{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:30:13Z","timestamp":1792096213532,"version":"4.4.0"},"reference-count":63,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Liver regeneration after partial hepatectomy (PH) is critically influenced by redox balance, which may be severely disrupted under drug-induced liver injury. This study evaluated oxidative stress parameters and inflammatory markers in rats subjected to 70% PH following acetaminophen (APAP)-induced toxicity and assessed the preventive effect of the microalga Desmodesmus armatus. Reactive oxygen species (superoxide anion, hydroxyl radical, and hydrogen peroxide), antioxidant enzyme activities (superoxide dismutase and glutathione peroxidase), serum aminotransferases, bilirubin, and C-reactive protein were analyzed 0\u2013168 h post-hepatectomy. APAP intoxication markedly increased mitochondrial ROS production, suppressed mitochondrial antioxidant enzyme activity, and prolonged elevations of ALT, AST, bilirubin, and CRP, accompanied by severe histological damage. Preventive administration of D. armatus suspension (10 mL\/kg body weight at 1.5 \u00d7 106 and 1.5 \u00d7 107 cells\/mL) attenuated oxidative stress in a dose-dependent manner. It significantly reduced ROS levels, restored mitochondrial antioxidant defenses, decreased cytolytic and cholestatic markers, and mitigated systemic inflammation. Overall, D. armatus exhibited hepatoprotective and redox-modulating properties, which may contribute to a more favorable microenvironment for liver recovery under toxic conditions. These findings highlight the potential of microalgae-based interventions as supportive strategies for reducing liver injury and improving recovery following acute liver injury.<\/jats:p>","DOI":"10.3390\/antiox15040492","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:02:33Z","timestamp":1776261753000},"page":"492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oxidative Stress and Antioxidant Defense During Liver Regeneration After Acetaminophen Toxicity: The Preventive Potential of the Microalga Desmodesmus armatus"],"prefix":"10.3390","volume":"15","author":[{"given":"Halyna P.","family":"Kopylchuk","sequence":"first","affiliation":[{"name":"Educational and Scientific Institute of Biology, Chemistry and Natural Resources, Yuriy Fedkovych Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanna M.","family":"Nykolaichuk","sequence":"additional","affiliation":[{"name":"Educational and Scientific Institute of Biology, Chemistry and Natural Resources, Yuriy Fedkovych Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariia S.","family":"Ursatyi","sequence":"additional","affiliation":[{"name":"Educational and Scientific Institute of Biology, Chemistry and Natural Resources, Yuriy Fedkovych Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larysa M.","family":"Cheban","sequence":"additional","affiliation":[{"name":"Educational and Scientific Institute of Biology, Chemistry and Natural Resources, Yuriy Fedkovych Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-8351","authenticated-orcid":false,"given":"Oleksii","family":"Skorokhod","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Systems Biology, University of Turin, via Accademia Albertina 13, 10123 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana M.","family":"Voloshchuk","sequence":"additional","affiliation":[{"name":"Educational and Scientific Institute of Biology, Chemistry and Natural Resources, Yuriy Fedkovych Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1812","DOI":"10.1002\/ctm2.1812","article-title":"Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations","volume":"14","author":"Liu","year":"2024","journal-title":"Clin. 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