{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:48:42Z","timestamp":1774950522544,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This study aims to develop and characterize novel dermatocosmetic formulations designed to hydrate the skin, improve its appearance, reduce wrinkles, and provide antioxidant, anti-ageing, antimicrobial, and anti-inflammatory benefits, along with potential protection against UVA and UVB radiation. The formulations contain the following ingredients: xanthan gum (0.5%), Calendula officinalis oil (5%), Argania spinosa oil (5%), Helianthus annuus oil (5%), liposomes containing a hydroalcoholic extract of pomace from local red or white grapes (2%), an olive oil-based emulsifier (6%), vitamin E (0.5%), cetearyl alcohol (3%), propylene glycol (8%), and purified water (up to 100%). The natural ingredients used in these formulations, i.e., the red or white grape pomace extract from the aforementioned Romanian varieties, the oils of Calendula officinalis, Argania spinosa, and Helianthus annuus, xanthan gum, and the olive oil-based emulsifier (Olliva), promote the concept of \u2018green cosmetics\u2019. The use of liposomes to deliver bioactive substances from hydroalcoholic extracts allows the gradual release of active ingredients into the skin. An alternative for incorporating grape pomace extract into a cream-type matrix involves the use of liposomes. Liposomes loaded with red or white grape pomace extract were prepared using the thin-film hydration technique, followed by ultrasonication and extrusion. The obtained formulations were characterized using bio-physico-chemical analysis procedures in terms of consistency, colour, homogeneity, aroma, pH, stretch, texture, stability, and antioxidant activity\/free radical scavenging capacity, as well as in vitro polyphenol release behaviour. These newly developed dermatocosmetic formulations were the subject of a patent application in Romania.<\/jats:p>","DOI":"10.3390\/antiox15040421","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:45:53Z","timestamp":1774615553000},"page":"421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Grape Pomace Extract-Loaded Liposomes Enriched Cream Formulations for Skincare"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-7732","authenticated-orcid":false,"given":"Cristiana","family":"Radulescu","sequence":"first","affiliation":[{"name":"Faculty of Sciences and Arts, Valahia University of Targoviste, 13 Sinaia Alley, 130004 Targoviste, Romania"},{"name":"Doctoral School Chemical Engineering and Biotechnology, National University of Science and Technology Politehnica of Bucharest, 313 Splaiul Independen\u021bei, 060042 Bucharest, Romania"},{"name":"Academy of Romanian Scientists, 3 Ilfov, 050044 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu Lucian","family":"Olteanu","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Arts, Valahia University of Targoviste, 13 Sinaia Alley, 130004 Targoviste, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona-Daniela","family":"Pavaloiu","sequence":"additional","affiliation":[{"name":"Synthesis of Bioactive Substances and Pharmaceutical Technologies Department, National Institute for Chemical-Pharmaceutical Research and Development\u2014ICCF, 112 Vitan Avenue, 3rd District, 031299 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1028-0822","authenticated-orcid":false,"given":"Fawzia","family":"Sha\u2019at","sequence":"additional","affiliation":[{"name":"Synthesis of Bioactive Substances and Pharmaceutical Technologies Department, National Institute for Chemical-Pharmaceutical Research and Development\u2014ICCF, 112 Vitan Avenue, 3rd District, 031299 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2523-647X","authenticated-orcid":false,"given":"Gabriela","family":"Stanciu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Faculty of Applied Sciences and Engineering, Ovidius University of Constanta, 900527 Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela Nechifor","family":"(Tudorache)","sequence":"additional","affiliation":[{"name":"Doctoral School Chemical Engineering and Biotechnology, National University of Science and Technology Politehnica of Bucharest, 313 Splaiul Independen\u021bei, 060042 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Karastergiou, A., Gancel, A.-L., Jourdes, M., and Teissedre, P.-L. 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