{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:02:42Z","timestamp":1771048962364,"version":"3.50.1"},"reference-count":81,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["MOST 110-2320-B-039-051-MY3"],"award-info":[{"award-number":["MOST 110-2320-B-039-051-MY3"]}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU112-MF-74"],"award-info":[{"award-number":["CMU112-MF-74"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU113-MF-73"],"award-info":[{"award-number":["CMU113-MF-73"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Coffee-derived materials from diverse botanical sources (beans, leaves, fruit and spent grounds) contain bioactive polyphenolic compounds, alkaloids, and diterpenes with potential dermatological applications. This review critically evaluates evidence quality across study designs. In vitro studies demonstrate antioxidant, anti-aging, anti-inflammatory, photoprotective, wound-healing, and antimicrobial activities. Animal models show photoprotection and wound-healing effects. These studies highlight the multifunctional dermatological value of coffee-derived materials as ingredients for cosmetic and therapeutic formulations aimed at combating skin aging, inflammation, and barrier dysfunction. Limited human trials (typically small sample sizes and short duration) report modest improvements in skin hydration, elasticity, barrier function, and reductions in erythema, transepidermal water loss, and ultraviolet-induced damage, though methodological limitations constrain interpretation. Observational epidemiological studies report inverse associations between coffee consumption and melanoma\/basal cell carcinoma risk, but residual confounding by sun exposure, lifestyle factors, and genetic susceptibility precludes causal inference. Critical translational barriers include insufficient pharmacokinetic characterization, inadequate extract standardization across sources and processing methods, formulation challenges, bioavailability uncertainties, and limited independent validation. While preclinical evidence supports diverse biological activities and suggests multifunctional potential for cosmetic and therapeutic applications, current evidence remains insufficient to recommend coffee-derived products as a primary evidence-based dermatological intervention. Overall, large-scale, independent clinical trials with adequate duration and clinically meaningful endpoints are essential for translating laboratory findings into validated clinical applications.<\/jats:p>","DOI":"10.3390\/antiox15020244","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:28:11Z","timestamp":1770910091000},"page":"244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Dermatological Benefits of Coffee Extracts and Their Derivatives"],"prefix":"10.3390","volume":"15","author":[{"given":"Hsiao-Fang","family":"Liao","sequence":"first","affiliation":[{"name":"Ph.D. Program for Biotechnology Industry, College of Life Science, China Medical University, Taichung 406040, Taiwan"},{"name":"Department of Cosmeceutics, School of Pharmacy, China Medical University, Taichung 406040, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, China Medical University Hospital, Taichung 404327, Taiwan"},{"name":"School of Medicine, China Medical University, Taichung 404333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Ching","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, School of Pharmacy, China Medical University, Taichung 406040, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsen-Jung","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Medical University, Taichung 406040, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Lung","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Safety Health and Environmental Engineering, National Yunlin University of Science and Technology, Yunlin 604301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-910X","authenticated-orcid":false,"given":"Hsiu-Mei","family":"Chiang","sequence":"additional","affiliation":[{"name":"Ph.D. Program for Biotechnology Industry, College of Life Science, China Medical University, Taichung 406040, Taiwan"},{"name":"Department of Cosmeceutics, School of Pharmacy, China Medical University, Taichung 406040, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"32577","DOI":"10.1021\/acs.jafc.5c11408","article-title":"Simultaneous Recovery of Mannooligosaccharides and Chlorogenic Acids from Spent Coffee Grounds: Integration of Enzymatic Hydrolysis with Natural Deep Eutectic Solvent Extraction","volume":"73","author":"Ge","year":"2025","journal-title":"J. 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