{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:24:53Z","timestamp":1793834693390,"version":"4.6.1"},"reference-count":212,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Metabolic diseases are strongly associated with chronic systemic inflammation and oxidative stress, which disrupt the microbiota\u2013gut\u2013brain (MGB) axis and promote neuroinflammation. Dysbiosis favors the release of proinflammatory metabolites, reactive oxygen species (ROS), and lipopolysaccharides (LPS), increasing intestinal permeability and triggering systemic immune responses that reach the central nervous system (CNS) through a weakened blood\u2013brain barrier (BBB). This review summarizes current knowledge on the pathophysiological mechanisms linking the MGB axis, metabolic disorders, and neuroinflammation, as well as the therapeutic potential of antioxidants. A literature search was conducted in PubMed, Web of Science, Scopus, and ScienceDirect and included original research articles, reviews, clinical trials, and meta-analyses related to microbiota, neuroinflammation, oxidative stress, and antioxidant interventions. Evidence indicates that dysbiosis exacerbates metabolic dysfunction by activating the nuclear factor kappa B (NF-\u03baB) and NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathways, while excessive ROS production impairs mitochondrial function, neuronal survival, and cognitive processes. Antioxidant strategies, including polyphenols, omega-3 fatty acids, curcumin, vitamins C and E, and probiotics, can restore microbial diversity, reinforce intestinal and BBB integrity, and modulate oxidative and inflammatory signaling. In conclusion, supplements and bacteria with antioxidant properties show promising therapeutic effects by targeting oxidative stress mechanisms involved in metabolic diseases and their pathological consequences, such as dysbiosis and neuroinflammation.<\/jats:p>","DOI":"10.3390\/antiox15040522","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:01:24Z","timestamp":1776848484000},"page":"522","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Microbiota\u2013Gut\u2013Brain Axis Disruption, Neuroinflammation, and Potential Antioxidant-Based Treatments in Metabolic Diseases"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-4762","authenticated-orcid":false,"given":"Jazm\u00edn","family":"Carro-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Laboratorio de Neurociencia Traslacional, Escuela Superior de Medicina, Instituto 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(2023). New Insights and Potential Therapeutic Interventions in Metabolic Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310672"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tins.2017.02.005","article-title":"Obesity-Induced Neuroinflammation: Beyond the Hypothalamus","volume":"40","author":"Muccioli","year":"2017","journal-title":"Trends Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.bdj.2016.865","article-title":"The Oral Microbiome\u2014An Update for Oral Healthcare Professionals","volume":"221","author":"Kilian","year":"2016","journal-title":"Br. Dent. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S462","DOI":"10.1513\/AnnalsATS.201605-356AW","article-title":"The Lung Microbiome and Airway Disease","volume":"13","author":"Lynch","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuroscience.2018.02.012","article-title":"Inflammation as a Possible Link Between Dyslipidemia and Alzheimer\u2019s Disease","volume":"376","author":"Bellozi","year":"2018","journal-title":"Neuroscience"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Scheithauer, T.P.M., Rampanelli, E., Nieuwdorp, M., Vallance, B.A., Verchere, C.B., van Raalte, D.H., and Herrema, H. (2020). Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.571731"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2018.03.015","article-title":"Neurotransmitter Modulation by the Gut Microbiota","volume":"1693","author":"Strandwitz","year":"2018","journal-title":"Brain Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Van Dyken, P., and Lacoste, B. (2018). Impact of Metabolic Syndrome on Neuroinflammation and the Blood\u2013Brain Barrier. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00930"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zatterale, F., Longo, M., Naderi, J., Raciti, G.A., Desiderio, A., Miele, C., and Beguinot, F. (2020). Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.01607"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bandala, C., C\u00e1rdenas-Rodr\u00edguez, N., Reyes-Long, S., Cortes-Altamirano, J.L., Garciadiego-C\u00e1zares, D., Lara-Padilla, E., Ib\u00e1\u00f1ez-Cervantes, G., Mancilla-Ram\u00edrez, J., G\u00f3mez-Manzo, S., and Alfaro-Rodr\u00edguez, A. (2022). Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative. Antioxidants, 11.","DOI":"10.3390\/antiox11101972"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Ma, B., Barathan, M., Ng, M.H., and Law, J.X. (2025). Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26073148"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.gtc.2017.08.006","article-title":"The Brain-Gut Axis and Stress in Inflammatory Bowel Disease","volume":"46","author":"Bernstein","year":"2017","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_13","first-page":"137","article-title":"Brain-Gut Axis and Its Role in the Control of Food Intake","volume":"55","author":"Konturek","year":"2004","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1073\/pnas.77.9.5515","article-title":"Brain Regulation of Gastric Secretion: Influence of Neuropeptides","volume":"77","author":"Vale","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Agust\u00ed, A., Garc\u00eda-Pardo, M.P., L\u00f3pez-Almela, I., Campillo, I., Maes, M., Roman\u00ed-P\u00e9rez, M., and Sanz, Y. (2018). Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00155"},{"key":"ref_16","first-page":"203","article-title":"The Gut-Brain Axis: Interactions between Enteric Microbiota, Central and Enteric Nervous Systems","volume":"28","author":"Carabotti","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.tins.2016.09.002","article-title":"Psychobiotics and the Manipulation of Bacteria\u2013Gut\u2013Brain Signals","volume":"39","author":"Sarkar","year":"2016","journal-title":"Trends Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrgastro.2016.200","article-title":"Brain\u2013Gut\u2013Microbiota Axis\u2014Mood, Metabolism and Behavior","volume":"14","author":"Dinan","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E2960","DOI":"10.1073\/pnas.1720696115","article-title":"Chronic Stress Promotes Colitis by Disturbing the Gut Microbiota and Triggering Immune System Response","volume":"115","author":"Gao","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Herrera-Quintana, L., Iturbe-Sanz, P., Olivares-Arancibia, J., V\u00e1zquez-Lorente, H., and Plaza-Diaz, J. (2026). Interplay of Microbiome, Oxidative Stress and Inflammation in Health and Disease. Antioxidants, 15.","DOI":"10.3390\/antiox15020222"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2263209","DOI":"10.1080\/19490976.2023.2263209","article-title":"Low-Level Inflammation, Immunity, and Brain-Gut Axis in IBS: Unraveling the Complex Relationships","volume":"15","author":"Yuan","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Choudhary, A.K. (2025). Neuroinflammation and Cognitive Health in Type 2 Diabetes. Med. Res. Arch., 13.","DOI":"10.18103\/mra.v13i8.6866"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e20241232","DOI":"10.1084\/jem.20241232","article-title":"Lipid Metabolism and Neuroinflammation: What Is the Link?","volume":"222","author":"Tiwari","year":"2025","journal-title":"J. Exp. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Caliman-Sturdza, O.A., Vaz, J.A., Lupaescu, A.V., Lobiuc, A., Bran, C., and Gheorghita, R.E. (2026). Antioxidant and Anti-Inflammatory Activities of Probiotic Strains. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27021079"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/nutraceuticals4040031","article-title":"Potential Applications of the Anti-Inflammatory, Antithrombotic and Antioxidant Health-Promoting Properties of Curcumin: A Critical Review","volume":"4","author":"Rapti","year":"2024","journal-title":"Nutraceuticals"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Martins-Gomes, C., Nunes, F.M., and Silva, A.M. (2024). Natural Products as Dietary Agents for the Prevention and Mitigation of Oxidative Damage and Inflammation in the Intestinal Barrier. Antioxidants, 13.","DOI":"10.3390\/antiox13010065"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Riaz Rajoka, M.S., Thirumdas, R., Mehwish, H.M., Umair, M., Khurshid, M., Hayat, H.F., Phimolsiripol, Y., Pallar\u00e9s, N., Mart\u00ed-Quijal, F.J., and Barba, F.J. (2021). Role of Food Antioxidants in Modulating Gut Microbial Communities: Novel Understandings in Intestinal Oxidative Stress Damage and Their Impact on Host Health. Antioxidants, 10.","DOI":"10.3390\/antiox10101563"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Yu, Z., and Muehleman, V. (2023). Eating Disorders and Metabolic Diseases. Int. J. Environ. Res. Public. Health, 20.","DOI":"10.3390\/ijerph20032446"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Dynda\u0142, K., Pa\u0144czyszyn-Trzewik, P., and Sowa-Ku\u0107ma, M. (2025). Metabolic Modulators in Depression: Emerging Molecular Mechanisms and Therapeutic Opportunities. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26178755"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.molmet.2013.09.005","article-title":"Neuroinflammatory Basis of Metabolic Syndrome","volume":"2","author":"Purkayastha","year":"2013","journal-title":"Mol. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and Metabolic Disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Mostafavi Abdolmaleky, H., and Zhou, J.-R. (2024). Gut Microbiota Dysbiosis, Oxidative Stress, Inflammation, and Epigenetic Alterations in Metabolic Diseases. Antioxidants, 13.","DOI":"10.3390\/antiox13080985"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Masenga, S.K., Kabwe, L.S., Chakulya, M., and Kirabo, A. (2023). Mechanisms of Oxidative Stress in Metabolic Syndrome. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097898"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6564585","DOI":"10.1155\/2021\/6564585","article-title":"Blood\u2013Brain Barrier Overview: Structural and Functional Correlation","volume":"2021","author":"Alahmari","year":"2021","journal-title":"Neural Plast."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Shimizu, F., and Nakamori, M. (2024). Blood\u2013Brain Barrier Disruption in Neuroimmunological Disease. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202408.1175.v1"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Dama, A., Shpati, K., Daliu, P., Dumur, S., Gorica, E., and Santini, A. (2024). Targeting Metabolic Diseases: The Role of Nutraceuticals in Modulating Oxidative Stress and Inflammation. Nutrients, 16.","DOI":"10.3390\/nu16040507"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Cha, H.-J. (2025). Tight Junction Proteins at the Crossroads of Inflammation, Barrier Function, and Disease Modulation. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26178115"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/j.2040-4603.2018.tb00017.x","article-title":"Impact of Metabolic Diseases on Cerebral Circulation: Structural and Functional Consequences","volume":"8","author":"Coucha","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Zeng, J., Cheong, L.Y.T., and Lo, C.H. (2025). Therapeutic Targeting of Obesity-Induced Neuroinflammation and Neurodegeneration. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1456948"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jagp.2023.06.001","article-title":"Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer\u2019s Disease, and Depression","volume":"31","author":"Ly","year":"2023","journal-title":"Am. J. Geriatr. Psychiatry Off. J. Am. Assoc. Geriatr. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Le Thuc, O., Stobbe, K., Cansell, C., Nahon, J.-L., Blondeau, N., and Rov\u00e8re, C. (2017). Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines. Front. Endocrinol., 8.","DOI":"10.3389\/fendo.2017.00197"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"100585","DOI":"10.1016\/j.obmed.2025.100585","article-title":"Cytokines as Key Players in Obesity Low Grade Inflammation and Related Complications","volume":"54","author":"Uti","year":"2025","journal-title":"Obes. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/jnc.15228","article-title":"24S-Hydroxycholesterol: Cellular Effects and Variations in Brain Diseases","volume":"157","author":"Sodero","year":"2021","journal-title":"J. Neurochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuron.2017.12.002","article-title":"Microglial Ramification, Surveillance, and Interleukin-1\u03b2 Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1","volume":"97","author":"Madry","year":"2018","journal-title":"Neuron"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00401-018-1856-5","article-title":"Interplay among Gut Microbiota, Intestinal Mucosal Barrier and Enteric Neuro-Immune System: A Common Path to Neurodegenerative Diseases?","volume":"136","author":"Pellegrini","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e24420","DOI":"10.1002\/jcla.24420","article-title":"Obesity and Gut\u2013Microbiota\u2013Brain Axis: A Narrative Review","volume":"36","author":"Asadi","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Megur, A., Baltriukien\u0117, D., Bukelskien\u0117, V., and Burokas, A. (2021). The Microbiota\u2013Gut\u2013Brain Axis and Alzheimer\u2019s Disease: Neuroinflammation Is to Blame?. Nutrients, 13.","DOI":"10.3390\/nu13010037"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"112449","DOI":"10.1016\/j.exger.2024.112449","article-title":"Associated between Cognition, Brain-Derived Neurotrophic Factor (BDNF) and Macronutrients in Normal and Overweight Postmenopausal Women","volume":"192","author":"Mruczyk","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity Is Associated with Hypothalamic Injury in Rodents and Humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.51847\/N1hvOB1anS","article-title":"Hypothalamic Neuroinflammation Induced by Obesity and the Effect of Liraglutide","volume":"12","author":"Batarseh","year":"2022","journal-title":"J. Adv. Pharm. Educ. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lim, J.S., Kwak, S., Yu, M.-H., Park, M.-N., Baek, H.S., Kang, J., Hong, J.-H., Kim, J.K., Lee, H.W., and Lee, S.-W. (2025). Western Diet-Induced Visceral Adipose Tissue Inflammation Promotes Alzheimer\u2019s Disease Pathology via Microglial Activation in a Mouse Model. Front. Aging Neurosci., 17.","DOI":"10.3389\/fnagi.2025.1644988"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.peptides.2007.04.023","article-title":"Adipokines and the Blood\u2013Brain Barrier","volume":"28","author":"Pan","year":"2007","journal-title":"Peptides"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/physrev.00028.2020","article-title":"The Physiological Control of Eating: Signals, Neurons, and Networks","volume":"102","author":"Watts","year":"2022","journal-title":"Physiol. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1523\/JNEUROSCI.4861-12.2014","article-title":"Leptin Modulates the Intrinsic Excitability of AgRP\/NPY Neurons in the Arcuate Nucleus of the Hypothalamus","volume":"34","author":"Baver","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1016\/j.cell.2025.06.010","article-title":"Brain Control of Energy Homeostasis: Implications for Anti-Obesity Pharmacotherapy","volume":"188","author":"Johansen","year":"2025","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Jouque, V., Miralpeix, C., L\u00f3pez-Gambero, A.J., Nicolas, J.C., Quarta, C., and Cota, D. (2025). Beyond Satiety: Unraveling the Complex Roles of POMC Neurons in Behavior and Metabolism. Rev. Endocr. Metab. Disord.","DOI":"10.1007\/s11154-025-09993-2"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Kasbi, N.A., Stopschinski, B.E., Polyak, A.G., Malladi, A.R., Manouchehri, N., Scherer, P.E., and Stuve, O. (2025). Leptin as a Potential Modifier of Neuroinflammation: Contrasting Roles in Alzheimer\u2019s Disease and Multiple Sclerosis. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27010168"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"7385160","DOI":"10.1155\/2021\/7385160","article-title":"Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis","volume":"2021","author":"Jiang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/neuroglia3040008","article-title":"Overview of Neuroglia Activation, Chronic Neuroinflammation, Remodeling, and Impaired Cognition Due to Perivascular Adipose Tissue-Derived Extracellular Vesicle Exosomes in Obesity and Diabetes","volume":"3","author":"Hayden","year":"2022","journal-title":"Neuroglia"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"107615","DOI":"10.1016\/j.phrs.2025.107615","article-title":"High-Fat Diet and Neuroinflammation: The Role of Mitochondria","volume":"212","author":"Song","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1210\/endrev\/bnac023","article-title":"The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans","volume":"44","author":"Sewaybricker","year":"2022","journal-title":"Endocr. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Jiang, S., Liu, H., and Li, C. (2021). Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases. Foods, 10.","DOI":"10.3390\/foods10081854"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"20026","DOI":"10.1038\/s41598-019-56538-0","article-title":"High-Fat Diet-Induced Metabolic Syndrome and Oxidative Stress in Obese Rats Are Ameliorated by Yogurt Supplementation","volume":"9","author":"Lasker","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"100574","DOI":"10.1016\/j.jnha.2025.100574","article-title":"Acute High-Fat High-Sugar Diet Rapidly Increases Blood\u2013Brain Barrier Permeability in Mice","volume":"29","author":"Leidmaa","year":"2025","journal-title":"J. Nutr. Health Aging"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ubaldo-Reyes, L.M., Espitia-Bautista, E., Barajas-Mart\u00ednez, A., Mart\u00ednez-Tapia, R., Rodr\u00edguez-Mata, V., Noriega-Navarro, R., Escalona, R., Castillo-Hern\u00e1ndez, J., P\u00e9rez-Torres, A., and Navarro, L. (2024). High-Fat Diet-Induced Blood\u2013Brain Barrier Dysfunction: Impact on Allodynia and Motor Coordination in Rats. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202409.1979.v1"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12974-024-03297-z","article-title":"TLR4-Dependent Neuroinflammation Mediates LPS-Driven Food-Reward Alterations during High-Fat Exposure","volume":"21","author":"Huwart","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Darwish, R., Alcibahy, Y., Bucheeri, S., Albishtawi, A., Tama, M., Shetty, J., and Butler, A.E. (2024). The Role of Hypothalamic Microglia in the Onset of Insulin Resistance and Type 2 Diabetes: A Neuro-Immune Perspective. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252313169"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in Neurodegenerative Diseases: Mechanism and Potential Therapeutic Targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Manu, D.R., Slevin, M., Barcutean, L., Forro, T., Boghitoiu, T., and Balasa, R. (2023). Astrocyte Involvement in Blood\u2013Brain Barrier Function: A Critical Update Highlighting Novel, Complex, Neurovascular Interactions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417146"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","article-title":"The Blood\u2013Brain Barrier in Systemic Inflammation","volume":"60","author":"Varatharaj","year":"2017","journal-title":"Brain. Behav. Immun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"13493","DOI":"10.1038\/s41598-020-70326-1","article-title":"Acute Increases in Brain-Derived Neurotrophic Factor Following High or Moderate-Intensity Exercise Is Accompanied with Better Cognition Performance in Obese Adults","volume":"10","author":"Inoue","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"163","DOI":"10.7570\/jomes20107","article-title":"Association of Circulating Brain-Derived Neurotrophic Factor with Cognition among Adult Obese Population","volume":"30","author":"Katuri","year":"2021","journal-title":"J. Obes. Metab. Syndr."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Toader, C., Serban, M., Munteanu, O., Covache-Busuioc, R.-A., Enyedi, M., Ciurea, A.V., and Tataru, C.P. (2025). From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26094271"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"106358","DOI":"10.1016\/j.phrs.2022.106358","article-title":"Inside the Diabetic Brain: Insulin Resistance and Molecular Mechanism Associated with Cognitive Impairment and Its Possible Therapeutic Strategies","volume":"182","author":"Dutta","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1007\/s12035-018-1195-5","article-title":"Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models","volume":"56","author":"Rom","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.brainresbull.2019.04.011","article-title":"Insulin Treatment Protects the Brain against Neuroinflammation by Reducing Cerebral Cytokines and Modulating Mitochondrial Function","volume":"149","author":"Canteiro","year":"2019","journal-title":"Brain Res. Bull."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e2501527122","DOI":"10.1073\/pnas.2501527122","article-title":"Loss of Insulin Signaling in Microglia Impairs Cellular Uptake of A\u03b2 and Neuroinflammatory Response Exacerbating AD-like Neuropathology","volume":"122","author":"Chen","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Vinuesa, A., Pomilio, C., Gregosa, A., Bentivegna, M., Presa, J., Bellotto, M., Saravia, F., and Beauquis, J. (2021). Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer\u2019s Disease. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.653651"},{"key":"ref_79","first-page":"3461","article-title":"Dysbiosis of Gram-Negative Gut Microbiota and the Associated Serum Lipopolysaccharide Exacerbates Inflammation in Type 2 Diabetic Patients with Chronic Kidney Disease","volume":"18","author":"Salguero","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.angio.2016.06.005","article-title":"Actualizaci\u00f3n en el diagn\u00f3stico, tratamiento y prevenci\u00f3n de la neuropat\u00eda diab\u00e9tica perif\u00e9rica","volume":"69","year":"2017","journal-title":"Angiolog\u00eda"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13098-024-01346-4","article-title":"The Relationship between Diabetes and the Dementia Risk: A Meta-Analysis","volume":"16","author":"Cao","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_82","first-page":"227","article-title":"Emerging Role of Macrophages in Neuropathic Pain","volume":"51","author":"Tong","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"O\u2019Hagan, R., Berg, A.R., Hong, C.G., Parel, P.M., Mehta, N.N., and Teague, H.L. (2022). Systemic Consequences of Abnormal Cholesterol Handling: Interdependent Pathways of Inflammation and Dyslipidemia. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.972140"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-physiol-021014-071656","article-title":"Hypothalamic Inflammation in the Control of Metabolic Function","volume":"77","author":"Valdearcos","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Mosalmanzadeh, N., and Pence, B.D. (2024). Oxidized Low-Density Lipoprotein and Its Role in Immunometabolism. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252111386"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12944-023-01817-z","article-title":"HDL and LDL Have Distinct, Opposing Effects on LPS-Induced Brain Inflammation","volume":"22","author":"Yates","year":"2023","journal-title":"Lipids Health Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"100736","DOI":"10.1016\/j.jlr.2024.100736","article-title":"Microglial Activation and Hypothalamic Structural Plasticity in HFD Obesity: Insights from Semaglutide and Minocycline","volume":"66","author":"Rong","year":"2024","journal-title":"J. Lipid Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of Neuroinflammation in Neurodegeneration Development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Adamu, A., Li, S., Gao, F., and Xue, G. (2024). The Role of Neuroinflammation in Neurodegenerative Diseases: Current Understanding and Future Therapeutic Targets. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1347987"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.14283\/jpad.2024.90","article-title":"Metabolic Syndrome Status Changes and Cognitive Functioning: Insights from the Lifelines Cohort Study","volume":"11","author":"Frentz","year":"2024","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Li, Z., Jiang, Y., Long, C., Peng, X., Tao, J., Pu, Y., and Yue, R. (2024). Bridging Metabolic Syndrome and Cognitive Dysfunction: Role of Astrocytes. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1393253"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Plakkot, B., Di Agostino, A., and Subramanian, M. (2023). Implications of Hypothalamic Neural Stem Cells on Aging and Obesity-Associated Cardiovascular Diseases. Cells, 12.","DOI":"10.3390\/cells12050769"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1113\/JP285058","article-title":"Hypertension, Blood\u2013Brain Barrier Disruption and Changes in Intracranial Pressure","volume":"603","author":"Colombari","year":"2025","journal-title":"J. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/HYPERTENSIONAHA.115.03624","article-title":"Angiotensin-II, the Brain, and Hypertension: An Update","volume":"66","author":"Young","year":"2015","journal-title":"Hypertension"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The Gut Microbiota\u2013Brain Axis in Behavior and Brain Disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/bs.pmbts.2022.06.031","article-title":"Chapter Six\u2014Gut Dysbiosis and Metabolic Diseases","volume":"Volume 191","author":"Das","year":"2022","journal-title":"Progress in Molecular Biology and Translational Science"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41577-019-0198-4","article-title":"The Intestinal Microbiota Fuelling Metabolic Inflammation","volume":"20","author":"Tilg","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Solanki, R., Karande, A., and Ranganathan, P. (2023). Emerging Role of Gut Microbiota Dysbiosis in Neuroinflammation and Neurodegeneration. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1149618"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An Insight into Gut Microbiota and Its Functionalities","volume":"76","author":"Adak","year":"2018","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Du, Y., He, C., An, Y., Huang, Y., Zhang, H., Fu, W., Wang, M., Shan, Z., Xie, J., and Yang, Y. (2024). The Role of Short Chain Fatty Acids in Inflammation and Body Health. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25137379"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nature08530","article-title":"Regulation of Inflammatory Responses by Gut Microbiota and Chemoattractant Receptor GPR43","volume":"461","author":"Maslowski","year":"2009","journal-title":"Nature"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of Short Chain Fatty Acids by the Gut Microbiota and Their Impact on Human Metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Human Gut Microbes Associated with Obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Riggen-Bueno, V., Del Toro-Arreola, S., Baltazar-D\u00edaz, T.A., Vega-Maga\u00f1a, A.N., Pe\u00f1a-Rodr\u00edguez, M., Casta\u00f1o-Jim\u00e9nez, P.A., S\u00e1nchez-Orozco, L.V., Vera-Cruz, J.M., and Bueno-Topete, M.R. (2024). Intestinal Dysbiosis in Subjects with Obesity from Western Mexico and Its Association with a Proinflammatory Profile and Disturbances of Folate (B9) and Carbohydrate Metabolism. Metabolites, 14.","DOI":"10.3390\/metabo14020121"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-Talk between Akkermansia muciniphila and Intestinal Epithelium Controls Diet-Induced Obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nm.4358","article-title":"Gut Microbiome and Serum Metabolome Alterations in Obesity and after Weight-Loss Intervention","volume":"23","author":"Liu","year":"2017","journal-title":"Nat. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2009.01514.x","article-title":"Diversity, Metabolism and Microbial Ecology of Butyrate-Producing Bacteria from the Human Large Intestine","volume":"294","author":"Louis","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/ijo.2015.84","article-title":"The Role of Short Chain Fatty Acids in Appetite Regulation and Energy Homeostasis","volume":"39","author":"Byrne","year":"2015","journal-title":"Int. J. Obes."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 Trafficking and Its Influence on LPS-Induced pro-Inflammatory Signaling","volume":"78","author":"Ciesielska","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2414796","DOI":"10.1080\/19490976.2024.2414796","article-title":"The Effects of Gut Microbiota on Appetite Regulation and the Underlying Mechanisms","volume":"16","author":"Yu","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s40168-021-01107-9","article-title":"Fecal Microbiota Transplantation Protects Rotenone-Induced Parkinson\u2019s Disease Mice via Suppressing Inflammation Mediated by the Lipopolysaccharide-TLR4 Signaling Pathway through the Microbiota-Gut-Brain Axis","volume":"9","author":"Zhao","year":"2021","journal-title":"Microbiome"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Rutsch, A., Kantsj\u00f6, J.B., and Ronchi, F. (2020). The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.604179"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Alfadul, H., Sabico, S., and Al-Daghri, N.M. (2022). The Role of Interleukin-1\u03b2 in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.901616"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm.3265","article-title":"Activation of the Nlrp3 Inflammasome in Infiltrating Macrophages by Endocannabinoids Mediates Beta Cell Loss in Type 2 Diabetes","volume":"19","author":"Jourdan","year":"2013","journal-title":"Nat. Med."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Marcos, J.L., Olivares-Barraza, R., Ceballo, K., Wastavino, M., Ortiz, V., Riquelme, J., Mart\u00ednez-Pinto, J., Mu\u00f1oz, P., Cruz, G., and Sotomayor-Z\u00e1rate, R. (2023). Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021468"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/JME-19-0132","article-title":"Butyrate Modulates Diabetes-Linked Gut Dysbiosis: Epigenetic and Mechanistic Modifications","volume":"64","author":"Noureldein","year":"2020","journal-title":"J. Mol. Endocrinol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s00253-012-4323-6","article-title":"Alterations of the Gut Microbiota in High-Fat Diet Mice Is Strongly Linked to Oxidative Stress","volume":"97","author":"Qiao","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jare.2021.09.005","article-title":"Interplay of Gut Microbiota and Oxidative Stress: Perspective on Neurodegeneration and Neuroprotection","volume":"38","author":"Shandilya","year":"2022","journal-title":"J. Adv. Res."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Misrani, A., Tabassum, S., and Yang, L. (2021). Mitochondrial Dysfunction and Oxidative Stress in Alzheimer\u2019s Disease. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.617588"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Kunst, C., Schmid, S., Michalski, M., T\u00fcmen, D., Buttensch\u00f6n, J., M\u00fcller, M., and G\u00fclow, K. (2023). The Influence of Gut Microbiota on Oxidative Stress and the Immune System. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051388"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Hong, Y., Boiti, A., Vallone, D., and Foulkes, N.S. (2024). Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution. Antioxidants, 13.","DOI":"10.3390\/antiox13030312"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop Between NLRP3 Inflammasome and Reactive Oxygen Species","volume":"36","author":"Dominic","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/cdd.2010.19","article-title":"TNF-\u03b1-Induced ROS Production Triggering Apoptosis Is Directly Linked to Romo1 and Bcl-XL","volume":"17","author":"Kim","year":"2010","journal-title":"Cell Death Differ."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Faraonio, R. (2022). Oxidative Stress and Cell Senescence Process. Antioxidants, 11.","DOI":"10.3390\/antiox11091718"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.3390\/cimb45080420","article-title":"Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications","volume":"45","author":"Caturano","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2011.10.003","article-title":"Role of Oxidative Stress in the Pathogenesis of Nonalcoholic Steatohepatitis","volume":"52","author":"Rolo","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/pathophysiology31030023","article-title":"Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health","volume":"31","author":"Semenova","year":"2024","journal-title":"Pathophysiology"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Braccia, D.J., Jiang, X., Pop, M., and Hall, A.B. (2021). The Capacity to Produce Hydrogen Sulfide (H2S) via Cysteine Degradation Is Ubiquitous in the Human Gut Microbiome. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.705583"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/carcin\/23.3.529","article-title":"Enterococcus faecalis Produces Extracellular Superoxide and Hydrogen Peroxide That Damages Colonic Epithelial Cell DNA","volume":"23","author":"Huycke","year":"2002","journal-title":"Carcinogenesis"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e03263-19.","DOI":"10.1128\/mBio.03263-19","article-title":"Endotoxin Producers Overgrowing in Human Gut Microbiota as the Causative Agents for Nonalcoholic Fatty Liver Disease","volume":"11","author":"Fei","year":"2020","journal-title":"mBio"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Baldelli, V., Scaldaferri, F., Putignani, L., and Del Chierico, F. (2021). The Role of Enterobacteriaceae in Gut Microbiota Dysbiosis in Inflammatory Bowel Diseases. Microorganisms, 9.","DOI":"10.3390\/microorganisms9040697"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Daca, A., and Jarzembowski, T. (2024). From the Friend to the Foe\u2014Enterococcus faecalis Diverse Impact on the Human Immune System. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042422"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Zhang, L., Deng, M., Liu, J., Zhang, J., Wang, F., and Yu, W. (2024). The Pathogenicity of Vancomycin-Resistant Enterococcus faecalis to Colon Cancer Cells. BMC Infect. Dis., 24.","DOI":"10.1186\/s12879-024-09133-2"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Carbonero, F., Benefiel, A.C., Alizadeh-Ghamsari, A.H., and Gaskins, H.R. (2012). Microbial Pathways in Colonic Sulfur Metabolism and Links with Health and Disease. Front. Physiol., 3.","DOI":"10.3389\/fphys.2012.00448"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-Fat-Induced Taurocholic Acid Promotes Pathobiont Expansion and Colitis in Il10\u2212\/\u2212Mice","volume":"487","author":"Devkota","year":"2012","journal-title":"Nature"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Xu, J., and Lu, Y. (2025). The Microbiota-Gut-Brain Axis and Central Nervous System Diseases: From Mechanisms of Pathogenesis to Therapeutic Strategies. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1583562"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.3168\/jds.2024-25722","article-title":"Comparing the Antioxidant Effects of Single and Binary Combinations of Lactiplantibacillus plantarum in Vitro and in Vivo and Their Application in Yogurt","volume":"108","author":"Yang","year":"2025","journal-title":"J. Dairy Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.copbio.2012.08.005","article-title":"Bacteria as Vitamin Suppliers to Their Host: A Gut Microbiota Perspective","volume":"24","author":"LeBlanc","year":"2013","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_141","first-page":"1","article-title":"Beneficial Effects of Antioxidative Lactic Acid Bacteria","volume":"3","author":"Nakagawa","year":"2017","journal-title":"AIMS Microbiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nutres.2021.09.001","article-title":"Vitamins, the Gut Microbiome and Gastrointestinal Health in Humans","volume":"95","author":"Pham","year":"2021","journal-title":"Nutr. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in Gut Microbiota Control Inflammation in Obese Mice through a Mechanism Involving GLP-2-Driven Improvement of Gut Permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"16731","DOI":"10.1073\/pnas.0804812105","article-title":"Faecalibacterium prausnitzii Is an Anti-Inflammatory Commensal Bacterium Identified by Gut Microbiota Analysis of Crohn Disease Patients","volume":"105","author":"Sokol","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Breyner, N.M., Michon, C., de Sousa, C.S., Vilas Boas, P.B., Chain, F., Azevedo, V.A., Langella, P., and Chatel, J.M. (2017). Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-\u03baB Pathway. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.00114"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"100352","DOI":"10.1016\/j.microb.2025.100352","article-title":"The Association between the Health of the Intestines and the Human Body with Akkermansia muciniphila","volume":"7","author":"Tabatabaei","year":"2025","journal-title":"Microbe"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1007\/s00253-021-11362-3","article-title":"The Interaction of Akkermansia muciniphila with Host-Derived Substances, Bacteria and Diets","volume":"105","author":"Hagi","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"C\u00e1rdenas-Rodr\u00edguez, N., Bandala, C., Vanoye-Carlo, A., Ignacio-Mej\u00eda, I., G\u00f3mez-Manzo, S., Hern\u00e1ndez-Cruz, E.Y., Pedraza-Chaverri, J., Carmona-Aparicio, L., and Hern\u00e1ndez-Ochoa, B. (2021). Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19. Antioxidants, 10.","DOI":"10.3390\/antiox10060971"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Plamada, D., and Vodnar, D.C. (2021). Polyphenols\u2014Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics. Nutrients, 14.","DOI":"10.3390\/nu14010137"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Nemzer, B.V., Al-Taher, F., Kalita, D., Yashin, A.Y., and Yashin, Y.I. (2025). Health-Improving Effects of Polyphenols on the Human Intestinal Microbiota: A Review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26031335"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Wang, X., Qi, Y., and Zheng, H. (2022). Dietary Polyphenol, Gut Microbiota, and Health Benefits. Antioxidants, 11.","DOI":"10.3390\/antiox11061212"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jtemb.2017.10.005","article-title":"The Possible Protective Effects of Vitamin E and Selenium Administration in Oxidative Stress Caused by High Doses of Glucocorticoid Administration in the Brain of Rats","volume":"45","author":"Beytut","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1038\/s41467-020-19793-8","article-title":"Vitamin D Metabolites and the Gut Microbiome in Older Men","volume":"11","author":"Thomas","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"21641","DOI":"10.1038\/s41598-020-77806-4","article-title":"The Potential Role of Vitamin D Supplementation as a Gut Microbiota Modifier in Healthy Individuals","volume":"10","author":"Singh","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"551","DOI":"10.21873\/anticanres.13984","article-title":"The Effect of Various Doses of Oral Vitamin D3 Supplementation on Gut Microbiota in Healthy Adults: A Randomized, Double-Blinded, Dose\u2013Response Study","volume":"40","author":"Charoenngam","year":"2020","journal-title":"Anticancer Res."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Gawron-Skarbek, A., Guligowska, A., Prymont-Przymi\u0144ska, A., Nowak, D., and Kostka, T. (2023). The Anti-Inflammatory and Antioxidant Impact of Dietary Fatty Acids in Cardiovascular Protection in Older Adults May Be Related to Vitamin C Intake. Antioxidants, 12.","DOI":"10.3390\/antiox12020267"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Gothandapani, D., and Makpol, S. (2023). Effects of Vitamin E on the Gut Microbiome in Aging and Its Relationship with Age-Related Diseases: A Review of the Current Literature. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914667"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Godos, J., Romano, G.L., Gozzo, L., Laudani, S., Paladino, N., Dominguez Azp\u00edroz, I., Mart\u00ednez L\u00f3pez, N.M., Giampieri, F., Quiles, J.L., and Battino, M. (2024). Resveratrol and Vascular Health: Evidence from Clinical Studies and Mechanisms of Actions Related to Its Metabolites Produced by Gut Microbiota. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1368949"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Cai, T.-T., Ye, X.-L., Li, R.-R., Chen, H., Wang, Y.-Y., Yong, H.-J., Pan, M.-L., Lu, W., Tang, Y., and Miao, H. (2020). Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.01249"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1742-2094-4-25","article-title":"Resveratrol Potently Reduces Prostaglandin E2 Production and Free Radical Formation in Lipopolysaccharide-Activated Primary Rat Microglia","volume":"4","author":"Bhatia","year":"2007","journal-title":"J. Neuroinflamm."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1038\/s41380-021-01160-8","article-title":"Omega-3 Polyunsaturated Fatty Acids Protect against Inflammation through Production of LOX and CYP450 Lipid Mediators: Relevance for Major Depression and for Human Hippocampal Neurogenesis","volume":"26","author":"Borsini","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.clnesp.2024.06.053","article-title":"Role of Omega-3 Fatty Acids Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) as Modulatory and Anti-Inflammatory Agents in Noncommunicable Diet-Related Diseases\u2014Reports from the Last 10 Years","volume":"63","author":"Banaszak","year":"2024","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/nu2030355","article-title":"Omega-3 Fatty Acids and Inflammatory Processes","volume":"2","author":"Calder","year":"2010","journal-title":"Nutrients"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Zhu, J., and He, L. (2024). The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion. Microorganisms, 12.","DOI":"10.3390\/microorganisms12040642"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5056\/jnm23065","article-title":"The Effect of Curcumin on the Gut-Brain Axis: Therapeutic Implications","volume":"29","author":"Enayati","year":"2023","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures","volume":"15","author":"Peng","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"103144","DOI":"10.1016\/j.jksus.2024.103144","article-title":"Probiotic Potential of Lactobacillus agilis against Oxidative, Inflammatory and Diabetic Stresses","volume":"36","author":"Khan","year":"2024","journal-title":"J. King Saud Univ.-Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e1900457","DOI":"10.1002\/mnfr.201900457","article-title":"Ameliorative Effects of Probiotic Lactobacillus paracasei NL41 on Insulin Sensitivity, Oxidative Stress, and Beta-Cell Function in a Type 2 Diabetes Mellitus Rat Model","volume":"63","author":"Zeng","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Zeng, Z., Yang, Y., Zhong, X., Dai, F., Chen, S., and Tong, X. (2023). Ameliorative Effects of Lactobacillus paracasei L14 on Oxidative Stress and Gut Microbiota in Type 2 Diabetes Mellitus Rats. Antioxidants, 12.","DOI":"10.3390\/antiox12081515"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"100093","DOI":"10.1016\/j.metop.2021.100093","article-title":"Probiotic and Resveratrol Normalize GLP-1 Levels and Oxidative Stress in the Intestine of Diabetic Rats","volume":"10","author":"Pegah","year":"2021","journal-title":"Metab. Open"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jff.2016.11.027","article-title":"The Ameliorative Effects of Probiotic Lactobacillus fermentum Strain RS-2 on Alloxan Induced Diabetic Rats","volume":"28","author":"Kumar","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"20801","DOI":"10.1021\/acs.jafc.3c04665","article-title":"Amelioration of Type 2 Diabetes Using Four Strains of Lactobacillus probiotics: Effects on Gut Microbiota Reconstitution-Mediated Regulation of Glucose Homeostasis, Inflammation, and Oxidative Stress in Mice","volume":"71","author":"Song","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.1016\/j.clnu.2021.05.027","article-title":"Effects of Probiotic Supplementation on Anthropometric and Metabolic Characteristics in Adults with Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"40","author":"Hadi","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Stadlbauer, V., Leber, B., Lemesch, S., Trajanoski, S., Bashir, M., Horvath, A., Tawdrous, M., Stojakovic, T., Fauler, G., and Fickert, P. (2015). Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141399"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ismej.2014.99","article-title":"Modulation of Gut Microbiota during Probiotic-Mediated Attenuation of Metabolic Syndrome in High Fat Diet-Fed Mice","volume":"9","author":"Wang","year":"2015","journal-title":"ISME J."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1365-2249.2008.03788.x","article-title":"Effects of Bifidobacterium animalis Administered during Lactation on Allergic and Autoimmune Responses in Rodents","volume":"154","author":"Ezendam","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3109\/08923970903200716","article-title":"Oral Administration of Probiotic Bacteria, Lactobacillus casei and Bifidobacterium breve, Does Not Exacerbate Neurological Symptoms in Experimental Autoimmune Encephalomyelitis","volume":"32","author":"Kobayashi","year":"2010","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Lavasani, S., Dzhambazov, B., Nouri, M., F\u00e5k, F., Buske, S., Molin, G., Thorlacius, H., Alenfall, J., Jeppsson, B., and Westr\u00f6m, B. (2010). A Novel Probiotic Mixture Exerts a Therapeutic Effect on Experimental Autoimmune Encephalomyelitis Mediated by IL-10 Producing Regulatory T Cells. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009009"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"412946","DOI":"10.1155\/2015\/412946","article-title":"Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate","volume":"2015","author":"Liu","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.psyneuen.2013.02.008","article-title":"Effects of Lactobacillus helveticus on Murine Behavior Are Dependent on Diet and Genotype and Correlate with Alterations in the Gut Microbiome","volume":"38","author":"Ohland","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2015.12.047","article-title":"Clostridium butyricum Pretreatment Attenuates Cerebral Ischemia\/Reperfusion Injury in Mice via Anti-Oxidation and Anti-Apoptosis","volume":"613","author":"Sun","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Myles, E.M., O\u2019Leary, M.E., Smith, R., MacPherson, C.W., Oprea, A., Melanson, E.H., Tompkins, T.A., and Perrot, T.S. (2020). Supplementation with Combined Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 Across Development Reveals Sex Differences in Physiological and Behavioral Effects of Western Diet in Long\u2013Evans Rats. Microorganisms, 8.","DOI":"10.3390\/microorganisms8101527"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.psyneuen.2017.02.014","article-title":"Probiotic Treatment Reduces Depressive-like Behavior in Rats Independently of Diet","volume":"79","author":"Abildgaard","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12974-018-1055-2","article-title":"Decreased Microglial Activation through Gut-Brain Axis by Prebiotics, Probiotics, or Synbiotics Effectively Restored Cognitive Function in Obese-Insulin Resistant Rats","volume":"15","author":"Chunchai","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12967-019-02169-y","article-title":"The Potential Therapeutic Effects of the Gut Microbiome Manipulation by Synbiotic Containing-Lactobacillus Plantarum on Neuropsychological Performance of Diabetic Rats","volume":"18","author":"Morshedi","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Lee, S.H.F., Ahmad, S.R., Lim, Y.C., and Zulkipli, I.N. (2022). The Use of Probiotic Therapy in Metabolic and Neurological Diseases. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.887019"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1186\/s12967-023-04306-0","article-title":"The Effects of Probiotics Supplementation on Glycemic Control among Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"21","author":"Li","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e3655","DOI":"10.1002\/dmrr.3655","article-title":"Probiotics, Prebiotics, and Synbiotics in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Clinical Trials","volume":"40","author":"Moravejolahkami","year":"2024","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"106399","DOI":"10.1016\/j.phrs.2022.106399","article-title":"Probiotics and Synbiotics Supplementation Improve Glycemic Control Parameters in Subjects with Prediabetes and Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review, Meta-Analysis, and Meta-Regression of Randomized Clinical Trials","volume":"184","author":"Naseri","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Wang, X., Chen, L., Zhang, C., Shi, Q., Zhu, L., Zhao, S., Luo, Z., and Long, Y. (2024). Effect of Probiotics at Different Intervention Time on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1392306"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.clnu.2021.11.037","article-title":"Meta-Analysis of Randomized Controlled Trials of the Effects of Probiotics on Type 2 Diabetes in Adults","volume":"41","author":"Zhang","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Nesci, A., Carnuccio, C., Ruggieri, V., D\u2019Alessandro, A., Di Giorgio, A., Santoro, L., Gasbarrini, A., Santoliquido, A., and Ponziani, F.R. (2023). Gut Microbiota and Cardiovascular Disease: Evidence on the Metabolic and Inflammatory Background of a Complex Relationship. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24109087"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00394-015-0852-y","article-title":"Interaction of Dietary Compounds, Especially Polyphenols, with the Intestinal Microbiota: A Review","volume":"54","author":"Tarko","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"895","DOI":"10.18388\/abp.2015_1154","article-title":"The Impact of Polyphenols on Bifidobacterium Growth","volume":"62","author":"Gwiazdowska","year":"2015","journal-title":"Acta Biochim. Pol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1210\/jc.2015-3351","article-title":"Two Healthy Diets Modulate Gut Microbial Community Improving Insulin Sensitivity in a Human Obese Population","volume":"101","author":"Haro","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1700300.","DOI":"10.1002\/mnfr.201700300","article-title":"Consumption of Two Healthy Dietary Patterns Restored Microbiota Dysbiosis in Obese Patients with Metabolic Dysfunction","volume":"61","author":"Haro","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S0954422410000041","article-title":"New Hypotheses for the Health-Protective Mechanisms of Whole-Grain Cereals: What Is beyond Fiber?","volume":"23","author":"Fardet","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Martemucci, G., Khalil, M., Di Luca, A., Abdallah, H., and D\u2019Alessandro, A.G. (2024). Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions. Metabolites, 14.","DOI":"10.3390\/metabo14060327"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"10356","DOI":"10.1039\/D1FO02017J","article-title":"Phenolic Compounds That Cross the Blood\u2013Brain Barrier Exert Positive Health Effects as Central Nervous System Antioxidants","volume":"12","year":"2021","journal-title":"Food Funct."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Kurhaluk, N., Kami\u0144ski, P., Bilski, R., Ko\u0142odziejska, R., Wo\u017aniak, A., and Tkaczenko, H. (2025). Role of Antioxidants in Modulating the Microbiota\u2013Gut\u2013Brain Axis and Their Impact on Neurodegenerative Diseases. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083658"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s41043-025-00773-x","article-title":"The Effect of Probiotic-Fortified Kefir on Depression, Appetite, Oxidative Stress, and Inflammatory Parameters in Iranian Overweight and Obese Elderly: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","volume":"44","author":"Noori","year":"2025","journal-title":"J. Health Popul. Nutr."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pnpbp.2018.02.007","article-title":"The Effects of Vitamin D and Probiotic Co-Supplementation on Mental Health Parameters and Metabolic Status in Type 2 Diabetic Patients with Coronary Heart Disease: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"84","author":"Raygan","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13048-019-0480-x","article-title":"Vitamin D and Probiotic Co-Supplementation Affects Mental Health, Hormonal, Inflammatory and Oxidative Stress Parameters in Women with Polycystic Ovary Syndrome","volume":"12","author":"Ostadmohammadi","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13048-018-0457-1","article-title":"The Effects of Probiotic and Selenium Co-Supplementation on Parameters of Mental Health, Hormonal Profiles, and Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome","volume":"11","author":"Jamilian","year":"2018","journal-title":"J. Ovarian Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1007\/s12011-020-02572-3","article-title":"The Effects of Probiotic and Selenium Co-Supplementation on Clinical and Metabolic Scales in Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"199","author":"Jamilian","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_206","first-page":"770","article-title":"The Effect of Probiotic Supplementation on Depressive Symptoms and Quality of Life in Patients After Myocardial Infarction: Results of a Preliminary Double-Blind Clinical Trial","volume":"81","author":"Moludi","year":"2019","journal-title":"Biopsychosoc. Sci. Med."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1038\/s41598-021-81204-9","article-title":"Probiotics as a Treatment for Prenatal Maternal Anxiety and Depression: A Double-Blind Randomized Pilot Trial","volume":"11","author":"Browne","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/1028415X.2018.1477349","article-title":"Synbiotic Supplementation, Systemic Inflammation, and Symptoms of Brain Disorders in Elders: A Secondary Study from a Randomized Clinical Trial","volume":"23","author":"Louzada","year":"2020","journal-title":"Nutr. Neurosci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/1028415X.2019.1646975","article-title":"Effect of Synbiotic and Probiotic Supplementation on Serum Brain-Derived Neurotrophic Factor Level, Depression and Anxiety Symptoms in Hemodialysis Patients: A Randomized, Double-Blinded, Clinical Trial","volume":"24","author":"Haghighat","year":"2021","journal-title":"Nutr. Neurosci."},{"key":"ref_210","unstructured":"Ba\u00f1uls, C. (2026, January 14). New Dietary Intervention Strategies on the Intestinal Microbiota to Improve Mental Health Subjects with Obesity: Therapeutic Potential of a Synbiotic, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06901739?tab=researcher."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Hy\u017cy, A., Rozenek, H., Gondek, E., and Jaworski, M. (2025). Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies. Foods, 14.","DOI":"10.3390\/foods14020176"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota\u2013Gut\u2013Brain Axis and Its Therapeutic Applications in Neurodegenerative Diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/4\/522\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:42:46Z","timestamp":1776850966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/15\/4\/522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":212,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["antiox15040522"],"URL":"https:\/\/doi.org\/10.3390\/antiox15040522","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}