{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:21:19Z","timestamp":1785410479945,"version":"3.56.0"},"reference-count":72,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council Taiwan","award":["114-2314-B-415-001-MY3"],"award-info":[{"award-number":["114-2314-B-415-001-MY3"]}]},{"name":"National Science and Technology Council Taiwan","award":["114-2811-B-415-001"],"award-info":[{"award-number":["114-2811-B-415-001"]}]},{"award":["114-2314-B-415-001-MY3"],"award-info":[{"award-number":["114-2314-B-415-001-MY3"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"publisher"}]},{"award":["114-2811-B-415-001"],"award-info":[{"award-number":["114-2811-B-415-001"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Non-arteritic anterior ischemic optic neuropathy (NAION) is a leading cause of sudden vision loss, yet no effective therapy exists to preserve retinal ganglion cells (RGCs) after ischemic injury. Nostoc commune (NC), an edible cyanobacterium with established antioxidant and anti-inflammatory activities, has emerged as a potential functional bioresource with relevance to ocular health. Here, we investigated the therapeutic effects of a crude aqueous extract of NC using a rodent model of anterior ischemic optic neuropathy (rAION). NC treatment significantly improved RGC survival, reduced apoptosis, attenuated macrophage and microglial activation (ED-1, Iba1), suppressed proinflammatory cytokine expression (IL-6), enhanced the reparative marker Ym1+2, and preserved optic-nerve myelination. Functionally, NC administration restored visual signaling as demonstrated by improved Flash Visual Evoked Potential amplitudes. Immunoblot analysis showed increased phosphorylation of PI3K\/AKT\/mTOR\/p70S6K signaling components in retinal tissue following NC treatment. Proteomic profiling further demonstrated that NC extract comprises a coordinated repertoire of phycobiliproteins, antioxidant enzymes, and stress-response proteins that may collectively contribute to its biological effects. Together, these findings suggest that Nostoc commune extract may serve as a promising functional food-derived candidate for protecting RGCs and preserving visual function following ischemic optic neuropathy. Further studies are required to identify its active constituents, optimize formulation strategies, and evaluate its translational potential.<\/jats:p>","DOI":"10.3390\/antiox15050541","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:40:12Z","timestamp":1777981212000},"page":"541","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nostoc commune Extract Attenuates Oxidative Stress and Neuroinflammation in Ischemic Optic Neuropathy Through PI3K\/AKT\/mTOR Signaling"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8732-2097","authenticated-orcid":false,"given":"Jia-Ying","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Biochemical Science and Technology, National Chiayi University, Chiayi City 600355, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Hsun","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biochemical Science and Technology, National Chiayi University, Chiayi City 600355, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ling","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Taichung Tzu Chi Hospital, Taichung 427213, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siu-Fung","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Taichung Tzu Chi Hospital, Taichung 427213, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien-Yang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Taichung Tzu Chi Hospital, Taichung 427213, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Huang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Taichung Tzu Chi Hospital, Taichung 427213, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Taichung Tzu Chi Hospital, Taichung 427213, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Man","family":"Cheang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Taichung Tzu Chi Hospital, Taichung 427213, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-3095","authenticated-orcid":false,"given":"Shun-Ping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biochemical Science and Technology, National Chiayi University, Chiayi City 600355, Taiwan"},{"name":"Department of Ophthalmology, Taichung Tzu Chi Hospital, Taichung 427213, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. 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