{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:33:25Z","timestamp":1768509205847,"version":"3.49.0"},"reference-count":100,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["101156161"],"award-info":[{"award-number":["101156161"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swiss State Secretariat for Education, Research and Innovation"},{"DOI":"10.13039\/100017578","name":"Foundation Heart of Mainz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017578","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chinese government-sponsored PhD stipend","award":["202308210118"],"award-info":[{"award-number":["202308210118"]}]},{"name":"DFG project","award":["DA 523\/19-1"],"award-info":[{"award-number":["DA 523\/19-1"]}]},{"name":"Robert M\u00fcller Foundation"},{"name":"(Young) Scientists of the DZHK (German Center for Cardiovascular Research), Partner Site Rhine-Main, Mainz, Germany"},{"name":"EXPOHEALTH"},{"name":"Wahl-Stumpf Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Particulate matter (PM) is a significant contributor to air pollution-associated negative health effects, and cardiovascular disease patients are more susceptible to air pollution-mediated damage of the heart and vessels. The present study investigated the protective effects against PM-induced cardiovascular damage by classic cardiovascular drugs, as used for the standard therapy of cardiovascular disease patients. Male C57BL\/6J mice were exposed to ambient PM2.5 (&lt;2.5 \u00b5m) for 3 days with or without treatment with the cholesterol-lowering drug atorvastatin (20 mg\/kg\/d) or the angiotensin-converting enzyme (ACE) inhibitor captopril (50 mg\/kg\/d). Both drugs mitigated PM2.5-induced systolic blood pressure increases and partially prevented endothelial dysfunction, as reflected by a mixed effect on endothelial nitric oxide synthase phosphorylation. Both drugs ameliorated reactive oxygen species (ROS) formation and phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX-2) expression in the vasculature of PM2.5-exposed mice. Pulmonary ROS levels showed a minor improvement by the treatments, whereas Nox2 mRNA expression was not diminished. Only captopril showed some anti-inflammatory effects in the heart and lung of PM2.5-exposed mice, whereas both drugs failed to reduce systemic inflammation measured in plasma. These findings offer new insights into potential mitigation strategies for PM2.5-induced cardiovascular complications, particularly for patients at higher cardiovascular risk, like those with coronary artery or ischemic heart disease or hypertension.<\/jats:p>","DOI":"10.3390\/antiox15010106","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:52:57Z","timestamp":1768319577000},"page":"106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiotensin-Converting Enzyme (ACE) Inhibitors and Statins Mitigate Negative Cardiovascular and Pulmonary Effects of Particulate Matter in a Mouse Exposure Model"],"prefix":"10.3390","volume":"15","author":[{"given":"Tristan","family":"Junglas","sequence":"first","affiliation":[{"name":"Molecular Cardiology, Department for Cardiology 1, University Medical Center Mainz, 55131 Mainz, 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