{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:19:32Z","timestamp":1790605172785,"version":"4.1.0"},"reference-count":271,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Next Generation EU\u2014Finanziato dall\u2019Unione Europea","award":["CUP J5521004240001-DM 737\/2021"],"award-info":[{"award-number":["CUP J5521004240001-DM 737\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Alcohol is a molecule whose multiple effects in living organisms exemplify how profound biological complexity can arise from an exceptionally simple chemical structure interacting with the cellular biochemical machinery. This review was conceived to provide an up-to-date synthesis of the current knowledge on the multifaceted consequences of alcohol oxidative metabolism and alcohol-derived oxidative stress, ranging from disruption of subcellular and cellular homeostasis to impairment of organ function. This study primarily focuses on the consequences of alcohol metabolism and on the mechanisms by which the rise of its main metabolite, acetaldehyde, and of reactive oxygen species (ROS), generates oxidative stress by-products and molecular adducts responsible for compromising cellular energy balance and antioxidant defense mechanisms. In particular, this review aims to provide an exhaustive representation of the mechanisms, causes, and consequences of alcohol oxidative metabolism: this is accomplished by taking into account alcohol-induced modifications of gene expression of cellular antioxidant determinants, the role of epigenetic mechanisms, and that of gene polymorphisms linked to alcohol-dependent oxidative stress and responsible for serious diseases such as, among others, alcoholic hepatitis, cirrhosis, and hepatocellular carcinoma. In addition, this review highlights the role of alcohol oxidative metabolism in the brain, which, in the acute setting, activates the dopaminergic system mainly involved in alcohol reinforcing properties and, upon chronic exposure, contributes to neurodegenerative disorders. Finally, a dedicated paragraph explores autophagy as an integrative mechanism underlying the effects of alcohol-related oxidative stress across multiple organs, including the liver, heart, and brain.<\/jats:p>","DOI":"10.3390\/antiox15020216","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:33:50Z","timestamp":1770384830000},"page":"216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Timeless and Stainless Alcohol: Concentric Waves from Its Oxidative Metabolism and Related Oxidative Stress"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-4903","authenticated-orcid":false,"given":"Riccardo","family":"Maccioni","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-7556","authenticated-orcid":false,"given":"Simone","family":"Tambaro","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society (NVS), Division of Neurogeriatrics, Karolinska Institutet, 17164 Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Doro","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9439-6090","authenticated-orcid":false,"given":"Valentina","family":"Bassareo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-9858","authenticated-orcid":false,"given":"Alessandra T.","family":"Peana","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-9319","authenticated-orcid":false,"given":"Elio","family":"Acquas","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/j.1530-0277.1998.tb03695.x","article-title":"Effects of moderate alcohol consumption on the central nervous system","volume":"22","author":"Eckardt","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12954-024-01105-8","article-title":"Exploring and describing alcohol harm reduction interventions: A scoping review of literature from the past decade in the western world","volume":"21","author":"Perrin","year":"2024","journal-title":"Harm Reduct. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e12465","DOI":"10.1590\/1414-431x2023e12465","article-title":"Evaluation of oxidative stress markers in ethanol users","volume":"56","author":"Moraes","year":"2023","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0009-8981(96)06434-0","article-title":"Ethanol metabolism, cirrhosis and alcoholism","volume":"257","author":"Lieber","year":"1997","journal-title":"Clin. Chim. Acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/mutage\/gew016","article-title":"Increased levels of the acetaldehyde-derived DNA adduct N2-ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to Alcohol","volume":"31","author":"Balbo","year":"2016","journal-title":"Mutagenesis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cotox.2018.10.003","article-title":"Lipid peroxidation derived reactive aldehydes in alcoholic liver disease","volume":"13","author":"Ali","year":"2019","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17756","DOI":"10.3748\/wjg.v20.i47.17756","article-title":"Pathogenesis of alcoholic liver disease: Role of oxidative metabolism","volume":"20","author":"Ceni","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100413","DOI":"10.1016\/j.jlr.2023.100413","article-title":"Zonal expression of StARD1 and oxidative stress in alcoholic-related liver disease","volume":"64","author":"Fucho","year":"2023","journal-title":"J. Lipid Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Metro, D., Corallo, F., Fedele, F., Buda, M., Manasseri, L., Buono, V.L., Quartarone, A., and Bonanno, L. (2022). Effects of Alcohol Consumption on Oxidative Stress in a Sample of Patients Recruited in a Dietary Center in a Southern University Hospital: A Retrospective Study. Medicina, 58.","DOI":"10.3390\/medicina58111670"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"14766","DOI":"10.1038\/s41598-021-94302-5","article-title":"Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues","volume":"11","author":"Stojsavljevic","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"113399","DOI":"10.1016\/j.bbr.2021.113399","article-title":"Metformin improved memory impairment caused by chronic ethanol consumption during adolescent to adult period of rats: Role of oxidative stress and neuroinflammation","volume":"411","author":"Baradaran","year":"2021","journal-title":"Behav. Brain Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kozlov, A.V., Javadov, S., and Sommer, N. (2024). Cellular ROS and Antioxidants: Physiological and Pathological Role. Antioxidants, 13.","DOI":"10.3390\/antiox13050602"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.4103\/1673-5374.357906","article-title":"Neuronal nitric oxide synthase\/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy","volume":"18","author":"Xu","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103386","DOI":"10.1016\/j.redox.2024.103386","article-title":"Chronic alcohol consumption aggravates acute kidney injury through integrin \u03b21\/JNK signaling","volume":"77","author":"Zhan","year":"2024","journal-title":"Redox Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13195-024-01542-4","article-title":"Association of oxidative stress and inflammatory metabolites with Alzheimer\u2019s disease cerebrospinal fluid biomarkers in mild cognitive impairment","volume":"16","author":"Ahmad","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kolota, A., Glabska, D., Oczkowski, M., and Gromadzka-Ostrowska, J. (2020). Oxidative Stress Parameters in the Liver of Growing Male Rats Receiving Various Alcoholic Beverages. Nutrients, 12.","DOI":"10.3390\/nu12010158"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e70268","DOI":"10.1002\/mco2.70268","article-title":"Oxidative Stress: Signaling Pathways, Biological Functions, and Disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1258\/ebm.2012.011421","article-title":"DNA damage and neurotoxicity of chronic alcohol abuse","volume":"237","author":"Kruman","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.reprotox.2013.08.003","article-title":"Over-expression of Nrf2 diminishes ethanol-induced oxidative stress and apoptosis in neural crest cells by inducing an antioxidant response","volume":"42","author":"Chen","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1038\/s41598-017-04233-3","article-title":"Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy","volume":"7","author":"Yoshizaki","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1530\/JOE-14-0662","article-title":"The role of Nrf2 in oxidative stress-induced endothelial injuries","volume":"225","author":"Chen","year":"2015","journal-title":"J. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Tessua, K.K., Munseri, P., and Matuja, S.S. (2021). Outcomes within a year following first ever stroke in Tanzania. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0246492"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.redox.2012.10.001","article-title":"The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer","volume":"1","author":"Kansanen","year":"2013","journal-title":"Redox Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4110\/in.2009.9.1.12","article-title":"Heme oxygenase-1: Its therapeutic roles in inflammatory diseases","volume":"9","author":"Pae","year":"2009","journal-title":"Immune Netw."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"109574","DOI":"10.1016\/j.cbi.2021.109574","article-title":"Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants","volume":"345","author":"Rashid","year":"2021","journal-title":"Chem.-Biol. Interact."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1124\/mol.104.002048","article-title":"Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-\u03baB DNA binding activity","volume":"66","author":"Wu","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1089\/ars.2010.3586","article-title":"Glutathione peroxidase-1 in health and disease: From molecular mechanisms to therapeutic opportunities","volume":"15","author":"Lubos","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev-physiol-060821-014008","article-title":"Alcohol-Associated Tissue Injury: Current Views on Pathophysiological Mechanisms","volume":"84","author":"Simon","year":"2022","journal-title":"Annu. Rev. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/acer.15049","article-title":"The vicious cycle between (neuro)inflammation and alcohol use disorder: An opportunity to develop new medications?","volume":"47","author":"Leko","year":"2023","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101480","DOI":"10.1016\/j.jcmgh.2025.101480","article-title":"An Nrf2-NF-\u03baB Crosstalk Controls Hepatocyte Proliferation in the Normal and Injured Liver","volume":"19","author":"Kuklin","year":"2025","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zeng, T., Guo, F.F., Zhang, C.L., Song, F.Y., Zhao, X.L., and Xie, K.Q. (2013). Roles of cytochrome P4502E1 gene polymorphisms and the risks of alcoholic liver disease: A meta-analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054188"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Tadokoro, T., Oura, K., Nakahara, M., Fujita, K., Tani, J., Morishita, A., and Kobara, H. (2025). Genetic Polymorphisms of ALDH2 and ADH1B in Alcohol-Induced Liver Injury: Molecular Mechanisms of Inflammation and Disease Progression in East Asian Populations. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26178328"},{"key":"ref_34","first-page":"99","article-title":"Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males","volume":"5","author":"Yokoyama","year":"1996","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"12940","DOI":"10.1074\/jbc.M607959200","article-title":"Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: Roles of residues 475 and 487","volume":"282","author":"Larson","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.gene.2008.12.021","article-title":"Origin and dispersal of atypical aldehyde dehydrogenase ALDH2487\u204eLys","volume":"435","author":"Luo","year":"2009","journal-title":"Gene"},{"key":"ref_37","first-page":"274","article-title":"Alcohol metabolism\u2019s damaging effects on the cell: A focus on reactive oxygen generation by the enzyme cytochrome P450 2E1","volume":"29","author":"Koop","year":"2006","journal-title":"Alcohol. Res. Health"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.freeradbiomed.2007.11.004","article-title":"CYP2E1 and oxidative liver injury by Alcohol","volume":"44","author":"Lu","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1470-2045(09)70019-1","article-title":"Alcohol and genetic polymorphisms: Effect on risk of alcohol-related cancer","volume":"10","author":"Tehard","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.redox.2015.06.021","article-title":"Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney","volume":"6","author":"Harris","year":"2015","journal-title":"Redox Biol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Chiorcea-Paquim, A.M. (2022). 8-oxoguanine and 8-oxodeoxyguanosine Biomarkers of Oxidative DNA Damage: A Review on HPLC-ECD Determination. Molecules, 27.","DOI":"10.3390\/molecules27051620"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"103856","DOI":"10.1016\/j.redox.2025.103856","article-title":"Oxidatively damaged DNA in DNA repair-deficient and ethanol-exposed fetal brains induces gene dysregulation and mitochondrial dysfunction associated with neurodevelopmental disorders","volume":"87","author":"Cheng","year":"2025","journal-title":"Redox Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s11033-025-10985-3","article-title":"Comprehensive review on alcohol-induced protein modifications in hepatic mitochondrial membranes and their functional implications","volume":"52","author":"Gouthami","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/alcalc\/agl017","article-title":"Chronic ethanol consumption decreases mitochondrial and glycolytic production of ATP in liver","volume":"41","author":"Young","year":"2006","journal-title":"Alcohol Alcohol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"112185","DOI":"10.1016\/j.intimp.2024.112185","article-title":"cGAS\/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice","volume":"134","author":"Zhao","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Grazioli, S., and Pugin, J. (2018). Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00832"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrg.2016.59","article-title":"The molecular hallmarks of epigenetic control","volume":"17","author":"Allis","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41576-022-00468-7","article-title":"Histone post-translational modifications\u2014Cause and consequence of genome function","volume":"23","author":"Burton","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cbpa.2019.01.024","article-title":"The roles of microRNAs in epigenetic regulation","volume":"51","author":"Yao","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tips.2023.11.002","article-title":"The rise of epitranscriptomics: Recent developments and future directions","volume":"45","author":"Cerneckis","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"111502","DOI":"10.1016\/j.cellsig.2024.111502","article-title":"Role of reactive oxygen species in regulating epigenetic modifications","volume":"125","author":"Chen","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e12855","DOI":"10.1111\/adb.12855","article-title":"Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data","volume":"26","author":"Dugue","year":"2021","journal-title":"Addict. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s41380-019-0449-6","article-title":"Genome-wide methylation in alcohol use disorder subjects: Implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1)","volume":"26","author":"Gatta","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"19430","DOI":"10.1038\/srep19430","article-title":"DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/aje\/kwz032","article-title":"Alcohol and DNA Methylation: An Epigenome-Wide Association Study in Blood and Normal Breast Tissue","volume":"188","author":"Wilson","year":"2019","journal-title":"Am. J. Epidemiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/mp.2016.192","article-title":"A DNA methylation biomarker of alcohol consumption","volume":"23","author":"Liu","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"154315","DOI":"10.1016\/j.tox.2025.154315","article-title":"The role of DNA methylation in alcohol-mediated neurodevelopmental toxicity","volume":"519","author":"Gao","year":"2026","journal-title":"Toxicology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neubiorev.2020.08.018","article-title":"Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications","volume":"118","author":"Ciafre","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1523\/JNEUROSCI.4571-14.2015","article-title":"DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity","volume":"35","author":"Barbier","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/adb.12047","article-title":"MeCP2 regulates ethanol sensitivity and intake","volume":"19","author":"Chen","year":"2014","journal-title":"Addict. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Jarczak, J., Miszczak, M., and Radwanska, K. (2023). Is DNA methylation in the brain a mechanism of alcohol use disorder?. Front. Behav. Neurosci., 17.","DOI":"10.3389\/fnbeh.2023.957203"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/mnfr.201200077","article-title":"Folate, alcohol, and liver disease","volume":"57","author":"Medici","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.bbadis.2011.01.016","article-title":"Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH\/NAD+ system","volume":"1812","author":"Watson","year":"2011","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0741-8329(02)00226-4","article-title":"Role of abnormal methionine metabolism in alcoholic liver injury","volume":"27","author":"Lu","year":"2002","journal-title":"Alcohol"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bcp.2007.05.005","article-title":"Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: Possible involvement of mitochondrial S-adenosylmethionine transport","volume":"74","author":"Song","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.35946\/arcr.v35.1.04","article-title":"Alcohol, DNA methylation, and cancer","volume":"35","author":"Woodhoo","year":"2013","journal-title":"Alcohol. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zheng, Q., Wang, H., Yan, A., Yin, F., and Qiao, X. (2023). DNA Methylation in Alcohol Use Disorder. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210130"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.2174\/0109298673256937231004093143","article-title":"The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol use Disorders","volume":"31","author":"Fanfarillo","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Garcia-Guede, A., Vera, O., and Ibanez-de-Caceres, I. (2020). When Oxidative Stress Meets Epigenetics: Implications in Cancer Development. Antioxidants, 9.","DOI":"10.3390\/antiox9060468"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Zheng, K., Lyu, Z., Chen, J., and Chen, G. (2024). 5-Hydroxymethylcytosine: Far Beyond the Intermediate of DNA Demethylation. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252111780"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/s12276-022-00822-z","article-title":"8-Oxoguanine: From oxidative damage to epigenetic and epitranscriptional modification","volume":"54","author":"Hahm","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/alcalc\/ags004","article-title":"Gene-selective histone H3 acetylation in the absence of increase in global histone acetylation in liver of rats chronically fed Alcohol","volume":"47","author":"Park","year":"2012","journal-title":"Alcohol Alcohol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.alcohol.2010.06.003","article-title":"Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes","volume":"44","author":"Choudhury","year":"2010","journal-title":"Alcohol"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.7150\/ijbs.49535","article-title":"Emerging Roles of SIRT1 in Alcoholic Liver Disease","volume":"16","author":"Ren","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_78","first-page":"88","article-title":"Sirtuin 1 signaling and alcoholic fatty liver disease","volume":"4","author":"You","year":"2015","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"O\u2019Brien, J., Hayder, H., Zayed, Y., and Peng, C. (2018). Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00402"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.3390\/biom5043309","article-title":"Role of microRNAs in Alcohol-Induced Multi-Organ Injury","volume":"5","author":"Natarajan","year":"2015","journal-title":"Biomolecules"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Prins, S.A., Przybycien-Szymanska, M.M., Rao, Y.S., and Pak, T.R. (2014). Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0083166"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Markopoulos, G.S., Roupakia, E., Tokamani, M., Alabasi, G., Sandaltzopoulos, R., Marcu, K.B., and Kolettas, E. (2018). Roles of NF-\u03baB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer. Biomedicines, 6.","DOI":"10.3390\/biomedicines6020040"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/acer.12209","article-title":"MiR-214 promotes the alcohol-induced oxidative stress via down-regulation of glutathione reductase and cytochrome P450 oxidoreductase in liver cells","volume":"38","author":"Dong","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Lippai, D., Bala, S., Csak, T., Kurt-Jones, E.A., and Szabo, G. (2013). Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070945"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jhep.2016.01.035","article-title":"The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis","volume":"64","author":"Bala","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"G385","DOI":"10.1152\/ajpgi.00111.2018","article-title":"Knockout of microRNA-21 attenuates alcoholic hepatitis through the VHL\/NF-\u03baB signaling pathway in hepatic stellate cells","volume":"315","author":"Wu","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/gutjnl-2016-311861","article-title":"MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47(phox)-oxidative stress pathway in neutrophils","volume":"66","author":"Li","year":"2017","journal-title":"Gut"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Maccioni, R., Lorrai, I., Torres, I., Puliga, R., Repunte-Canonigo, V., and Sanna, P.P. (2025). N6-methyladenosine RNA methylation is a novel epitranscriptomic regulator of excessive alcohol drinking and vulnerability to relapse. bioRxiv.","DOI":"10.1101\/2025.11.16.688690"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Liu, Y., and Zhang, H. (2022). RNA m6A Modification Changes in Postmortem Nucleus Accumbens of Subjects with Alcohol Use Disorder: A Pilot Study. Genes, 13.","DOI":"10.3390\/genes13060958"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2294515","DOI":"10.1080\/15592294.2023.2294515","article-title":"Chronic intermittent ethanol exposure-induced m6A modifications around mRNA stop codons of opioid receptor genes","volume":"19","author":"Liu","year":"2024","journal-title":"Epigenetics"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Cruise, T.M., Kotlo, K., Malovic, E., and Pandey, S.C. (2023). Advances in DNA, histone, and RNA methylation mechanisms in the pathophysiology of alcohol use disorder. Adv. Drug Alcohol Res., 3.","DOI":"10.3389\/adar.2023.10871"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Yao, J., Liu, P., Teng, X., Kong, D., Han, B., Cui, C., Yin, M., Yan, X., Zhao, A., and Ye, Y. (2025). Alcohol-induced disruption of hepatic m 6 A modification exacerbates alcohol-associated steatohepatitis by impairing liver immune microenvironment homeostasis. Hepatology, ahead of print.","DOI":"10.1097\/HEP.0000000000001374"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"105286","DOI":"10.1016\/j.phrs.2020.105286","article-title":"DNA methylation of FTO promotes renal inflammation by enhancing m6A of PPAR-\u03b1 in alcohol-induced kidney injury","volume":"163","author":"Yu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMra2207599","article-title":"Alcohol-Associated Hepatitis","volume":"387","author":"Bataller","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cld.2016.02.004","article-title":"Pathogenesis of Alcoholic Liver Disease","volume":"20","author":"Dunn","year":"2016","journal-title":"Clin. Liver Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1194\/jlr.R119000547","article-title":"Alcohol effects on hepatic lipid metabolism","volume":"61","author":"Jeon","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Dewidar, B., Meyer, C., Dooley, S., and Meindl-Beinker, A.N. (2019). TGF-\u03b2 in Hepatic Stellate Cell Activation and Liver Fibrogenesis-Updated 2019. Cells, 8.","DOI":"10.3390\/cells8111419"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Ramos-Tovar, E., and Muriel, P. (2020). Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver. Antioxidants, 9.","DOI":"10.3390\/antiox9121279"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: Mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1530-0277.2008.00827.x","article-title":"Molecular mechanisms of alcoholic fatty liver","volume":"33","author":"Purohit","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"29342","DOI":"10.1074\/jbc.M202411200","article-title":"Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)","volume":"277","author":"You","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.alcohol.2004.07.004","article-title":"Molecular mechanisms of alcoholic fatty liver: Role of sterol regulatory element-binding proteins","volume":"34","author":"You","year":"2004","journal-title":"Alcohol"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1126\/science.aad4017","article-title":"Complementation of mitochondrial electron transport chain by manipulation of the NAD+\/NADH ratio","volume":"352","author":"Titov","year":"2016","journal-title":"Science"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Chen, T.H., Wang, H.C., Chang, C.J., and Lee, S.Y. (2024). Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021314"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Mari, M., de Gregorio, E., de Dios, C., Roca-Agujetas, V., Cucarull, B., Tutusaus, A., Morales, A., and Colell, A. (2020). Mitochondrial Glutathione: Recent Insights and Role in Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9100909"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0741-8329(93)90067-X","article-title":"Mitochondrial glutathione depletion in alcoholic liver disease","volume":"10","author":"Hirano","year":"1993","journal-title":"Alcohol"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1139\/cjpp-2017-0487","article-title":"The antioxidant and antiapoptotic effect of boric acid on hepatoxicity in chronic alcohol-fed rats","volume":"96","author":"Sogut","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/flgastro-2022-102362","article-title":"Improving survival in alcohol-related hepatitis: What\u2019s new?","volume":"15","author":"Shearer","year":"2024","journal-title":"Frontline Gastroenterol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1056\/NEJMoa1101214","article-title":"Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis","volume":"365","author":"Thevenot","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_112","unstructured":"Dukic, M., Radonjic, T., Jovanovic, I., Zdravkovic, M., Todorovic, Z., Kraisnik, N., Arandelovic, B., Mandic, O., Popadic, V., and Nikolic, N. (2023). Alcohol, Inflammation, and Microbiota in Alcoholic Liver Disease. Int. J. Mol. Sci., 24."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Skryabin, V. (2025). Gut microbiota and alcohol use disorder: A new frontier in treatment and recovery. BJPsych Bull., 1\u20138.","DOI":"10.1192\/bjb.2025.10129"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"100220","DOI":"10.1016\/j.jhepr.2020.100220","article-title":"Gut dysbiosis as a driver in alcohol-induced liver injury","volume":"3","author":"Fairfield","year":"2021","journal-title":"JHEP Rep."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Yue, R., Wei, X., Hao, L., Dong, H., Guo, W., Sun, X., Zhao, J., Zhou, Z., and Zhong, W. (2023). Promoting intestinal antimicrobial defense and microbiome symbiosis contributes to IL-22-mediated protection against alcoholic hepatitis in mice. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1289356"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-\u03baB: A pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0168-8278(00)80219-6","article-title":"Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: Effect of corticosteroids","volume":"32","author":"Taieb","year":"2000","journal-title":"J. Hepatol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e00306","DOI":"10.14309\/ctg.0000000000000306","article-title":"No Effect in Alcoholic Hepatitis of Gut-Selective, Broad-Spectrum Antibiotics on Bacterial Translocation or Hepatic and Systemic Inflammation","volume":"12","author":"Stoy","year":"2021","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1001\/jama.2023.4902","article-title":"Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis: A Randomized Clinical Trial","volume":"329","author":"Louvet","year":"2023","journal-title":"JAMA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"747","DOI":"10.4014\/jmb.2312.12031","article-title":"Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome","volume":"34","author":"Chae","year":"2024","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"127292","DOI":"10.1016\/j.micres.2022.127292","article-title":"Acute sleep deprivation exacerbates systemic inflammation and psychiatry disorders through gut microbiota dysbiosis and disruption of circadian rhythms","volume":"268","author":"Yang","year":"2023","journal-title":"Microbiol. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2447824","DOI":"10.1080\/19490976.2024.2447824","article-title":"Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner","volume":"17","author":"Qing","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_123","first-page":"178","article-title":"Current Management and Future Treatment of Alcoholic Hepatitis","volume":"16","author":"Mitchell","year":"2020","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.tem.2022.01.002","article-title":"Gut barrier disruption and chronic disease","volume":"33","author":"Martel","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1093\/eurheartj\/ehae362","article-title":"Alcoholic cardiomyopathy: An update","volume":"45","author":"Dominguez","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41569-023-00839-5","article-title":"The role of aldehyde dehydrogenase 2 in cardiovascular disease","volume":"20","author":"Zhang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/acer.14811","article-title":"Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice","volume":"46","author":"Hu","year":"2022","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.echo.2016.07.014","article-title":"Light to Moderate Habitual Alcohol Consumption Is Associated with Subclinical Ventricular and Left Atrial Mechanical Dysfunction in an Asymptomatic Population: Dose-Response and Propensity Analysis","volume":"29","author":"Hung","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000510863","article-title":"Schisandrin B Protects against Acute Ethanol-Induced Cardiac Injury by Downregulating Autophagy via the NOX4\/ROS Pathway","volume":"106","author":"Tao","year":"2021","journal-title":"Pharmacology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1111\/acer.12459","article-title":"Acute alcohol modulates cardiac function as PI3K\/Akt regulates oxidative stress","volume":"38","author":"Umoh","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_131","unstructured":"Jain, A., Yelamanchili, V.S., Brown, K.N., and Goel, A. (2025). Holiday Heart Syndrome. StatPearls, StatPearls Publishing."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.alcohol.2018.08.006","article-title":"Alcohol-induced mitochondrial DNA damage promotes injurious crosstalk between alveolar epithelial cells and alveolar macrophages","volume":"80","author":"Sadikot","year":"2019","journal-title":"Alcohol"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3A","DOI":"10.1016\/S0735-1097(86)80023-7","article-title":"Alcoholic cardiomyopathy and sudden cardiac death","volume":"8","author":"Vikhert","year":"1986","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e70714","DOI":"10.1111\/jcmm.70714","article-title":"Astaxanthin Prevented Acute Alcoholic Cardiomyopathy by Maintenance of Mitophagy-Mediated Mitochondrial Homeostasis","volume":"29","author":"Fan","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"130245","DOI":"10.1016\/j.bbagen.2022.130245","article-title":"Deficiency in Beclin1 attenuates alcohol-induced cardiac dysfunction via inhibition of ferroptosis","volume":"1866","author":"Liu","year":"2022","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1053\/j.jrn.2019.01.011","article-title":"Alcohol Consumption and Incident Kidney Disease: Results From the Atherosclerosis Risk in Communities Study","volume":"30","author":"Hu","year":"2020","journal-title":"J. Ren. Nutr."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.mayocp.2019.06.014","article-title":"Alcohol Consumption and Progression of Chronic Kidney Disease: Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease","volume":"95","author":"Joo","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/labinvest.2014.71","article-title":"Tumor necrosis factor-\u03b1-induced reduction of glomerular filtration rate in rats with fulminant hepatic failure","volume":"94","author":"Wang","year":"2014","journal-title":"Lab. Investig."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e14273","DOI":"10.14814\/phy2.14273","article-title":"Periconceptional ethanol exposure induces a sex specific diuresis and increase in AQP2 and AVPR2 in the kidneys of aged rat offspring","volume":"7","author":"Dorey","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.euroneuro.2008.10.005","article-title":"Serum creatine kinase activity differentiates alcohol syndromes of dependence, withdrawal and delirium tremens","volume":"19","author":"Segal","year":"2009","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"199","DOI":"10.35946\/arcr.v37.2.05","article-title":"Alcohol\u2019s Effects on Lung Health and Immunity","volume":"37","author":"Simet","year":"2015","journal-title":"Alcohol Res."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Santilli, A., Shapiro, D., Han, Y., Sangwan, N., and Cresci, G.A.M. (2024). Tributyrin Supplementation Rescues Chronic-Binge Ethanol-Induced Oxidative Stress in the Gut-Lung Axis in Mice. Antioxidants, 13.","DOI":"10.3390\/antiox13040472"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-3-319-09614-8_5","article-title":"Implications of acetaldehyde-derived DNA adducts for understanding alcohol-related carcinogenesis","volume":"Volume 815","author":"Balbo","year":"2015","journal-title":"Biological Basis of Alcohol-Induced Cancer; Advances in Experimental Medicine and Biology"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Baldari, S., Di Modugno, F., Nistico, P., and Toietta, G. (2022). Strategies for Efficient Targeting of Tumor Collagen for Cancer Therapy. Cancers, 14.","DOI":"10.3390\/cancers14194706"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neuropharm.2004.06.032","article-title":"Dopamine and drug addiction: The nucleus accumbens shell connection","volume":"47","author":"Bassareo","year":"2004","journal-title":"Neuropharmacology"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/acer.12709","article-title":"The \u201cfirst hit\u201d toward alcohol reinforcement: Role of ethanol metabolites","volume":"39","author":"Israel","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: A neurocircuitry analysis","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Dharavath, R.N., Pina-Leblanc, C., Tang, V.M., Sloan, M.E., Nikolova, Y.S., Pangarov, P., Ruocco, A.C., Shield, K., Voineskos, D., and Blumberger, D.M. (2023). GABAergic signaling in alcohol use disorder and withdrawal: Pathological involvement and therapeutic potential. Front. Neural Circuits, 17.","DOI":"10.3389\/fncir.2023.1218737"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pneurobio.2018.10.001","article-title":"Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence","volume":"171","author":"Alasmari","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/7854_2017_2","article-title":"Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol","volume":"Volume 39","author":"Allen","year":"2018","journal-title":"The Behavioral Neuroscience of Drug Discrimination; Current Topics in Behavioral Neurosciences"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/FBP.0000000000000606","article-title":"The role of opioidergic system in modulating cost\/benefit decision-making in alcohol-preferring AA rats and Wistar rats","volume":"32","author":"Oinio","year":"2021","journal-title":"Behav. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.alcohol.2025.08.004","article-title":"A conceptual framework for the intersection of hyperalgesia and hyperkatifeia in alcohol addiction","volume":"129","author":"Koob","year":"2025","journal-title":"Alcohol"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1038\/ncomms2682","article-title":"Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel","volume":"4","author":"Sauguet","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1007\/s11064-014-1243-0","article-title":"Alcohol selectivity of \u03b23-containing GABAA receptors: Evidence for a unique extracellular alcohol\/imidazobenzodiazepine Ro15-4513 binding site at the \u03b1+\u03b2\u2212 Subunit interface in \u03b1\u03b23\u03b4 GABAA receptors","volume":"39","author":"Wallner","year":"2014","journal-title":"Neurochem. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1073\/pnas.0437926100","article-title":"Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons","volume":"100","author":"Roberto","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1136\/bmj.1.4825.1450-c","article-title":"Antabuse addiction","volume":"1","author":"Chevens","year":"1953","journal-title":"Br. Med. J."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.167.3926.1749","article-title":"Alkaloids from catecholamines in adrenal tissue: Possible role in alcoholism","volume":"167","author":"Cohen","year":"1970","journal-title":"Science"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.167.3920.1005","article-title":"Alcohol, amines, and alkaloids: A possible biochemical basis for alcohol addiction","volume":"167","author":"Davis","year":"1970","journal-title":"Science"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neubiorev.2011.07.009","article-title":"Piecing together the puzzle of acetaldehyde as a neuroactive agent","volume":"36","author":"Correa","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neubiorev.2011.07.007","article-title":"Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: Old and new vistas","volume":"36","author":"Hipolito","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Peana, A.T., and Acquas, E. (2013). Behavioral and biochemical evidence of the role of acetaldehyde in the motivational effects of ethanol. Front. Behav. Neurosci., 7.","DOI":"10.3389\/fnbeh.2013.00086"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Peana, A.T., Sanchez-Catalan, M.J., Hipolito, L., Rosas, M., Porru, S., Bennardini, F., Romualdi, P., Caputi, F.F., Candeletti, S., and Polache, A. (2017). Mystic Acetaldehyde: The Never-Ending Story on Alcoholism. Front. Behav. Neurosci., 11.","DOI":"10.3389\/fnbeh.2017.00081"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Polache, A., and Granero, L. (2013). Salsolinol and ethanol-derived excitation of dopamine mesolimbic neurons: New insights. Front. Behav. Neurosci., 7.","DOI":"10.3389\/fnbeh.2013.00074"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1471-4159.1974.tb04380.x","article-title":"The acetaldehyde content in rat brain during ethanol metabolism","volume":"23","author":"Sippel","year":"1974","journal-title":"J. Neurochem."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0006-2952(76)90094-0","article-title":"Brain acetaldehyde after ethanol administration","volume":"25","author":"Tabakoff","year":"1976","journal-title":"Biochem. Pharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pneurobio.2005.03.003","article-title":"The role of acetaldehyde in the neurobehavioral effects of ethanol: A comprehensive review of animal studies","volume":"75","author":"Quertemont","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1874473710801010003","article-title":"Putative role of brain acetaldehyde in ethanol addiction","volume":"1","author":"Deng","year":"2008","journal-title":"Curr. Drug Abus. Rev."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-3-642-28720-6_198","article-title":"What is in that drink: The biological actions of ethanol, acetaldehyde, and salsolinol","volume":"Volume 13","author":"Deehan","year":"2013","journal-title":"Behavioral Neurobiology of Alcohol Addiction; Current Topics in Behavioral Neurosciences"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Enrico, P., and Diana, M. (2017). On the Accuracy of In Vivo Ethanol and Acetaldehyde Monitoring, a Key Tile in the Puzzle of Acetaldehyde as a Neuroactive Agent. Front. Behav. Neurosci., 11.","DOI":"10.3389\/fnbeh.2017.00097"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"re7","DOI":"10.1126\/scisignal.128re7","article-title":"Ethanol\u2019s molecular targets","volume":"1","author":"Harris","year":"2008","journal-title":"Sci. Signal."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/alcalc\/agg056","article-title":"In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis","volume":"38","author":"Jamal","year":"2003","journal-title":"Alcohol Alcohol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1111\/acer.70126","article-title":"High-throughput quantitation of acetaldehyde and ethanol in mice using gas chromatography\/mass spectrometry positive chemical ionization","volume":"49","author":"Lin","year":"2025","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1111\/acer.13156","article-title":"Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC-MS","volume":"40","author":"Heit","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.brainresbull.2003.09.013","article-title":"Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate","volume":"62","author":"Correa","year":"2003","journal-title":"Brain Res. Bull."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s00213-004-1911-x","article-title":"Behavioral characterization of acetaldehyde in C57BL\/6J mice: Locomotor, hypnotic, anxiolytic and amnesic effects","volume":"177","author":"Quertemont","year":"2004","journal-title":"Psychopharmacology"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"257","DOI":"10.15288\/jsa.2002.63.257","article-title":"Effect of acetaldehyde on acute tolerance and ethanol consumption in drinker and nondrinker rats","volume":"63","author":"Tampier","year":"2002","journal-title":"J. Stud. Alcohol"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1111\/j.1460-9568.2007.05887.x","article-title":"Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system","volume":"26","author":"Melis","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1530-0277.2009.00907.x","article-title":"Ethanol-induced extracellular signal regulated kinase: Role of dopamine D1 receptors","volume":"33","author":"Ibba","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/syn.20811","article-title":"Acetaldehyde elicits ERK phosphorylation in the rat nucleus accumbens and extended amygdala","volume":"64","author":"Vinci","year":"2010","journal-title":"Synapse"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/oxfordjournals.alcalc.a008128","article-title":"Distribution of catalase in rat brain: Aminergic neurons as possible targets for ethanol effects","volume":"31","author":"Zimatkin","year":"1996","journal-title":"Alcohol Alcohol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1111\/j.1530-0277.1998.tb03958.x","article-title":"Distribution and kinetics of ethanol metabolism in rat brain","volume":"22","author":"Zimatkin","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0741-8329(85)90074-6","article-title":"A correlation between voluntary ethanol consumption and brain catalase activity in the rat","volume":"2","author":"Aragon","year":"1985","journal-title":"Alcohol"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0028-3908(92)90150-N","article-title":"The effect of 3-amino-1,2,4-triazole on voluntary ethanol consumption: Evidence for brain catalase involvement in the mechanism of action","volume":"31","author":"Aragon","year":"1992","journal-title":"Neuropharmacology"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/0024-3205(85)90579-X","article-title":"Blockade of ethanol induced conditioned taste aversion by 3-amino-1,2,4-triazole: Evidence for catalase mediated synthesis of acetaldehyde in rat brain","volume":"37","author":"Aragon","year":"1985","journal-title":"Life Sci."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-2952(92)90042-H","article-title":"Ethanol metabolism in rat brain homogenates by a catalase-H2O2 system","volume":"44","author":"Aragon","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0091-3057(91)90397-K","article-title":"Effect of 3-amino-1,2,4-triazole on ethanol-induced narcosis, lethality and hypothermia in rats","volume":"39","author":"Aragon","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/13556219772570","article-title":"Catalase and the production of brain acetaldehyde: A possible mediator of the psychopharmacological effects of ethanol","volume":"2","author":"Smith","year":"1997","journal-title":"Addict. Biol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1530-0277.2011.01606.x","article-title":"Reward and relapse: Complete gene-induced dissociation in an animal model of alcohol dependence","volume":"36","author":"Quintanilla","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1530-0277.2011.01439.x","article-title":"Ethanol as a prodrug: Brain metabolism of ethanol mediates its reinforcing effects","volume":"35","author":"Karahanian","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/acer.12101","article-title":"The alcohol deprivation effect: Marked inhibition by anticatalase gene administration into the ventral tegmental area in rats","volume":"37","author":"Tampier","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0741-8329(96)00006-7","article-title":"The regulation of alcohol consumption in rats: The role of alcohol-metabolizing enzymes\u2014Catalase and aldehyde dehydrogenase","volume":"13","author":"Gill","year":"1996","journal-title":"Alcohol"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/978-1-4615-7718-8_22","article-title":"Acetaldehyde and its condensation products as markers in alcoholism","volume":"Volume 6","author":"Collins","year":"1988","journal-title":"Recent Developments in Alcoholism"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/2271143a0","article-title":"Salsolinol, an alkaloid derivative of dopamine formed in vitro during alcohol metabolism","volume":"227","author":"Yamanaka","year":"1970","journal-title":"Nature"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0024-3205(75)80004-X","article-title":"Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication","volume":"16","author":"Collins","year":"1975","journal-title":"Life Sci."},{"key":"ref_195","first-page":"366","article-title":"Involvement of \u03bc-opioid receptor in the salsolinol-associated place preference in rats exposed to conditioned fear stress","volume":"24","author":"Matsuzawa","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.alcohol.2014.07.003","article-title":"Salsolinol, free of isosalsolinol, exerts ethanol-like motivational\/sensitization effects leading to increases in ethanol intake","volume":"48","author":"Quintanilla","year":"2014","journal-title":"Alcohol"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/0024-3205(79)90093-6","article-title":"Opiate-like activity of salsolinol on the electrically stimulated guinea pig ileum","volume":"25","author":"Hamilton","year":"1979","journal-title":"Life Sci."},{"key":"ref_198","first-page":"3","article-title":"Opiate receptor binding and analgesic effects of the tetrahydroisoquinolines salsolinol and tetrahydropapaveroline","volume":"27","author":"Fertel","year":"1980","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0006-8993(82)90297-9","article-title":"Action of ethanol and salsolinol on opiate receptor function","volume":"232","author":"Lucchi","year":"1982","journal-title":"Brain Res."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0014-2999(81)90194-1","article-title":"Tetrahydroisoquinolines (TIQs) do not act on opiate receptors in the guinea-pig ileum","volume":"71","author":"North","year":"1981","journal-title":"Eur. J. Pharmacol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0006-8993(81)90876-3","article-title":"Rat brain salsolinol and blood-brain barrier","volume":"224","author":"Origitano","year":"1981","journal-title":"Brain Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-009-1751-9","article-title":"Locomotor stimulant effects of acute and repeated intrategmental injections of salsolinol in rats: Role of \u03bc-opioid receptors","volume":"209","author":"Hipolito","year":"2010","journal-title":"Psychopharmacology"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.neuint.2011.04.014","article-title":"Induction of conditioned place preference and dopamine release by salsolinol in posterior VTA of rats: Involvement of \u03bc-opioid receptors","volume":"59","author":"Hipolito","year":"2011","journal-title":"Neurochem. Int."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/acer.12034","article-title":"Microinjections of acetaldehyde or salsolinol into the posterior ventral tegmental area increase dopamine release in the nucleus accumbens shell","volume":"37","author":"Deehan","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1124\/jpet.111.186833","article-title":"Salsolinol stimulates dopamine neurons in slices of posterior ventral tegmental area indirectly by activating \u03bc-opioid receptors","volume":"341","author":"Xie","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/cbdd.13523","article-title":"Molecular modeling of salsolinol, a full Gi protein agonist of the \u03bc-opioid receptor, within the receptor binding site","volume":"94","year":"2019","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1530-0277.2007.00572.x","article-title":"The reinforcing properties of salsolinol in the ventral tegmental area: Evidence for regional heterogeneity and the involvement of serotonin and dopamine","volume":"32","author":"Rodd","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Berrios-Carcamo, P., Quintanilla, M.E., Herrera-Marschitz, M., Vasiliou, V., Zapata-Torres, G., and Rivera-Meza, M. (2016). Racemic Salsolinol and its Enantiomers Act as Agonists of the \u03bc-Opioid Receptor by Activating the Gi Protein-Adenylate Cyclase Pathway. Front. Behav. Neurosci., 10.","DOI":"10.3389\/fnbeh.2016.00253"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00204-006-0131-z","article-title":"Effect of direct infusion of acetaldehyde on dopamine and dopamine-derived salsolinol in the striatum of free-moving rats using a reverse microdialysis technique","volume":"81","author":"Wang","year":"2007","journal-title":"Arch. Toxicol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/adb.12097","article-title":"Key role of salsolinol in ethanol actions on dopamine neuronal activity of the posterior ventral tegmental area","volume":"20","author":"Melis","year":"2015","journal-title":"Addict. Biol."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Bassareo, V., Frau, R., Maccioni, R., Caboni, P., Manis, C., Peana, A.T., Migheli, R., Porru, S., and Acquas, E. (2021). Ethanol-Dependent Synthesis of Salsolinol in the Posterior Ventral Tegmental Area as Key Mechanism of Ethanol\u2019s Action on Mesolimbic Dopamine. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.675061"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41398-024-03112-6","article-title":"Receptor and metabolic insights on the ability of caffeine to prevent alcohol-induced stimulation of mesolimbic dopamine transmission","volume":"14","author":"Bassareo","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Teixeira, F.B., Santana, L.N., Bezerra, F.R., De Carvalho, S., Fontes-Junior, E.A., Prediger, R.D., Crespo-Lopez, M.E., Maia, C.S., and Lima, R.R. (2014). Chronic ethanol exposure during adolescence in rats induces motor impairments and cerebral cortex damage associated with oxidative stress. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101074"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12974-020-01972-5","article-title":"Chronic alcohol-induced neuroinflammation involves CCR2\/5-dependent peripheral macrophage infiltration and microglia alterations","volume":"17","author":"Lowe","year":"2020","journal-title":"J. Neuroinflam."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: The devil is in the details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Teleanu, D.M., Niculescu, A.G., Lungu, I.I., Radu, C.I., Vladacenco, O., Roza, E., Costachescu, B., Grumezescu, A.M., and Teleanu, R.I. (2022). An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115938"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.toxlet.2017.11.002","article-title":"Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity","volume":"283","author":"Henriques","year":"2018","journal-title":"Toxicol. Lett."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biopsych.2025.04.013","article-title":"Astrocytes and Alcohol Throughout the Lifespan","volume":"99","author":"Guizzetti","year":"2026","journal-title":"Biol. Psychiatry"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1089\/ars.2013.5745","article-title":"Redox control of microglial function: Molecular mechanisms and functional significance","volume":"21","author":"Rojo","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Simpson, D.S.A., and Oliver, P.L. (2020). ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9080743"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"176048","DOI":"10.1016\/j.ejphar.2023.176048","article-title":"The \u201cmolecular soldiers\u201d of the CNS: Astrocytes, a comprehensive review on their roles and molecular signatures","volume":"959","author":"Rupareliya","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1574884713666180228110310","article-title":"Minocycline in Alcohol Withdrawal Induced Anxiety and Alcohol Relapse in Rats","volume":"13","author":"Gajbhiye","year":"2018","journal-title":"Curr. Clin. Pharmacol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.expneurol.2007.11.017","article-title":"Increased MCP-1 and microglia in various regions of the human alcoholic brain","volume":"210","author":"He","year":"2008","journal-title":"Exp. Neurol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0165-5728(98)00183-0","article-title":"Astrocyte expression of monocyte chemoattractant protein-1 is differentially regulated by transforming growth factor \u03b2","volume":"91","author":"Weiss","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/acer.12367","article-title":"Cerebrospinal fluid monocyte chemoattractant protein-1 in alcoholics: Support for a neuroinflammatory model of chronic alcoholism","volume":"38","author":"Umhau","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/npp.2015.4","article-title":"CRF-amplified neuronal TLR4\/MCP-1 signaling regulates alcohol self-administration","volume":"40","author":"June","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"fcab154","DOI":"10.1093\/braincomms\/fcab154","article-title":"Role of inflammation in alcohol-related brain abnormalities: A translational study","volume":"3","author":"Lanquetin","year":"2021","journal-title":"Brain Commun."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/acer.13416","article-title":"Nalmefene Prevents Alcohol-Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4","volume":"41","author":"Montesinos","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"kyaf008","DOI":"10.1093\/discim\/kyaf008","article-title":"Inflammation\u2019s impact on the interaction between oligodendrocytes and axons","volume":"4","author":"Green","year":"2025","journal-title":"Discov. Immunol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ibneur.2024.06.006","article-title":"Effects of adolescent alcohol exposure on oligodendrocyte lineage cells and myelination in mice: Age and subregion differences","volume":"17","author":"Huang","year":"2024","journal-title":"IBRO Neurosci. Rep."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/glia.23164","article-title":"Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder","volume":"65","author":"Newville","year":"2017","journal-title":"Glia"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"14777","DOI":"10.1523\/JNEUROSCI.3189-13.2014","article-title":"Alcohol binge drinking during adolescence or dependence during adulthood reduces prefrontal myelin in male rats","volume":"34","author":"Vargas","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Guo, F., Zhang, Y.F., Liu, K., Huang, X., Li, R.X., Wang, S.Y., Wang, F., Xiao, L., Mei, F., and Li, T. (2021). Chronic Exposure to Alcohol Inhibits New Myelin Generation in Adult Mouse Brain. Front. Cell. Neurosci., 15.","DOI":"10.3389\/fncel.2021.732602"},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Lorrai, I., Maccioni, R., Wu, C., Shankula, C., Marquez-Gaytan, J., Torres, I., Puliga, R., Repunte-Canonigo, V., and Sanna, P.P. (2025). Sphingosine-1-phosphate (S1P) signaling as a novel therapeutic target for alcohol abuse. bioRxiv.","DOI":"10.1101\/2025.11.15.688635"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/14656566.2024.2360653","article-title":"Promising immunomodulators for management of substance and alcohol use disorders","volume":"25","author":"Acuna","year":"2024","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Tsermpini, E.E., Iljes, A.P., and Dolzan, V. (2022). Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review. Antioxidants, 11.","DOI":"10.3390\/antiox11071374"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1007\/s00213-019-05205-3","article-title":"Targeting neuroinflammation with minocycline in heavy drinkers","volume":"236","author":"Petrakis","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Squeglia, L.M., Tomko, R.L., Baker, N.L., Kirkland, A.E., McClure, E.A., and Gray, K.M. (2025). A Randomized Controlled Trial of N-acetylcysteine for Adolescent and Young Adult Alcohol Use Disorder. J. Am. Acad. Child Adolesc. Psychiatry, in press.","DOI":"10.1016\/j.jaac.2025.09.025"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.2174\/092986711803414368","article-title":"Antioxidant therapy: Current status and future prospects","volume":"18","author":"Firuzi","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Altanam, S.Y., Darwish, N., and Bakillah, A. (2025). Exploring the Interplay of Antioxidants, Inflammation, and Oxidative Stress: Mechanisms, Therapeutic Potential, and Clinical Implications. Diseases, 13.","DOI":"10.3390\/diseases13090309"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"ENEURO.0456-22.2023","DOI":"10.1523\/ENEURO.0456-22.2023","article-title":"A History of Repeated Alcohol Intoxication Promotes Cognitive Impairment and Gene Expression Signatures of Disease Progression in the 3xTg Mouse Model of Alzheimer\u2019s Disease","volume":"10","author":"Sanna","year":"2023","journal-title":"eNeuro"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12974-025-03501-8","article-title":"Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer\u2019s disease associated with inflammasome activation and ASC speck propagation","volume":"22","author":"Brezani","year":"2025","journal-title":"J. Neuroinflamm."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Chandrashekar, D.V., Steinberg, R.A., Han, D., and Sumbria, R.K. (2023). Alcohol as a Modifiable Risk Factor for Alzheimer\u2019s Disease-Evidence from Experimental Studies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119492"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1016\/S2468-2667(18)30022-7","article-title":"Contribution of alcohol use disorders to the burden of dementia in France 2008\u201313: A nationwide retrospective cohort study","volume":"3","author":"Schwarzinger","year":"2018","journal-title":"Lancet Public Health"},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Beydoun, M.A., Beydoun, H.A., Gamaldo, A.A., Teel, A., Zonderman, A.B., and Wang, Y. (2014). Epidemiologic studies of modifiable factors associated with cognition and dementia: Systematic review and meta-analysis. BMC Public Health, 14.","DOI":"10.1186\/1471-2458-14-643"},{"key":"ref_246","first-page":"e12370","article-title":"Alcohol use disorder is associated with higher risks of Alzheimer\u2019s and Parkinson\u2019s diseases: A study of US insurance claims data","volume":"14","author":"Zhang","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41398-025-03619-6","article-title":"Alcohol addiction and Alzheimer\u2019s disease: A molecular collision course","volume":"15","author":"Chang","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"ENEURO.0118-24.2024","DOI":"10.1523\/ENEURO.0118-24.2024","article-title":"Transcriptional Patterns in Stages of Alzheimer\u2019s Disease Are Cell-Type-Specific and Partially Converge with the Effects of Alcohol Use Disorder in Humans","volume":"11","author":"Joshi","year":"2024","journal-title":"eNeuro"},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Song, H., Lee, J., Lee, Y., Kim, S., and Kang, S. (2025). Reactive Oxygen Species as a Common Pathological Link Between Alcohol Use Disorder and Alzheimer\u2019s Disease with Therapeutic Implications. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26073272"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: Recent advances","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1053\/gast.2002.33613","article-title":"Alcohol and mitochondria: A dysfunctional relationship","volume":"122","author":"Hoek","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Shang, P., Lindberg, D., Starski, P., Peyton, L., Hong, S.I., Choi, S., and Choi, D.S. (2020). Chronic Alcohol Exposure Induces Aberrant Mitochondrial Morphology and Inhibits Respiratory Capacity in the Medial Prefrontal Cortex of Mice. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.561173"},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Liu, Z., Liu, Y., Gao, R., Li, H., Dunn, T., Wu, P., Smith, R.G., Sarkar, P.S., and Fang, X. (2014). Ethanol suppresses PGC-1\u03b1 expression by interfering with the cAMP-CREB pathway in neuronal cells. PLoS ONE, 9, Erratum in PLoS ONE 2014, 9, e108118.","DOI":"10.1371\/journal.pone.0108118"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2008.03.005","article-title":"Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1\u03b1 in rats","volume":"370","author":"Lieber","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/advan.00052.2006","article-title":"PGC-1\u03b1: A key regulator of energy metabolism","volume":"30","author":"Liang","year":"2006","journal-title":"Adv. Physiol. Educ."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0022-3565(24)29435-0","article-title":"Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: Protective effects of antioxidants","volume":"298","author":"Mansouri","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_257","first-page":"73","article-title":"The effect of chronic alcohol consumption on mitochondrial DNA mutagenesis in human blood","volume":"637","author":"Ringleb","year":"2008","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"ref_258","first-page":"a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Frosch","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/WNR.0000000000001661","article-title":"IL-6 and IL-1\u03b2 upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus","volume":"32","author":"Jiang","year":"2021","journal-title":"Neuroreport"},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Bartolome, F., Carro, E., and Alquezar, C. (2022). Oxidative Stress in Tauopathies: From Cause to Therapy. Antioxidants, 11.","DOI":"10.3390\/antiox11081421"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.freeradbiomed.2010.09.013","article-title":"Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for A\u03b2 accumulation in AD brain","volume":"49","author":"Owen","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0014-5793(00)02323-1","article-title":"Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal","volume":"486","author":"Perez","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.freeradbiomed.2004.11.005","article-title":"Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations","volume":"38","author":"Liu","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jnr.10525","article-title":"Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells","volume":"71","author":"Smith","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.nbd.2015.06.013","article-title":"Oxidative stress and lipid peroxidation are upstream of amyloid pathology","volume":"84","author":"Arimon","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1021\/acschemneuro.3c00486","article-title":"Oxidative Stress Occurs Prior to Amyloid A\u03b2 Plaque Formation and Tau Phosphorylation in Alzheimer\u2019s Disease: Role of Glutathione and Metal Ions","volume":"14","author":"Roy","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"100973","DOI":"10.1016\/j.mam.2021.100973","article-title":"Autophagy in liver diseases: A review","volume":"82","author":"Qian","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12929-023-00975-7","article-title":"Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis","volume":"30","author":"Liu","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"e0534","DOI":"10.1097\/HC9.0000000000000534","article-title":"Mitochondrial quality control in alcohol-associated liver disease","volume":"8","author":"Thoudam","year":"2024","journal-title":"Hepatol. Commun."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/jcp.25934","article-title":"Acute ethanol exposure-induced autophagy-mediated cardiac injury via activation of the ROS-JNK-Bcl-2 pathway","volume":"233","author":"Zhu","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Ruiter-Lopez, L., Khan, M.A.S., Wang, X., and Song, B.J. (2025). Roles of Oxidative Stress and Autophagy in Alcohol-Mediated Brain Damage. Antioxidants, 14.","DOI":"10.3390\/antiox14030302"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/2\/216\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:31:07Z","timestamp":1770726667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/2\/216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":271,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["antiox15020216"],"URL":"https:\/\/doi.org\/10.3390\/antiox15020216","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]}}}