{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:06:12Z","timestamp":1776776772423,"version":"3.51.2"},"reference-count":53,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Military Health Service"},{"name":"French Directorate General for Armament","award":["BIOMEDEF SAN 1\u20132311"],"award-info":[{"award-number":["BIOMEDEF SAN 1\u20132311"]}]},{"name":"French Ministry of the Armed Forces and War Veterans"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Basal blood pressure (BP) is partly determined by systemic vascular resistance, which is modulated by vasoactive pathways, including gaseous messengers. Carbon monoxide (CO), continuously generated by the constitutive enzyme heme oxygenase-2 (HO-2) encoded by HMOX2, promotes vascular smooth muscle relaxation and may contribute to interindividual variability in resting BP. The functional single-nucleotide polymorphism rs4786504_T&gt;C has been associated with higher HMOX2 expression in C-allele carriers, providing a plausible biological link between genetic variation in the HO-2\/CO pathway and vascular redox signaling. We investigated this association in forty young, healthy, normotensive adults studied under controlled laboratory conditions during a 4-day sleep deprivation protocol, with repeated standardized daytime BP measurements (478 observations). Linear mixed-effects models were adjusted for major physiological and behavioral covariates. T-allele carriers (C\/T + T\/T) exhibited higher diastolic BP (\u03b2 = +6.08 mmHg, 95%CI [1.32\u201310.84], p = 0.017) and mean arterial pressure (\u03b2 = +5.28 mmHg, 95%CI [0.28\u201310.29], p = 0.046) than C\/C homozygotes, with no effect on systolic BP or heart rate. The association remained consistent across sensitivity and additive genetic models. This hypothesis-generating study provides preliminary evidence in humans, albeit limited by sample size, of a link between a functional HMOX2 variant and resting BP, consistent with a possible contribution of constitutive HO-2 activity to BP regulation.<\/jats:p>","DOI":"10.3390\/antiox15040518","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:42:45Z","timestamp":1776771765000},"page":"518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Functional HMOX2 Genetic Variant Is Associated with Resting Diastolic and Mean Arterial Pressure in Healthy Humans"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6534-7347","authenticated-orcid":false,"given":"Vincent","family":"Beauchamps","sequence":"first","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Vigilance, Fatigue, Sommeil et Sant\u00e9 Publique (VIFASOM), Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"},{"name":"Acad\u00e9mie de Sant\u00e9 des Arm\u00e9es (ACASAN), \u00c9cole du Val-de-Gr\u00e2ce (EVDG), 75004 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3176-8405","authenticated-orcid":false,"given":"Julianne","family":"Touron","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Vigilance, Fatigue, Sommeil et Sant\u00e9 Publique (VIFASOM), Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-7352","authenticated-orcid":false,"given":"Danielle","family":"Gomez-Merino","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Vigilance, Fatigue, Sommeil et Sant\u00e9 Publique (VIFASOM), Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrien","family":"Lagraniere","sequence":"additional","affiliation":[{"name":"Acad\u00e9mie de Sant\u00e9 des Arm\u00e9es (ACASAN), \u00c9cole du Val-de-Gr\u00e2ce (EVDG), 75004 Paris, France"},{"name":"H\u00f4pital National d\u2019Instruction des Arm\u00e9es Percy, 92140 Clamart, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-1383","authenticated-orcid":false,"given":"Carine","family":"Malle","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Vigilance, Fatigue, Sommeil et Sant\u00e9 Publique (VIFASOM), Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claire","family":"Erkel","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Vigilance, Fatigue, Sommeil et Sant\u00e9 Publique (VIFASOM), Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1168-480X","authenticated-orcid":false,"given":"Damien","family":"L\u00e9ger","sequence":"additional","affiliation":[{"name":"Vigilance, Fatigue, Sommeil et Sant\u00e9 Publique (VIFASOM), Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"},{"name":"Assistance Publique\u2014H\u00f4pitaux de Paris (APHP), H\u00f4tel-Dieu, Centre du Sommeil et de la Vigilance, 75004 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-813X","authenticated-orcid":false,"given":"Mounir","family":"Chennaoui","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Vigilance, Fatigue, Sommeil et Sant\u00e9 Publique (VIFASOM), Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-2319","authenticated-orcid":false,"given":"Fabien","family":"Sauvet","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Vigilance, Fatigue, Sommeil et Sant\u00e9 Publique (VIFASOM), Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"},{"name":"Acad\u00e9mie de Sant\u00e9 des Arm\u00e9es (ACASAN), \u00c9cole du Val-de-Gr\u00e2ce (EVDG), 75004 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5635-8220","authenticated-orcid":false,"given":"Pierre A.","family":"Fabries","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), 91220 Br\u00e9tigny-sur-Orge, France"},{"name":"Vigilance, Fatigue, Sommeil et Sant\u00e9 Publique (VIFASOM), Universit\u00e9 Paris Cit\u00e9, 75004 Paris, France"},{"name":"US Army Research Institute of Environmental Medicine (USARIEM), 10 General Greene Ave., Natick, MA 01760, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/ng.3667","article-title":"The Genetics of Blood Pressure Regulation and Its Target Organs from Association Studies in 342,415 Individuals","volume":"48","author":"Ehret","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"S\u00f5ber, S., Org, E., Kepp, K., Juhanson, P., Eyheramendy, S., Gieger, C., Lichtner, P., Klopp, N., Veldre, G., and Viigimaa, M. (2009). Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006034"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"eadj9797","DOI":"10.1126\/sciadv.adj9797","article-title":"Genetic Determinants of Blood Pressure and Heart Rate Identified through ENU-Induced Mutagenesis with Automated Meiotic Mapping","volume":"10","author":"Teixeira","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1073\/pnas.93.2.795","article-title":"Heme Oxygenase 2: Endothelial and Neuronal Localization and Role in Endothelium-Dependent Relaxation","volume":"93","author":"Zakhary","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/paa.1999.111.5.438","article-title":"Heme Oxygenase: Recent Advances in Understanding Its Regulation and Role","volume":"111","author":"Elbirt","year":"1999","journal-title":"Proc. Assoc. Am. Physicians"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.57.4.3","article-title":"Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications","volume":"57","author":"Wu","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"ref_7","first-page":"604981","article-title":"A Review on Hemeoxygenase-2: Focus on Cellular Protection and Oxygen Response","volume":"2014","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.12659\/MSM.908992","article-title":"Contribution of Heme Oxygenase 2 to Blood Pressure Regulation in Response to Swimming Exercise and Detraining in Spontaneously Hypertensive Rats","volume":"24","author":"Caner","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"R1822","DOI":"10.1152\/ajpregu.00319.2009","article-title":"Blood Pressure and Renal Blow Flow Responses in Heme Oxygenase-2 Knockout Mice","volume":"297","author":"Stec","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jash.2013.04.004","article-title":"Sex-Specific Effects of Heme Oxygenase-2 Deficiency on Renovascular Hypertension","volume":"7","author":"Stout","year":"2013","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00424-011-0924-7","article-title":"Cysteine Residue 911 in C-Terminal Tail of Human BK(Ca)\u03b1 Channel Subunit Is Crucial for Its Activation by Carbon Monoxide","volume":"461","author":"Telezhkin","year":"2011","journal-title":"Pflugers Arch."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"C302","DOI":"10.1152\/ajpcell.00360.2016","article-title":"Biological Signaling by Carbon Monoxide and Carbon Monoxide-Releasing Molecules","volume":"312","author":"Motterlini","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e12495","DOI":"10.1111\/micc.12495","article-title":"The Contribution of Carbon Monoxide to Vascular Tonus","volume":"25","year":"2018","journal-title":"Microcirculation"},{"key":"ref_14","unstructured":"Hall, J.E. (2020). Guyton and Hall Textbook of Medical Physiology, Elsevier Health Sciences."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/humu.22935","article-title":"HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans","volume":"37","author":"Yang","year":"2016","journal-title":"Hum. Mutat."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Fabries, P., Drogou, C., Sauvet, F., Nespoulous, O., Erkel, M.-C., Marchandot, V., Bouaziz, W., Lepetit, B., Hamm-Hornez, A.-P., and Malgoyre, A. (2022). The HMOX2 Polymorphism Contributes to the Carotid Body Chemoreflex in European Sea-Level Residents by Regulating Hypoxic Ventilatory Responses. Front. Med., 9.","DOI":"10.3389\/fmed.2022.1000786"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mancuso, C. (2025). The Heme Oxygenase\/Biliverdin Reductase System and Its Genetic Variants in Physiology and Diseases. Antioxidants, 14.","DOI":"10.3390\/antiox14020187"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin Is an Antioxidant of Possible Physiological Importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","article-title":"Heme Oxygenase-1\/Carbon Monoxide: From Basic Science to Therapeutic Applications","volume":"86","author":"Ryter","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Duvigneau, J.C., Esterbauer, H., and Kozlov, A.V. (2019). Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways. Antioxidants, 8.","DOI":"10.3390\/antiox8100475"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/08037051.2018.1527177","article-title":"2018 Practice Guidelines for the Management of Arterial Hypertension of the European Society of Cardiology and the European Society of Hypertension","volume":"27","author":"Williams","year":"2018","journal-title":"Blood Press"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH Guidelines for the Management of Arterial Hypertension The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)","volume":"41","author":"Mancia","year":"2023","journal-title":"J. Hypertens."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.mbp.0000189788.05736.5f","article-title":"Validation of the Omron 705IT (HEM-759-E) Oscillometric Blood Pressure Monitoring Device According to the British Hypertension Society Protocol","volume":"11","author":"Coleman","year":"2006","journal-title":"Blood Press. Monit."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1097\/HJH.0000000000002888","article-title":"Relationships between Cardiovascular Risk Factors and White-Coat Hypertension Diagnosed by Home Blood Pressure Recordings in a Middle-Aged Population","volume":"39","author":"Johansson","year":"2021","journal-title":"J. Hypertens."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/ajh\/hpac082","article-title":"Home Blood Pressure Compared With Office Blood Pressure in Relation to Dysglycemia","volume":"35","author":"Engvall","year":"2022","journal-title":"Am. J. Hypertens."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/01.CIR.0000154900.76284.F6","article-title":"Recommendations for Blood Pressure Measurement in Humans and Experimental Animals: Part 1: Blood Pressure Measurement in Humans: A Statement for Professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research","volume":"111","author":"Pickering","year":"2005","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1097\/HJH.0000000000002843","article-title":"European Society of Hypertension Council and the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability 2021 European Society of Hypertension Practice Guidelines for Office and Out-of-Office Blood Pressure Measurement","volume":"39","author":"Stergiou","year":"2021","journal-title":"J. Hypertens."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/CS20130140","article-title":"Sex and Gender Differences in Control of Blood Pressure","volume":"125","author":"Maranon","year":"2013","journal-title":"Clin. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1113\/JP272167","article-title":"Quantifying Sympathetic Neuro-haemodynamic Transduction at Rest in Humans: Insights into Sex, Ageing and Blood Pressure Control","volume":"594","author":"Briant","year":"2016","journal-title":"J. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/MNH.0000000000000404","article-title":"Gender Differences in Hypertension","volume":"27","author":"Reckelhoff","year":"2018","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/01.CIR.96.1.308","article-title":"Hemodynamic Patterns of Age-Related Changes in Blood Pressure. The Framingham Heart Study","volume":"96","author":"Franklin","year":"1997","journal-title":"Circulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1161\/01.HYP.0000094221.86888.AE","article-title":"Influence of Weight Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials","volume":"42","author":"Neter","year":"2003","journal-title":"Hypertension"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/1947-2714.127751","article-title":"Body Mass Index Relates to Blood Pressure among Adults","volume":"6","author":"Dua","year":"2014","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/1874192401509010005","article-title":"Association of High Blood Pressure with Body Mass Index, Smoking and Physical Activity in Healthy Young Adults","volume":"9","author":"Papathanasiou","year":"2015","journal-title":"Open Cardiovasc. Med. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2165\/00003495-200767002-00002","article-title":"Heart Rate as an Independent Risk Factor for Cardiovascular Disease: Current Evidence and Basic Mechanisms","volume":"67","author":"Palatini","year":"2007","journal-title":"Drugs"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1520-037X.2001.00529.x","article-title":"Aerobic Exercise and Resting Blood Pressure: A Meta-Analytic Review of Randomized, Controlled Trials","volume":"4","author":"Kelley","year":"2001","journal-title":"Prev. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1161\/01.HYP.0000184225.05629.51","article-title":"Effects of Endurance Training on Blood Pressure, Blood Pressure-Regulating Mechanisms, and Cardiovascular Risk Factors","volume":"46","author":"Cornelissen","year":"2005","journal-title":"Hypertension"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/01.HYP.27.6.1318","article-title":"Effects of Insufficient Sleep on Blood Pressure Monitored by a New Multibiomedical Recorder","volume":"27","author":"Tochikubo","year":"1996","journal-title":"Hypertension"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pcad.2008.10.003","article-title":"Cardiovascular, Inflammatory, and Metabolic Consequences of Sleep Deprivation","volume":"51","author":"Mullington","year":"2009","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1152\/japplphysiol.00851.2009","article-title":"Effect of Acute Sleep Deprivation on Vascular Function in Healthy Subjects","volume":"108","author":"Sauvet","year":"2010","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.HYP.37.2.187","article-title":"Association between Smoking and Blood Pressure: Evidence from the Health Survey for England","volume":"37","author":"Primatesta","year":"2001","journal-title":"Hypertension"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.2174\/138161210792062920","article-title":"Cigarette Smoking and Hypertension","volume":"16","author":"Virdis","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1161\/01.CIR.0000069826.36125.B4","article-title":"Current Perspectives on Arterial Stiffness and Pulse Pressure in Hypertension and Cardiovascular Diseases","volume":"107","author":"Safar","year":"2003","journal-title":"Circulation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.2174\/138161210792062867","article-title":"Oxidative Stress and Endothelial Dysfunction: Say NO to Cigarette Smoking!","volume":"16","author":"Grassi","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/ATVBAHA.113.300156","article-title":"Smoking and Cardiovascular Disease: Mechanisms of Endothelial Dysfunction and Early Atherogenesis","volume":"34","author":"Messner","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1152\/ajplegacy.1948.153.2.298","article-title":"Volume Elasticity Characteristics of the Human Aorta and Prediction of the Stroke Volume from the Pressure Pulse","volume":"153","author":"Remington","year":"1948","journal-title":"Am. J. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.CIR.100.4.354","article-title":"Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease? The Framingham Heart Study","volume":"100","author":"Franklin","year":"1999","journal-title":"Circulation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/bies.20005","article-title":"Carbon Monoxide in Biology and Medicine","volume":"26","author":"Ryter","year":"2004","journal-title":"Bioessays"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Choi, Y.K., and Kim, Y.-M. (2021). Regulation of Endothelial and Vascular Functions by Carbon Monoxide via Crosstalk With Nitric Oxide. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.649630"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Mancuso, C. (2023). The Impact of Heme Oxygenase-2 on Pharmacological Research: A Bibliometric Analysis and Beyond. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1156333"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/gtmb.2010.0103","article-title":"Association of Heme Oxygenase-1 Gene Polymorphisms with Essential Hypertension and Blood Pressure in the Chinese Han Population","volume":"15","author":"Lin","year":"2011","journal-title":"Genet. Test. Mol. Biomark."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4110\/in.2009.9.1.12","article-title":"Heme Oxygenase-1: Its Therapeutic Roles in Inflammatory Diseases","volume":"9","author":"Pae","year":"2009","journal-title":"Immune Netw."},{"key":"ref_53","first-page":"552","article-title":"Sample Size Calculation in Clinical Trials: Part 13 of a Series on Evaluation of Scientific Publications","volume":"107","author":"Wachtlin","year":"2010","journal-title":"Dtsch. Arztebl. Int."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/4\/518\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:17:44Z","timestamp":1776773864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/4\/518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":53,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["antiox15040518"],"URL":"https:\/\/doi.org\/10.3390\/antiox15040518","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}