{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:44:36Z","timestamp":1790876676983,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Federal Ministry for Education and Research","award":["BMBF 01EO1503"],"award-info":[{"award-number":["BMBF 01EO1503"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KA 4035\/1-1"],"award-info":[{"award-number":["KA 4035\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008454","name":"Boehringer Ingelheim Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008454","id-type":"DOI","asserted-by":"crossref"}]},{"name":"DFG","award":["WE4361\/14-1"],"award-info":[{"award-number":["WE4361\/14-1"]}]},{"DOI":"10.13039\/100010447","name":"DZHK","doi-asserted-by":"crossref","award":["FKZ 81X3210105"],"award-info":[{"award-number":["FKZ 81X3210105"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003042","name":"Else Kroner-Fresenius Foundation","doi-asserted-by":"crossref","award":["2021_2020_EKEA.14"],"award-info":[{"award-number":["2021_2020_EKEA.14"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Introduction: The pro-inflammatory cytokine interleukin-17A (IL-17A) has a key role in the inflammatory cascade and promotes vascular inflammation and dysfunction. In addition, IL-17A is centrally involved in several autoimmune diseases. IL-17A deficiency has been linked to reduced vascular inflammation associated with attenuated arterial hypertension under long-term angiotensin II (Ang II) exposure for four weeks. This is of interest as IL-17A is one factor linking several autoimmune diseases with cardiovascular comorbidity. So far, little is known about the effects of IL-17A during the early stages of vascular dysfunction development\u2014an interval possibly representing an optimal therapeutic window. Methods: Mice lacking the IL-17A receptor alpha (IL-17RAdel) and wild-type counterparts were treated with Ang II for one week (1 mg\/kg bodyweight\/week). We assessed systemic oxidative stress formation and vascular function, as well as inflammatory cells in the vessel wall. In parallel, C57BL\/6J mice treated with Ang II received anti-IL-17A therapy, to evaluate the same parameters. Results: Both IL-17RA-deficient mice and anti-IL-17A-treated C57BL\/6J mice exhibited an attenuated oxidative stress response and mitigated vascular inflammation following one week of Ang II treatment. These effects did not significantly prevent the onset of Ang II-induced vascular dysfunction at that timepoint. Conclusions: After one week of Ang II treatment, antagonizing IL-17RA or IL-17A only partially reduced\/attenuated the Ang II-induced effects on the vasculature. In the context of IL-17A-driven autoimmune diseases with associated vascular pathology, our findings suggest that anti-inflammatory therapies alone may not be sufficient to attenuate vascular impairment. A combined approach including agents with direct protective vascular effects may be required for effective intervention for the associated vascular comorbidity.<\/jats:p>","DOI":"10.3390\/antiox15020229","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:07:06Z","timestamp":1770725226000},"page":"229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antagonizing IL-17A Reduces Vascular Inflammation and Attenuates Oxidative Stress Formation but Does Not Significantly Improve Vascular Dysfunction Induced by One Week of Angiotensin II Treatment"],"prefix":"10.3390","volume":"15","author":[{"given":"Rebecca","family":"Jung","sequence":"first","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4127-269X","authenticated-orcid":false,"given":"Annika","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Knopp","sequence":"additional","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Molitor","sequence":"additional","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Perius","sequence":"additional","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-7095","authenticated-orcid":false,"given":"Jens","family":"Posma","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata","family":"Garlapati","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-4150","authenticated-orcid":false,"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"German Center for Cardiovascular Research, Partner Site Rhine-Main, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-0094","authenticated-orcid":false,"given":"Andreas","family":"Daiber","sequence":"additional","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"German Center for Cardiovascular Research, Partner Site Rhine-Main, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Lurz","sequence":"additional","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"German Center for Cardiovascular Research, Partner Site Rhine-Main, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-2781","authenticated-orcid":false,"given":"Philip","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"German Center for Cardiovascular Research, Partner Site Rhine-Main, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Waisman","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Wild","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Department of Internal Medicine and Nephrology, University Hospital Marburg, 35033 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4462-3747","authenticated-orcid":false,"given":"Susanne Helena","family":"Karbach","sequence":"additional","affiliation":[{"name":"Center for Cardiology\u2014Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, 55131 Mainz, 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