{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:00:39Z","timestamp":1790625639183,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2021-127566NB-I00"],"award-info":[{"award-number":["PID2021-127566NB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"award":["PID2021-127566NB-I00"],"award-info":[{"award-number":["PID2021-127566NB-I00"]}],"id":[{"id":"https:\/\/ror.org\/05r0vyz12","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Chronic kidney disease (CKD) is associated with persistent inflammation and increased oxidative stress. Trace elements play an important role in these processes as modulators of redox balance, acting either as cofactors of antioxidant systems or as potential inducers of pro-oxidant mechanisms. In this study, the serum profile of trace elements with antioxidant and pro-oxidant relevance was characterized by inductively coupled plasma mass spectrometry (ICP-MS) in hemodialysis patients. Results were compared with those from a healthy control group, and associations with biochemical and hematological parameters were explored. A cross-sectional observational study was conducted including 117 hemodialysis patients and 82 healthy controls, determining a panel of eight trace elements (Zn, Se, Cu, Mn, As, Cr, Co, and Ni). The method showed adequate sensitivity, satisfactory precision for most elements, and acceptable trueness. Hemodialysis patients exhibited significantly lower serum concentrations of Zn and Se, together with greater interindividual variability, as well as higher concentrations of elements with potential pro-oxidant effects, including As, Cr, Co, and Ni. Within this group, Zn and Se were mainly associated with markers of the protein compartment, Cu with ceruloplasmin and inflammatory markers, and Cr and Ni with parameters of renal function and vitamin D status.<\/jats:p>","DOI":"10.3390\/antiox15040457","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:49:44Z","timestamp":1775641784000},"page":"457","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trace Element Imbalance and Redox-Relevant Serum Profile in Hemodialysis: A Validated Multielement ICP-MS Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Sara","family":"Valderrama-Sanz","sequence":"first","affiliation":[{"name":"Clinical Analysis Service, Hospital Virgen de los Lirios, Pol\u00edgono de Caramanchel s\/n, 03804 Alcoi, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Tortosa-Carreres","sequence":"additional","affiliation":[{"name":"Laboratory Department, Hospital Univeritari i Polit\u00e8cnic la Fe, Av Fernando Abril Martorell 106, 46026 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Molina-Gasset","sequence":"additional","affiliation":[{"name":"Clinical Analysis Service, Hospital Virgen de los Lirios, Pol\u00edgono de Caramanchel s\/n, 03804 Alcoi, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Luis","family":"Todol\u00ed-Torr\u00f3","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Nutrition and Food Sciences, University of Alicante, Carretera San Vicente del Raspeig s\/n, 03690 San Vicente del Raspeig, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"ref_1","unstructured":"GBD Chronic Kidney Disease Collaboration (2020). 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