Bio-Chemical Diversity, Authenticity and Quality Control Methods with Future Perspectives","volume":"110","author":"Farag","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.foodchem.2017.11.108","article-title":"Phospholipids Composition and Molecular Species of Large Yellow Croaker (Pseudosciaena crocea) Roe","volume":"245","author":"Liang","year":"2018","journal-title":"Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"125947","DOI":"10.1016\/j.foodchem.2019.125947","article-title":"Comparative Lipid Profile of Four Edible Shellfishes by UPLC-Triple TOF-MS\/MS","volume":"310","author":"Li","year":"2020","journal-title":"Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"105096","DOI":"10.1016\/j.jfca.2022.105096","article-title":"UHPLC-Q-Exactive Orbitrap MS\/MS Based Untargeted Lipidomics Reveals Fatty Acids and Lipids Profiles in Different Parts of Capelin (Mallotus villosus)","volume":"116","author":"Yin","year":"2022","journal-title":"J. Food Compos. Anal."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"740073","DOI":"10.1016\/j.aquaculture.2023.740073","article-title":"Beyond Fish Oil: Assessing the Implications of Alternative Dietary Lipid Sources for Turbot (Scophthalmus maximus) on Growth, Nutrient Utilization and Muscle Quality","volume":"578","author":"Monteiro","year":"2023","journal-title":"Aquaculture"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.foodchem.2009.01.002","article-title":"Oxidative Stability of Lipid Components of Mullet (Mugil cephalus) Roe and Its Product \u201cBottarga\u201d","volume":"115","author":"Rosa","year":"2009","journal-title":"Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.foodchem.2014.09.154","article-title":"The Effects of Different Extraction Methods on Composition and Storage Stability of Sturgeon Oil","volume":"173","author":"Hao","year":"2015","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jfoodeng.2011.10.011","article-title":"Supercritical Fluid Extraction of Fish Oil from Fish By-Products: A Comparison with Other Extraction Methods","volume":"109","author":"Jaime","year":"2012","journal-title":"J. Food Eng."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"132949","DOI":"10.1016\/j.foodchem.2022.132949","article-title":"Extraction of Edible Oils and Amino Acids from Eel By-Products Using Clean Compressed Solvents: An Approach of Complete Valorization","volume":"388","author":"Park","year":"2022","journal-title":"Food Chem."},{"key":"ref_57","first-page":"83","article-title":"Investigation on Fish Oil Extraction by Enzyme Extraction and Wet Reduction Methods and Quality Analysis","volume":"11","author":"Taati","year":"2018","journal-title":"AACL Bioflux"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/1\/95\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T13:03:20Z","timestamp":1768223000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/1\/95"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["antiox15010095"],"URL":"https:\/\/doi.org\/10.3390\/antiox15010095","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]}}}