{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:27:35Z","timestamp":1785421655970,"version":"3.56.0"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160786"],"award-info":[{"award-number":["82160786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82160786"],"award-info":[{"award-number":["82160786"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Guizhou Provincial Science and Technology Program Project","award":["ZSYS2025015"],"award-info":[{"award-number":["ZSYS2025015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Alcohol-associated liver disease (ALD) is a prevalent chronic liver disease worldwide, with unclear pathogenesis and limited effective treatments. Mori Fructus polysaccharide (MFP-1) exhibits good therapeutic potential for ALD, but its mechanism remains unclear. This study aims to elucidate how MFP-1 mitigates ALD. An integrated multi-omics approach, encompassing quantitative proteomics, metabolomics, and lipidomics, was employed to systematically characterize the hepatic response to MFP-1 in ALD. MFP-1 coordinates metabolic reprogramming by regulating fatty acid synthesis and \u03b2-oxidation. It also enhances branched-chain amino acid catabolism via the 2-oxocarboxylic acid pathway, optimizing energy generation and amino acid utilization. MFP-1 protects against ALD by simultaneously targeting multiple metabolic vulnerabilities. These findings elucidate the mechanistic basis of MFP-1\u2019s hepatoprotective effects and highlight its potential for improving ALD.<\/jats:p>","DOI":"10.3390\/antiox15040443","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:26:12Z","timestamp":1775121972000},"page":"443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multi-Omics Integration Analysis Reveals That Mori Fructus Polysaccharide Ameliorates Liver Injury via Regulating Liver Metabolic Function Through Inhibiting Lipid Metabolism, Enhancing Glycolysis, and Promoting Amino Acid Utilization"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-0209","authenticated-orcid":false,"given":"Qingfang","family":"Deng","sequence":"first","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Key Laboratory of Plateau Wetland Conservation and Restoration, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University, Guiyang 550025, China"},{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baitong","family":"Jing","sequence":"additional","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Key Laboratory of Plateau Wetland Conservation and Restoration, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University, Guiyang 550025, China"},{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7213-5676","authenticated-orcid":false,"given":"Ruhai","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Key Laboratory of Plateau Wetland Conservation and Restoration, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University, Guiyang 550025, China"},{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Key Laboratory of Plateau Wetland Conservation and Restoration, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University, Guiyang 550025, China"},{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Key Laboratory of Plateau Wetland Conservation and Restoration, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University, Guiyang 550025, China"},{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Key Laboratory of Plateau Wetland Conservation and Restoration, Guizhou Normal University, Guiyang 550025, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University, Guiyang 550025, China"},{"name":"The Research Center for Quality Control of 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