{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T06:03:02Z","timestamp":1772517782422,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFC2503003"],"award-info":[{"award-number":["2022YFC2503003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guizhou Science and Technology Cooperation Platform Talent Program","award":["GCC [2023]048"],"award-info":[{"award-number":["GCC [2023]048"]}]},{"name":"National Natural Science Foundation of China Youth Fund Project","award":["82405036"],"award-info":[{"award-number":["82405036"]}]},{"name":"Unveiling and Leading Project of the State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine","award":["JBGS-FAMP202304"],"award-info":[{"award-number":["JBGS-FAMP202304"]}]},{"name":"Open Fund of the State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine","award":["112"],"award-info":[{"award-number":["112"]}]},{"name":"Guizhou Provincial Health Commission Science and Technology Fund","award":["gzwkj2024-516"],"award-info":[{"award-number":["gzwkj2024-516"]}]},{"name":"Launch Fund for High-Level Talents at Guizhou Medical University","award":["008"],"award-info":[{"award-number":["008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Fluoride-induced osteoarthritis (F-OA) is a debilitating manifestation of endemic fluorosis, with limited preventive or therapeutic strategies. Rosa roxburghii juice (RRJ), a traditional medicinal\/edible product, has shown protective effects against skeletal fluorosis, yet its active constituents and molecular mechanisms are not fully understood. In this study, an integrated strategy combining bioinformatics analysis, network pharmacology, molecular docking and dynamics simulations, limited proteolysis\u2013mass spectrometry (LiP\u2013MS), and in vitro experiments was employed to systematically elucidate the protective mechanisms of RRJ against F-OA. Forty-four core F-OA-associated genes were identified, with TP53 and the p53 signaling pathway emerging as central regulatory hubs. Quercetin, Epicatechin, Emodin, and Ellagic acid were screened as key bioactive components of RRJ and demonstrated strong binding affinity toward core targets, including TP53. Cellular experiments showed that these compounds significantly attenuated sodium fluoride-induced cellular injury. LiP\u2013MS analysis further revealed widespread protein conformational remodeling following treatment, with TP53 exhibiting pronounced structural sensitivity. Mechanistically, these active compounds mitigated fluoride-induced pathological changes by suppressing p53 mRNA expression and restoring proteasome-mediated p53 degradation. This study provides systematic pharmacological evidence supporting Rosa roxburghii fruit as a promising functional food for the prevention and management of skeletal fluorosis and F-OA.<\/jats:p>","DOI":"10.3390\/antiox15030309","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:55:01Z","timestamp":1772463301000},"page":"309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic Insights into Active Components of Rosa Roxburghii Juice Against Fluoride-Induced Osteoarthritis"],"prefix":"10.3390","volume":"15","author":[{"given":"Youqi","family":"Du","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"The Department of Pharmacology of Materia Medica (The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province and The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability), School of Pharmaceutical Sciences, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"The Key Laboratory of Optimal Utilization of Natural Medicine Resources (The Union Key Laboratory of Guiyang City-Guizhou Medical University), School of Pharmaceutical Sciences, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"Guizhou International Joint Research Center for Druggability Evaluation of Natural Medicines, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youwen","family":"Du","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences Guizhou Medical University, No. 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State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"The Department of Pharmacology of Materia Medica (The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province and The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability), School of Pharmaceutical Sciences, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"The Key Laboratory of Optimal Utilization of Natural Medicine Resources (The Union Key Laboratory of Guiyang City-Guizhou Medical University), School of Pharmaceutical Sciences, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"Guizhou International Joint Research Center for Druggability Evaluation of Natural Medicines, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"The Department of Pharmacology of Materia Medica (The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province and The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability), School of Pharmaceutical Sciences, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"The Key Laboratory of Optimal Utilization of Natural Medicine Resources (The Union Key Laboratory of Guiyang City-Guizhou Medical University), School of Pharmaceutical Sciences, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"Guizhou International Joint Research Center for Druggability Evaluation of Natural Medicines, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianqing","family":"Tian","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"The Department of Pharmacology of Materia Medica (The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province and The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability), School of Pharmaceutical Sciences, Guizhou Medical University, No. 6 Ankang Avenue, Guiyang 561113, China"},{"name":"The Key Laboratory of Optimal Utilization of Natural Medicine Resources (The Union Key Laboratory of Guiyang City-Guizhou Medical University), School 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