{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:35:18Z","timestamp":1770222918689,"version":"3.49.0"},"reference-count":93,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001663","name":"Volkswagen Foundation","doi-asserted-by":"publisher","award":["90233"],"award-info":[{"award-number":["90233"]}],"id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Academic Exchange Service","award":["57722940"],"award-info":[{"award-number":["57722940"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is regarded as a disease of the brain. Cumulative evidence increasingly supports a full-body view on this disorder, with the liver and kidneys playing an important role in amyloid clearance. The latter is likely potentiated by caloric restriction (CR), whose impact on the metabolism of amyloid-handling tissues is poorly understood. We studied the sex-specific effects of amyloidosis and CR on oxidative and metabolic processes in APPPS1 mice that express amyloidogenic proteins. Wild-type (WT) and APPPS1 mice were either fed ad libitum (AL) or received 70% of their AL caloric intake (CR). Compared to age-matched WT controls, the brain, liver, and kidney of 9-month-old AL APPPS1 mice exhibited higher levels of oxidative stress markers, higher superoxide dismutase, and lower catalase activities. These differences were sex- and tissue-specific, with kidneys showing the largest AD-induced differences between sexes. In addition, APPPS1 mice possessed higher pyruvate kinase activity than WT mice in all organs and higher hexokinase and phosphofructokinase activities in the brain, with stronger effects in males. CR intensified the accumulation of lipid peroxides in the liver and the female brain but decreased it in the female kidney. CR potentiated glycolysis, predominantly in females and modulated glutathione-dependent enzymes, in a sex-dependent manner.<\/jats:p>","DOI":"10.3390\/antiox15020191","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:48:08Z","timestamp":1770025688000},"page":"191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Body-Wide Glycolytic Shift, Oxidative Stress, and Sex-Specific Effect of Caloric Restriction in a Mouse Model of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"given":"Myroslava V.","family":"Vatashchuk","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Vasyl Stefanyk Carpathian National University, 57 Shevchenko Str., 76018 Ivano-Frankivsk, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-2656","authenticated-orcid":false,"given":"Viktoriia V.","family":"Hurza","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Vasyl Stefanyk Carpathian National University, 57 Shevchenko Str., 76018 Ivano-Frankivsk, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Institute of Physiology, Eberhard Karls University of T\u00fcbingen, 15 Keplerstra\u00dfe, 72074 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-8910","authenticated-orcid":false,"given":"Maria M.","family":"Bayliak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Vasyl Stefanyk Carpathian National University, 57 Shevchenko Str., 76018 Ivano-Frankivsk, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmytro V.","family":"Gospodaryov","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Vasyl Stefanyk Carpathian National University, 57 Shevchenko Str., 76018 Ivano-Frankivsk, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-3330","authenticated-orcid":false,"given":"Volodymyr I.","family":"Lushchak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Vasyl Stefanyk Carpathian National University, 57 Shevchenko Str., 76018 Ivano-Frankivsk, Ukraine"},{"name":"Research and Development University, 13a Shota Rustaveli Str., 76018 Ivano-Frankivsk, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-5654","authenticated-orcid":false,"given":"Olga","family":"Garaschuk","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Institute of Physiology, Eberhard Karls University of T\u00fcbingen, 15 Keplerstra\u00dfe, 72074 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S1474-4422(16)00127-7","article-title":"Genetic Variations Underlying Alzheimer\u2019s Disease: Evidence from Genome-Wide Association Studies and Beyond","volume":"15","author":"Cuyvers","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.tins.2023.03.005","article-title":"Moving beyond Amyloid and Tau to Capture the Biological Heterogeneity of Alzheimer\u2019s Disease","volume":"46","author":"Lee","year":"2023","journal-title":"Trends Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)31561-0","article-title":"Sex and Gender: Modifiers of Health, Disease, and Medicine","volume":"396","author":"Barnes","year":"2020","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00441-014-1798-8","article-title":"Network-Wide Dysregulation of Calcium Homeostasis in Alzheimer\u2019s Disease","volume":"357","author":"Brawek","year":"2014","journal-title":"Cell Tissue Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative Stress, Dysfunctional Glucose Metabolism and Alzheimer\u2019s Disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. 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