{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:12:50Z","timestamp":1785413570547,"version":"3.56.0"},"reference-count":157,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"South Korea government","award":["RS-2023-00212894"],"award-info":[{"award-number":["RS-2023-00212894"]}]},{"name":"South Korea government","award":["RS-2025-02273042"],"award-info":[{"award-number":["RS-2025-02273042"]}]},{"name":"Ministry of Education","award":["RS-2023-00301914"],"award-info":[{"award-number":["RS-2023-00301914"]}]},{"award":["RS-2023-00301914"],"award-info":[{"award-number":["RS-2023-00301914"]}],"id":[{"id":"https:\/\/ror.org\/00b3tsf98","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Korea government","award":["RS-2024-00404285"],"award-info":[{"award-number":["RS-2024-00404285"]}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"crossref","award":["P0025489"],"award-info":[{"award-number":["P0025489"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"crossref"}]},{"award":["P0025489"],"award-info":[{"award-number":["P0025489"]}],"id":[{"id":"https:\/\/ror.org\/008nkqk13","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Oxidative stress disrupts protein function through direct oxidation and triggers adaptive post-translational modifications. Among these, small ubiquitin-like modifier (SUMO)-ylation mediates fast and reversible remodeling of nuclear and cytoplasmic proteins. Redox regulation of the SUMO E1\u2013E2 conjugation complex and specific SUMO proteases, such as SENP1 and SENP3, allows ROS to influence SUMO turnover and substrate selectivity. This defines SUMOylation as a versatile stress-response module under oxidative stress. In this review, we describe oxidative stress-induced remodeling of SUMO conjugation and deconjugation, with a focus on SUMO2\/3 responses that transiently adjust transcription, DNA damage repair, and nuclear body dynamics. We discuss disease-relevant SUMO targets and pathological alterations in SUMO regulation across four major disease categories: neurodegenerative diseases, cardiovascular disease, cancer, and diabetes\/metabolic diseases. In addition, we summarize emerging evidence connecting redox-sensitive SUMO remodeling to germ-cell function and reproductive health. Together, these perspectives highlight the dual role of SUMOylation as both a driver of stress adaptation and a tractable target for informing therapeutic strategies targeting the SUMO pathway.<\/jats:p>","DOI":"10.3390\/antiox15040453","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:11:28Z","timestamp":1775445088000},"page":"453","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ROS\u2013SUMO Crosstalk in Oxidative Stress: Disease Mechanisms and Reproductive Health"],"prefix":"10.3390","volume":"15","author":[{"given":"Ann-Yae","family":"Na","sequence":"first","affiliation":[{"name":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3837-9867","authenticated-orcid":false,"given":"Hyun-Shik","family":"Lee","sequence":"additional","affiliation":[{"name":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-9887","authenticated-orcid":false,"given":"Hong-Yeoul","family":"Ryu","sequence":"additional","affiliation":[{"name":"KNU G-LAMP Project Group, KNU Institute of Basic Sciences, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Binek, A., Castans, C., Jorge, I., Bagwan, N., Rodr\u00edguez, J.M., Fern\u00e1ndez-Jim\u00e9nez, R., Gal\u00e1n-Arriola, C., Oliver, E., G\u00f3mez, M., and Clemente-Morag\u00f3n, A. 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